Breaking News
September 22, 2018 - Brigham Genomic Medicine program unravels 30 medical mysteries
September 22, 2018 - New system harnesses power of bubbles to destroy dangerous biofilms
September 22, 2018 - Inflammation plays crucial role in preventing heart attacks and strokes, study reveals
September 22, 2018 - Calorie dense, nutrient deficient meals common across the world
September 22, 2018 - Researchers develop technology to study behavior of implants without animal testing
September 22, 2018 - First gut bacteria in newborns may have lasting effect on ability to ward off chronic diseases
September 22, 2018 - Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species
September 22, 2018 - Insulin treatment shows great potential against chronic bowel inflammation
September 22, 2018 - ‘Liking Gap’ Might Stand in Way of New Friendships
September 22, 2018 - Simple factors that can avoid harmful side effects in type 2 diabetes
September 22, 2018 - ALSAM Foundation invests additional $2 million for drug discovery and development projects
September 22, 2018 - Study findings may advance discussion of how to effectively curb human-wildlife conflict
September 22, 2018 - Dopamine neurons may involve in conditions ranging from Parkinson’s disease to schizophrenia
September 22, 2018 - Protein C and Protein S Tests: MedlinePlus Lab Test Information
September 22, 2018 - Obesity and diabetes—two reasons why we should be worried about the plastics that surround us
September 22, 2018 - Concern over fussy eating prompts parents to use non-responsive feeding practices
September 22, 2018 - Novel mathematical approach uncovers existence of unsuspected biological cycles
September 22, 2018 - Cancer Research UK invests £14 million to transform London into cancer biotherapeutics hub
September 22, 2018 - Scientists predict how well the body will fight lung cancer by analyzing immune cell shapes
September 22, 2018 - New outbreak of rare eye disease identified in contact lens wearers
September 22, 2018 - Iterum Initiates SURE 2 and SURE 3 Phase 3 Clinical Trials of IV and Oral Sulopenem in Complicated Urinary Tract and Complicated Intra-abdominal Infections
September 22, 2018 - Research finds divide in dental health accessibility between city and regional areas
September 22, 2018 - Premature babies show better brain development when fed breast milk, finds study
September 22, 2018 - Novel system uses AI to detect abnormalities in fetal hearts
September 22, 2018 - UNC scientists reveal new approach to prevent obesity and diabetes
September 22, 2018 - CWRU receives NIH grant to learn how non-coding genes contribute to spread of colorectal cancer
September 22, 2018 - Scientists better understand influenza virus and how it spreads
September 22, 2018 - Scientists to focus on length of time when a person is alive and healthy
September 22, 2018 - Study shows positive financial impacts of Medicaid expansion for low-income Michigan residents
September 22, 2018 - Innovative approach for developing vaccine against most prevalent human malaria parasite
September 22, 2018 - Survey estimates caregiving costs for family members
September 22, 2018 - Inhibiting NF-kB improves heart function in a mouse model of Duchenne muscular dystrophy
September 22, 2018 - Introducing new EMR system may affect several aspects of clinic workflow
September 22, 2018 - Study finds why some human genes are more popular with biomedical researchers
September 22, 2018 - Finding epigenetic signature appears to predict inflammation risk in serious type of IBD
September 22, 2018 - Researchers develop light-based technique to measure very weak magnetic fields
September 22, 2018 - UAB researchers study dysfunction of the immune system associated with NSAID carprofen
September 22, 2018 - QIAGEN and DiaSorin launch automated, CE-marked workflow for high-throughput TB screening
September 22, 2018 - EFS checklist provides user-friendly tool for evaluating feeding skills in preterm infants
