Breaking News
April 25, 2019 - Feces transplantation is effective and provides economic benefits
April 25, 2019 - Eisenhower Health first in Southern California to offer new lung valve treatment for COPD/emphysema
April 25, 2019 - Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers
April 25, 2019 - Porvair Sciences offers highly effective P3 microplate for biological sample clean-up
April 25, 2019 - Air pollution increases risk for respiratory hospitalization among childhood cancer survivors
April 25, 2019 - We are sitting more! How bad is that?
April 25, 2019 - ADHD Screening: MedlinePlus Lab Test Information
April 25, 2019 - Cellular alterations increase vulnerability of obese and diabetic individuals to infection
April 25, 2019 - Association Insurance Pushes On Despite Court Ruling
April 25, 2019 - Traditional and e-cigarette users may be more receptive to smoking cessation interventions
April 25, 2019 - Delving into tumor’s cellular lineage may offer clues for customized therapies
April 25, 2019 - Two studies uncover brain mechanisms underlying decision making process
April 25, 2019 - Cardiometabolic Risk Better ID’d in Children Reclassified to Higher BP
April 25, 2019 - How the obesity epidemic is taking a toll on our bones and joints
April 25, 2019 - E-cigarettes contaminated with dangerous microbial toxins
April 25, 2019 - Researchers document specific characteristics of storefront tobacco advertisements
April 25, 2019 - Oncotype DX-guided treatment could reduce cost for breast cancer care, study suggests
April 25, 2019 - New review highlights how lifestyle affects our genes
April 25, 2019 - Study provides evidence that blood tests can detect Alzheimer’s risk
April 25, 2019 - Computer program mimics natural speech using brain signals from epilepsy patients
April 25, 2019 - Physicians turning to antibiotic alternatives for long-term acne treatment
April 25, 2019 - Preschool Is Prime Time to Teach Healthy Lifestyle Habits
April 25, 2019 - Study finds insidious and persistent discrimination among physician mothers
April 25, 2019 - Newly identified skin-gut communication helps illuminate link between food allergy and eczema
April 25, 2019 - Thiazide use linked with reduced risk of low energy fractures in people with Alzheimer’s
April 25, 2019 - Some women are biologically more resilient than others to PTSD
April 25, 2019 - The Current issue of “The view from here” is concerned with Partnerships and Alliances
April 25, 2019 - Imaging method reveals long-lived patterns in cells of the eye
April 25, 2019 - Podcast: KHN’s ‘What The Health?’ The Abortion Wars Rage On
April 25, 2019 - Prolonged exposure therapy is more effective in treating veterans with PTSD, alcohol use disorder
April 24, 2019 - Our artificial cornea breakthrough could lead to self-assembling organs
April 24, 2019 - A Stanford black, female, gay surgery resident speaks out
April 24, 2019 - Donna Lynne on Extreme Sports, Lessons From the '60s, and Taking CUIMC to the Next Level
April 24, 2019 - Pain Clinics’ Doctors Needlessly Tested Hundreds Of Urine Samples, Court Records Show
April 24, 2019 - Researchers uncover potential clue to halt destruction of nerve cells in people with ALS
April 24, 2019 - Study uncovers reasons for poor mental health in bisexual people
April 24, 2019 - Screenings, interventions, and referrals can help adolescents overcome substance abuse
April 24, 2019 - Febrile seizures following vaccination are self-resolving and not dangerous
April 24, 2019 - Flow-UV inline UV-Visible spectrometer monitors dispersion in real time
April 24, 2019 - Rates of Marijuana Use in Cancer Patients on the Rise in U.S.
April 24, 2019 - Versatile drug may protect baby from hazards of intraamniotic infections
