Breaking News
October 16, 2018 - New research identifies modifiable dementia risk factor in elderly people
October 16, 2018 - Zebrafish study uncovers molecular ‘brake’ that helps control eye lens development
October 16, 2018 - Overlapping copy number variations underlie autism and schizophrenia in Japanese patients
October 16, 2018 - Majority of Americans’ ancestry can be traced through existing DNA databases
October 16, 2018 - Patients coerced into mental health care less likely to perceive treatment as effective
October 16, 2018 - What you need to know about autism spectrum disorder
October 16, 2018 - Antidepressants can be used to treat Alzheimer’s disease
October 16, 2018 - Study uncovers important role of PRMT1 in dilated cardiomyopathy
October 16, 2018 - Nutritional quality of breakfast linked to cardiovascular and metabolic risk factors in children
October 16, 2018 - Study uses novel approach to investigate genetic origins of mental illnesses
October 16, 2018 - Scientists develop dual anthrax-plague vaccine
October 16, 2018 - Poor Outcomes for Hispanic Infants With Congenital Heart Dz
October 16, 2018 - Global study finds youngest in class more likely to be diagnosed with ADHD
October 16, 2018 - Researchers sequence two selfish genes in the fungus Neurospora intermedia
October 16, 2018 - Survey results highlight the need for better communication between patients and HCPs about bacterial vaginosis
October 16, 2018 - Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration
October 16, 2018 - Researchers create open access database on healthy immunity
October 16, 2018 - Rice University chemist wins big award to study small surfaces
October 16, 2018 - Study finds 43% drop in stroke rate
October 16, 2018 - Researchers identify basic relationships of cell cycle and cellular senescence in the placenta
October 16, 2018 - UA professor receives NSF grant to develop antifouling materials for medical implants
October 16, 2018 - Obesity Doubles Odds for Colon Cancer in Younger Women
October 16, 2018 - Adults with ADHD not constrained in creativity
October 16, 2018 - Raising visibility for people and students with chronic illness and disability
October 16, 2018 - Allele awarded NIH grant to develop nanoantibody therapies for treatment of sepsis
October 16, 2018 - Only 59% of young adults undergoing surgery are fluid responsive
October 16, 2018 - Research points to potential new treatment for hearing loss
October 16, 2018 - MDI Biological Laboratory receives $1.2 million SEPA grant to promote data literacy
October 16, 2018 - Vast majority of dementia cases may arise from spontaneous genetic errors
October 16, 2018 - New project aims to deliver fast, effective treatment for autoimmune rheumatic diseases
October 16, 2018 - Study identifies molecular switch that controls fate of milk-producing breast cells
October 16, 2018 - Research shows diet has little influence on precursor to gout
October 16, 2018 - “Without Dr. Shumway doing his miracle work, three generations would not be here”: A Stanford heart transplant patient’s story
October 16, 2018 - Non-invasive brain stimulation sheds light on neurobiology underlying implicit bias
October 16, 2018 - Researchers demonstrate integrated technique to control production of cell therapeutics
October 16, 2018 - Breast tomosynthesis detects 34% more tumors than traditional mammography
October 16, 2018 - Rhode Island Hospital, Brown receive $800,000 grant to keep up fight against opioid epidemic
October 16, 2018 - UVA partners with health systems in AVIA network’s Medicaid Transformation Project
October 16, 2018 - Trevena Announces Oliceridine FDA Advisory Committee Meeting Outcome
October 16, 2018 - Study reveals early warning signs of heart problems in patients with newly diagnosed lupus
October 16, 2018 - Connecting the dots of Alzheimer’s disease
October 16, 2018 - New publication offers evidence-based content for global breast imaging medical community
October 16, 2018 - ‘EinsteinVision’ that improves hand-eye coordination of surgeons introduced at Harefield Hospital
October 16, 2018 - WRAIR clinical study evaluates safety and immunogenicity of Marburg vaccine
October 16, 2018 - Ketamine can be considered as alternative to opioids for short-term pain control in ED
October 16, 2018 - Endurance exercise training beneficially alters gut microbiota composition
October 15, 2018 - FDA Approves Yutiq (fluocinolone acetonide intravitreal implant) for Chronic Non-Infectious Posterior Segment Uveitis
October 15, 2018 - Birthing Options for Full-Term Pregnancy
October 15, 2018 - Stressed, toxic, zombie cells seen for first time in Alzheimer’s
October 15, 2018 - Concussion researchers study head motion in high school football hits | News Center
October 15, 2018 - Neuropsychiatric symptoms related to earliest stages of Alzheimer’s brain pathology
October 15, 2018 - Neck collar device may help protect the brain of female high school soccer players
October 15, 2018 - Research reveals how the inner ear processes speech
October 15, 2018 - Many parents still skeptical about safety and effectiveness of flu shot, survey finds
October 15, 2018 - Payer Policies May Discourage Non-Pharma Tx for Low Back Pain
October 15, 2018 - Exercise may delay cognitive decline in people with rare Alzheimer’s disease
October 15, 2018 - Researchers modify CRISPR to reorganize genome | News Center
October 15, 2018 - Innovative brain tumor operation set to tailor to patients’ needs
October 15, 2018 - Findings offer new insight into early changes that occur during AD pathology
October 15, 2018 - Neurons regulating reproductive hormone release have different activity in epileptic mice
October 15, 2018 - More parents are concerned about taking babies swimming in public pools
October 15, 2018 - Health Tip: Know the Risk Factors for Lower Back Pain
October 15, 2018 - Study shows cigarillo flavors enhanced by high-intensity sweeteners
October 15, 2018 - Study traces hospital-acquired bloodstream infections to patients’ own bodies | News Center
October 15, 2018 - Abnormal vision in childhood can affect development of brain areas responsible for attention
October 15, 2018 - Study highlights need for increased support for alcohol-related liver disease patients
October 15, 2018 - Color-changing contact lens could help doctors to monitor eye disease medications
October 15, 2018 - Tobacco heating products cause less staining to teeth than conventional cigarettes
October 15, 2018 - Young adults who are obese can expect to lose up to 10 years in life expectancy
October 15, 2018 - Scientists uncover how proteins meet on the cell membrane
October 15, 2018 - Affordable housing with supportive social services for senior citizens can reduce hospital use
October 15, 2018 - Schiller Easy Pulse Saves Lives
October 15, 2018 - The latest ECG device from Schiller
October 15, 2018 - Following a Tissue Sample
October 15, 2018 - Prisoners need drug and alcohol treatments but AA programs aren’t the answer
October 15, 2018 - Andrea Califano and Jordan Orange Elected to National Academy of Medicine
October 15, 2018 - The impending risk of African Swine Fever Virus
October 15, 2018 - Breastfeeding reduces the number of antibiotic-resistant bacteria in infant gut
October 15, 2018 - Researchers develop comprehensive molecular atlas of postnatal mouse heart development
October 15, 2018 - ObsEva SA Presents Clinical Data from Phase III IMPLANT 2 Trial of Nolasiban in IVF at the American Society of Reproductive Medicine (ASRM) Annual Meeting
Researchers develop technology to study behavior of implants without animal testing

