Breaking News
October 22, 2017 - Gung Ho for Green Tea
October 22, 2017 - Cancer mortality rates continue to drop, according to national report
October 22, 2017 - Early Statin in Stroke; 'Chinese Finger Trap' Valve; Disasters Hurt Vasculature, Too
October 22, 2017 - Lifelong Asthma Struggle: NIH Study Helps Jeff Long Battle Illness
October 22, 2017 - Legalising marijuana can increase use: French study
October 22, 2017 - FDA Approves 2nd Gene Therapy
October 22, 2017 - A quarter of nursing home residents are colonized with drug-resistant bacteria
October 22, 2017 - Gestational Diabetes Ups Long-Term CVD Risk (CME/CE)
October 22, 2017 - Genetics Home Reference: age-related hearing loss
October 22, 2017 - Tracing cell death pathway points to drug targets for brain damage, kidney injury, asthma
October 22, 2017 - Does Your Dog 'Talk' to You?
October 22, 2017 - Are e-cigarettes bad for the heart? Study sheds light
October 22, 2017 - ACG: Half of Gastro Docs Experience Burnout
October 22, 2017 - A Journey with Mid-Life Hearing Loss: Don't Wait to Seek Help for Hearing Issues
October 22, 2017 - Peruvian congress approves legalization of medicinal pot
October 22, 2017 - Most Americans Shouldn't See Big Rise in Obamacare Premiums
October 22, 2017 - Zinc may help to prevent, treat esophageal cancer
October 22, 2017 - Morning Break: Record Year for FDA? Bogus Doc Nets $25 Million; Team Doc as Molester
October 22, 2017 - Chicken and Food Poisoning
October 22, 2017 - NY State Medicaid expansion widened racial gap in access to high-quality cancer surgery
October 22, 2017 - Even a Little Walking Can Lengthen Your Life
October 22, 2017 - Cancer drugs that halt tumors can also shrink them
October 22, 2017 - In RA, COPD Admissions Rise (CME/CE)
October 22, 2017 - Love and Life without Gluten
October 22, 2017 - Women can be just as daring and risky as men, new studies show
October 22, 2017 - Study unlocks complexities of cell death process that plays key role in health and disease
October 22, 2017 - Dana-Farber, Brigham and Women's Cancer Center certified to offer new CAR T-cell therapy
October 22, 2017 - ObesityWeek: Effective approaches to prevent and treat pediatric obesity
October 21, 2017 - Health Highlights: Oct. 19, 2017
October 21, 2017 - Spondyloarthritis: Symptoms, treatments, and causes
October 21, 2017 - New Guidelines a Boon for Skin Cancer Staging
October 21, 2017 - Future of Asthma Monitoring
October 21, 2017 - A new form of psychotherapy for suicidal patients
October 21, 2017 - Health Tip: Protect Yourself Against Breast Cancer
October 21, 2017 - Adult-onset Still's disease: Symptoms, diagnosis, and treatment
October 21, 2017 - Opioid Not Best Migraine Choice (CME/CE)
October 21, 2017 - Don't Let Asthma Define You: Sylvia Granados-Maready Uses Her Competitive Edge Against Condition
October 21, 2017 - How parents can improve the car ride home with young athletes
October 21, 2017 - Injectable Products by SCA Pharmaceuticals: Recall – Potential Contamination
October 21, 2017 - Donating plasma: What are the side effects and risks?
October 21, 2017 - Do Obesity and Depression Have Immunometabolic Ties? (CME/CE)
October 21, 2017 - Newer Blood Thinners May Not Bring Higher Bleeding Risk
October 21, 2017 - Investigating the most common genetic contributor to Parkinson's disease
October 21, 2017 - Health Tip: Don't Spread Infectious Disease
October 21, 2017 - Bipolar disorder: Brain mechanism could be key for prevention
October 21, 2017 - Pregnant RA Patients Often Stop Biologic Tx: Study (CME/CE)
October 21, 2017 - Be Wary of Shopping for Pet Meds Online
October 21, 2017 - Newly described process in Parkinson's protein as a potential new therapy route
October 21, 2017 - HPV Vaccine Safe for Adult Women: Study
October 21, 2017 - Osteoporosis: Biology behind age-related bone loss revealed
October 21, 2017 - Hormone Tx Promising for Preventing Women's Midlife Depression
October 21, 2017 - The Upsides and Downsides of Telecommuting
October 21, 2017 - Engineered protein treatment found to reduce obesity in mice, rats and primates
October 21, 2017 - New Genes Linked to Restless Legs Syndrome
October 21, 2017 - No relief in sight for those suffering from sciatica
October 21, 2017 - 'This Is About Saving Lives': What We Heard This Week
October 21, 2017 - 3 Million Americans Say They Carry Handguns Every Day
October 21, 2017 - Night shift work linked to an increased risk of obesity
October 21, 2017 - Avoiding Alcohol Helps the Heart Beat Better
October 21, 2017 - Exposure to heavy metals may increase risk of autism
October 21, 2017 - Derms: Oral Contraceptives as Acne Tx Warrant Caution
October 21, 2017 - How Foods Labeled 'Healthy' Can Still Make You Fat
October 21, 2017 - ALS patient behind ice bucket challenge: I will bounce back
October 21, 2017 - FDA Advisory Committee Unanimously Recommends Approval of Investigational Luxturna (voretigene neparvovec) for Patients with Biallelic RPE65-mediated Inherited Retinal Disease
October 21, 2017 - Household bleach may raise chronic lung disease risk
October 21, 2017 - Patient Care vs Primary Care: Is There a Problem Here?
October 21, 2017 - State Laws Help Reduce Concussions in Youth Sports
October 21, 2017 - Study indicates proof of concept for using a surrogate liquid biopsy to provide genetic profile of retinoblastoma tumors
October 21, 2017 - Story-based videos hold promise for encouraging Latinas to seek help for anxiety and depression
October 21, 2017 - Study identifies predictors of poor outcomes in Duchenne muscular dystrophy patients
October 21, 2017 - New study explores how herpes simplex virus may change during familial transmission
October 21, 2017 - Researchers analyze frequency of mislabeling in herbal and dietary supplements
October 21, 2017 - Direct‐acting antiviral therapy linked to 71% reduction in liver cancer risk
October 21, 2017 - NAFLD linked to higher cardiovascular risk in women, but not in men
October 21, 2017 - Study finds increasing health care costs for patients with alcoholic cirrhosis
October 21, 2017 - Liver cirrhosis mortality found to be greater than that of five major cancers
October 21, 2017 - VUMC reaches new milestone after performing 2,000th liver transplant
October 21, 2017 - Study examines risk of using liver organs from hepatitis C positive donors
October 21, 2017 - Daily aspirin therapy linked to reduced risk of HBV‐related liver cancer
October 21, 2017 - Increased use of split liver transplantation could decrease pediatric waitlist deaths
C-section kids could be at greater risk of being overweight due to differences in their gut bacteria