April 24, 2019 - Financial transparency may diminish trust in doctors, new study finds
April 24, 2019 - Calling all Riders: Velocity Extends Free Registration 
April 24, 2019 - The Homeless Are Dying In Record Numbers On The Streets Of L.A.
April 24, 2019 - Researchers use brain scans to provide better understanding of unconscious bias
April 24, 2019 - Blocking BRAF ubiquitination may be an effective treatment approach in melanoma
April 24, 2019 - Simple mobility test helps predict hospital readmission in elderly heart attack patients
April 24, 2019 - Novel fluorescence imaging system helps surgeons remove small ovarian tumors
April 24, 2019 - Uncovering the Structure of HIV Integrase to Inform Drug Discovery
April 24, 2019 - Medical Marijuana Use Rising Among Cancer Patients
April 24, 2019 - Artificial intelligence approach optimizes embryo selection for IVF
April 24, 2019 - Doctor or detective? Sleuthing mysteries in medical school
April 24, 2019 - CUIMC Community Gives Blood During Spring 2019 Columbia University Blood Drive
April 24, 2019 - Americans Overwhelmingly Want Federal Protections Against Surprise Medical Bills
April 24, 2019 - Making Laboratories More Efficient with the Most Modern LIMS on the Market
April 24, 2019 - Treating cancer patients with personalized, combination therapies improves outcomes
April 24, 2019 - Researchers engineer new molecules to help stop lung cancer
April 24, 2019 - Acupuncture can be a wonderful tool for preventing number of diseases
April 24, 2019 - Daily life disability before hip replacement may predict poor post-operative outcomes
April 24, 2019 - Study finds involuntary staying in housing estates to be a potential health risk
April 24, 2019 - Older kidney disease patients starting dialysis die at higher rates than previously thought
April 24, 2019 - Time-restricted eating shows promise for controlling blood glucose levels
April 24, 2019 - Ambiguous genitalia in newborns may be more common than previously thought
April 24, 2019 - Research provides important insight on the brain-body connection
April 24, 2019 - In 10 Years, Half Of Middle-Income Elders Won’t Be Able To Afford Housing, Medical Care
April 24, 2019 - Researchers study how E. coli clones have become major cause of drug-resistant infections
April 24, 2019 - Bacterial and fungal toxins found in popular electronic cigarettes
April 24, 2019 - Factors affecting absorption of ‘sunshine vitamin’ during spring/summer months
April 24, 2019 - Texting helps improve medication adherence, health outcomes for patients with schizophrenia
April 24, 2019 - Cochrane Review looks at different ways to use nicotine replacement therapies
April 24, 2019 - New review on relationship between COPD and Type 2 diabetes
April 24, 2019 - Brain areas linked to memory and emotion aid odor navigation in humans
April 24, 2019 - Brain stimulation reverses age-related memory loss
April 24, 2019 - Amid Opioid Prescriber Crackdown, Health Officials Reach Out To Pain Patients
April 24, 2019 - $4 million NIH award will help establish UCI Skin Biology Resource-based Center
April 24, 2019 - Cancer drugs reprogram genes in breast tumors to prevent endocrine resistance, finds study
April 24, 2019 - Combination-imaging technique provides new window into macaque brain connections
April 24, 2019 - Researchers identify new allergen responsible for allergy to durum wheat
April 24, 2019 - Researchers define role of rare, influential cells in the bone marrow
April 24, 2019 - DNA rearrangement may predict poor outcomes in multiple myeloma
NIH “Inclusion Across the Lifespan” policy supports research involving underrepresented age groups

