Breaking News
November 19, 2018 - Short Interpregnancy Intervals Tied to Adverse Outcome Risk
November 19, 2018 - New mothers’ breastfeeding pain can affect infant health
November 19, 2018 - Stanford Medicine magazine reports on ways digital technology is transforming health care | News Center
November 19, 2018 - Human drugs alter cricket personality
November 19, 2018 - Insilico Medicine to introduce ‘Cure a disease in a year’ program at Biodata World Congress 2018
November 19, 2018 - Experts debate over whether gut or brain is more important in regulating appetite
November 19, 2018 - Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising
November 19, 2018 - Low-Carb Diets May Work By Boosting Calorie Burn
November 19, 2018 - Key molecule responsible for learning and memory discovered
November 19, 2018 - New blood test developed for early diagnosis of ovarian cancer
November 19, 2018 - Researchers identify molecule to fight myotubular myopathy
November 19, 2018 - New solution to stop spread of brain cancer
November 19, 2018 - Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds
November 19, 2018 - Scientists equip new virus that kills carcinoma cells with protein
November 19, 2018 - Novel approach could provide painless, efficient alternative for treating eye diseases
November 19, 2018 - Protein in cell membranes of sperm plays key role in finding their way to eggs
November 19, 2018 - Parents who decline flu vaccination for their child may be exposed to limited information
November 19, 2018 - Mirati Presents Data From Ongoing Phase 2 Clinical Trial Of Mocetinostat In Combination With Durvalumab At The SITC 33rd Annual Meeting
November 19, 2018 - FDA warns of common diabetes meds’ link to dangerous genital infection
November 19, 2018 - New methods for preserving shoulder function, quality of life in breast cancer patients
November 19, 2018 - Surprising discovery about BH4 may rekindle interest in once-promising pathway
November 19, 2018 - Nabriva Therapeutics Completes Submission of New Drug Application to U.S. Food and Drug Administration for Intravenous Contepo to Treat Complicated Urinary Tract Infections
November 19, 2018 - Beating breast cancer only to die of opioid use – a sad Appalachian story
November 19, 2018 - Workplace bullying or violence linked to higher risk of cardiovascular problems
November 19, 2018 - Changes in Risk Indicators of MetS Severity Tied to T2DM Risk
November 19, 2018 - ‘Game-changing’ skin sensor could improve life for a million hydrocephalus patients
November 19, 2018 - Alcohol ads on social media sites with pro-drinking comments increase desire to drink
November 19, 2018 - Neural networks could replace marker genes in RNA sequencing
November 19, 2018 - Obese adolescents feel less food enjoyment than those with normal weight, study reveals
November 18, 2018 - Goodbye ‘Gluten-Free’? Celiac Disease Vaccine May Make It Possible
November 18, 2018 - Skin ages when the main cells in the dermis lose their identity and function
November 18, 2018 - Rainforest vine compound makes pancreatic cancer cells susceptible to nutrient starvation
November 18, 2018 - A new mechanism in the control of inflammation
November 18, 2018 - Age-related decline in abstract reasoning ability predicts depressive symptoms over time
November 18, 2018 - Scientists succeed in increasing stability, biocompatibility of light-transducing nanoparticles
November 18, 2018 - Sugar, a ‘sweet’ tool to understand brain injuries
November 18, 2018 - Pharmacist-Led Effort Cuts Inappropriate Rx in Older Adults
November 18, 2018 - Novel discovery could lead to new cancer, autoimmune disease therapy
November 18, 2018 - AHA and ADA launch new initiative to help people with type 2 diabetes reduce heart disease risk
November 18, 2018 - Balanced production of pro and anti-inflammatory cytokines at two years of age protects against malaria
November 18, 2018 - New pharmacological agent shows promise for prevention of heart rhythm disorders
November 18, 2018 - All That Social Media May Boost Loneliness, Not Banish It
November 18, 2018 - Scientists shine new light on link between obesity and cancer
November 18, 2018 - Risk factors for cardiovascular disease closely track with changes in diet patterns
November 18, 2018 - Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
November 18, 2018 - Detectable HIV-1 in treated human liver cells found to be inert
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
November 18, 2018 - Poverty blamed on widening north-south gap in young adult deaths in England
November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
November 18, 2018 - Fine particle air pollution is a public health emergency hiding in plain sight
November 18, 2018 - In-hospital mortality higher among patients with drug-resistant infections
November 17, 2018 - Research shines new, explanatory light on link between obesity and cancer
November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
November 17, 2018 - Tracking Preemies’ Head Size May Yield IQ Clues
November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - New strategy to hinder emergence of antimicrobial-resistant pathogens
November 17, 2018 - Sexuality education before age 18 may reduce risk of sexual assault in college
November 17, 2018 - Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure
November 17, 2018 - New model of FSHD could be useful to study effectiveness of experimental therapeutics
November 17, 2018 - FDA approves antibacterial drug to treat travelers’ diarrhea
November 17, 2018 - Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers
November 17, 2018 - Largest parasitic worm genetic study hatches novel treatment possibilities
November 17, 2018 - UCLA biologists uncover how head injuries can lead to serious brain disorders
November 17, 2018 - Static and dynamic physical activities offer varying protection against heart disease
November 17, 2018 - Obesity significantly increases risk of Type 2 diabetes and coronary artery disease
November 17, 2018 - New method to analyze cell membrane complexes could revolutionize the way we study diseases
November 17, 2018 - Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission
November 17, 2018 - People with rare cancers can benefit from genomic profiling, shows research
November 17, 2018 - NIH awards over $1.8 million to husband-and-wife doctors to test new breast cancer approach
November 17, 2018 - Four-in-one antibody used to fight flu shows promise in mice
November 17, 2018 - New approach allows pathogens to be starved by blocking important enzymes
November 17, 2018 - Higher body mass index could cause depression even without health problems
November 17, 2018 - Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension
November 17, 2018 - FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated Systemic Anaplastic Large Cell Lymphoma or Other CD30-Expressing Peripheral T-Cell Lymphomas
November 17, 2018 - ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy
November 17, 2018 - UT Southwestern scientists selected to receive 2019 Edith and Peter O’Donnell Awards
Influenza virus can evolve resistance to experimental antiviral drug

