July 18, 2018 Osaka University-led study shows how a high-fat diet and systemic inflammation contribute to prostate cancer progression Osaka – Inflammation and evasion of the immune system have been reported to be some of the new hallmarks of cancer. Notably, a high-fat diet (HFD) causes obesity and chronic inflammation, and studies conducted on mice […]Continue Reading ...
“These circulating tumor cells are so few that if you just take a regular blood sample, those test tubes likely won’t even have a single circulating tumor cell in them,” said Gambhir, the Virginia and D.K. Ludwig Professor of Clinical Investigation in Cancer Research. It would be like searching for a grain of sand in […]Continue Reading ...
July 3, 2018 Using sound waves, an international team of researchers has developed a gentle, contact-free method for separating circulating tumor cells from blood samples that is fast and efficient enough for clinical use. Circulating tumor cells (CTCs) are small pieces of a tumor that break away and flow through the bloodstream. They contain a […]Continue Reading ...
July 2, 2018 Scientists have discovered that cancerous cells in an aggressive type of childhood brain tumor work together to infiltrate the brain, and this finding could ultimately lead to much needed new treatments, according to a new study published in Nature Medicine today (Monday). In the study, funded by Cancer Research UK with support […]Continue Reading ...
June 29, 2018 Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. In this review, the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy is discussed in relation to immune check point inhibitors, regulatory T cells (Treg), […]Continue Reading ...
June 26, 2018 Researchers in Sweden have shown how data-driven AI could contribute to a better understanding of how prostate cancer develops, and even improve clinical diagnosis and treatment of the disease. Every cancer tumor is unique, with characteristics that change over time. This so-called heterogeneity is due to competing clones within a given tumor, […]Continue Reading ...
June 26, 2018 A novel, intelligent theranostic agent for precise tumor diagnosis and therapy has been developed that remains as small molecules while circulating in the bloodstream, can then self-assemble into larger nanostructures in the tumor, and be activated by the tumor microenvironment for therapy guided by photoacoustic imaging. The research was presented at the […]Continue Reading ...
June 20, 2018 A type of highly malignant brain tumor contains a large number of cells involved in the formation of new blood vessels, helping it proliferate and spread. Targeting these cells could hinder tumor growth, according to new research published in the Pertanika Journal of Science & Technology. Astrocytomas are tumors that can be […]Continue Reading ...
July 11, 2018 Researchers from the University of California San Diego have identified an unexpected mechanism that could help determine whether a cancer patient will respond to immunotherapy. Ideally, the immune system identifies tumors as threatening elements and deploys immune cells (T cells) to find and kill them. However, tumor cells have evolved to employ […]Continue Reading ...
July 4, 2018 A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children’s of Alabama. The findings, presented today at the International Symposium on Pediatric Neuro-Oncology in Denver, also showed preliminary evidence of […]Continue Reading ...
July 2, 2018 Tumors that develop at the transition of the stomach to the esophagus, so-called adenocarcinomas of the gastroesophageal transition (AEG), are still difficult to treat and the chances of recovery are still low. Researchers at the Comprehensive Cancer Center of MedUni Vienna and AKH Vienna have now been able to show that patients […]Continue Reading ...
June 29, 2018 So-called “hot” tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to “cold” tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists–until now. A team from Penn Medicine’s Abramson Cancer Center (ACC) discovered that whether a tumor is hot or […]Continue Reading ...
June 26, 2018 A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors (NETs). Lutathera-177 (177Lu)-DOTATATE (trade name Lutathera), a peptide receptor radionuclide tharapy (PRRT) with […]Continue Reading ...
June 21, 2018 Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report. Adoptive T cell therapy appears to reprogram the metabolism of tumor cells, increasing their level of reactive oxygen species, or ROS, and their destruction, […]Continue Reading ...
June 11, 2018 A protein in the cell nucleus already targeted therapeutically for several types of cancer has now been linked to an aggressive form of pediatric liver cancer called hepatoblastoma (HBL), according to a study published in the Nature journal Communications Biology. Scientists at Cincinnati Children’s Hospital Medical Center conducted extensive biological and genetic […]Continue Reading ...
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