Breaking News
May 28, 2018 - Antibody removes Alzheimer’s plaques, in mice
May 28, 2018 - Community paramedicine program for older adults reduced number of 911 calls, improved health
May 28, 2018 - AAP: Congress Urged to Act to Prevent Firearm Deaths
May 28, 2018 - Subjective memory may be marker for cognitive decline
May 28, 2018 - Illinois looks at medical marijuana use for opioid dependence
May 28, 2018 - Specific neurons may cause male aggressiveness
May 28, 2018 - New consensus statement outlines evidence-based medical opinion on abusive head trauma
May 28, 2018 - E-Cigarettes Don’t Help Smokers Quit, But Cash Might
May 28, 2018 - New screening tool developed to assess tanning addiction
May 28, 2018 - Unhappy combination of alcohol, anger, and aggressive behavior
May 28, 2018 - Loyola survey identifies significant group of burn patients with elevated PTSD symptoms
May 28, 2018 - Cancer cells co-opt pain-sensing ‘wasabi receptor’ to survive oxidative stress
May 27, 2018 - New way of grouping atoms could herald novel materials, drugs and computers
May 27, 2018 - Less is more? Gene switch for healthy aging found
May 27, 2018 - Breast cancer survivors do not receive recommended level of screening after surgery
May 27, 2018 - Recommendations Developed for Managing Postpartum Pain
May 27, 2018 - Rheumatoid Arthritis (RA) | Arthritis Basics | Arthritis Types | Arthritis
May 27, 2018 - ‘Life support’ for transplant livers better than freezing: study
May 27, 2018 - Tree nut consumption linked to improved type 2 diabetes health
May 27, 2018 - Income and education gap causes racial differences in health behaviors, study shows
May 27, 2018 - Even at ‘Safe’ Levels, Air Pollution Puts Seniors at Risk
May 27, 2018 - Obstructive sleep apnea linked to thinning of calvaria, skull base
May 27, 2018 - Epigem’s Managing Director sets the bar for life sciences industry at VentureFest
May 27, 2018 - CPAP may reduce resting heart rate in prediabetic patients
May 27, 2018 - Study reveals striking disparities in health care access and quality across most nations
May 27, 2018 - The Yogi masters were right—meditation and breathing exercises can sharpen your mind
May 27, 2018 - SLU researcher aims to find solutions for diabetes patients at risk of hypoglycemia
May 27, 2018 - Scientists uncover the cause of insulin resistance in obesity
May 27, 2018 - $2.3 million NIH grant to support new project on oxytocin neurons and social behavior
May 27, 2018 - Less Driving Tied to Lower Cardiovascular Disease Risk
May 27, 2018 - Genetics Home Reference: LMNA-related congenital muscular dystrophy
May 27, 2018 - Long-term psychological study confirms time is the best medicine against homesickness
May 27, 2018 - Study explores if CPAP treatment can improve sexual QOL for sleep apnea patients
May 27, 2018 - Study investigates role played by brain in prosocial behavior
May 27, 2018 - New Guidelines Mean 1 in 3 Adults May Need Blood Pressure Meds
May 27, 2018 - Cerebrospinal Fluid (CSF) Analysis: MedlinePlus Lab Test Information
May 27, 2018 - Kids in tough neighborhoods head to ER more often
May 27, 2018 - Exercise alters brain’s dopamine system to help treat addiction, study finds
May 27, 2018 - Sepsis patients treated and released from ED for outpatient follow-up experience good outcomes
May 27, 2018 - Initiative cuts overuse of tests, treatments for bronchiolitis
May 27, 2018 - Study links ‘sleep spindles’ to memory reactivation
May 27, 2018 - Scientists develop new method to speed up genome evolution of baker’s yeast
May 27, 2018 - Sunscreen pills are fake says FDA
May 27, 2018 - Study finds increasing wealth gap between households of seniors and families with children
May 27, 2018 - Link between tuberculosis and Parkinson’s disease discovered
May 27, 2018 - Doctors call on health authorities for permission to provide stroke patients with life-saving treatment
May 26, 2018 - Couples who eat seafood-rich diet tend to get pregnant faster
May 26, 2018 - NIH summit presents recommendations to accelerate treatment development for Alzheimer’s disease
May 26, 2018 - Medication-related harm found to be common among older adults, but preventable
May 26, 2018 - Lunaphore and Vitro announce partnership to develop ISH protocols for RNA, DNA targets
May 26, 2018 - Cryoablation Efficacious for Cancer Pain, Review Finds
May 26, 2018 - Link between IBD and Parkinson’s might allow doctors to slow down condition
May 26, 2018 - Study finds fewer than 5% of low-income, urban mothers use prenatal vitamins before pregnancy
May 26, 2018 - California hospitals urge moms to favor breast milk over formula
May 26, 2018 - Most concussion patients do not receive follow-up care after hospital discharge, says study
May 26, 2018 - Lifetime risks of developing Alzheimer’s dementia vary by age, gender
May 26, 2018 - Researchers find novel ways to improve participation in clinical research
May 26, 2018 - Researchers develop methods for measuring free-base nicotine levels in e-cigarettes
May 26, 2018 - AHA: Preterm Birth Could Warn of Mom’s Future Heart Risks
May 26, 2018 - Some calories more harmful than others
May 26, 2018 - Study links cell size with commitment to division
May 26, 2018 - Researchers develop new, rapid blood test to detect liver damage
May 26, 2018 - Researchers discover cascade of immune processes linked to poor outcomes in aggressive breast cancer
May 26, 2018 - New research will use mathematics to solve mysteries in cell biology
May 26, 2018 - Proposed National Resilience Strategy to reverse catastrophic increases in ‘deaths of despair’
May 26, 2018 - Mice remain slim on burger diet
May 26, 2018 - BMC receives $13.5 million award to test methods for delivering childhood anxiety treatment
May 26, 2018 - ‘Right to Try Act’ will not benefit terminally-ill patients
May 26, 2018 - Study reveals novel statistical algorithm to identify potential disease genes
May 26, 2018 - Two genes play vital roles in malignant brain cancer
May 26, 2018 - Study explores link between groundwater lithium and diagnoses of bipolar disorder, dementia
May 26, 2018 - Researchers reveal stimulatory effects of myelin on young neural cells
May 26, 2018 - Small part of cellular protein that helps form long-term memories also drives neurodegeneration
May 26, 2018 - Four-legged friends can have heart issues, too
May 26, 2018 - Scientists create small, self-contained spaces inside mammalian cells
May 26, 2018 - Better Social Support Network Protects Black Men Against HIV
May 26, 2018 - National Heart, Lung, and Blood Institute (NHLBI)
May 26, 2018 - Burnout, depression can affect ophthalmology residents, study finds
May 26, 2018 - Latinos and African Americans more likely to experience serious depression than Whites
May 26, 2018 - Data from past epidemic could help improve response to future Ebola outbreaks
Researchers chart a new way to look at concussion