Influenza virus can evolve resistance to experimental antiviral drug

image_pdfDownload PDFimage_print

The influenza virus can evolve resistance to an anti-flu drug currently in development for use in pandemics but only if there are multiple genetic mutations, a study has found.

Scientists at Imperial College London, in collaboration with Public Health England, have discovered that two genetic mutations would be needed for the virus to develop resistance to favipiravir, an experimental antiviral developed in Japan.

Favipiravir is not currently licensed in the UK for the treatment of flu but has shown to be effective in clinical trials to date and has the potential to be used in the event of a flu pandemic where other drugs, such as Tamiflu, might fail.

The researchers caution that the influenza virus has only so far been shown to develop resistance to the drug in laboratory studies, and it is unclear if the same would happen in a pandemic. However, their findings highlight a mechanism by which influenza and other viruses could potentially overcome such drugs used in the event of an outbreak and so should be closely monitored.

It was previously thought that the influenza virus was unable to overcome favipiravir, with laboratory, animal and clinical studies showing little evidence of resistance. However, the latest findings, published this week in the journal PNAS, are the first to show that influenza could develop resistance to the drug.

Professor Wendy Barclay, from the Department of Medicine and Action Medical Research Chair in Virology at Imperial, who led the research, said: “We’re alerting the world to the fact that RNA viruses, like influenza, can readily adapt to their environment and evolve, and that while favipiravir could be a potentially important drug in a pandemic situation, resistance can emerge.”

Favipiravir acts by targeting an enzyme called RNA polymerase used by influenza to copy its genetic material. Clinical trials have shown the drug to be effective in treating flu in humans and it has also been tested against other RNA viruses, like ebola and chikungunya, which rely on the same type of enzyme to replicate, showing promise in pre-clinical trials.

In the latest study, Professor Barclay and colleagues from the NIHR Health Protection Research Unit in Respiratory Infections at Imperial explored how influenza might potentially evolve to counter the drug.

When influenza was grown in the presence of favipiravir in cell cultures, the virus was able to evolve, uncovering a combination of two key mutations that enabled it to become resistant to the antiviral.

The first of the mutations caused a change in the RNA polymerase enzyme itself, blocking the drug’s effect, but it came at a cost for the virus and affected its ability to reproduce.

However, this loss of fitness was countered by the second mutation, which restored the virus’s ability to thrive and spread.

According to the researchers, it is unclear whether this combination of mutations could occur readily in viruses in the wild, but their findings are the first to show a clear genetic mechanism by which resistance to the drug could potentially come about in influenza strains around the world.

They add that while their work focused on flu, other research groups have reported the same mutation in chikungunya – another RNA virus which uses the same enzyme to replicate – suggesting that there may be a general mechanism by which other RNA viruses could become resistant to the drug.

“Favipiravir is still an important drug and should be in the pipeline to be used in the event we need it, but we now know that viruses can develop resistance to it,” explained Professor Barclay. “We need to look out for these mutations and monitor for them, particularly if we are using this drug in outbreak situations and in patients that might have prolonged disease, as those are conditions where you might see resistance emerging.”

Dr Maria Zambon, from Public Health England, said: “We have shown that resistance can emerge to this antiviral, which has not been shown previously and we need to factor this in to our pandemic preparedness. However, pandemic planning is multifaceted and includes vaccines, antivirals and good hygiene messaging.”

Professor Barclay added: “This research is a great illustration of the success of NIHR Health Protection Research Units. Not only do the findings contribute to the scientific knowledge base, they also make an important contribution to our public health knowledge about how we use these drugs and the importance of surveillance to spot the emergence of such mutations.”

Source:

http://www3.imperial.ac.uk/

Tagged with:

About author

Related Articles