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Vending Machine Narcotics; Delayed Carbon Monoxide Symptoms; Vitamin E and Neuropathy

Vending Machine Narcotics; Delayed Carbon Monoxide Symptoms; Vitamin E and Neuropathy

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To reduce dependency on street drugs cut with fentanyl, the British Columbia Center for Disease Control plans to install armored vending machines that dispense hydromorphone (Dilaudid) pills for people at high risk of opioid overdose. Fentanyl was detected in 83% of overdose deaths in the province last year. (Washington Post)

Acute brain lesions were associated with the development of delayed neurological sequelae in patients who experienced carbon monoxide poisoning. Imaging during the acute phase of poisoning may help identify patients at risk. (JAMA Neurology)

A surprise disclosure revealed that the FDA placed a partial clinical hold on Solid Biosciences’ gene therapy for Duchenne muscular dystrophy, which dropped the price of the company’s IPO. The safety of its gene therapy may be why James Wilson, MD, resigned recently from Solid’s scientific advisory board. (Barron’s)

No TOMMORROW for Takeda: Its phase III TOMMORROW trial of the diabetes drug pioglitazone (Actos) for Alzheimer’s disease stopped after a futility analysis showed an inadequate treatment effect. Meanwhile, Biogen has added to its pipeline Karyopharm’s KPT-350, which may help treat conditions like ALS by crossing the blood-brain barrier more readily than other SINE compounds. (Fierce Biotech)

Amgen and Novartis announced positive results from their phase IIIb LIBERTY study of the calcitonin gene-related peptide inhibitor erenumab (Aimovig) in patients with episodic migraine who experienced previous preventive treatment failures. (Endpoints News)

Injury to mitochondria by oligomeric amyloid beta (OAβ ) triggers a cascade of events that occur early in Alzheimer’s disease and may offer a promising therapeutic target. “Pretreatment with a novel CoQ10 analogue protects neuronal mitochondria from OAβ-induced mitochondrial changes,” researchers wrote in Alzheimer’s & Dementia.

The Vitamin E in Neuroprotection Study (VENUS) concluded that supplementation with 400 mg/day oral mixed tocotrienols for 1 year did not improve overall diabetic peripheral neuropathy symptoms. (JAMA Neurology)

Fans of Neil Diamond donated refunded concert ticket money to Parkinson’s research. Diamond canceled concerts after announcing he had Parkinson’s disease. (Rolling Stone)

Baseline high frequency oscillation rates and amplitudes vary significantly in different brain structures and between homologous structures in the left and right hemispheres; this is important when evaluating patients who have drug-resistant epilepsy for surgery. (Neurology)

Flushing senescent cells in the brain may inhibit the effects of sporadic Parkinson’s and other chronic neurodegenerative diseases. “Our data suggest that exposure to certain environmental toxins promotes accumulation of senescent cells in the aging brain, which can contribute to dopaminergic neurodegeneration,” researchers wrote, adding that therapies that target senescent or “zombie” cells may constitute a strategy for treating sporadic Parkinson’s. (Cell Reports)

2018-01-30T11:30:00-0500

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