Breaking News
June 17, 2018 - Sunovion Announces FDA Acceptance of New Drug Application for Apomorphine Sublingual Film (APL-130277)
June 17, 2018 - Bid to beat obesity focuses on fat that keeps us warm
June 17, 2018 - Work Stress May Increase Risk of Developing Atrial Fibrillation
June 17, 2018 - New Zealand’s secret recipe for active school travel: The neighborhood built environment
June 17, 2018 - New Medscape report reveals sexual harassment rate of physicians
June 17, 2018 - Surgical Blood Transfusions Tied to Clot Risk
June 17, 2018 - CDC chief makes $375K, far exceeding his predecessors’ pay
June 17, 2018 - Education linked to higher risk of short-sightedness
June 17, 2018 - Patients with Moderate-to-Severe Ulcerative Colitis Achieved Clinical and Endoscopic Remission with Mirikizumab in Phase 2 Trial
June 17, 2018 - UA registers a more customised multifocal lens to correct presbyopia
June 17, 2018 - U.S. FDA and European Medicines Agency Accept Regulatory Submissions for Review of Talazoparib for Metastatic Breast Cancer Patients with an Inherited BRCA Mutation
June 17, 2018 - Vaginal estrogen tablets, moisturizers and placebo gel all can improve vaginal discomfort
June 17, 2018 - Addition of Bezafibrate Beneficial in Primary Biliary Cholangitis
June 17, 2018 - Radiation Therapy for Cancer – National Cancer Institute
June 17, 2018 - Technology could help pregnant women detect health complications
June 17, 2018 - Study finds drop in frequent use of ED after Affordable Care Act
June 17, 2018 - Do Antipsychotic Meds for Kids Raise Diabetes Risk?
June 17, 2018 - New light shed on mechanisms of paediatric epilepsy
June 17, 2018 - People who deeply grasp the pain or happiness of others also process music differently in the brain
June 16, 2018 - Scientists discover how cancer-targeting ‘Natural Killer’ cells are fueled in the body
June 16, 2018 - New England Journal of Medicine Publishes Pivotal Cemiplimab Trials Showing Positive Results in Advanced Cutaneous Squamous Cell Carcinoma
June 16, 2018 - Annual Report to the Nation: overall cancer mortality continues to decline, prostate cancer mortality has stabilized
June 16, 2018 - Ibuprofen, acetaminophen more effective than opioids in treating dental pain
June 16, 2018 - Intra-Cellular Therapies Initiates Rolling Submission of New Drug Application for Lumateperone for Treatment of Schizophrenia
June 16, 2018 - Price competition for generic drugs linked to increase in manufacturing-related recalls
June 16, 2018 - Researchers develop biomimetic nanosystem to deliver therapeutic proteins to target tumors
June 16, 2018 - Negative Pressure Wound Tx No Benefit for Lower Limb Open Fx
June 16, 2018 - Should I Get Screened for Prostate Cancer?
June 16, 2018 - Biochemist, physicist team to see antibacterial TCS deform mitochondria
June 16, 2018 - New 2D Superresolution mode for ZEISS Airyscan offers higher resolution in live cell imaging
June 16, 2018 - Money Spurs Those With Heart Disease to Step Lively
June 16, 2018 - Lower Dose of Prostate Cancer Drug with Food
June 16, 2018 - New findings demonstrate how the food we eat affects biochemical signals in the gut
June 16, 2018 - Scientists develop method to determine metabolic activity of neural networks
June 16, 2018 - Topical gel may lower breast cancer risk in women with dense breast tissue
June 16, 2018 - Research team diagnoses asthma with nasal brush test
June 16, 2018 - Dacomitinib Shows More than Seven-Month Improvement in Overall Survival Compared to an Established Therapy in Advanced NSCLC with EGFR-Activating Mutations
June 16, 2018 - Novel PET imaging noninvasively pinpoints colitis inflammation
June 16, 2018 - New clinical trial of MS drug will be first to recognize needs of wheelchair users
June 16, 2018 - Evoke Announces FDA Submission of New Drug Application for Gimoti
