Breaking News
November 15, 2018 - Researchers develop tool that speeds up analysis and publication of biomedical data
November 15, 2018 - Scientists identify mechanism used by lung cancer cells to obtain glucose
November 15, 2018 - Abnormalities in development of the brain could be involved in onset of autism, finds new study
November 15, 2018 - Soy protein equally effective as animal protein in building muscle strength
November 15, 2018 - American Academy of Pediatrics, Nov. 2-6
November 15, 2018 - Dopamine drives early addiction to heroin
November 15, 2018 - Variance in gut microbiome in Himalayan populations linked to dietary lifestyle | News Center
November 15, 2018 - Reducing Cardiovascular Disease: The Amish Way
November 15, 2018 - King’s researchers launch charter to guide organizations to engage abuse survivors in research
November 15, 2018 - Enable Injections enters into development agreements with UCB and Apellis Pharmaceuticals
November 15, 2018 - TGen North collaborates with NARBHA Institute to advance human health
November 15, 2018 - Researchers discover molecular basis for therapeutic actions of an African folk medicine
November 15, 2018 - Human Cell Atlas study of early pregnancy shows how mother’s immune system is modified
November 15, 2018 - New guidelines for detecting and managing sarcopenia to be launched in the UK
November 15, 2018 - Researchers explore role of dietary composition on energy expenditure
November 15, 2018 - Elsevier launches Entellect™ Platform, unlocking value by creating AI-ready life sciences data
November 15, 2018 - Now that cannabis is legal in Canada, let’s use it to tackle the opioid crisis
November 15, 2018 - In the Spotlight: At the intersection of tech, health, and ethics
November 15, 2018 - Traditional Glaucoma Test Can Miss Severity of the Disease
November 15, 2018 - Researchers directly connect activities of genes with instinctive behavior in male cichlids
November 15, 2018 - Salk researchers report new methods to identify AD drug candidates with anti-aging properties
November 15, 2018 - St. Jude Hospital announces availability of largest collections of leukemia samples
November 15, 2018 - Attenua Announces First Patient Treated in Phase 2 Clinical Trial in Chronic Cough with Bradanicline
November 15, 2018 - Designing a novel cell-permeable peptide chimera to promote wound healing
November 15, 2018 - NEI investigators combine two imaging modalities to view the retina in unprecedented detail
November 15, 2018 - Determining how hearts develop to better understand congenital heart defects
November 15, 2018 - Maverick immune cells can act independently to identify and kill cancer cells, finds research
November 15, 2018 - Advanced AI and big data methods to tackle dementia
November 15, 2018 - Report reveals increase in pancreatic cancer death rates across Europe
November 15, 2018 - Luxia Scientific announces availability of its gut microbiome test in Luxembourg
November 15, 2018 - New diabetes drugs linked to increased risk of lower-limb amputation and ketoacidosis
November 15, 2018 - Lilly Submits New Drug Application to the FDA for Lasmiditan for Acute Treatment of Migraine
November 15, 2018 - Heart failure patients shouldn’t stop meds even if condition improves: study
November 15, 2018 - RetiPharma secures funding to develop new peptide drug for treating degenerative eye disorders
November 15, 2018 - Breakthrough research could lead to a new wave of cancer-fighting antibodies
November 15, 2018 - Mylan and Biocon launch new insulin glargine biosimilar in the UK
November 15, 2018 - For wildfire safety, only particular masks guard against toxic particulate matter
November 15, 2018 - New study of tribe shows influence of Western diet and lifestyle on blood pressure
November 15, 2018 - Scientists harness power of natural killer cells to treat children with neuroblastoma
November 15, 2018 - Investigating foodborne disease outbreak in Bosnia and Herzegovina based on simulation game
November 15, 2018 - Recommendations Issued for Management of Bradycardia
November 15, 2018 - Benefit unclear due to a lack of suitable studies
November 15, 2018 - TAMEST recognizes UT Southwestern’s Ralph DeBerardinis for changing our understanding of cancer
November 15, 2018 - Researchers discover key factors behind intestinal inflammation in CVID patients
November 15, 2018 - CityU develops first microarrayed 3D neuronal culture platform
November 15, 2018 - Expert suggests ways to control uncomfortable vaginal symptoms in diabetic women
November 15, 2018 - New edition of Red Journal focuses on roles of imaging in radiation oncology
November 15, 2018 - Doctors Aren’t Promoting Breastfeeding’s Cancer-Protection Benefit
November 15, 2018 - Collection of demonstration projects highlights value of patient engagement in research
November 15, 2018 - Technique to ‘listen’ to a patient’s brain during tumour surgery
November 15, 2018 - Seven-year-old returns to life as a “normal, healthy child” following bone marrow transplant
November 15, 2018 - AMSBIO expands range of high quality FFPE cancer cell line controls
November 15, 2018 - Marijuana use by kidney donors has no effect on transplant outcomes
November 15, 2018 - Exploring NMR Spectroscopy Applications through Interesting Infographics
November 15, 2018 - Chapman University wins additional $2.9 million NIH grant to study Alzheimer’s disease
November 15, 2018 - Microgel powder reduces infection and promotes healing
November 15, 2018 - Suicidal patients with prescribed access to psychotropic drugs should be closely monitored
November 15, 2018 - Nitric oxide-releasing technology shows potential to reduce healing time of diabetic foot ulcers
November 15, 2018 - Mass shootings may trigger unnecessary blood donations
November 15, 2018 - From heart disease to cancer: New study tracks shift of county death rates
November 15, 2018 - Preventing falls with new sensor technology
November 15, 2018 - Promising technology could improve detection, diagnosis of fatal ovarian cancer
November 15, 2018 - AAP updates concussion recommendations for children and teens
November 15, 2018 - Two genomic tests help identify most effective treatment for breast cancer patients
November 15, 2018 - Researchers evaluate efficacy of salivary biomarkers for early detection of oral cancer
November 15, 2018 - NIH awards $3.5 million to continue development of robotic system for treating brain tumors
November 15, 2018 - Researchers succeed in building protein nanotubes from tiny scaffolds
November 15, 2018 - Rectal bleeding
November 15, 2018 - Nasal delivery of weight-loss hormone eases breathing problems in sleeping mice
November 15, 2018 - $9.6 million grant to fund research on vascular risk factors for brain aging, dementia | News Center
November 15, 2018 - Gum disease linked with diabetes
November 15, 2018 - Study identifies unique functional brain networks associated with ASD behaviors in infancy
November 15, 2018 - EU and industry-funded project aims to personalize diabetes treatment
November 15, 2018 - NIH researchers shed light on causes of HBV-associated acute liver failure
November 14, 2018 - FDA Alert: Implanted Pumps: Safety Communication
November 14, 2018 - Weight loss & acute Porphyria
November 14, 2018 - Researchers identify three sub-types of depression
November 14, 2018 - The puzzle of a mutated gene lurking behind many Parkinson’s cases | News Center
November 14, 2018 - The mystery viruses far worse than flu
November 14, 2018 - Research highlights physical changes in the brain of self-injuring teen girls
Special chemical that makes brain tumours glow pink to help neurosurgeons operate