Researchers chart a new way to look at concussion

image_pdfDownload PDFimage_print

A Portland State University research team studying concussion has published an interactive diagram showing the many facets of mild traumatic brain injury (TBI) – from sleep problems to mood disorders to the increased danger of dementia—and how they connect with and affect each other.

The diagram and its accompanying web-based presentation are part of a new article the team published in Frontiers in Neurology. The article is a follow-up to a paper the team published last fall calling for the use of systems science as a new way of understanding the puzzling and complex nature of TBI.

“This paper is a big step forward beyond that initial effort,” said lead author and PSU systems scientist Erin Kenzie. “Our causal-loop diagram shows how specific variables and processes interact to influence concussion recovery. By analyzing patterns in the feedback dynamics, we can better understand how recovery might be facilitated or impeded.”

Kenzie said standard medical research can examine certain variables of TBI in isolation, but is not designed for capturing the big picture. That’s why she and her team are pursuing a systems approach, which has helped scientists understand other complex conditions such as cardiovascular disease, obesity, drug abuse and depression.

“Recovery from concussion, and TBI more generally, is dependent on a wide variety of factors that interact with each other. For this project, we zoomed out to the systems level to sketch out how the variables interact,” she said. “We want to better understand why some people seem to recover quickly from concussion, while others suffer more lasting symptoms and deficits.”

Kenzie said this preliminary model will help researchers identify new areas for research, contribute to a new classification system for TBI and enable clinicians to consider concussion from a new perspective.

The interactive platform walks users through the model and allows them to zoom in, pan, see connections, view supporting citations for each link in the model, and insert their own comments.

“We’d love to see users get engaged and provide feedback,” Kenzie said. “We hope this sparks a discussion about how to make sense of complex medical challenges like TBI.”

The article and the diagram are the culmination of four years of research, which has was funded by the Brain Trauma Foundation and the Department of Defense.


Explore further:
Study calls for new approach to studying concussion

More information:
Erin S. Kenzie et al, The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery With Causal-Loop Diagramming, Frontiers in Neurology (2018). DOI: 10.3389/fneur.2018.00203

Journal reference:
Frontiers in Neurology

Provided by:
Portland State University

Tagged with:

About author

Related Articles