June 16, 2018 - New study links gray hair with immune system activity and viral infection
June 16, 2018 - Various E-cigarette flavorings may increase risk of cardiovascular disease
June 16, 2018 - Research sheds light on pathways involved in transmitting itch sensations from skin to brain
June 16, 2018 - Eminent biologist resigns over allegations of gender discrimination and sexual harassment
June 16, 2018 - Consuming sugary soft drinks can make you fat
June 16, 2018 - CDC: Preterm Births Increased in United States During 2014-2016
June 16, 2018 - Adolescents with hay fever have higher rates of anxiety and depression, lower resistance to stress
June 16, 2018 - Metabolic process providing energy to heart muscle fails to mature in babies with hypertrophy
June 16, 2018 - TU Graz researchers manipulate enzymes to build ring-shaped molecular structures
June 16, 2018 - Looking Good! Plastic Surgery for Men Surges
June 16, 2018 - Discovery of how HIV hedges its bets opens the door to new therapies
June 15, 2018 - Researchers evaluate left ventricular systolic function after pulmonary valve replacement
June 15, 2018 - New resource launched based on first-hand experiences of premature baby loss
June 15, 2018 - About Teen Pregnancy | Teen Pregnancy | Reproductive Health
June 15, 2018 - In southern Mozambique, one out of three people diagnosed with HIV do not disclose their status
June 15, 2018 - Researchers discover genomic characteristics that define testicular germ cell cancer
June 15, 2018 - Engineers create first 3D computer model to show breast duct development
June 15, 2018 - ANU scientists invent new system that could help crack down on illegal drug trade
June 15, 2018 - Study shows remarkable plasticity of the brain in finding work-arounds after catastrophic injuries
June 15, 2018 - Study finds higher response to anti-PD1 immunotherapy in older melanoma patients
June 15, 2018 - New Data from Phase 1 Study of Ivosidenib or Enasidenib in Combination with Azacitidine Demonstrate Robust Responses and a Well Tolerated Safety Profile in Newly Diagnosed IDHm AML Patients
June 15, 2018 - Smoking, lack of exercise linked to early death after divorce
June 15, 2018 - Researchers identify gene enhancer that affects sex determination
June 15, 2018 - New collaboration integrates Intabio’s Blaze solution with Bruker’s mass spectrometers
June 15, 2018 - Blood samples can be used to uncover genetic secrets inside the brain
June 15, 2018 - Palatin Technologies Announces FDA Acceptance for Review of Bremelanotide NDA
June 15, 2018 - Can you rely on the drugs that your doctor prescribes?
June 15, 2018 - WHO: Paraguay achieves malaria-free status
June 15, 2018 - Investigating Enamel Nanostructure with Nanoindentation
June 15, 2018 - FDA Approves Moxidectin for the Treatment of River Blindness
June 15, 2018 - Researchers discover cell structure that plays a role in epigenetic inheritance
June 15, 2018 - Study shows how using service dogs may provide physiological benefits to veterans with PTSD
June 15, 2018 - New chemical solution could reduce chances of infection associated with root canal work
June 15, 2018 - Fat and carb rich foods preferred by the brain
June 15, 2018 - Scientists discover unique feature in the ‘antennae’ of light-sensing neurons
June 15, 2018 - Researchers observe increase in activity of neurons grown on single layer of graphene
June 15, 2018 - Researchers find enzyme responsible for aircraft noise-related vascular damage
June 15, 2018 - Study shows improvements in adherence, outcomes of gout patients receiving text message reminders
June 15, 2018 - Accelerated brain maturation linked to stress in childhood
June 15, 2018 - FDA Alert: Compounded Products Containing Triamcinolone-Moxifloxacin by Guardian Pharmacy Services (Dallas, Texas): Alert to Health Professionals
New total-body PET scanner could revolutionize patient diagnosis and care

