Breaking News
March 22, 2019 - Less invasive valve replacement can be safe and effective alternative for healthier patients
March 22, 2019 - Aphasia research reveals new, complex interactions between thought and language
March 22, 2019 - Artificial neural networks can predict how different areas in the brain respond to words
March 22, 2019 - Age-related changes to gut microbiome have adverse impact on vascular health, study shows
March 22, 2019 - Isolated seniors chat online to prevent cognitive decline
March 22, 2019 - Karyopharm Announces FDA Extension of Review Period for Selinexor New Drug Application
March 22, 2019 - Eruptive xanthomatosis
March 22, 2019 - Cause of vascular disease in kidney failure reversed in animal model
March 22, 2019 - Researchers discover possible new therapeutic strategy for pancreatic cancer
March 22, 2019 - Ebola spreads to second largest city in DRC
March 22, 2019 - Perivascular spaces contribute to worse cognitive health in older adults
March 22, 2019 - Adolescent daily users more likely to obtain electronic cigarettes from commercial sources
March 22, 2019 - FDA Approves Genentech’s Tecentriq in Combination With Chemotherapy for the Initial Treatment of Adults With Extensive-Stage Small Cell Lung Cancer
March 22, 2019 - Diabetes myths and facts: MedlinePlus Medical Encyclopedia
March 22, 2019 - TGen and ABL pursue global rollout of advanced TB test
March 22, 2019 - Traffic light labels influence people to choose healthier and more sustainable meals
March 22, 2019 - Alzheimer’s patients using antiepileptic drugs have twice the risk of pneumonia, study shows
March 22, 2019 - Skin diseases may be more prevalent than previously thought
March 22, 2019 - Overall rates of death from breast cancer are falling across the EU
March 22, 2019 - Novel plasmid could hold key to control of mosquito-borne illness
March 22, 2019 - Female Emergency Physicians Paid Less Than Males
March 22, 2019 - Estimated average glucose (eAG): MedlinePlus Medical Encyclopedia
March 22, 2019 - Experimental drug could be new option for type 2 diabetes
March 22, 2019 - Five Things To Know About The Electronic Health Records Mess
March 22, 2019 - TMJ disorders could be treated with tissue-engineered implants after successful animal study
March 22, 2019 - Team-based approach is key to successful care of pregnant women with heart failure
March 22, 2019 - Study identifies gene variant associated with accelerated cellular aging
March 21, 2019 - Salk scientists show how background noise from neurons can interrupt focused attention
March 21, 2019 - New class of drugs could help treat patients diagnosed with ovarian cancer
March 21, 2019 - Tecentriq Approved for Small Cell Lung Cancer
March 21, 2019 - Adipocyte glucocorticoid receptors play a role in developing steroid diabetes
March 21, 2019 - Climate change can affect nutrient content of crops, harming human health
March 21, 2019 - Podcast: KHN’s ‘What The Health’ Surprise! Fixing Surprise Medical Bills Is Harder Than it Looks
March 21, 2019 - Chemistry researchers patent new method for making anti-leukemia compounds
March 21, 2019 - UIC scientists identify hidden proteins in bacteria
March 21, 2019 - New Australian drug trial achieves remarkable results in patients with acute myeloid leukemia
March 21, 2019 - Females live longer when they have help raising offspring
March 21, 2019 - How did orthodontists sell orthodontics?
March 21, 2019 - In the Spotlight: From dietitian to physician assistant student
March 21, 2019 - The CRISPR Revolution: What You Need to Know
March 21, 2019 - FDA Chief Calls For Stricter Scrutiny Of Electronic Health Records
March 21, 2019 - Combined glucocorticoid and antioxidant therapy could benefit premature babies
March 21, 2019 - Low levels of certain eye proteins could serve as predictor for Alzheimer’s
March 21, 2019 - Post-traumatic holocaust survivors transmit negative views on aging to offspring
March 21, 2019 - City of Hope receives $7.5 million in grant awards to study cutaneous T cell lymphoma
March 21, 2019 - New video game-led training device helps stroke survivors regain arm mobility
March 21, 2019 - Compounds in coffee could slow prostate cancer growth
March 21, 2019 - New mobile DNA element in Wolbachia may contribute to improved disease control strategies
March 21, 2019 - Phase 2 Clinical Trial of Bermekimab Shows Potential New Standard of Care for Treatment of Hidradenitis Suppurativa, Including Significant Pain Reduction without Antibiotics
March 21, 2019 - More than one-third of patients risk major bleeding by doubling up on blood thinners
March 21, 2019 - A skeptical look at popular diets: Thumbs up for Mediterranean
March 21, 2019 - PTSD After Cardiac Arrest Predicts More Heart Trouble
March 21, 2019 - Role of immunological imprinting in elicitation of new antibodies
March 21, 2019 - Breast cancer relapse predictor tool may soon be a reality
March 21, 2019 - New computer program developed by TGen lights up cancer-causing genetic mutations
March 21, 2019 - FDA warns two breast implant makers for failure to comply with post-approval study requirements
March 21, 2019 - Butler Hospital receives COBRE grant to enhance research on neuropsychiatric illnesses
March 21, 2019 - Majority of osteoporosis clinical practice guidelines ignore patients’ voices
March 21, 2019 - Generic messages don’t help patients to lose weight
March 21, 2019 - Eisai and Imbrium Therapeutics Announce U.S. FDA Filing Acceptance of New Drug Application for Lemborexant for the Treatment of Insomnia
March 21, 2019 - Two-drug combos using popular calcium channel blocker show superiority in lowering BP
March 21, 2019 - Q BioMed and Mannin Research collaborate with McMaster University to develop GDF15 biomarker glaucoma diagnostic kit
March 21, 2019 - First-in-human pilot study shows positive results for ‘bacteria-phobic’ catheter
March 21, 2019 - Itamar Medical launches next-generation WatchPAT system for home sleep apnea testing
March 21, 2019 - Study estimates health and economic impacts of healthy food prescriptions
March 21, 2019 - Detecting fungal disease in crops with multispectral imaging system
March 21, 2019 - MIT announces creation of the Alana Down Syndrome Center
March 21, 2019 - Next-generation LVAD device clinically superior, safer for heart failure patients
March 21, 2019 - Allergan Announces FDA Approval of Avycaz (ceftazidime and avibactam) for Pediatric Patients
March 21, 2019 - Mutations in noncoding genes could play big role in regulating cancer, study finds
March 21, 2019 - A medical student’s thoughts on Match Day
March 21, 2019 - Are eggs good or bad for you?
March 21, 2019 - New analysis reveals precision oncology insights for colorectal cancer
March 21, 2019 - Pollutants appear to weaken immune system and increase pathogen virulence
March 21, 2019 - Researchers develop and validate scale for rating severity of mononucleosis
March 21, 2019 - Scientists identify generation of key immune response in mice on introducing solid food
March 21, 2019 - New nanomaterial could restore internal structure of damaged bones
March 21, 2019 - Selective destruction of prostate tumor as effective as complete prostate removal
March 21, 2019 - 2011 to 2015 Saw Increase in Psychiatric ED Visits for Youth
March 21, 2019 - Tapeworm drug targets common vulnerability in tumor cells
Study links aortic stiffness with lower cerebral blood flow

