Breaking News
November 17, 2018 - FDA announces new actions to limit sale of e-cigarettes to youth
November 17, 2018 - Warmer winter temperatures related to higher crime rates
November 17, 2018 - MCO places increasing emphasis on helping people find and access healthy food
November 17, 2018 - Group of students aim to improve malaria diagnosis using old smartphones
November 17, 2018 - Transplantation of feces may protect preterm children from deadly bowel disease
November 17, 2018 - Researchers explore whether low-gluten diets can be recommended for people without allergies
November 17, 2018 - New and better marker for assessing patients after cardiac arrest
November 17, 2018 - For 7-year-old with failing bone marrow, a life-saving transplant | News Center
November 17, 2018 - New first-line treatment for peripheral T-cell lymphoma approved by FDA
November 17, 2018 - Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony
November 17, 2018 - Breakthrough in the treatment of Restless Legs Syndrome
November 16, 2018 - FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Hepatocellular Carcinoma (HCC) Who Have Been Previously Treated with Sorafenib
November 16, 2018 - Eagle Books | Native Diabetes Wellness Program
November 16, 2018 - Patients with common heart failure more likely to have lethal heart rhythms
November 16, 2018 - How AI could help veterinarians code their notes | News Center
November 16, 2018 - Bias-based bullying does more harm to students than generalized bullying
November 16, 2018 - Researchers find first direct evidence that cerebellum plays role in cognitive functions
November 16, 2018 - Non-coding genetic variant plays key role in endothelial function and disease incidence
November 16, 2018 - EMA recommends first all-oral treatment to tackle deadly sleeping sickness
November 16, 2018 - Drug used to treat dizziness may slow down growth of triple-negative breast cancer
November 16, 2018 - AHA: Icosapent Ethyl Cuts CV Risk From Elevated Triglycerides
November 16, 2018 - ‘Orphan’ RNAs make cancer deadlier, but potentially easier to diagnose
November 16, 2018 - Air Cube touches down at hospital | News Center
November 16, 2018 - CRISPR-based tool shown to enhance cell-based immunotherapy
November 16, 2018 - Mechanisms that govern HIV latency differ in the gut and blood, finds study
November 16, 2018 - Researchers unravel mystery of NPM1 protein in acute myeloid leukemia
November 16, 2018 - High school students less likely to select milk, fruit for lunch when fruit juice is available
November 16, 2018 - Football coaches with great emotional competence are more successful
November 16, 2018 - Researchers awarded $10 million grant to address root causes of asthma in Puerto Rico
November 16, 2018 - Health Tip: Manage Morning Sickness
November 16, 2018 - Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
November 16, 2018 - ACC Latin America Conference brings experts to discuss latest cardiovascular science
November 16, 2018 - Pooled analysis of Intersect ENT’s steroid releasing implants in patients after frontal sinus surgery to be published
November 16, 2018 - Expectations about pain intensity can become self-fulfilling prophecies
November 16, 2018 - NIH awards $3.4 million to UC researchers to study gastrointestinal lymphatic system
November 16, 2018 - Highlighting Advances in Bioengineering and Analytical Technologies with eBooks
November 16, 2018 - Scientist Dr David Taylor of MR Solutions is a finalist in the BMW i UK Tech Founder Awards
November 16, 2018 - Earlier treatment could help reverse autistic-like behavior in tuberous sclerosis
November 16, 2018 - Sucking your baby’s pacifier could improve their health
November 16, 2018 - Vegetables and salad may include bacteria that are resistant to antibiotics
November 16, 2018 - Autism linked to prolonged connection between brain regions
November 16, 2018 - Endocrine Society chooses four Diabetes Caucus leaders as winners of Diabetes Champion Award
November 16, 2018 - Brain and muscle cells found within kidney organoids
November 16, 2018 - Person’s sex hormones may play key role in trauma survival, finds study
November 16, 2018 - PTEN Genetic Test: MedlinePlus Lab Test Information
November 16, 2018 - Toxic metal pollution linked with development of autism spectrum disorder
November 16, 2018 - Calcified nodules in the retina increase risk for progression to late stages of AMD
November 16, 2018 - ZEISS teams up with arivis AG to offer complete 3D imaging solutions
November 16, 2018 - Georgia State professor receives $1.2 million grant to study how the brain controls eating behavior
November 16, 2018 - Specific bacterial toxins reduce number of cells suppressing immune response
November 16, 2018 - Review by ID physician improves outcomes for outpatient parenteral antimicrobial therapy
November 16, 2018 - Conditions that produce signs similar to arthritis
November 16, 2018 - New artificial intelligence-based method predicts treatment effectiveness
November 16, 2018 - AHA: Dapagliflozin Noninferior to Placebo for MACE in T2DM
November 16, 2018 - Surgery remains best treatment for appendicitis, Stanford study finds
November 16, 2018 - Non-surgical fistula creation system Ellipsys becomes key focus of attention at CiDA
November 16, 2018 - Researchers find no link between ‘allergy friendly’ dogs and lower risk of asthma
November 16, 2018 - Researchers elucidate new rules of connectivity of neurons in the neocortex
November 16, 2018 - Treating children with ‘bubble baby disease’
November 16, 2018 - Nexus announces availability of Arsenic Trioxide Injection in the US
November 16, 2018 - Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis
November 16, 2018 - AHA: PTSD Common Among Those Who Suffer Tear in the Aorta’s Wall
November 16, 2018 - Many RA patients’ pain related to central nervous system
November 16, 2018 - Changes in Himalayan gut microbiomes linked to diet
November 16, 2018 - Inhibition of prostaglandin E2 enhances ability to combat infectious colitis
November 16, 2018 - Chronic dry eye can slow reading rate and disrupt day to day tasks
November 16, 2018 - Researchers develop new drug molecule that inhibits inflammation
November 16, 2018 - Dementia symptoms peak in winter and spring, study finds
November 16, 2018 - Stanford tobacco researcher weighs in on JUUL
November 16, 2018 - Increasing omega-3 fatty acid intake during pregnancy reduces risk of premature birth, review finds
November 16, 2018 - Researchers find no link between infants waking up at night and later developmental problems
November 16, 2018 - Both parents and children agree about confidential medical services
November 16, 2018 - FDA warns against use of unapproved pain medications with implanted pumps
November 16, 2018 - Precision medicine-based approach to slow or reverse biologic drivers of Alzheimer’s disease
November 16, 2018 - Study provides new insight into norovirus outbreaks, may help guide efforts to develop vaccines
November 16, 2018 - Inexpensive, portable air purifier could help protect the heart from pollution
November 16, 2018 - New 15-minute scan could help diagnose brain damage in babies up to two years old
November 16, 2018 - Deep brain stimulation not effective for treating early Alzheimer’s
November 16, 2018 - Traditional chemotherapy superior to new alternative for oropharyngeal cancers | News Center
November 16, 2018 - What This Pond Protist Does With Its Genome Will Astound You
ConnectToBrain project seeks to improve techniques for brain stimulation in current clinical use

