Oct 31 2018 Researchers of Valencia’s Polytechnic University (UPV), the University of Notre Dame (USA) and the Technological University of Auckland (New Zealand), along with multinational company Zimmer, have developed a new material that improves the quality and durability of the articular cartilage implants used in knee operations. According to the tests carried out, with […]Continue Reading ...
Knee joint injuries are typically related to sports, such as football, rugby or ice hockey, but people often do not know that such injuries may lead to joint inflammation and post-traumatic osteoarthritis. In advanced post-traumatic osteoarthritis, joint cartilage breaks down completely, causing severe joint pain, lack of mobility and even social isolation. However, the mechanisms […]Continue Reading ...
Researchers from the Faculty of Chemical Technology, Kaunas University of Technology (KTU), Lithuania are developing an artificial bone, which can be used for treating of the most common joint disease – osteoarthritis. The bi-functional composite imitates the complex osteochondral structure of a joint, i.e. both cartilage and bone tissues. According to the World Health Organization, […]Continue Reading ...
In an Arthritis & Rheumatology study of 221 patients with knee osteoarthritis and meniscal tears, increases in inflammation of the synovial membrane–whether persistently extensive or intermittent–were linked with cartilage damage over time.Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow. A new study describing the methods used for […]Continue Reading ...
June 22, 2018 Tissue-engineered articular cartilage (AC) for repairing cartilage damaged by trauma or disease can be made to more closely mimic natural AC if mechanical stimulation of particular magnitude and duration is applied during the development process. A detailed review of the different stimulation techniques used and how to determine optimal loading parameters for […]Continue Reading ...
May 4, 2018 A researcher at the Keck School of Medicine of USC has been awarded two grants totaling more than $4 million to support osteoarthritis research. A $3.4 million R01 grant from the National Institutes of Health will fund research on the mechanisms behind the development, progression and prevention of osteoarthritis. A $750,000 grant […]Continue Reading ...
A team of Spanish scientists has designed a bioreactor that allows to grow, in four weeks, human cartilage tissues in scaffolds generated by 3D printing. Likewise, said bioreactor allows real‑time monitoring through the analysis of ultrasonic signals. The team of researchers is composed of doctors, biologists, physicists and engineers led by the University of Granada […]Continue Reading ...
Development of BioPen. Credit: Biofabrication, doi: https://doi.org/10.1088/1758-5090/aad8d Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage in a form effective for implantation remains challenging in musculoskeletal tissue engineering. Existing surgical techniques including autologous chondrocyte implantation (ACI) and matrix-induced […]Continue Reading ...
Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the […]Continue Reading ...
August 13, 2018 Platelet-rich plasma (PRP) is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells (MSCs). The effects of PRP treatment on cartilage […]Continue Reading ...
June 25, 2018 To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow. A new study describing the methods used for matrix decellularization and […]Continue Reading ...
Scientists have just discovered why babies need to move in the womb to develop strong bones and joints. It turns out there are some key molecular interactions that are stimulated by movement and which guide the cells and tissues of the embryo to build a functionally robust yet malleable skeleton. If an embryo doesn’t move, […]Continue Reading ...
Development of cartilage tissue from mesenchymal stem/stromal cells after eight weeks in vivo: Inhibition of the signaling pathway of the protein BMP leads to the maintenance of stable cartilage tissue, indicated by red staining (left). In contrast, the control group shows a development towards bone tissue (right). Credit: University of Basel, Department of Biomedicine Researchers […]Continue Reading ...
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