WHIPPANY, N.J., Oct. 21, 2018 /PRNewswire/ — Bayer and Loxo Oncology, Inc. (Nasdaq: LOXO), today announced updated clinical data for larotrectinib in adult and pediatric patients with TRK fusion cancer across 24 unique tumor types. The update included approximately one year of additional follow-up for a primary dataset of 55 patients as well as results […]Continue Reading ...
Scientists are making strides in developing liquid biopsies for brain tumors by detecting tumor DNA in the fluid from around the brain and spine. Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumor biopsies. A less intrusive test […]Continue Reading ...
Nanosystems that deliver anticancer drugs or imaging materials to tumors are showing significant progress, particularly those that respond to tumor-related stimuli, according to a review published in the journal Science and Technology of Advanced Materials. However, further research is still required to make sure these delivery systems are stable, non-toxic and biodegradable. Nanocarriers designed to […]Continue Reading ...
Oct 19 2018 An interview with Dr. Andrew Ewald, Ph.D., discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis. What is the tumor microenvironment and how is it linked to metastasis? The tumor microenvironment is a general term describing all the things that are a part of the […]Continue Reading ...
A new blood test for children with brain tumors offers a safer approach than surgical biopsies and may allow doctors to measure the effectiveness of treatment even before changes are identified on scans, according to research led by UCSF Benioff Children’s Hospitals and Children’s National Health System. Unlike a standard brain biopsy, which entails drilling […]Continue Reading ...
Changes in any of several genes are involved in the formation of Wilms tumor. Wilms tumor is often associated with mutations in the WT1 gene, CTNNB1 gene, or AMER1 gene. These genes provide instructions for making proteins that regulate gene activity and promote the growth and division (proliferation) of cells. WT1, CTNNB1, and AMER1 gene […]Continue Reading ...
U of T scientists use nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer Scientists at the University of Toronto’s Leslie Dan Faculty of Pharmacy have seen remarkable success combining tumor modulating nanoparticles with doxorubicin to enhance chemotherapy response in pre-clinical model breast cancer. This combination approach also appears to boost anti-tumor […]Continue Reading ...
FLX Bio, Inc., a clinical-stage, biopharmaceutical company focused on the development of oral small-molecule drugs that target drivers of cancer and other immune-related disorders, today announced that the first patient has been treated in its Phase 1/2 clinical trial of FLX475 in patients with various advanced cancers. FLX475 is an oral, small molecule CCR4 antagonist […]Continue Reading ...
Instead of destroying a tumors’ blood supply, a first-ever University of Guelph study has proven that opening up the vessels is potentially more effective when it comes to fighting ovarian cancer. This is because open vessels provide a clear pathway for treatment to attack the tumor. “There hasn’t been much hope for women with ovarian […]Continue Reading ...
Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered a method by which fibroblasts surrounding pancreatic cancer cells can be reprogrammed to suppress, rather than promote, tumor cell growth. Image Credit: CSHL, 2018 The research was published today in the journal Cancer Discovery, and details a signaling pathway in pancreatic tumors that could help them […]Continue Reading ...
Researchers at La Jolla Institute for Immunology (LJI) and UC San Diego have been awarded $ 4.5 million as part of the National Cancer Institute’s Cancer Moonshot initiative. The funding will support research to develop new and improved immunotherapeutic treatment options for patients with head and neck cancer. Led by LJI Professor Stephen Schoenberger, Ph.D., […]Continue Reading ...
Oct 15 2018 One of the biggest challenges facing surgeons carrying out the removal of a brain tumor is working out how much of it they can remove without damaging the patient’s life afterwards. A wrong decision can leave people unable to speak, move or think clearly. Now, scientists at the University of Cambridge are […]Continue Reading ...
Resistance to therapy is a major problem in cancer patients as the cells that resist to therapy is at the root of tumor relapse and is associated with high morbidity and mortality. A better understanding of the mechanisms associated with resistance to therapy is essential for the development of better strategies to definitively eradicate cancer […]Continue Reading ...
A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 1 in […]Continue Reading ...
A malignant tumor is characterized by its ability to spread around its surroundings. To do so, tumor cells stick to the surrounding tissue (mainly collagen) and use forces to propel. The journal Nature Physics published a study by a team led by Xavier Trepat, ICREA researcher at the Institute for Bioengineering of Catalonia (IBEC) and […]Continue Reading ...
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