Breaking News
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
October 19, 2018 - Juul e-cigarettes pose addiction risk for young users | News Center
October 19, 2018 - Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei
October 19, 2018 - New DNA vaccine strategy protects mice against lethal challenge by multiple H3N2 viruses
October 19, 2018 - Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
October 19, 2018 - Muscle mass plays a critical role in health, shows research
October 19, 2018 - Study finds undiagnosed prediabetes in many infertile men
October 19, 2018 - The Current issue of “The view from here” is concerned with Nanotherapeutic strategies
October 19, 2018 - Delay in replacing the Pap smear with HPV screening is costing lives
October 19, 2018 - Physicians battle pediatric diseases of ear, nose, throat in Zimbabwe | News Center
October 19, 2018 - Researchers investigate why some cancers affect only young women
October 19, 2018 - Drugmakers funnel millions to lawmakers; a few dozen get $100,000-plus
October 19, 2018 - Unselfish people tend to have more children and receive higher salaries
October 19, 2018 - New findings reveal potential cellular players in tumor microenvironment
October 19, 2018 - Human brain cell transplant offers insights into neurological conditions
October 19, 2018 - Parental education associated with increased family health care spending
October 19, 2018 - New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women
October 19, 2018 - Father’s exposure to nicotine may cause cognitive deficits in descendants
October 19, 2018 - Could we prevent Alzheimer’s disease by treating herpes?
October 19, 2018 - Nurse-led care can be more successful in managing gout
October 19, 2018 - Trump administration, pharma exchange verbal volleys on drug-price transparency
October 19, 2018 - Duke researchers find way to detect blood doping in athletes
October 19, 2018 - Many primary care doctors are still prescribing sedative drugs for older adults
October 19, 2018 - Finger length can predict sexuality in women say researchers
October 19, 2018 - Study finds differences in side-effects experienced by male and female OG cancer patients
October 19, 2018 - Dysfunction of single gene leads to miscarriages
October 19, 2018 - Few Seniors Who Self-Harm Referred for Mental Health Care
October 19, 2018 - Don’t sweat the sweet stuff
October 19, 2018 - URMC researchers discover new approach to deliver therapeutics to the brain
October 19, 2018 - Speech Pathology Australia raises awareness about Developmental Language Disorder
October 19, 2018 - Middlemen suppliers can increase drug prices and hospital bills, say Johns Hopkins researchers
October 19, 2018 - Survey finds high prevalence of HTLV-1 infection among teens and adults in Gabon
October 19, 2018 - Bliss funds research to find whether parental touch can help alleviate pain in premature infants
October 19, 2018 - Human neurons employ highly compartmentalized signaling, study shows
October 19, 2018 - Ultromics expands multiple clinical trials for coronary heart disease to the U.S.
October 19, 2018 - $11 million NIH grant for Clemson University helps launch new center for musculoskeletal research
October 19, 2018 - A new approach identified to control Zika virus, dengue fever
October 19, 2018 - Head Blows Without Concussion May Not Damage Brain, Study Claims
October 19, 2018 - US opioid use not declined, despite focus on abuse and awareness of risk
October 19, 2018 - Next-generation RNA sequencing technology sheds new light on human mitochondrial diseases
October 19, 2018 - UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery
October 19, 2018 - The immune system also plays a key role in day-to-day function of healthy organs
October 19, 2018 - New tool may reveal how the brain structure impacts brain activity, human behavior
October 19, 2018 - Trump Administration announces ‘Winning on Reducing Food Waste’ initiative
October 19, 2018 - For-profit nursing home residents more likely to experience health issues caused by substandard care
October 19, 2018 - Incidence of stroke has risen steadily among marijuana users, show studies
October 19, 2018 - Conceptual framework proposed to examine role of exercise in multiple sclerosis
October 19, 2018 - Near infrared spectroscopy technique for accurate evaluation of chondral injuries
October 19, 2018 - Scientists receive $5.1 million grant to develop stem cell-based therapy for blinding retinal conditions
October 19, 2018 - Shorter physician encounters associated with antibiotic prescribing
October 19, 2018 - In the Spotlight: Enjoying research and exploring opportunities
October 19, 2018 - Physical activity lowers cardiovascular mortality risk in frail older adults
October 19, 2018 - New imaging tool helps visualize how sound-induced vibrations travel through the ear
October 19, 2018 - Key insights into the application, production of bioactive materials
October 19, 2018 - New urea sorbent could speed up the development of wearable artificial kidney
October 19, 2018 - Intensive care patients’ muscles less able to use fats for energy
October 19, 2018 - FDA Advisory Committee Recommends Approval of Dsuvia for the Treatment of Moderate-to-Severe Acute Pain
Children of mothers with type 1 diabetes have a higher body mass index