September 22, 2018 - Family history in blacks, Latinos associated with higher risk of AFib
September 22, 2018 - Researchers identify new genetic disorder in a human patient
September 22, 2018 - Cardiac MR With Contrast Feasible in Developing World
September 22, 2018 - Daily low-dose aspirin doesn’t reduce heart-attack risk in healthy people
September 21, 2018 - Children with asthma found to be disadvantaged in education and future occupation
September 21, 2018 - Interaction of chemical slurry and ancient shale in fracking wastewater causes radioactivity
September 21, 2018 - Scientists use mice to study transmission of Lyme disease bacteria by infected ticks
September 21, 2018 - Researchers find that sample size is key factor determining accuracy of study results
September 21, 2018 - Study shows how the drive to eat overpowers the brain’s signal to stop
September 21, 2018 - 30 Million Americans Now Have Diabetes
September 21, 2018 - Thousands of breast cancer gene variants engineered and analyzed
September 21, 2018 - The current fellowship interview process is cumbersome — Stanford researchers have a better idea
September 21, 2018 - Progenitor cells for human bone and cartilage have been identified
September 21, 2018 - Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy
September 21, 2018 - SLU’s College professor receives NIH grant to develop I-TEST project
September 21, 2018 - DermTech completes enrollment in clinical study to assess DNA damage and reversal
September 21, 2018 - Grieving patients treated with talk therapy have lower risk of suicide and psychiatric illness
September 21, 2018 - NIH and FDA call for eliminating involvement of RAC in human gene therapy experiments
September 21, 2018 - New system uses algorithm to convert 2D videos into 3D printed ‘motion sculptures’
September 21, 2018 - Sea squirt model reveals key molecules in dopaminergic neuron differentiation
September 21, 2018 - Effective management of neonatal abstinence syndrome requires coordinated ‘cascade of care’
September 21, 2018 - Refugees seek care for wounds of war
September 21, 2018 - Under the sea, in an octopus’ garden on ecstacy
September 21, 2018 - Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort
September 21, 2018 - Giving kids honest information about water consumption may help them make healthy choices
September 21, 2018 - Horwitz Prize Awarded for Work on Hormones
September 21, 2018 - CHMP issues positive opinion supporting use of Trelegy Ellipta in broader group of COPD patients
September 21, 2018 - Scientists discover new molecules that work together to remove unwanted DNA
September 21, 2018 - Dr. Fenella France to deliver 2019 Plenary Lecture
September 21, 2018 - New research finds that MHC-II molecules have more influence on tumors than MHC-I
September 21, 2018 - Researchers study effects of cardiac cycle in simple learning task
September 21, 2018 - FDA takes new steps to address opioid crisis by approving Opioid Analgesic Risk Evaluation and Mitigation Strategy
September 21, 2018 - Positive Barhemsys Phase 3 Treatment Data Published in Anesthesia & Analgesia
September 21, 2018 - Celiac Disease Screening: MedlinePlus Lab Test Information
September 21, 2018 - Autism linked to egg cells’ difficulty creating large proteins
September 21, 2018 - Tweaking nuclear pores could provide new avenue to battle against cancer
September 21, 2018 - Experts warn health care providers to slow down in allowing smart pill in patient care settings
September 21, 2018 - MoreGrasp reports breakthrough development of grasp neuroprosthetics activated by thought control
September 21, 2018 - Study reveals new way to target HER2-negative metastatic breast cancer
September 21, 2018 - CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL
September 21, 2018 - Study offers solid link between visceral organs and brain’s reward, motivation system
Flu, Tdap Vax Safe for Babies 6 Months Later