New total-body PET scanner could revolutionize patient diagnosis and care

image_pdfDownload PDFimage_print

The new total-body PET/CT scanner could revolutionize our understanding and treatment of disease through analysis of better imaging data from the whole body. In The Journal of Nuclear Medicine (JNM) featured January article, scientists at the University of California, Davis (UC Davis), outline the development and benefits of this innovative diagnostic tool and explain how maximizing PET sensitivity will advance clinical research and patient care.

Positron emission tomography (PET) is widely considered the most sensitive technique available for non-invasively studying physiology, metabolism and molecular pathways in the living human being. However, there have been drawbacks, including low signal-to-noise ratio (SNR) affecting image quality, long imaging times and concerns regarding radiation dose.

Total-body PET, which encompasses the entire body within the field of view and allows imaging of all the tissues and organs of the body simultaneously, promises to be a game changer.

“It will offer the ability to detect throughout the whole body the location of focal pathologies, including cancer, infection, and inflammation at considerably lower levels of disease activity than is currently possible,” explains Terry Jones, DSc, clinical professor of diagnostic radiology at UC Davis.

He points out, “It will also reduce the time taken to scan the whole body by at least a factor of 10, leading to scan times that could be less than one minute. This, for example, will make it far easier to scan infant and pediatric subjects without anesthesia or sedation.”

Radiation exposure is reduced as well. Jones notes, “Whole-body PET scans could be performed for a radiation dose roughly equivalent to that received from a round-trip transatlantic flight.”

By covering the entire body at once, sensitivity is increased by a factor of ~40 for total-body imaging, or a factor of ~4-5 for imaging a single organ such as the brain or heart. Significant improvements in timing resolution could lead to even further sensitivity gains.

The JNM article states, “Total-body PET offers several opportunities to change the methodological approach to cancer detection and staging, and this same methodology could also be applied to other systemic conditions, including inflammation (e.g. sarcoidosis), vascular disease, sepsis and infectious disease. The increased sensitivity and dynamic range of total-body PET will allow imaging at high SNR at much later times after tracer injection.”

Jones adds, “The ability to study the simultaneous interaction of specific molecular/physiological processes between all the tissues/organs of the body–‘systems biology’ of the human body in health and disease–is especially relevant for functional brain-body, and body-brain interactions that occur in certain psychological, psychiatric, neurological, and inflammatory conditions.”

This new technology is nearing clinical readiness. UC Davis, in collaboration with United Imaging Healthcare, has completed the design of the first prototype total-body PET/CT scanner, called EXPLORER, and components are currently being fabricated and tested. The CT scan is acquired as the patient moves into the PET scanner. A smaller-scale, mini-EXPLORER is for researchers to conduct total-body PET imaging in nonhuman primates.

Total-body PET/CT was initially conceived for clinical research, and it will be a boon for researchers. For example, the ability to determine the pharmacokinetics of new drugs in all the organs and tissues of the body at very low masses and radiation doses has the potential to accelerate the translation of new therapeutic agents to clinical practice.

It has become clear, however, that the new scanner will also impact patient diagnosis and care. “The applications of nuclear medicine will expand considerably across internal medicine at a rate not witnessed to-date, and will become more evenly distributed across the age spectrum,” says Jones. “There will be a considerable stimulus/investment to develop new imaging biomarkers especially within immunology and endocrinology.”

He anticipates changes in nuclear medicine departments as well, stating, “One total-body PET scanner could take on the work load of three-to-four conventional PET scanners, and being able to receive imaging biomarkers from more distant distribution centers [due to the scanner’s increased sensitivity, which gives biomarkers increased shelf life], will minimize the need for costly in-house biomarker production.”

Addressing the cost issue, Jones also points out, “As the impact of high-sensitivity, total-body PET scanning becomes apparent, this will provide a major stimulus to physicists, chemists, and engineers to develop lower-cost detectors for total-body surveillance.”

In short, Jones sees the development of total-body PET/CT as “nuclear medicine coming of age.”

Source:

http://www.snmmi.org/NewsPublications/NewsDetail.aspx?ItemNumber=25689

Tagged with:

About author

Related Articles