ConnectToBrain project seeks to improve techniques for brain stimulation in current clinical use

image_pdfDownload PDFimage_print

The costs associated with neurological diseases amount to 1000 billion euros per year in Europe alone. The methods for brain stimulation therapy to be developed in the ConnectToBrain project are expected to save up to a billion euros annually in Europe with considerable cuts to both cost of care and duration of sick leaves.

The inner workings of the neurological system can be compared to a symphony orchestra. The various regions of the brain all “listen” to each other via internal neural pathways, not unlike musicians following the sound of all the instruments and the instructions of the conductor. Neurological conditions such as schizophrenia, stroke, or substance dependence impinge on the activity of the brain’s neural connections and disrupt a person’s ability to function–making the orchestra play out of tune and time.

The ConnectToBrain project seeks to radically improve the techniques for brain stimulation in current clinical use. Synergistically complementing the research group of Aalto University Professor Risto Ilmoniemi, other research groups include the team of Professor Emeritus Gian Luca Romani from “G. d’Annunzio” University of Chieti-Pescara, Italy, and the group of Professor Ulf Ziemann from the University of Tübingen, Germany.

Currently, stimulation treatment involves activating single sites in the brain with magnetic pulses, one at a time, in sequences running into the thousands. The new technology that the ConnectToBrain project will implement, called multi-locus transcranial magnetic stimulation (mTMS), will be able to switch between individual stimulation points at intervals of only a few milliseconds.

‘The difference between the old and new technology is comparable to a concert pianist playing her instrument delicately with both hands, adjusting her timbre while listening to the music–rather than mindlessly strumming a single note while wearing ear plugs,’ says Aalto University Professor Risto Ilmoniemi.

The stimulation process will be controlled by intelligent software. The control algorithm will start at selected sites in the brain and will then automatically and rapidly move on to change the focus depending on how the stimulated neural pathways react and transform. The technique also allows the system to couple to the ongoing electrical rhythms in the brain.

‘The algorithm has to be able to read and interpret the map of brain connections in real time, and to decide in just a tiny fraction of a second when and where to stimulate next. This is challenging because the measured signals are weak, and brain activity is very complicated. Machine learning techniques will help us optimise our algorithms for the task,’ says Gian Luca Romani.

By exciting the networks of neuronal pathways associated with conditions such as depression, the researchers hope that the algorithm can restore the pathways to a healthy state. Depression can restrict brain functions, and treatment aims to invigorate them. Conversely, in conditions such as epilepsy, certain brain functions need to be slowed down.

‘First we need to learn more about brain dynamics and how to activate and strengthen neuronal connections that function poorly. We’ll need clinical trials combining and comparing magnetic stimulation with pharmaceuticals and traditional means of rehabilitation. Finally, we need to engage the research and clinical community in order to spread the knowledge of the new methodology,’ says Ulf Ziemann.

Source:

https://www.aalto.fi/news/erc-synergy-grant-worth-eu10m-will-help-develop-new-techniques-for-brain-research-disease

Tagged with:

About author

Related Articles