Study links aortic stiffness with lower cerebral blood flow

image_pdfDownload PDFimage_print
Credit: copyright American Heart Association

Greater aortic stiffness is related to lower cerebral blood flow, especially among individuals with increased genetic predisposition to Alzheimer’s disease, according to research from Vanderbilt University Medical Center.

The study, published recently in Circulation, supports emerging evidence that arterial stiffness, a hypertension-related factor, may play a role in cognitive decline, said Angela Jefferson, Ph.D., professor of Neurology and director of the Vanderbilt Memory and Alzheimer’s Center.

The study, which was conducted in older adults, showed a pronounced effect in the cognitively normal participants who carried the APOE4 gene, a susceptibility risk factor for Alzheimer’s disease. It coincides with evidence announced in July at the Alzheimer’s Association International Conference in Chicago that suggested intensive lowering of blood pressure in aging adults reduces the risk of mild cognitive impairment and may have implications for the prevention of Alzheimer’s disease and dementia.

“Given our study results and the recent SPRINT MIND findings, we have to strongly consider whether more aggressive medical management of vascular risk factors, and hypertension in particular, can result in better late-life cognitive outcomes for aging adults,” Jefferson said. “Collectively, results suggest that the answer is yes.”

She and colleagues at Vanderbilt used cardiac magnetic resonance imaging to assess aortic stiffness across the aortic arch. The aorta, the largest artery in the body, is a compliant and flexible artery that naturally stiffens with age.

“The aorta constricts and dilates more than 40 million times per year,” said Jefferson, the lead author of the study. “This amount of mechanical activity was perfectly fine back when life expectancy was 35 years of age, but life expectancy has more than doubled over the last couple of centuries.

“The aorta cannot withstand the excessive mechanical stress associated with so many additional years of constricting and dilating. As a result, the extracellular matrix within the vessel wall breaks down, and the aorta becomes increasingly stiff with age.

“It transitions from a flexible tube, like a garden hose, to something far stiffer, like a lead or concrete pipe,” Jefferson said.

The study’s findings add to a growing body of research detailing the strong connection between cardiovascular function and brain health as people age. A better understanding of this connection may lead to earlier detection and targeted interventions to prevent or mitigate consequences associated with aortic stiffening, including downstream cerebrovascular damage and further increases in blood pressure.

The research involved 270 participants in the Vanderbilt Memory and Aging Project, an ongoing interdisciplinary, longitudinal study being carried out at the Vanderbilt Memory and Alzheimer’s Center. In addition to cardiac magnetic resonance imaging, participants also underwent brain magnetic resonance imaging.

“We examined blood flow in the brain using a sophisticated neuroimaging technique,” Jefferson said. “Plus, we included a reactivity condition in which participants wear a mask that delivers just enough carbon dioxide to assess how responsive the cerebral vasculature is to subtle changes in arterial gas concentrations. If the vessels are healthy, they should dilate or expand to deliver more blood and oxygen to the brain.”

Participants with the APOE4 gene had a more pronounced association between greater stiffness and lower cerebral blood flow, which was greatest in the temporal region of the brain.

“While there was an association between higher aortic stiffness, measured by pulse wave velocity, and reduced blood flow throughout the brain, what was particularly interesting is the interaction we discovered with the APOE4 gene,” Jefferson said.

“Higher aortic stiffness related to lower cerebral blood flow in the temporal lobes, reflecting brain regions where Alzheimer’s disease pathology first evolves. It is interesting that this Alzheimer’s genetic risk factor modified the association in that way.”


Explore further:
Research links heart function to brain’s memory center

Journal reference:
Circulation

Provided by:
Vanderbilt University

Tagged with:

About author

Related Articles