Breaking News
December 15, 2017 - How well can digital assistants answer questions on sex?
December 15, 2017 - NIH-funded study to explore hearing loss risk in Detroit firefighters
December 15, 2017 - Caris Life Sciences reveals identification of new mechanism of action to treat NHL
December 15, 2017 - Loyola Medicine study finds high success rate for diabetic Charcot foot surgery
December 15, 2017 - Bone marrow edema does not increase due to intense physical activity, study finds
December 15, 2017 - Human ‘common cold’ virus kills healthy chimpanzees in Uganda
December 15, 2017 - Experience of reflex walking refines perception of biological motion during early infancy
December 15, 2017 - FDA Approves Admelog (insulin lispro) Rapid-Acting “Follow-On” Insulin Product to Treat Diabetes
December 14, 2017 - Friday Feedback: Good Idea for Ex-Pharma Exec to Run HHS?
December 14, 2017 - More than 200 people sickened onboard Ovation of Seas cruise
December 14, 2017 - FDA announces new approach for sharing updates on antibiotics, antifungal drugs to physicians
December 14, 2017 - Steroid study provides new insights into medicines’ side effects
December 14, 2017 - Government announces plans to include eye test reminder during driving license renewal
December 14, 2017 - Non-ionizing radiation from magnetic fields could have adverse biological impacts on health
December 14, 2017 - Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk
December 14, 2017 - Researchers develop new method for quickly detecting signs of multiple sclerosis
December 14, 2017 - In era of increased competition, hospitals fret over ratings
December 14, 2017 - Female veterans experience improvement in low back pain with course of chiropractic care
December 14, 2017 - Relieving Symptoms of Cystic Fibrosis with Exercise
December 14, 2017 - FDA Alert: Blue Pearl All Natural Male Enhancement Supplement: Recall
December 14, 2017 - CardioBrief: In Defense Of ORBITA
December 14, 2017 - Definition of High Blood Pressure Drops: MedlinePlus Health News
December 14, 2017 - Drug may help surgical patients stop opioids sooner
December 14, 2017 - Researchers develop biosensor that enables development of new health tests
December 14, 2017 - Radiation therapy can be used to treat patients with life-threatening heart rhythm
December 14, 2017 - UVA researchers developing tool to help prostate cancer patients weigh treatment options
December 14, 2017 - Experts tell Congress how to cut drug prices
December 14, 2017 - Researchers use cryptographic techniques to decode activity of motor neurons
December 14, 2017 - Study finds changes in the heart after spinal cord injury
December 14, 2017 - Health Highlights: Dec. 12, 2017
December 14, 2017 - Pelzman’s Picks: How States Can Cut Disparities in Care and Costs
December 14, 2017 - New Hemophilia Treatment Stems Bleeding Episodes: MedlinePlus Health News
December 14, 2017 - Onetime ‘world’s heaviest man’ has second surgery in Mexico
December 14, 2017 - Belgian researchers create transplantable artificial ovary prototype
December 14, 2017 - Using atraumatic needles for lumbar punctures decreases risk of complications
December 14, 2017 - Outpatient total knee replacement surgery linked to higher rates of complications
December 14, 2017 - Social impairments can be corrected by brain stimulation
December 14, 2017 - Studies reveal possibility for memory T cells to serve a dual purpose
December 14, 2017 - Antibody-Drug Conjugate Ups PFS in Untreated Hodgkin’s
December 14, 2017 - Study finds reading information aloud to yourself improves memory
December 14, 2017 - Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies
December 14, 2017 - Living Lyme disease bacteria found months after antibiotic treatment
December 14, 2017 - These annual checkups help seniors not only survive but thrive
December 14, 2017 - Study reveals impact of diabetes during pregnancy on baby’s heart
December 14, 2017 - Hydraulic fracturing is harmful to infants health, study states
December 14, 2017 - Huntington’s disease drug clears initial hurdles
December 14, 2017 - TPU researchers create 3D-printed models of children’s hearts
December 14, 2017 - Brain responses of children with inherited dyslexia risk predict their future reading speed
December 14, 2017 - People diagnosed with schizophrenia or bipolar disorder may actually have treatable condition
December 14, 2017 - Study: New Furosemide Formulation Simplifies Administration for HF
December 14, 2017 - Discrimination harms your health—and your partner’s
December 14, 2017 - Having older brothers may increase the likelihood of being gay
December 14, 2017 - New scientific yardstick released to help early detection of Alzheimer’s disease
December 14, 2017 - New finding demonstrates what happens at cellular level during onset of type2 diabetes
December 14, 2017 - Study identifies potassium as key to circadian rhythms in red blood cells
December 14, 2017 - Good friends might be your best brain booster as you age
December 14, 2017 - NIH expected to award up to $70 million to launch Alzheimer’s Clinical Trials Consortium
December 14, 2017 - Pitting pathogens against each other could prevent drug resistance emerging
December 14, 2017 - Study provides new insights into development of Sonic Hedgehog medulloblastoma
December 14, 2017 - Dr. Reddy’s Announces Approval of Impoyz (clobetasol propionate) Cream for Plaque Psoriasis
December 14, 2017 - Gene Screens Can Alter Perception, Behavior
December 14, 2017 - Can Scrotal Vein Condition Hike Heart Risks?: MedlinePlus Health News
December 14, 2017 - Molecules in spit may be able to diagnose and predict length of concussions
December 14, 2017 - Children’s Colorado and RxRevu partner to help prescribers better meet needs of pediatric patients
December 14, 2017 - Researchers discover new way to attack drug-resistant prostate cancer cells
December 14, 2017 - Scientists develop new, high resolution method for identifying microbial species and strains
December 14, 2017 - Declining trend of salmonellosis cases has leveled off in the EU
December 14, 2017 - Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes
December 14, 2017 - How to Perk Up the Holidays for Hospital Patients
December 14, 2017 - Prolonged Sedation May be Bad for Baby’s Brain
December 14, 2017 - The pediatric submersion score predicts children at low risk for injury following submersions
December 14, 2017 - Video game helps doctors to quickly recognize trauma patients who need high levels of care
December 14, 2017 - Younger persons newly-diagnosed with type 2 diabetes have poorer health than older patients
December 14, 2017 - Clinician re-examines evidence on re-use of catheters and UTIs in people with spinal cord injuries
December 14, 2017 - UK and Russian researchers join forces against AMR
December 14, 2017 - Results of Bariatric Surgery Hold Up Over Time
December 14, 2017 - High-intensity exercise delays Parkinson’s progression
December 14, 2017 - Protein structure could pave way for effective drugs to treat cystic fibrosis
December 14, 2017 - Minority people less likely to see dermatologist for psoriasis treatment
December 14, 2017 - Study indicates decline in use of chemotherapy for early stage breast cancer patients
The skinny on lipid immunology

