More than 30 years have passed since the amyloid precursor protein was first identified. In the late 1980s, several research teams across the globe traced the protein fragment found in amyloid plaques back to a gene located on chromosome 21. The gene encodes a longer protein that is cleaved into several fragments, one of which […]Continue Reading ...
An interview with Dr. Lloyd Tran from NeuroActiva, discussing the major barriers to Alzheimer’s research and development over the past 40 years, and how the IUFAA are working to overcome these challenges. Why have so many Alzheimer’s drugs failed in the past 40 years? It has now been 112 years since Dr. Alois Alzheimer first […]Continue Reading ...
A UCL-led study has confirmed that some vials of a hormone used in discontinued medical treatments contained seeds of a protein implicated in Alzheimer’s disease, and are able to seed amyloid pathology in mice. The research, published in Nature, follows on from the team’s 2015 study that found evidence of amyloid pathology in people who […]Continue Reading ...
Researchers at the University of Texas have developed a new vaccine that reduces the build-up of the toxic proteins associated with Alzheimer’s disease and proven its efficacy in an animal model. The research may pave the way for a clinical trial. Toxic amyloid plaques (red) and tau tangles (brown) form on the brain of a […]Continue Reading ...
Brain scans are one method used to measure the amount of amyloid in the brain, which may be a sign of mild cognitive impairment. Credit: The University of Miami Miller School of Medicine Finding an effective way to identify people with mild cognitive impairment who are most likely to go on to develop Alzheimer’s disease […]Continue Reading ...
Scientists at the University of Leeds have used cryo-electron microscopes to reveal the structure of amyloid – the abnormal protein that accumulates in the body and causes diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Credit: University of Leeds The high-powered, “game-changing” microscopes use electrons rather than light to visualize the shape of samples at near-atomic […]Continue Reading ...
Oct 12 2018 Scientists at the University of Waterloo have discovered that antidepressant medications can be used to treat Alzheimer’s disease. The study, recently published in ACS Chemical Neuroscience, found that selective serotonin uptake inhibitors (SSRI medication) can delay the development and growth of amyloid-beta proteins, which can clump together and form a plaque, contributing […]Continue Reading ...
For many years amyloid β protein was considered to be a promising therapeutic target in Alzheimer’s disease but, for a long time, research results were very disappointing. The protein, which, together with tau protein, is regarded as a significant biomarker for Alzheimer’s disease, has now made a comeback. Also, a recent Phase III study conducted […]Continue Reading ...
Credit: CC0 Public Domain A hypothesis which has been the standard way of explaining how the body develops Alzheimer’s Disease for almost 30 years is flawed, according to a University of Manchester biologist. The amyloid cascade hypothesis argues that a series of stages, starting from the deposition of a starch-like protein called amyloid and ending […]Continue Reading ...
PET scan of a human brain with Alzheimer’s disease. Credit: public domain Researchers at King’s College London have discovered a vicious feedback loop underlying brain degeneration in Alzheimer’s disease which may explain why so many drug trials have failed. The study also identifies a clinically approved drug which breaks the vicious cycle and protects against […]Continue Reading ...
In a report in The American Journal of Pathology investigators describe the generation of a successful novel transgenic rat model that accumulates amyloid specifically in brain blood vessels and strongly mimics many of the associated detrimental changes that are observed in humans – a condition known as cerebral amyloid angiopathy (CAA), which is also commonly […]Continue Reading ...
The century old mission to understand how the proteins responsible for amyloid-based diseases such as Alzheimer’s, Huntingdon’s and Parkinson’s work has taken major steps forward in the last 12 months, thanks to a revolution in a powerful microscopy technique used by scientists. High-powered microscopes using electrons instead of light to ‘see’ the actual shape of […]Continue Reading ...
Compared to a control (left), a soluble version of TLR5 (right) reduces the formation of amyloid plaques (brown) in the brains of mice that produce large amounts of human β-amyloid. Credit: Chakrabarty et al., 2018 Researchers at the University of Florida have discovered that a modified version of an important immune cell protein could be […]Continue Reading ...
What is Amyloid Formation? An amyloid is a fibrous material made from protein. A protein is a chain of amino acids and, unlike other polymers, the way this chain is arranged in 3D is often unique. The building blocks of protein structures, which are often referred to as a protein’s secondary structure, are mostly alpha-helical, […]Continue Reading ...
TUESDAY, Sept. 11, 2018 — Feeling drowsy during the day might mean you have an increased risk for Alzheimer’s, new research suggests. The long-term study included 123 adults with an average age of 60 when the study began. The findings showed that those who were very sleepy during the day had a nearly threefold increased […]Continue Reading ...
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