Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
New review explores potentially safer therapies for treating chronic abdominal pain

New review explores potentially safer therapies for treating chronic abdominal pain

An estimated 2 million people in the U.S. are addicted to prescription opioids-;powerful doctor-prescribed medications for chronic or severe pain. The drugs are commonly prescribed to treat gastrointestinal pain caused by conditions such as Crohn’s disease and irritable bowel syndrome (IBS), raising the risk of addiction among this population. A review published ahead of print in the American Journal of Physiology-;Gastrointestinal and Liver Physiology explores newer, potentially safer therapies for treating chronic abdominal pain with lower risks of addiction and side effects.

Opioid drugs treat pain by binding to specialized nerve cells (called opioid receptors) in the brain and other parts of the body, including the gastrointestinal tract and spinal cord. Long-term use of opioids for chronic, generalized abdominal pain-;also called visceral pain-;can change the way the opioid receptors work, leading to addiction. Opioids can also cause respiratory depression-;slowed breathing and a reduced ability to properly inhale and exhale-;which can be fatal if not treated quickly.

IBS, pancreatitis and visceral pain may not respond to non-opioid painkillers or medications called neuromodulators, such as antidepressants. More and more, doctors have been prescribing opioid drugs for these challenging gastrointestinal conditions. “From 1997 to 2008, opioid prescriptions for chronic abdominal pain more than doubled in U.S. outpatient clinics,” wrote the review’s author, Michael Camilleri, MD, of the Mayo Clinic.

The main mechanism that opioids use to reduce pain is through stimulation of the Mu-receptors. New approaches for treating abdominal pain include drugs that pinpoint different types of pain receptors, not only opioid receptors. In addition, newer generations of opioid medications may be able to relieve pain without the risk of addiction or respiratory depression. Potential new treatments include:

  • Oliceridine, a drug that binds with a specific component of the Mu-opioid receptor without activating the part of the receptor that causes severe constipation or breathing to slow down.
  • New formulations of opioids that are chemically modified so that the painkiller is only activated in inflamed areas. This approach has the potential to relieve pain in patients with intestinal inflammation, such as Crohn’s disease.
  • Nociceptin/orphanin FQ opioid peptide (NOP) receptors, which are involved in pain relief. Some people with IBS have reduced NOP in their colon and this may result in greater pain sensation. There are new medications in development that can replace the deficient NOP and inhibit pain sensation.
  • Buprenorphine, a partial opiate agonist. This type of drug is an opioid that does not produce the full effect of respiratory depression that other opioids do. New formulations are being developed to act on different types of receptors to reduce the potential to become addicted.
  • Cannabinoid agents, medications that target the endocannabinoid system, which controls visceral pain, nausea and vomiting.

“These are all novel approaches for the treatment of visceral pain with peripherally-restricted or targeted mechanisms, and they … [bode] well for the future hope of developing peripheral visceral analgesics for IBS and chronic abdominal pain,” Camilleri wrote.

Source:

http://www.the-aps.org/mm/hp/Audiences/Public-Press/2018/12.html

Posted in: Medical Research News | Medical Condition News | Pharmaceutical News

Tags: Abdominal Pain, Addiction, Brain, Cannabinoid, Constipation, Crohn’s Disease, Depression, Doctor, Drugs, Gastrointestinal Tract, Inflammation, Irritable Bowel Syndrome, Liver, Nausea, Nerve, Opioids, Pain, Painkiller, Pancreatitis, Physiology, Receptor, Research, Respiratory, Vomiting

Tagged with:

About author

Related Articles