Flu, Tdap Vax Safe for Babies 6 Months Later

image_pdfDownload PDFimage_print

Action Points

  • Note that this analysis of an administrative database suggests that maternal vaccination during pregnancy does not increase the risk of insane mortality.
  • Be aware that this was not a randomized study. Vaccination may be a proxy for other healthful behaviors.

There was no association between pregnant mothers who received the influenza or tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccines and the risk of infant death or hospitalization, researchers found.

In the case-control study, there was no such increased risk in the first 6 months of life among infants whose mothers received these vaccines, reported Lakshmi Sukumaran, MD, of the CDC, and colleagues.

Writing in Pediatrics, they noted that the Advisory Committee on Immunization Practices (ACIP) currently recommends both the Tdap and influenza vaccines during pregnancy — with a preference for the Tdap vaccine to be administered from 27 to 36 weeks gestation, specifically to protect infants from pertussis disease.

Maternal immunization with these vaccines allows for “passive antibody transfer” to infants to protect them before they are eligible to receive the vaccine, the authors argued, citing the high hospitalization and mortality rates linked with pertussis cases in infants younger than 6 months, and the high hospitalization rate from influenza for young infants. The researchers also noted that 18 of 96 influenza-associated pediatric deaths occurred in children younger than 6 months during the 2013-2014 flu season.

But, Sukumaran et al added, despite “reassuring safety data,” vaccine safety is the primary reason cited by providers and patients who choose not to vaccinate during pregnancy, and that there are “limited safety studies” beyond the immediate neonatal period.

“Although the biologic plausibility is unclear for the association of maternal vaccination and infant hospitalization or death, there may be concerns of long-term effects on infants after any pregnancy exposure,” the researchers wrote.

They examined singleton live birth pregnancies in the Vaccine Safety Datalink from 2004 to 2014. Vaccine exposure was defined as a vaccine given from 7 days after the pregnancy to 7 days before the pregnancy end date. Infant controls were required to have at least one diphtheria-tetanus-acellular pertussis (DTaP) vaccine between 6 weeks and 6 months, to ensure that infants were “accessing the healthcare system.”

Overall, 413,034 live births were included. Among them, there were 25,222 infants with one or more hospitalizations and 157 deaths in the first 6 months of life. Of the hospitalized infants, about 18% had a respiratory cause for hospitalizations; about 2% had an influenza ICD-9 code and 3% had a pertussis ICD-9 code.

Examining infant deaths, the researchers found that 9% had a respiratory cause of death, though none were “considered caused by” influenza or pertussis infections. The most common causes of death were unknown causes (32%), sudden infant death syndrome (21%), and “certain conditions originating in the perinatal period” (17%). The mean age at death was 61 days, with a range of 1 to 180 days.

Hospitalized infants were more likely to have had mothers with pregnancy complications, but less likely to have been delivered via cesarean delivery or be of African American non-Hispanic or American Indian race, the authors added.

There was no association between infant hospitalization and maternal influenza vaccination (adjusted OR 1.00, 95% CI 0.96-1.04) or Tdap vaccination (adjusted OR 0.94, 95% CI 0.88-1.01), and none between infant mortality and maternal influenza vaccine (adjusted OR 0.96, 95% CI 0.54-1.69) or Tdap vaccine (adjusted OR 0.44, 95% CI 0.17-1.13).

However, the authors noted a “protective effect” associated with maternal Tdap vaccination and infant respiratory hospitalizations (adjusted OR 0.79, 95% CI 0.67-0.94, P=0.007). The researchers noted that this is consistent with the results of other published studies that looked at infant pertussis, but pointed out that only 3% of infants “hospitalized for respiratory causes” had a pertussis ICD-9 code. This could mean either that “infants with pertussis are not being appropriately diagnosed and tested” or there are other contributing factors, the team speculated.

Limitations to the data, the researchers said, include that the Vaccine Safety Datalink captures data on an insured population, and has a high rate of women with “adequate prenatal care” (which often translates into better health outcomes), and that there is a potential for bias because controls were required to have a DTaP vaccine record for inclusion to ensure access to healthcare utilization.

The study was supported by the Centers for Disease Control and Prevention (CDC); the Vaccine Safety Datalink project is funded by the CDC.

Sukumaran and co-authors reported having no conflicts of interest, and noted that the findings and conclusions are those of the authors and do not necessarily represent the official position of the CDC.

2018-02-20T16:30:00-0500

Tagged with:

About author

Related Articles