C-section kids could be at greater risk of being overweight due to differences in their gut bacteria

image_pdfDownload PDFimage_print

Researchers from NYU School of Medicine studied the effects of Caesarean section on the weights of the offspring in laboratory mice and found that they are more at risk of becoming overweight and obese.

They noted that mice that were born via C section gained 33 percent more weight on an average in 15 weeks after they were weaned compared to mice that were born vaginally. Female offspring were found to gain 70 percent more weight. The study was published online in Science Advances yesterday.

The team of researchers looked at the differences in the gut bacteria or the microbiome that lives within the intestines and provide animals with assistance in immunity, metabolism and digestion. They speculated that there might be alterations in these gut bacteria due to the advent and rise of antibiotic therapy as well as due to C-sections. And they decided to see if this had anything to do with the rising rates of obesity. The World Health Organization estimates that Caesarean sections are needed in around 15 percent of births due to risks posed to the baby and the mother. However actual numbers show that one in two babies are born via C-Section in several countries notably Dominican Republic, Brazil and Iran explain these researchers.

New baby being born during cesarean section. Image Credit: Chattapat / Shutterstock

New baby being born during cesarean section. Image Credit: Chattapat / Shutterstock

Human studies in the past have shown connections between C-sections and obesity. The whys and wherefores of this has not been explored and microbiome as the reason for this has also not been explored. This study was an attempt to understand this connection.

The researchers explain that the maternal microbes are transmitted to the babies as they are born vaginally and these microbes help teach the developing immune systems of the baby. Lead researcher and microbiologist Maria Dominguez-Bello, PhD, associate professor in the Department of Medicine at NYU School of Medicine, explained that this was the first study that showed that there was a direct association between C-section and increased body weight in mammals. She added that because the number of caesarean sections are on the rise, the effects of these on obesity becomes more and more important.

For this study the team chose 34 laboratory mice that were delivered by C-section and compared them with 35 mice that were born vaginally. They then checked on the weight gain of these mice and simultaneously used genomic techniques to analyse the DNA of the various gut bacteria that these mice were carrying since their birth up to their adulthood. Earlier studies provided a template of which bacteria normally colonize the guts of mice pups. Now they compared the gut bacteria of the mice born either by C-section or vaginally.

Their study revealed that the mice that were born via C section put on more weight and also had a significantly different gut bacteria. Gender did not play a role in these differences. Mice that were born normally with time had a normally maturing gut bacteria. Among mice born surgically, the microbiome developed rapidly initially but later in life they became relatively immature. Bacterial groups that are found more commonly among babies delivered vaginally include Bacteroides, Ruminococaceae, and Clostridiales. Earlier studies have shown that these bacteria are associated with lean body weight.

Dominguez-Bello is also leading a pilot study that checks for changes in the gut microflora and associates it with weight gain and obesity. That study found that if the babies born surgically could be swabbed with the mother’s birth canal fluids, they could get the bacteria that they would have if delivered via the vagina. More research is needed to this end to check if this is really feasible and holds true for large populations.

Source:

http://advances.sciencemag.org/content/3/10/eaao1874

729fa786-6d99-4577-9107-a9f76de904a4|0|.0

Posted in: Child Health News | Medical Research News

Tags: Antibiotic, Bacteria, Cesarean Section, C-section, Digestion, DNA, Genomic, Laboratory, Metabolism, Microbiome, Obesity, Vagina

Tagged with:

About author

Related Articles