Breaking News
August 14, 2018 - Reducing opioid prescriptions for one operation can also spill over to other procedures
August 14, 2018 - E-cigarettes not so safe but still better than cigarettes
August 14, 2018 - Researchers find link between common ‘harmless’ virus and cardiovascular damage
August 14, 2018 - Initiation of PIMs associated with higher risk of fracture-specific hospitalizations and mortality
August 14, 2018 - Genetically modified mosquitoes and special bed nets help tackle deadly diseases
August 14, 2018 - Advances in treating hep C lead to new option for transplant patients
August 14, 2018 - Study finds quality of doctor-patient discussions about lung cancer screening to be ‘poor’
August 14, 2018 - MSU researchers uncover the effects of aging on regenerative ability of kidneys
August 14, 2018 - Better conditioning, throwing mechanics can help reduce elbow injuries in young baseball pitchers
August 14, 2018 - Brain game doesn’t offer brain gain
August 14, 2018 - Reproductive choices facing women with disabilities require careful consideration
August 14, 2018 - Scientists pinpoint the cause of a rare childhood seizure disorder
August 14, 2018 - Lumpectomy plus radiation associated with reduced risk of breast cancer death, study finds
August 14, 2018 - UAB study shows how ion channel differentiates newborn and mature neurons in the brain
August 14, 2018 - Experts highlight key knowledge gaps that need to be addressed in Ebola vaccine research
August 14, 2018 - Discovery could lead to new drugs against infection and inflammation
August 14, 2018 - Infection Prevention Differs Between Small, Large Hospitals
August 14, 2018 - Mom still matters—In study, young adults tended to prioritize parents over friends
August 14, 2018 - Deep brain stimulation might benefit those with severe alcoholism, preliminary studies show
August 14, 2018 - Study finds increased rate of repeat pregnancies in women with intellectual and developmental disabilities
August 14, 2018 - Lighter sedation fails to reduce risk of postoperative delirium in older patients
August 13, 2018 - Asking better questions about person’s memory could improve doctors’ understanding of patients
August 13, 2018 - U.S. Trauma Doctors Push for Stricter Gun Controls
August 13, 2018 - Asthma and flu: a double whammy
August 13, 2018 - 5 Questions: Donna Zulman on engaging high-need patients in intensive outpatient programs | News Center
August 13, 2018 - Behavioral Nudges Lead to Drop in Prescriptions of Potent Antipsychotic
August 13, 2018 - Potential New Class of Drugs May Reduce Cardiovascular Risk by Targeting Gut Microbes
August 13, 2018 - How to get your kids to eat better
August 13, 2018 - The importance of hearing your patients
August 13, 2018 - Transmission of F. tularensis unlikely to happen through the food chain
August 13, 2018 - Researchers discover epigenetic mechanism underlying ischemic cardiomyopathy
August 13, 2018 - Adolescent health programs receive only a tiny share of international aid, finds research
August 13, 2018 - Fracture risk increases by 30% after gastric bypass, study shows
August 13, 2018 - Quality-improvement project to standardize feeding practices helps micro preemies gain weight
August 13, 2018 - Long-term cannabinoid exposure impairs memory, study shows
August 13, 2018 - New intervention to reduce risk of HIV in young transgender women
August 13, 2018 - Japan human trial tests iPS cell treatment for Parkinson’s
August 13, 2018 - Altered nitrogen metabolism may contribute to emergence of new cancer mutations
August 13, 2018 - Cycling provides greatest health benefits, study finds
August 13, 2018 - Scientists discover biomarker for kidney cancer
August 13, 2018 - New test predicts the risk of serious disease before symptoms appear
August 13, 2018 - Cianna Medical receives FDA 510(k) clearance to extend indication of SCOUT reflector for use in soft tissue localization
August 13, 2018 - Ground-breaking discovery offers new hope for treatment of Alzheimer’s, other neurological diseases
August 13, 2018 - Medical nutrition therapy provided by RDNs benefits patients with chronic kidney disease
August 13, 2018 - Prenatal Tdap vaccination not linked with increased risk of autism in children, study shows
August 13, 2018 - One-Third of Canadian Patients Get Hip Fx Repair Within 24 Hours
August 13, 2018 - ANA (Antinuclear Antibody) Test: MedlinePlus Lab Test Information
August 13, 2018 - Traffic jams in the brain
August 13, 2018 - NIH awards $6.5 million to establish multi-institution biomedical technology resource center
August 13, 2018 - New marker in the blood could help predict person’s risk of developing kidney cancer
August 13, 2018 - New biomarker may provide clues to create diagnostic tool for hypoglycemia-associated autonomic failure
August 13, 2018 - Oxidative Stress Hampers Blood Vessel Dilation in Men
August 13, 2018 - Parents’ Religious Beliefs May Affect Kids’ Suicide Risk: Study
August 13, 2018 - Measure of belly fat in older adults is linked with cognitive impairment
August 13, 2018 - FDA permits marketing of first mobile medical app for contraceptive use to prevent pregnancy
August 13, 2018 - NUS scientists develop new technology to customize optimal drug ‘cocktail’ for myeloma patients
August 13, 2018 - Disordered eating behaviors up for overweight young adults
August 13, 2018 - Connection between Alzheimer’s disease and degenerative eye diseases
August 13, 2018 - Employer expectation of checking email during nonwork hours affects health of workers and families
August 13, 2018 - Rotavirus vaccination reduces infant diarrhea deaths by 34% in rural Malawi
August 13, 2018 - Approval of drug derived from cannabis not necessarily a win for weed
August 13, 2018 - Study shows COPD risk in women with asthma can be reduced
August 13, 2018 - FIND and genedrive announce study agreement to evaluate HCV ID Kit
August 13, 2018 - One in two people putting their eye health at risk during summer, says eye research charity
August 13, 2018 - FDA Approves Galafold (migalastat) for the Treatment of Fabry Disease
August 13, 2018 - Is too much screen time harming children’s vision?
August 13, 2018 - GNA Biosolutions named as winner of AACC Disruptive Technology Award
August 13, 2018 - New ‘closed-loop’ brain stimulation method improves learning, memory, and skill acquisition
August 13, 2018 - FOXM1 contributes to treatment failure in acute myeloid leukemia
August 13, 2018 - Autoimmune response drives neurodegeneration in glaucoma
August 12, 2018 - Preschooler’s Perfectionism May Predict OCD in Adolescence
August 12, 2018 - Dry mouth problems may be associated with disease in the eyelids
August 12, 2018 - Proof-of-concept technology using nanoparticles could offer new approach for oral medications
August 12, 2018 - GSS sensors provide stable CO2 control for laboratory incubator applications
August 12, 2018 - For Seniors, Getting Physical Protects the Heart
August 12, 2018 - Updated Blood Pressure Guidelines: Lifestyle Changes are Key
August 12, 2018 - Review finds more effective drugs to stop bleeding after childbirth
August 12, 2018 - Study provides snapshot of mechanism behind cancer metastasis for the first time
August 12, 2018 - Birth study empowers pregnant women
August 12, 2018 - New drug makes rats to self-administer alcohol less frequently
Researchers develop ground-breaking approach for treatment of pneumonia

