Breaking News
January 17, 2019 - Pre-injury exercise reduces damage to both muscles and nerves, study finds
January 17, 2019 - Minimizing Antibody Size to Maximize Research Potential
January 17, 2019 - Research finds large genome in tiny forest defoliator
January 17, 2019 - Technology helps reduce the yearning for unhealthy food
January 17, 2019 - New Drug Application for Insomnia Disorder Treatment Lemborexant Submitted in the United States
January 17, 2019 - What you should know about teeth whitening
January 17, 2019 - Why Older Adults Should Eat More Protein (And Not Overdo Protein Shakes)
January 17, 2019 - Colorectal cancer mortality rates predicted to increase globally
January 17, 2019 - Scientists discover mutational signatures of tumor hypoxia
January 17, 2019 - New evidence shows how fever alters immune cells
January 17, 2019 - Researchers find new class of blood pressure-regulating peptides in vampire bat venom
January 17, 2019 - Promega to exhibit new Maxwell RSC48 platform at 2019 Festival of Genomics
January 17, 2019 - Study pinpoints immune cells that could be key to tackling hypertension
January 17, 2019 - Couples Intervention May Aid Partners of Diabetes Patients
January 17, 2019 - Your weight history may predict your heart failure risk
January 17, 2019 - Explore a cornucopia of accomplishments in prematurity research
January 17, 2019 - New study identifies four characteristics that predict severity of postpartum depression
January 17, 2019 - New, scalpel-free treatment for reducing Parkinson’s tremor gets FDA approval
January 17, 2019 - Neurobiologists uncover key component of how the human brain marks time
January 17, 2019 - LifeTime receives fund to develop a plan to embed its vision for healthier future
January 17, 2019 - WTC first responders at higher risk for head and neck cancers, study finds
January 17, 2019 - New NSF funded study may help physicians decrease brain injury deaths
January 17, 2019 - Ham bones contain peptides that could have cardioprotective effects
January 17, 2019 - Research finds how Candida albicans adapt to low oxygen levels to cause infection
January 17, 2019 - Cobra Biologics announces appointment of Dr Darrell Sleep as Director of Innovation
January 17, 2019 - Cellular protein that interacts with viruses appears to enable infection process of Zika virus
January 17, 2019 - Opioids Now More Deadly for Americans Than Traffic Accidents
January 17, 2019 - Women who start periods early are at greater risk of cardiovascular problems
January 17, 2019 - The brain-circuitry clash that keeps you from diving into that plate of ribs when you’re dining with royalty
January 17, 2019 - Poo transplant can successfully treat patients with ulcerative colitis
January 17, 2019 - Study suggests key role for glial cells in Parkinson’s disease
January 17, 2019 - Educational videos in clinical settings increase HPV vaccination rates among adolescents
January 17, 2019 - Better understanding of aggressive brain tumour
January 17, 2019 - Why is life expectancy in the U.S. going down? A Q&A
January 17, 2019 - The Electronics Industry Sees Money In Your Health
January 17, 2019 - Hypertension drug may improve effectiveness of ovarian cancer treatment
January 17, 2019 - Scientists reveal key mechanism in worms that controls cell’s response to stress
January 17, 2019 - How Patch Clamp Technology Can Benefit Ion Channel Research
January 16, 2019 - Researchers cultivate organoids that perfectly mimic blood vessels
January 16, 2019 - Sound Pharmaceuticals Advances Phase 2 Hearing Loss Clinical Trial in Cystic Fibrosis
January 16, 2019 - Unraveling the genetic causes of skin cancer
January 16, 2019 - Higher percentages of saturated fat in low-carb diets may not harm cholesterol levels, new analysis suggests
January 16, 2019 - Using bottled or tap water impacts health benefits of green tea
January 16, 2019 - Best trained alert dogs have potential to improve Type 1 diabetes patients’ quality of life
January 16, 2019 - States with lower incidence of melanoma have higher mortality rates
January 16, 2019 - Pollution on the London Underground found to be dangerously high
January 16, 2019 - Breast cancer cells in mice coaxed to turn into harmless fat cells
January 16, 2019 - Study connects the genetic background of autistic spectrum disorders with stem cell dysfunction
January 16, 2019 - When activated, ‘social’ brain circuits inhibit feeding behavior in mice | News Center
January 16, 2019 - How Exercise May Help Keep Our Memory Sharp
January 16, 2019 - Researchers identify a key regulator that stops excessive inflammation
January 16, 2019 - TGF-beta signaling pathway in uterine cells protects against cancer
January 16, 2019 - MD Anderson Cancer Center collaborates with Dragonfly for new immunotherapy drug clinical trials
January 16, 2019 - Drug Repurposing May Provide More Psychiatric Tx Options
January 16, 2019 - A new brain imaging study challenges the dominant theoretical model of autism spectrum disorders
January 16, 2019 - GoFundMe CEO: ‘Gigantic Gaps’ In Health System Showing Up In Crowdfunding
January 16, 2019 - Induced neuronal cells derived from fibroblasts are similar to neurons in the brain
January 16, 2019 - New study finds link between childhood abuse and suicide in later life
January 16, 2019 - Lifestyle and health factors that are good for the heart can also prevent diabetes
January 16, 2019 - Scientists take another step in understanding bacteria that cause Salmonella epidemic
January 16, 2019 - Look to Your Aunts, Uncles and Parents for Clues to Your Longevity
January 16, 2019 - Study finds ADHD drugs are unlikely to cause cardiac damage in children who take them
January 16, 2019 - Call The Midwife! (If The Doctor Doesn’t Object)
January 16, 2019 - Changes in hippocampal structural connectivity differentiate responders of electroconvulsive therapy
January 16, 2019 - Study sheds light on the deadly venom of Mojave rattlesnakes
January 16, 2019 - University of Nebraska to develop new drugs that prevent and counteract effects of radiation exposure
January 16, 2019 - Sugar-based stent makes precarious sewing process easier
January 16, 2019 - FDA-approved drug hampers cancer metastasis in animal model, shows study
January 16, 2019 - Memories of past meals influence future food intake in rats
January 16, 2019 - Low-level cannabis use can change the adolescent brain
January 16, 2019 - MTC in Rouen acquires Robocath’s R-One robot for future healthcare practitioner training
January 16, 2019 - OSSIO granted FDA 510(k) market clearance for OSSIOfiber Bone Pin Family
January 16, 2019 - Childhood body composition may play a role in future respiratory health
January 16, 2019 - Outdated commissioning methods are failing mental health services in the UK, reveals report
January 16, 2019 - Unconventional immune cells trigger disturbed cytokine production in human spondyloarthritis
January 16, 2019 - Patients Turn To GoFundMe When Money And Hope Run Out
January 16, 2019 - Researchers develop novel viral identification method
January 16, 2019 - Study proposes improvements in pharmacological study of cognitive function enhancers in schizophrenia
January 16, 2019 - Study points to potential new biomarker and drug target for amyotrophic lateral sclerosis
January 16, 2019 - Differences in geographic origin of genes may affect mitochondrial function
New 20-minute test diagnoses hidden heart condition

