Breaking News
January 21, 2019 - FDA Advisory Committee Votes on Zynquista (sotagliflozin) as Treatment for Adults with Type 1 Diabetes
January 21, 2019 - The causes and complications of snoring
January 21, 2019 - Placenta adapts and compensates when pregnant mothers have poor diets or low oxygen
January 21, 2019 - New implant could restore the transmission of electrical signals in injured central nervous system
January 21, 2019 - Rapid-acting fentanyl test strips found to be effective at reducing overdose risk
January 21, 2019 - Coronary Artery Calcium May Help Predict CVD in South Asians
January 21, 2019 - The mystery of the super-ager
January 21, 2019 - Scientists develop smart microrobots that can change shape depending on their surroundings
January 21, 2019 - Keep Moving to Keep Brain Sharp in Old Age
January 21, 2019 - Despite progress, gay fathers and their children still structurally stigmatized
January 21, 2019 - Merck recognized with 2018 Life Science Industry Award for best use of social media
January 21, 2019 - Coeur Wallis equips the canton of Valais with 260 SCHILLER defibrillators
January 21, 2019 - Scientists propose quick and pain-free method for diagnosing kidney cancer
January 21, 2019 - Signs of memory loss could point to hearing issues
January 21, 2019 - HeartFlow Analysis shows highest diagnostic performance for detecting coronary artery disease
January 21, 2019 - How Much Caffeine is Too Much?
January 21, 2019 - Take a timeout before you force your child to apologize
January 21, 2019 - Scientists design two AI algorithms to improve early detection of cognitive impairment
January 21, 2019 - Novel therapy for children with chronic hormone deficiency provides lifeline for parents
January 21, 2019 - Bioethicists call for oversight of poorly regulated, consumer-grade neurotechnology products
January 21, 2019 - Study shows hereditary hemochromatosis behind many cancers and joint diseases
January 21, 2019 - Short bouts of stairclimbing throughout the day can improve cardiovascular health
January 20, 2019 - Liver Transplant Survival May Improve With Race Matching
January 20, 2019 - Study implicates hyperactive immune system in aging brain disorders
January 20, 2019 - Cancer Diagnosis May Quadruple Suicide Risk
January 20, 2019 - Parkinson’s disease experts devise a roadmap
January 20, 2019 - Research brings new hope to treating degenerative brain diseases
January 20, 2019 - Scientists pinpoint a set of molecules that wire the body weight center of the brain
January 20, 2019 - Researchers get close to developing elusive blood test for Alzheimer’s disease
January 20, 2019 - UCLA researchers demonstrate new technique to develop cancer-fighting T cells
January 20, 2019 - Researchers discover how cancer cells avoid genetic meltdown
January 20, 2019 - Exercise makes even the ‘still overweight’ healthier: study
January 20, 2019 - University of Utah to establish first-of-its-kind dark sky studies minor in the US
January 20, 2019 - School-based nutritional programs reduce student obesity
January 20, 2019 - Improved maternity care practices in the southern U.S. reduce racial inequities in breastfeeding
January 20, 2019 - New enzyme biomarker test indicates diseases and bacterial contamination
January 20, 2019 - Republican and Democratic governors have different visions to transform health care, say researchers
January 20, 2019 - Researchers discover that spin flips happen in only half a picosecond in the course of a chemical reaction
January 20, 2019 - Suicide Risk Up More Than Fourfold for Cancer Patients
January 20, 2019 - Doctors find 122 nails in Ethiopian’s stomach
January 20, 2019 - UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms
January 20, 2019 - Researchers discover mechanism which drives leukemia cell growth
January 20, 2019 - AHA: Infection as a Baby Led to Heart Valve Surgery for Teen
January 20, 2019 - Injection improves vision in a form of childhood blindness
January 20, 2019 - Multiple sclerosis therapies delay progression of disability
January 20, 2019 - New study finds infrequent helmet use among bike share riders
January 20, 2019 - Clearing up information about corneal dystrophies
January 20, 2019 - Researchers describe new behavior in energy metabolism that refutes existing evidence
January 20, 2019 - New study takes first step toward treating endometriosis
January 20, 2019 - Researchers find how GREB1 gene promotes resistance to prostate cancer treatments
January 20, 2019 - Replacing Sitting Time With Activity Lowers Mortality Risk
January 20, 2019 - A simple, inexpensive intervention makes birth safer for moms and babies in parts of Africa
January 19, 2019 - New anti-inflammatory compound acts as ‘surge protector’ to reduce cancer growth
January 19, 2019 - Significant flaws found in recently released forensic software
January 19, 2019 - New Leash on Life? Staying Slim Keeps Pooches Happy, Healthy
January 19, 2019 - Men and women remember pain differently
January 19, 2019 - Rising air pollution linked with increased ER visits for breathing problems
January 19, 2019 - Study uses local data to model food consumption patterns among Seattle residents
January 19, 2019 - The brain’s cerebellum plays role in controlling reward and social behaviors, study shows
January 19, 2019 - Relationship between nurse work environment and patient safety
January 19, 2019 - Pioneering surgery restores movement to children paralyzed by acute flaccid myelitis
January 19, 2019 - Genetic variants linked with risk tolerance and risky behaviors
January 19, 2019 - New research provides better understanding of our early human ancestors
January 19, 2019 - First-ever tailored reporting guidance to improve patient care and outcomes
January 19, 2019 - 4.6 percent of Massachusetts residents have opioid use disorder
January 19, 2019 - New study suggests vital exhaustion as risk factor for dementia
January 19, 2019 - New antibiotic discovery heralds breakthrough in the fight against drug-resistant bacteria
January 19, 2019 - Ural Federal University scientists synthesize a group of multi-purpose fluorophores
January 19, 2019 - Researchers identify new therapeutic target in the fight against chronic liver diseases
January 19, 2019 - Preparation, characterization of Soyasapogenol B loaded onto functionalized MWCNTs
January 19, 2019 - FDA Approves Ontruzant (trastuzumab-dttb), a Biosimilar to Herceptin
January 19, 2019 - Tobacco use linked with higher use of opioids and sedatives
January 19, 2019 - Study delves deeper into developmental dyslexia
January 19, 2019 - Anti-vaccination movement one of the top health threats in 2019 says WHO
January 19, 2019 - Newly developed risk score more effective at identifying type 1 diabetes
January 19, 2019 - Highly effective protocol to prepare cannabis samples for THC/CBD analysis
January 19, 2019 - Prinston Pharmaceutical Inc. Issues Voluntary Nationwide Recall of Irbesartan and Irbesartan HCTZ Tablets Due to Detection of a Trace Amount of Unexpected Impurity, N-Nitrosodiethylamine (NDEA) in the Products
January 19, 2019 - How does solid stress from brain tumors cause neuronal loss, neurologic dysfunction?
January 19, 2019 - $14.7 million partnership to supercharge vaccine development
January 19, 2019 - Ian Fotheringham receives Charles Tennant Memorial Lecture award
TP53 Genetic Test: MedlinePlus Lab Test Information

