I hope that you all had a very pleasant holiday and have returned to work refreshed. I would guess, from the volume of submissions to the Drug Discovery Today EVISE site, there was a lot of desk clearing at the end of the year and a similar amount of New Year’s resolutions early in this […]Continue Reading ...
New research led by the University of Plymouth could identify how to target hypertension and other blood vessel problems — by using proteomics technology High blood pressure, or hypertension, is a leading cause of stroke and heart attacks worldwide – and one in four people have it. Now new research led by the University of […]Continue Reading ...
It’s known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. It’s further known that a major player in this pathway, YAP, drives many types of tumors. Now, researchers at Boston Children’s Hospital have solved an ongoing problem: how […]Continue Reading ...
WEDNESDAY, Sept. 26, 2018 — Many countries are falling short on targets to reduce mortality from non-communicable diseases (NCDs), according to a study published in the Sept. 22 issue of The Lancet. James E. Bennett, Ph.D., from Imperial College London, and colleagues explored worldwide trends in NCD mortality and progress toward the Sustainable Development Goal […]Continue Reading ...
David Porciani and his team demonstrated that specialized nucleic acid-based nanostructures could be used to target cancer cells while bypassing normal cells. Credit: Erica Overfelt, Bond Life Sciences Center More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the “magic bullet” concept—a method that clinicians might one day use to target invading microbes […]Continue Reading ...
August 14, 2018 More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the “magic bullet” concept — a method that clinicians might one day use to target invading microbes without harming other parts of the body. Although chemotherapies have been highly useful as targeted treatments for cancer, unwanted side effects still plague patients. […]Continue Reading ...
Reduced build-up of huntingtin protein (green) in cells from the brains of mice treated with Raphin1. Credit: Krzyzosiak et al./ Cell The new system builds on previous work by the same scientists in which they created functional synthetic versions of phosphatase proteins. These synthetic phosphatases are tethered to chips so they can be screened to […]Continue Reading ...
July 27, 2018 A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly “undruggable”. Scientists from the Medical Research Council (MRC) Laboratory of Molecular Biology, in Cambridge, UK, demonstrated the capabilities of the new system by identifying a molecule that could […]Continue Reading ...
Dec 5 2018 TARGET PharmaSolutions, Inc., a company focused on real-world evidence, is pleased to announce that Bristol Myers Squibb has entered into a strategic partnership for TARGET-IBD. TARGET-IBD is a longitudinal observational study that evaluates patients with Inflammatory Bowel Disease, including adult and pediatric patients with ulcerative colitis, Crohn’s disease and in determinate Colitis. […]Continue Reading ...
It is generally accepted that precise motor control in our daily life depends on acquisition of an internal model. One motor learning for an internal model is necessary for execution of precise movements in our daily life. There are two hypothetical internal models for motor learning: where to move (i.e. calculation of destination for a […]Continue Reading ...
Inhibition of miR-24-3p reduced growth of cancer cells and was found to regulate proteins as a potential treatment target for Mesothelioma (MPM). The new potential target, and the method researchers have used to identify it, is an important step in addressing this challenging disease. MPM is a lethal cancer with increasing worldwide incidence and resistance […]Continue Reading ...
August 14, 2018 The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology. Modern science allows us to accelerate this search through the use of computer technology and the introduction of automated processes. In the development of biologically active molecules, there are two basic concepts […]Continue Reading ...
August 10, 2018 Research published in Nature Medicine describes collaborative effort to reduce off-target CRISPR-Cas9 genome editing – removing barriers for human therapeutic applications Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects […]Continue Reading ...
By Sally Robertson, BScJuly 27, 2018 Scientists from the Medical Research Council Laboratory of Molecular Biology have used a new drug discovery system to specifically target enzymes called phosphatases, which were previously thought to be “undruggable.” Image Credit: Kateryna Kon / Shutterstock As reported in the journal Cell, the team were able to identify a […]Continue Reading ...
Scientists from the Medical Research Council (MRC) Laboratory of Molecular Biology, in Cambridge, UK, demonstrated the capabilities of the new system by identifying a molecule that could successfully target a phosphatase to reduce the accumulation of Huntington’s disease-associated proteins in the brains of mice. The findings, published in Cell, could enable scientists to screen […]Continue Reading ...
- CRISPR/Cas libraries could revolutionize drug discovery
- Allergic reaction during pregnancy may alter sexual-development in offspring’s brain
- Seeing through a robot’s eyes helps those with profound motor impairments
- Recent research shows that ease of breastfeeding after C-section differs culturally
- Newly discovered parameters offer more control over efficient release of drugs
- ‘De-tabooing’ of abortion- Women would like more support from health care community
- Anti-TB drugs can increase susceptibility to Mtb reinfection
- New survey indicates need of attention to neglected tropical diseases
- Innovative in vitro method to develop easy-to-swallow medicine for children and older people
- Sugary drinks could raise risk of early deaths finds study
- Lian wins ENGINE grant for stem-cell-based therapy to treat Type 1 diabetes
- Overall, Physicians Are Happy and Enjoy Their Lives
- Researchers discover how blood vessels protect the brain during inflammation
- CDC study shows modest improvement in optimal hospital breastfeeding policy
- Family-based prevention program to reduce alcohol use among older teens
- Remote monitoring of implanted defibrillators in heart failure patients prevents hospitalizations
- Appropriate doffing of personal protective equipment may reduce healthcare worker contamination
- Window screens can suppress mosquito populations, reduce malaria in Tanzania
- Researchers discover new biomarker for postoperative liver dysfunction
- Pregnancy history may be linked to cognitive function in older women, finds study