Breaking News
November 19, 2018 - New report calls for greater awareness and emphasis on scale and impact of atrial fibrillation
November 19, 2018 - In throes of turkey salmonella outbreak, don’t invite illness to your table
November 19, 2018 - UK health policies should be redesigned to become more accessible for men
November 19, 2018 - Short Interpregnancy Intervals Tied to Adverse Outcome Risk
November 19, 2018 - New mothers’ breastfeeding pain can affect infant health
November 19, 2018 - Stanford Medicine magazine reports on ways digital technology is transforming health care | News Center
November 19, 2018 - Human drugs alter cricket personality
November 19, 2018 - Insilico Medicine to introduce ‘Cure a disease in a year’ program at Biodata World Congress 2018
November 19, 2018 - Experts debate over whether gut or brain is more important in regulating appetite
November 19, 2018 - Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising
November 19, 2018 - Low-Carb Diets May Work By Boosting Calorie Burn
November 19, 2018 - Key molecule responsible for learning and memory discovered
November 19, 2018 - New blood test developed for early diagnosis of ovarian cancer
November 19, 2018 - Researchers identify molecule to fight myotubular myopathy
November 19, 2018 - New solution to stop spread of brain cancer
November 19, 2018 - Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds
November 19, 2018 - Scientists equip new virus that kills carcinoma cells with protein
November 19, 2018 - Novel approach could provide painless, efficient alternative for treating eye diseases
November 19, 2018 - Protein in cell membranes of sperm plays key role in finding their way to eggs
November 19, 2018 - Parents who decline flu vaccination for their child may be exposed to limited information
November 19, 2018 - Mirati Presents Data From Ongoing Phase 2 Clinical Trial Of Mocetinostat In Combination With Durvalumab At The SITC 33rd Annual Meeting
November 19, 2018 - FDA warns of common diabetes meds’ link to dangerous genital infection
November 19, 2018 - New methods for preserving shoulder function, quality of life in breast cancer patients
November 19, 2018 - Surprising discovery about BH4 may rekindle interest in once-promising pathway
November 19, 2018 - Nabriva Therapeutics Completes Submission of New Drug Application to U.S. Food and Drug Administration for Intravenous Contepo to Treat Complicated Urinary Tract Infections
November 19, 2018 - Beating breast cancer only to die of opioid use – a sad Appalachian story
November 19, 2018 - Workplace bullying or violence linked to higher risk of cardiovascular problems
November 19, 2018 - Changes in Risk Indicators of MetS Severity Tied to T2DM Risk
November 19, 2018 - ‘Game-changing’ skin sensor could improve life for a million hydrocephalus patients
November 19, 2018 - Alcohol ads on social media sites with pro-drinking comments increase desire to drink
November 19, 2018 - Neural networks could replace marker genes in RNA sequencing
November 19, 2018 - Obese adolescents feel less food enjoyment than those with normal weight, study reveals
November 18, 2018 - Goodbye ‘Gluten-Free’? Celiac Disease Vaccine May Make It Possible
November 18, 2018 - Skin ages when the main cells in the dermis lose their identity and function
November 18, 2018 - Rainforest vine compound makes pancreatic cancer cells susceptible to nutrient starvation
November 18, 2018 - A new mechanism in the control of inflammation
November 18, 2018 - Age-related decline in abstract reasoning ability predicts depressive symptoms over time
November 18, 2018 - Scientists succeed in increasing stability, biocompatibility of light-transducing nanoparticles
November 18, 2018 - Sugar, a ‘sweet’ tool to understand brain injuries
November 18, 2018 - Pharmacist-Led Effort Cuts Inappropriate Rx in Older Adults
November 18, 2018 - Novel discovery could lead to new cancer, autoimmune disease therapy
November 18, 2018 - AHA and ADA launch new initiative to help people with type 2 diabetes reduce heart disease risk
November 18, 2018 - Balanced production of pro and anti-inflammatory cytokines at two years of age protects against malaria
November 18, 2018 - New pharmacological agent shows promise for prevention of heart rhythm disorders
November 18, 2018 - All That Social Media May Boost Loneliness, Not Banish It
November 18, 2018 - Scientists shine new light on link between obesity and cancer
November 18, 2018 - Risk factors for cardiovascular disease closely track with changes in diet patterns
November 18, 2018 - Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
November 18, 2018 - Detectable HIV-1 in treated human liver cells found to be inert
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
November 18, 2018 - Poverty blamed on widening north-south gap in young adult deaths in England
November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
November 18, 2018 - Fine particle air pollution is a public health emergency hiding in plain sight
November 18, 2018 - In-hospital mortality higher among patients with drug-resistant infections
November 17, 2018 - Research shines new, explanatory light on link between obesity and cancer
November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
November 17, 2018 - Tracking Preemies’ Head Size May Yield IQ Clues
November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - New strategy to hinder emergence of antimicrobial-resistant pathogens
November 17, 2018 - Sexuality education before age 18 may reduce risk of sexual assault in college
November 17, 2018 - Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure
November 17, 2018 - New model of FSHD could be useful to study effectiveness of experimental therapeutics
November 17, 2018 - FDA approves antibacterial drug to treat travelers’ diarrhea
November 17, 2018 - Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers
November 17, 2018 - Largest parasitic worm genetic study hatches novel treatment possibilities
November 17, 2018 - UCLA biologists uncover how head injuries can lead to serious brain disorders
November 17, 2018 - Static and dynamic physical activities offer varying protection against heart disease
November 17, 2018 - Obesity significantly increases risk of Type 2 diabetes and coronary artery disease
November 17, 2018 - New method to analyze cell membrane complexes could revolutionize the way we study diseases
November 17, 2018 - Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission
November 17, 2018 - People with rare cancers can benefit from genomic profiling, shows research
November 17, 2018 - NIH awards over $1.8 million to husband-and-wife doctors to test new breast cancer approach
November 17, 2018 - Four-in-one antibody used to fight flu shows promise in mice
November 17, 2018 - New approach allows pathogens to be starved by blocking important enzymes
November 17, 2018 - Higher body mass index could cause depression even without health problems
November 17, 2018 - Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension
UD researcher investigates role of new compound in fighting age-related diseases