NIH “Inclusion Across the Lifespan” policy supports research involving underrepresented age groups

image_pdfDownload PDFimage_print

The pipeline of research supporting care as we age is about to look a bit more like the country it serves–and for good reason. Beginning this year, the National Institutes of Health (NIH), America’s premier institution for medical research, will for the first time in its history require NIH-funded scholars to eliminate arbitrary age limits in their work, age limits that previously allowed for excluding groups like older people without just cause. A series of articles recently published in the Journal of the American Geriatrics Society (JAGS) explores how the change came to fruition–in large part thanks to advocacy from organizations like the American Geriatrics Society (AGS) and its member experts–and why the change matters, particularly in a world where living longer is possible thanks to past breakthroughs originating at the NIH.

“Clinical research, much of it championed by NIH scientists, has made increased longevity with less morbidity a tangible reality,” said William Dale, MD, PhD, one of the co-authors for an article describing the policy change. “To keep up that momentum, we need greater attention to age in current and future scholarship. We all have unique physiological changes and medical care needs as we get older, and the insights we gain working with older people today will teach us how to be healthier tomorrow.”

Effective as of Jan. 25, the new NIH “Inclusion Across the Lifespan” policy supports research involving traditionally underrepresented age groups–specifically older people and children–by requiring approved justifications before any study participants can be excluded from NIH-funded work based on age alone. The policy also advocates for sensitivity in the language used to describe older adults, stressing the importance of building “respect and understanding” beginning with how we describe older participants in clinical research.

In an editorial authored by AGS representatives and published in JAGS (DOI: 10.1111/jgs.15784), geriatrics experts describe how influential stakeholders like the AGS worked closely with the NIH to ensure older adults would have more of a presence in future government-funded health scholarship.

“In workshops and comments submitted to NIH, we stressed that excluding trial participants based on arbitrary age restrictions complicates research and jeopardizes findings that could help those most likely to experience a disease or condition,” noted Cathleen Colon-Emeric, MD, MHS, co-author of the editorial. “We believe this new policy represents an opportunity for geriatrics researchers to develop better care for all our needs as we age.”

To support these mandates, the AGS authors advocate leading the charge by:

  • Making use of new and better data about older people to conduct deeper and more extensive analyses of treatments and interventions.
  • Helping colleagues across health care understand how to engage older adults in aging research. A related editorial in JAGS (DOI: 10.1111/jgs.15785), for example, describes a framework for supporting the inclusion of older adults in research by helping scientists pivot to specific priorities for recruiting older participants.
  • Advocating for older adults. The Inclusion Across the Lifespan policy advocates a paradigm shift from protecting vulnerable individuals “from research” to protecting them “through research.” AGS authors emphasized the importance of doing so by acknowledging that underrepresenting older adults and other groups in research studies can result in “unsafe and inappropriate care decisions” based on incomplete data.
  • Developing infrastructure and resources for review boards, research centers, and even individual researchers to adopt more inclusive practices–and more inclusive terminology–for older adults.

The new policy comes at a critical juncture. Even as older adults become one of the U.S.’s largest age groups, research still lags behind shifting demographics. A study conducted by colleagues from the National Institute of Aging (a division of the NIH) (DOI: 10.1111/jgs.15786), for example, examined the adequacy of age inclusivity in NIH-funded “Phase III” trials (so named because they are among the final stages of research regarding the safety and efficacy of treatments). Looking at work published from 1965 to 2015, the team determined that more that 33% of studies had upper-age limits, and that 25% of these studies specifically excluded people 65-years-old and older. Findings are even more stark for certain conditions common with age: More than 70% of trials for abnormal heartbeat, coronary atherosclerosis (build-up of fatty deposits in the coronary artery), heart attack, COPD (an umbrella term for progressive lung diseases), and lung cancer excluded people over 75.

“Advances in health and medicine aren’t just about discovering new treatments; they’re also about uncovering how those treatments improve health, safety, and independence for unique individuals–including older adults,” concluded Camille Vaughan, MD, MS, one of the authors on the AGS editorial. “The NIH is taking an important step toward ensuring research reflects reality. Groups like the AGS and its members are excited to be among the first to chart that new frontier.”

AGS ACTION POINTS

  • Beginning this year, the NIH will require funded scholars to eliminate arbitrary age limits in their work, which previously allowed for excluding people like older adults without scientific justification.
  • In an editorial authored by AGS representatives, geriatrics experts describe how important stakeholders worked with the NIH to ensure that older adults would have more of a presence in future research.
  • Geriatrics experts can help lead the charge for age inclusivity by working to (1) expand the knowledge base related to health in aging, (2) educate other disciplines about the needs of older study subjects, (3) advocate for older adults based on new findings, and (4) develop infrastructure and resources to affect change.

Source:

https://www.americangeriatrics.org/media-center/news/new-nih-research-policy-seeks-greater-inclusion-across-lifespan-ags-editorial

Tagged with:

About author

Related Articles