TP53 Genetic Test: MedlinePlus Lab Test Information

image_pdfDownload PDFimage_print

What is a TP53 genetic test?

A TP53 genetic test looks for a change, known as a mutation, in a gene called TP53 (tumor protein 53). Genes are the basic units of heredity passed down from your mother and father.

TP53 is a gene that helps stop the growth of tumors. It’s known as a tumor suppressor. A tumor suppressor gene works like the brakes on a car. It puts the “brakes” on cells, so they don’t divide too quickly. If you have a TP53 mutation, the gene may not be able to control the growth of your cells. Uncontrolled cell growth can lead to cancer.

A TP53 mutation can be inherited from your parents, or acquired later in life from the environment or from a mistake that happens in your body during cell division.

Acquired (also known as somatic) TP53 mutations are much more common. These mutations have been found in about half of all cases of cancer, and in many different types of cancer.

Other names: TP53 mutation analysis, TP53 full gene analysis, TP53 somatic mutation

What is it used for?

The test is used to look for a TP53 mutation. It is not a routine test. It is usually given to people based on family history, symptoms, or previous diagnosis of cancer.

Why do I need a TP53 genetic test?

You may need a TP53 test if:

  • You’ve been diagnosed with a bone or soft tissue cancer before the age of 45
  • You’ve been diagnosed with, pre-menopausal breast cancer, a brain tumor, leukemia, or lung cancer before the age of 46
  • You’ve had one or more tumors before the age of 46
  • One or more of your family members have been diagnosed with Li-Fraumeni syndrome and/or have had cancer before the age of 45

These are signs you may have an inherited mutation of the TP53 gene.

If you’ve been diagnosed with cancer and don’t have a family history of the disease, your health care provider may order this test to see if a TP53 mutation may be causing your cancer. Knowing whether you have the mutation can help your provider plan treatment and predict the likely outcome of your disease.

What happens during a TP53 genetic test?

A TP53 test is usually done on blood or bone marrow.

If you are getting a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

If you are getting a bone marrow test, your procedure may include the following steps:

  • You’ll lie down on your side or your stomach, depending on which bone will be used for testing. Most bone marrow tests are taken from the hip bone.
  • Your body will be covered with cloth, so that only the area around the testing site is showing.
  • The site will be cleaned with an antiseptic.
  • You will get an injection of a numbing solution. It may sting.
  • Once the area is numb, the health care provider will take the sample. You will need to lie very still during the tests.
  • The health care provider will use a special tool that twists into the bone to take out a sample of bone marrow tissue. You may feel some pressure on the site while the sample is being taken.
  • After the test, the health care provider will cover the site with a bandage.
  • Plan to have someone drive you home, since you may be given a sedative before the tests, which may make you drowsy.

Will I need to do anything to prepare for the test?

You usually don’t need any special preparations for a blood or bone marrow test.

Are there any risks to the test?

There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.

After a bone marrow test, you may feel stiff or sore at the injection site. This usually goes away in a few days. Your health care provider may recommend or prescribe a pain reliever to help.

What do the results mean?

If you’ve been diagnosed with Li-Fraumeni syndrome, it does not mean you have cancer, but your risk is higher than most people. But if you have the mutation, you can take steps to reduce your risk, such as:

  • More frequent cancer screenings. Cancer is more treatable when found in the early stages.
  • Making lifestyle changes, such as getting more exercise and eating a healthier diet
  • Chemoprevention, the taking of certain medicines, vitamins, or other substances to reduce the risk or delay the development of cancer.
  • Removing “at-risk” tissue

These steps will vary depending on your health history and family background.

If you have cancer and your results indicate an acquired TP53 mutation (a mutation was found, but you have no family history of cancer or Li-Fraumeni syndrome), your provider can use the information to help predict how your disease will develop and guide your treatment.

Is there anything else I need to know about a TP53 test?

If you’ve been diagnosed with or suspect you have Li-Fraumeni syndrome, it may help to speak to a genetic counselor. A genetic counselor is a specially trained professional in genetics and genetic testing. If you haven’t yet been tested, the counselor can help you understand the risks and benefits of testing. If you have been tested, the counselor can help you understand the results and direct you to support services and other resources.

Tagged with:

About author

Related Articles