Researchers develop technology to study behavior of implants without animal testing

image_pdfDownload PDFimage_print

An international team of researchers consisting of scientists from NUST MISIS and TU Dortmund University has developed a technology to study the behavior of orthopedic implants in laboratory conditions as close as possible to the human body. The technology is notable for its ethics: the research can be carried out in vitro – that is, without involving lab animals. The research article has been published in the Journal of the Mechanical Behavior of Biomedical Materials.

Endoprosthetics – replacing damaged joints or bones with a high-tech prosthesis – is a complicated surgery which uses the most advanced metal, ceramic, and polymer materials around.

Any implant material undergoes a number of tests, including those for biocompatibility and behavior in mechanically stressful conditions. Since the results of these studies in traditional laboratory settings are quite different from real wear factors, implants are placed in a laboratory animal to check the implant`s behavior inside a living organism. After some time, usually about a year, the implant is removed and the material’s biocompatibility and aging are evaluated.

Scientists from the NUST MISIS Center for Composite Materials together with their colleagues from TU Dortmund University have developed a technology that allows them to predict the wear of prosthetic materials under mechanical stress in an environment comparable to the real ones the materials are used in. Specially synthesized liquid simulating human blood plasma and a high-tech servo-hydraulic installation have thus completely replaced the need for an experimental live sample.

The biomimetic UHMWPE developed by researchers from the NUST MISIS Center for Composite Materials was used as a research material.

“We have provided the material and have proposed the use of synthetic plasma, and our colleagues from TU Dortmund University have developed a fatigue testing technology and conducted the experiment on their equipment. The material was subjected to two types of mechanical loads simulating the load of the femur and tibia: cyclic and static. Thanks to this experiment, we have proved that it is possible to predict the behavior of an orthopedic implant in the human body in vitro, without resorting to animal testing”, said Fedor Senatov, Candidate of Physical and Mathematical Sciences and research assistant at the NUST MISIS Center of Composite Materials.

“Our ambition was to offer an alternative that would reduce the number of animal tests that are ineffective and ethically-questionable in terms of fatigue assessment. The opportunity to propose a new method that would allow researchers to test implant materials for durability in the laboratory [was enticing]. Around the globe, there are still no standards for the study of an implant’s fatigue properties in a biomimetic environment associated with high risks of using new materials. We work with tests which allow us to accurately predict the service life of a material. Similar experiments have already been conducted by a research group led by Professor Walter (noted head of the research team from the German side) on metal and ceramic implants. For polymers, this experiment is unique, and has no analogs in the world”, said Marina Knyazeva, a representative of the research team from TU Dortmund University.

The economy of time is another significant advantage of the proposed technology. If the assessment of an implant’s chemical aging in a living organism takes about a year, the durability tests require decades. The process of chemical aging and wear can be significantly accelerated in conditions of in vitro. If the wear indicators are unsatisfactory, this will be immediately apparent and it will be possible to continue experiments with other samples.

However, it is too early to talk about the complete abandonment of the role of lab animals in testing materials for prosthetics.

“Our technology will allow us to compare several materials without testing any of them on animals. However, when the most optimal material from the list is found, it will need to be tested in vivo in living organisms. This is primarily due to the need to check the biocompatibility of the material, as well as its orthopedic parameters – because patients can meet a variety of features of the musculoskeletal system”, explained Fedor Senatov.

Thus, scientists have proposed a comprehensive technology for studying of behavior of implants where experiments on accelerated aging in vitro will allow them to predict the service life of a potential implant, and subsequent check its biocompatibility in vivo.

Source:

http://en.misis.ru/university/news/science/2018-09/5582/

About author

Related Articles