Special chemical that makes brain tumours glow pink to help neurosurgeons operate

image_pdfDownload PDFimage_print

A clinical trial has shown that a special chemical makes brain tumours glow pink. This can help neurosurgeons operate easily on them and remove them completely and safely say the researchers. The results of this study would be presented at the 2018 NCRI Cancer Conference in Glasgow between 4th and 6th November 2018.

‘Improving the intra-operative diagnosis of high-grade glioma using a fluorescence biomarker – result of the UK NCRI GALA-BIDD study,’ Kathreena Kurian et al. M

‘Improving the intra-operative diagnosis of high-grade glioma using a fluorescence biomarker – result of the UK NCRI GALA-BIDD study,’ Kathreena Kurian et al. M

According to the scientists the brain tumours called gliomas are specific. When patients with them consume a drink containing 5-aminolevulinic acid or 5-ALA, it accumulates in the tumour. 5-ALA is known to accumulate in cancer cells that are fast growing. The reason behind this is the fact that the tumours do not contain an enzyme that is necessary to break down the chemical. This chemical contained a pink colour that appeared in the tumours that are most aggressively growing. While operating the surgeon would be able to clearly visualize the tumour tissues and differentiate it from the healthy brain tissues, they add. This can make the operation easier and safer.

Glioma patients are usually treated with a surgery to completely remove the tumour. The chances of survival remain poor in these patients. In this clinical trial 99 glioma patients were included to participate at the Royal Liverpool Hospital, Kings College Hospital in London and Addenbrooke’s Hospital in Cambridge. They all had high-grade or aggressively growing gliomas. The patients were given a drink with 5-ALA just before surgery.

When operating the surgeons looked at the fluorescent tissues of the brain that contained the tumour tissues. In 85 patients they were clearly able to see the tumour tissues as glowing pink. Among these 81 were actually high grade gliomas as confirmed from pathological specimens removed from the brain. One of the glowing tumours was found to be actually low grade tumour. Among the 14 patients in whom there was no glow of the tumours, seven were found to be low grade and seven tumours could not be assessed for their severity.

According to researcher Dr Kathreena Kurian, associate professor in brain tumour research at the University of Bristol, this kind of a operative marker was “urgently needed”. She said it would help guide the neurosurgeons to find the worst bits. “The beauty of 5-ALA is that they can see where high-grade glioma is, while they’re operating,” she said.

Lead researcher Colin Watts, Professor of Neurosurgery and chair of the Birmingham brain cancer programme at the University of Birmingham said it was important that neurosurgeons distinguish cancer tissues from healthy tissues. He said, “This is the first prospective trial to show the benefits of using 5-ALA to improve the accuracy of diagnosing high-grade glioma during surgery. These results show that the marker is very good at indicating the presence and location of high-grade cancer cells.” “The advantage of this technique is that it may highlight more quickly high-grade disease within a tumour during neurosurgery. What this means is that more of the tumour can be removed more safely and with fewer complications, and that’s better for the patient,” he explained.

As a next step the team wants to look at patients with low grade tumours and analyse how this tool could be used among them. They explain that for low grade tumours other markers could be useful. The researchers are also planning clinical trials of this marker for children with gliomas. They also plan to assess if this marker can help detect tumours that have come back in the brains after having been successfully removed earlier.

Dr Paul Brennan, from Cancer Research UK in a statement said, “Highlighting the more aggressive tumour cells in real-time could help doctors achieve the delicate balance between removing as much of the tumour as possible while preserving surrounding healthy tissue. The fluorescent marker may also ease the burden of follow-up treatment, as cancer cells left behind after surgery require additional radiotherapy or chemotherapy.”

The National Institute for Health and Clinical Excellence has also given its approval for use of 5-ALA in patients with brain tumours before surgery this year.

Source:

https://www.ncri.org.uk/wp-content/uploads/2018/11/Kurian-Glioma-for-online.pdf

Tagged with:

About author

Related Articles