The human brain is comprised of billions of different types of cells. These cells are then organized into sophisticated networks, each of which determines a specific function of the brain. But how do the neurons, or nerve cells that form these networks, find the right network? And what happens when they don’t? To find out, […]Continue Reading ...
Researchers have succeeded in converting human skin cells into blood stem cells in an international collaboration project. “This is a first step on the way to generating fully functional blood stem cells in a petri dish which, in the future, could be transplanted into patients with blood diseases”, says Filipe Pereira, the researcher from Lund […]Continue Reading ...
Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients’ healthy tissue – often with fatal consequences. Researchers at the University of Zurich have now identified a molecule that plays a key role in this process. Blocking this molecule […]Continue Reading ...
Researchers have developed a way to grow human platelets in the laboratory from stem cells derived from fat tissue. The achievement, reported today in the journal Blood, suggests manufactured platelets could eventually reduce the reliance on donated platelets to help patients with cancer and other disorders. Platelets are a component of blood that helps with […]Continue Reading ...
Working in the lab of Craig Jordan, Ph.D., first author Courtney Jones shows that leukemia stem cells depend on amino acid metabolism, and that the drug venetoclax blocks this action, killing the cells. Credit: University of Colorado Cancer Center Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of […]Continue Reading ...
Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of your cells rip apart sugar to release the “bang” of energy. Sometimes they rip apart fats, and in a pinch, cells can even metabolize protein. Cancer cells do things a little differently. First, most cancer cells continue to depend […]Continue Reading ...
Rutgers scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer’s and Parkinson’s diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries. Stem cell transplantation, which shows promise as a treatment for central nervous system diseases, has been hampered by low cell survival rates, […]Continue Reading ...
A new study takes a close look at the content and potential implications of the new Texas law HB 810, which aims to expand assess of experimental stem cell interventions outside the realm of clinical trials under FDA oversight. HB 810 represents a new level of deregulation after the Right To Try laws and presents […]Continue Reading ...
Royal jelly — the specialized goop that honeybees use to cultivate a new queen for a hive — is legendary among elementary-school-aged science nerds. (I state this with confidence from my sample size of one.) Somehow nurse bees cultivate royalty from lowly larvae that would normally become plain Jane worker bees simply by tweaking their diet. It’s […]Continue Reading ...
Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. This breakthrough published in the journal ‘Nature’ will facilitate the manufacturing of pancreatic islet cells from stem cells and might help […]Continue Reading ...
Tracing the developmental lineage tree of HSPCs Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather the location of the mutations in the DNA is relevant. Using the mutation patterns in the hematopoietic stem and progenitor cells […]Continue Reading ...
Epigenetic therapies — targeting enzymes that alter what genes are turned on or off in a cell — are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant. Researchers at Boston Children’s Hospital now report that at least one epigenetic therapy that initially looked promising […]Continue Reading ...
Treating pre-cancerous stem cells at an early stage could be key to preventing bowel cancer in people born with a very high risk of the disease, according to a study in mice presented at the 2018 NCRI Cancer Conference. Previous research has suggested that stem cells play a key role in the development of cancer, […]Continue Reading ...
I’ve recently written here about the research tour de force that led to the identification of the human and mouse skeletal stem cell. These cells can generate bone, cartilage and the bone’s spongy interior during development and spring into action to repair fractures. Now researchers from the same lab, headed by regenerative medicine specialist and […]Continue Reading ...
You’ve probably seen the late night ads and the onslaught of cosmetic marketing – hyaluronic acid or hyaluronan, touted as the “fountain of youth,” the best moisturizer or skin plumper on the market. It turns out, this naturally occurring molecule, with high concentrations in the eyes, is necessary for creating stem cells in the limbus, […]Continue Reading ...
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