UD researcher investigates role of new compound in fighting age-related diseases

image_pdfDownload PDFimage_print

A University of Delaware researcher is investigating a novel compound’s role in combating age-related chronic diseases like mild cognitive disorder and dementia.

Christopher Martens, an assistant professor of Kinesiology and Applied Physiology, is studying a naturally occurring dietary supplement, nicotinamide riboside (NR) – a novel form of vitamin B3 – and its efficacy for boosting nicotinamide adenine dinucleotide (NAD+). His work is being funded by a grant from the National Institute on Aging.

“NAD+ is critically involved in just about every metabolic process in our cells,” said Martens, who earned his doctorate from UD before completing post-doctoral training at the University of Colorado Boulder. “It’s particularly important for generating adenosine triphosphate (ATP), which is the body’s primary form of energy, but it also helps boost enzymes responsible for protecting our cells against stress and damage.”

As we age, NAD+ levels decline. This is thought to contribute to broad impairments in older adults’ physiological function, including reductions in blood flow and cognitive abilities. The decline in NAD+ may play a role in the increased risk for chronic diseases. Restoring NAD+ back to a youthful level has been shown to reverse age-related declines in physiological function in mice, something that Martens’ Neurovascular Aging Laboratory now hopes to translate into therapies for improving physiological function in humans.

Martens first began studying the effects of NAD+ boosting compounds several years ago as a postdoctoral fellow at the University of Colorado Boulder. On March 29, he and his former postdoctoral mentor Doug Seals published a paper in the journal Nature Communications in which they demonstrated that chronic supplementation with NR (NIAGEN®) for six weeks boosts levels of NAD+ in the blood of middle-aged and older adults. They also published preliminary data suggesting that NR may lower blood pressure and aortic stiffness — two key risk factors for future development of cardiovascular disease. The study was conducted at the University of Colorado Boulder and included 24 lean and healthy men and women ages 55 to 79. No adverse effects were reported.

“Although future work is needed to confirm our findings, our paper opens the door to larger studies of NAD+ boosting molecules for slowing/reversing some of the detrimental effects of cardiovascular aging,” said Martens, who now works with UD’s Center for Cardiovascular Health.

Martens’ paper is the first to demonstrate the effectiveness of NR alone for raising NAD+ in humans and potentially treating age-related cardiovascular dysfunction.

Cardiovascular diseases are the No. 1 cause of death globally. However, the benefits of NAD+ may not be limited to improving cardiovascular health. Since joining the faculty at UD, Martens became interested in how cardiovascular risk factors such as high blood pressure and stiffening of the elastic arteries (i.e., the aorta and carotid arteries) relate to increased risk for mild cognitive disorder and dementia.

“The elastic arteries act as a buffer between the large pressure waves exiting the heart and more sensitive organs such as the brain,” Martens said. “This protection is lost with age as arteries stiffen, contributing to an increase in blood pressure and allowing damaging pressure waves to enter the brain, which may lead to cognitive impairment.”

Martens’ new grant seeks to study the blood pressure lowering effect of boosting NAD+ on brain blood flow and cognitive function in people with mild cognitive impairment (MCI) — a condition characterized by reduced memory abilities that often leads to the development of Alzheimer’s disease. The UD research team plans to enroll the first subjects in June.

Everybody normally loses some cognitive abilities with age, but some lose these much faster and dip into dementia (of which Alzheimer’s disease is the most common form). MCI is the gray area between normal cognitive aging and dementia.

“The person isn’t demented, but cognitive function suffers,” Martens said. “People with MCI still have the ability to perform the normal activities of daily living, but their cognitive abilities are lower than you would expect based on their age. And those who tend to lose memory over other domains of cognitive function are more likely to progress onto Alzheimer’s-related dementia.”

For years, pharmaceutical companies have unsuccessfully tried to treat people who already have Alzheimer’s disease. Martens said the answer to staving off the dreaded disease lies in earlier diagnosis and treatment, before the onset of dementia. Protecting the blood vessels by boosting NAD+ might be a promising place to start.

Source:

http://www.udel.edu/udaily/2018/april/christopher-martens-aging-research/

Tagged with:

About author

Related Articles