Researchers develop ground-breaking approach for treatment of pneumonia

image_pdfDownload PDFimage_print

A chance conversation between researchers at Queen’s University Belfast led to their combined expertise in developing a ground-breaking approach for the treatment of pneumonia.

The research team’s findings have recently been published in the prestigious leading Journal of Controlled Release.

Pneumonia is a serious inflammatory condition of the lungs, which is responsible for over 5% of all deaths in the UK each year, equivalent to over 3.2 million and also remains the leading infectious cause of death among children under five worldwide.

One of the most common causes of pneumonia is lung infection with the bacteria Klebsiella pneumoniae, the very bacteria that Professor Jose Bengoechea, Centre Director at the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University has spent much of his research career studying.

It was a chance conversation between Professor Bengoechea, Professor Cliff Taggart, a researcher at the Wellcome-Wolfson Institute for Experimental Medicine and their colleague Professor Chris Scott at the Centre for Cancer Research and Cell Biology that led to the discovery of this new groundbreaking treatment for pneumonia.

During this conversation the researchers realized that an idea Professor Scott was developing for cancer treatment could also be used for tackling deadly Klebsiella infections.

Professor Bengoechea explains: “This microbe is a particularly difficult bug to treat due to increasing number of isolates resistant to virtually all currently available antibiotics.

“It actually hides in the lung by sneaking inside immune cells, making it exceptionally hard to access with antibiotics. This hidden infection can then re-emerge and cause pneumonia in patients”.

It was the discussion of Professor Scott’s lab work using nanotechnology to target chemotherapy directly into cancer cells when the researchers realized that the same targeted approach could be used to get antibiotics directly to the deadly bacteria lurking in infected immune cells.

Professor Scott explains: “This is a perfect example of how thinking out of the box and combining very different expertise, you can have an eureka moment!

“These exciting research findings are very much in line with the research ethos of the University, which is centered on global challenges.

“Pneumonia remains a global health emergency. By developing this treatment that has proven to tackle this deadly strain of bacteria, our research partnership could change the lives of people across the world.”

The Queen’s team are continuing further research within the next 5 years to achieve a better understanding of how best to treat patients with pneumonia with this specialized technology.

About author

Related Articles