Children of mothers with type 1 diabetes have a higher body mass index

image_pdfDownload PDFimage_print
Children of mothers with type 1 diabetes have a higher body mass index
Credit: Win Nondakowit/Fotolia

Children of mothers with type 1 diabetes are at significantly higher risk of being overweight and of exhibiting insulin resistance. This was published by scientists from Helmholtz Zentrum München and the Technical University of Munich in the journal Diabetologia.

Type 1 diabetes is the most common metabolic disorder in childhood. But what effects does this condition have when sufferers themselves have children? It was already known that children of parents with type 1 diabetes are at much higher risk of developing the disease than the rest of the population. “Moreover, there were also sporadic indications from previous studies that children of mothers with type 1 diabetes are also at increased risk of having metabolic syndrome, as the intermittent high blood glucose levels in the uterus appear to have long-term effects on the child’s metabolism and body weight,” explains Dr. Andreas Beyerlein. “We now had the possibility to investigate this hypothesis with a large and appropriate dataset,” adds the statistician and epidemiologist, who led the study together with Prof. Dr. Anette-Gabriele Ziegler from the Institute of Diabetes Research at Helmholtz Zentrum München.

Nearly 2,800 children followed over an 18 year period

The starting point for their work were three large studies aimed at understanding the mechanisms underlying type 1 diabetes (TEENDIAB, BABYDIAB and BABYDIET). “In total, we studied data from nearly 2,800 children with a first-degree relative with type 1 diabetes,” explains lead author Anitha Pitchika. “Their metabolic status and body weight were tracked up to the age of 18.” “This analysis was possible only now with our dataset which contains such a large number of mothers with type 1 diabetes,” adds Anette-Gabriele Ziegler. “A few decades ago, mothers with this condition were often advised not to get pregnant due to the high risk of complications at birth.”

The researchers found that children of mothers with type 1 diabetes had a significantly higher body mass index than children from mothers without diabetes. “Children in the TEENDIAB study were for instance almost twice as likely to become overweight,” explains Andreas Beyerlein. Other parameters, such as waist circumference, fasting blood glucose level and risk for insulin resistance, were also significantly higher if the mother had type 1 diabetes. The scientists corrected for a number of possible confounding factors, such as the mother’s socioeconomic status and high birth weight.

To find out to what extent the differences were due to fundamental changes in the child’s metabolism, the researchers collected metabolomics data from 500 children in the TEENDIAB study. As it turned out, however, they did not find any significant changes in metabolic products and pathways caused by maternal type 1 diabetes.

“Our study shows that children of mothers with type 1 diabetes are not only at significantly higher risk of having the condition itself, but are also at greater risk of being overweight and developing insulin resistance,” says Anette-Gabriele Ziegler, summarizing the findings. “We would therefore advise that paediatricians should bear this correlation in mind, so that they can react on early warning signs in such children.”


Explore further:
Higher risk of heart defects in babies of mothers with type 1 diabetes

More information:
Anitha Pitchika et al. Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study, Diabetologia (2018). DOI: 10.1007/s00125-018-4688-x

Journal reference:
Diabetologia

Provided by:
Helmholtz Association of German Research Centres

Tagged with:

About author

Related Articles