New 20-minute test diagnoses hidden heart condition

image_pdfDownload PDFimage_print
Credit: CC0 Public Domain

New tests can diagnose ‘hidden’ heart diseases caused by problems with the small blood vessels supplying the heart, according to research funded by the British Heart Foundation (BHF) and presented at the Transcatheter Cardiovascular Therapeutics (TCT) conference today in San Diego.

The new tests are not yet standard in the NHS because, before now, there has not been enough evidence gathered about whether they would benefit patients. Now, researchers say that they should be routinely available to pinpoint the cause of chest pain.

Researchers from the University of Glasgow and the Golden Jubilee National Hospital performed the new ‘small vessel’ test which involves passing a thin, flexible wire into the heart and measuring how well a blood vessel relaxes.

The team performed the new test on 151 patients with chest pain who could not be diagnosed using currently available tests. The small vessel test results for half of the patients were made available to doctors to further guide the diagnosis and treatment, whereas, in the other half of the patients, the results were not disclosed. These patients followed standard care. The team found that the new tests were able to correctly diagnose four times as many patients as standard tests.

Even more importantly, 6 months later, symptoms of angina were less and quality of life was better in the patients whose care was guided by the new tests.

Chest pain originating from the heart is often a symptom of a condition called angina. Angina is triggered when the heart does not receive enough oxygen rich blood, often due to narrowed coronary arteries, the arteries which supply the heart itself. It often happens during exercise, cold weather and emotional stress and points to an underlying problem in the heart.

Doctors commonly recommend an angiogram, an invasive procedure which looks for narrowing of the heart’s main arteries. However, in around one half of patients with angina, this angiogram reveals no significant problems. Despite this, patients can experience severe chest pain and have a significantly higher risk of having a heart attack in the future.

In many people with angina, the pain may be caused by problems with the tiniest blood vessels in the heart—the micro vessels—which are too small to see with traditional tests. The conditions are called microvascular angina and vasospastic angina, which are commonly misdiagnosed. Because diagnosis is so difficult, patients are often left without firm answers about the cause of their chest pain.

Lead researcher Professor Colin Berry, Chair in Cardiology and Imaging at the University of Glasgow, said: “Microvascular angina and vasospastic angina are under-recognised problems. As the angiogram in these patients looks ‘clear’ they are commonly falsely reassured. Our study’s results indicate this to be the case.

“However, leaving microvascular angina and vasospastic angina undiagnosed and untreated presents a risk to patient wellbeing- these problems can be a precursor to a hospitalisation for chest pain and a heart attack – and symptoms persist in the longer term.

“We now hope to see this test rolled out across the country.”

Philippa Hobson, Senior Cardiac Nurse at the British Heart Foundation, which funded the research, said: “People living with microvascular angina suffer from crippling and frightening episodes of chest pain that dramatically affects their day to day life. They are unable to treat their symptoms effectively as their angiogram is essentially normal. Medication currently prescribed to people with diagnosed coronary heart disease does little to resolve their pain or reduce risk of heart attack, so they are left in limbo.

“This study is very reassuring news for sufferers who live in the fear of having a heart attack as for many, there is currently no conclusive proof they have heart disease.”


Explore further:
One type of heart disease requires special testing

More information:
Thomas J. Ford et al. Stratified Medical Therapy Using Invasive Coronary Function Testing In Angina: CorMicA Trial, Journal of the American College of Cardiology (2018). DOI: 10.1016/j.jacc.2018.09.006

Journal reference:
Journal of the American College of Cardiology

Provided by:
University of Glasgow

Tagged with:

About author

Related Articles