The skinny on lipid immunology

image_pdfDownload PDFimage_print
T-cell Receptors (gold, upper) on the surface of T-cells selectively bind the lipid antigen presenting molecule on dendritic cells, CD1b (lower), presenting a rare cellular phospholipid (gold), over common phospholipids found in membranes (pink, cyan and green), which in turn induces an autoimmune response. Credit: Shahine et al.

Phospholipids – fat molecules that form the membranes found around cells – make up almost half of the dry weight of cells, but when it comes to autoimmune diseases, their role has largely been overlooked. Recent research has pointed to a role for them in numerous diseases, including psoriasis, contact hypersensitivities and allergies. In a new study published in Science Immunology, researchers from Brigham and Women’s Hospital and Monash University in Australia reveal new insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases.

“Lipids have been under appreciated in immunology,” said co-corresponding author D. Branch Moody, MD, a principal investigator in the Division of Rheumatology, Immunology and Allergy. “We’ve been interested in autoimmune diseases for decades, and it’s thought that in certain autoimmune diseases like psoriasis, multiple sclerosis and type 1 diabetes are driven by particular tissues. The search for the particular molecules, known as antigens, that trigger autoimmune diseases has focused on proteins and peptides, but we should also be thinking about lipids as candidate antigens for autoimmune disease.”

For 30 years, researchers have known that T cells play an important role in autoimmune disorders, but it was thought that T cells could only respond to proteins. Previous studies conducted by investigators at the Brigham provided the first hint that a T cell could also respond to lipids. The newly published study suggests that many T cells can respond lipids, and illuminates the physical structures that make this recognition of lipids possible.

T cells are activated when another key part of the immune system, dendritic cells, present them with an antigen. Moody and his colleagues, Ildiko Van Rhijn and Tan-yun Cheng, set out to detect what molecules were being captured and presented, stimulating a T cell response. Using structural biology, Jamie Rossjohn and Adam Shahine of the Australian Research Council Centre of Excellence in Advanced Molecular Imaging at Monash University in Australia showed how a protein on the surface of dendritic cells – known as CD1b – binds to lipids. This complex of CD1b and a lipid then binds to a T cell receptor, activating an immune response.

“The advanced imaging facilities of the Australian Synchrotron have allowed us to generate three-dimensional models of T-cell receptor interaction against CD1b and lipid antigens,” said Shahine. “These results highlight the role of CD1b in a phospholipid-mediated immune response, and grant us a deeper understanding of the mechanisms of lipid-based autoimmune disease.”

The work may have implications for specific forms of autoimmune disease, including systemic lupus erythematosus. Previous studies have found that patients with lupus have antibodies that bind to phospholipids, which cause clotting and strokes. The new study shows that T cells also recognize phospholipids, opening up new perspectives on T cell and antibody cooperation in this disease.

“We now have these beautiful, three-dimensional images of how three different molecules can interact, which explains some detail about which part of the lipid matters. Knowing the precise structure of the complexes involved in this process could be useful for designing new kinds of lipids that could turn on or off the immune response,” said Moody.


Explore further:
Researchers find mechanism for precise targeting of the immune response

More information:
Science Immunology (2017). DOI: 10.1126/sciimmunol.aao1384

Journal reference:
Science Immunology

Provided by:
Brigham and Women’s Hospital

Tagged with:

About author

Related Articles