A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself. The recombinant protein molecule SA-4-1BBL has been used to enhance the therapeutic efficacy of cancer vaccines with success in pre-clinical animal […]Continue Reading ...
Around a glioblastoma, a very aggressive brain tumor, cells of the human immune system start helping the tumor instead of attacking it. To do research on what happens in the interaction of these cells, scientists of the University of Twente now created a 3D-bioprinted mini model of the brain. Compared to existing lab models, the […]Continue Reading ...
Credit: CC0 Public Domain A Massachusetts General Hospital (MGH)-led research team has demonstrated, for the first time, how solid stress—the physical forces exerted by the solid components of a tumor—impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death. In their report published in Nature Biomedical Engineering, the investigators […]Continue Reading ...
Following up on a groundbreaking 2018 study in which BIDMC’s Dipak Panigrahy, MD, demonstrated that dead and dying cancer cells killed by conventional cancer treatments paradoxically trigger inflammation that promotes tumor growth and metastasis, a new study led by Allison Gartung, PhD, describes a novel approach to suppressing chemotherapy-induced tumor growth in an ovarian cancer […]Continue Reading ...
Research led by Suresh Alahari, PhD, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has found a new role for a protein discovered by his lab in preventing the growth and spread of breast cancer. The results of the study, which could have a significant impact […]Continue Reading ...
Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called ‘neoadjuvant’ therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the surgeon to remove. In those cases, the patients are very […]Continue Reading ...
The importance of research into the role of the immune system in the development and therapy of oncological diseases was emphasized by the Royal Swedish Academy, which recently named James Allison and Tasuku Honjo recipients of the 2018 Nobel Prize in Physiology or Medicine for launching an effective new way to attack cancer by treating […]Continue Reading ...
Instead of tackling tumors head-on, an international team of researchers from the University of Geneva (UNIGE) and the Amsterdam UMC, location VUmc in Amsterdam has chosen to regulate their vascularization by intervening with cellular receptor that is overexpressed specifically in cancer blood vessels. By acting on the development of the blood vessels within the tumor, […]Continue Reading ...
Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma (GBM) progression by shutting down immune surveillance, indicating a potential new area of therapeutic investigation. Findings from the preclinical study led by Shulin Li, Ph.D., professor of Pediatrics, and Amy Heimberger, M.D., professor of Neurosurgery, […]Continue Reading ...
Researchers at the University of Toronto have discovered mutational signatures of tumor hypoxia (low oxygen) in 19 cancer types. The results could be used to help clinicians identify patients who would benefit from higher treatment doses. m63085 | Shutterstock In a landmark pan-cancer study analyzing more than 8,000 tumors across 19 different cancer types, researchers […]Continue Reading ...
It’s one of the first questions asked by many newly-diagnosed cancer patients–“What are my chances of beating this?” Often there is no clear answer, with survival rates differing widely depending on the cancer stage and available treatment options. However, post-operative testing that provides an accurate prediction of long-term treatment outcomes is the next best thing […]Continue Reading ...
A Massachusetts General Hospital (MGH)-led research team has demonstrated, for the first time, how solid stress – the physical forces exerted by the solid components of a tumor – impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death. In their report published in Nature Biomedical Engineering, the investigators […]Continue Reading ...
What Is Medulloblastoma? Medulloblastoma (meh-dull-oh-blass-TOE-muh) is a cancerous type of brain tumor. It develops in the cerebellum, a part of the brain near the bottom of the skull. Medulloblastoma can spread to the central nervous system (the brain and spinal cord). Most brain tumors in children are medulloblastoma. What Are the Signs & Symptoms of […]Continue Reading ...
Ohio researchers pioneer new computer imaging method to detect likelihood of cancer based on changes in blood vessels and regions outside tumor Scientists in Anant Madabhushi’s computational imaging lab at Case Western Reserve University have started thinking outside the box–or in their case, looking outside the tumor. They’re hoping that this novel computerized approach represents […]Continue Reading ...
Scientists at the Wake Forest Institute for Regenerative Medicine (WFIRM) have recently developed a process that may change the way cancer of the appendix is treated in the future. Researchers at WFIRM, in collaboration with the Department of Surgery – Surgical Oncology at Wake Forest Baptist Medical Center, have created a patient-specific tumor ‘organoid’ model […]Continue Reading ...
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