Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the […]Continue Reading ...
In an Arthritis & Rheumatology study of 221 patients with knee osteoarthritis and meniscal tears, increases in inflammation of the synovial membrane–whether persistently extensive or intermittent–were linked with cartilage damage over time.Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow. A new study describing the methods used for […]Continue Reading ...
June 22, 2018 Tissue-engineered articular cartilage (AC) for repairing cartilage damaged by trauma or disease can be made to more closely mimic natural AC if mechanical stimulation of particular magnitude and duration is applied during the development process. A detailed review of the different stimulation techniques used and how to determine optimal loading parameters for […]Continue Reading ...
May 4, 2018 A researcher at the Keck School of Medicine of USC has been awarded two grants totaling more than $4 million to support osteoarthritis research. A $3.4 million R01 grant from the National Institutes of Health will fund research on the mechanisms behind the development, progression and prevention of osteoarthritis. A $750,000 grant […]Continue Reading ...
Credit: Rush University Medical Center Osteoarthritis is one of the most common causes of chronic pain in the world. More than 30 million people in the United States alone suffer from osteoarthritis, or OA, which can affect any moveable joint of the body, including the knees, hips and hands. OA normally manifests itself as a […]Continue Reading ...
April 16, 2018 Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS. Certain mesenchymal stem/stromal cells from the bone marrow […]Continue Reading ...
Laboratory grown cartilage tissue with out mechanical stimulation (A), with one centrifugation consistent with day (B) and 3 centrifugations consistent with day (C). Credit score: Juha Prittinen Other floor topographies and fabrics supply attention-grabbing techniques to check cellular behaviour and probably supply novel answers for treating joint defects. Tissue engineering strategies that simulate local cartilage […]Continue Reading ...
August 13, 2018 Platelet-rich plasma (PRP) is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells (MSCs). The effects of PRP treatment on cartilage […]Continue Reading ...
June 25, 2018 To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow. A new study describing the methods used for matrix decellularization and […]Continue Reading ...
Scientists have just discovered why babies need to move in the womb to develop strong bones and joints. It turns out there are some key molecular interactions that are stimulated by movement and which guide the cells and tissues of the embryo to build a functionally robust yet malleable skeleton. If an embryo doesn’t move, […]Continue Reading ...
Development of cartilage tissue from mesenchymal stem/stromal cells after eight weeks in vivo: Inhibition of the signaling pathway of the protein BMP leads to the maintenance of stable cartilage tissue, indicated by red staining (left). In contrast, the control group shows a development towards bone tissue (right). Credit: University of Basel, Department of Biomedicine Researchers […]Continue Reading ...
Produced by the American Physical Therapy Association (APTA) and featuring a contribution from Dr Karen Hambly, a chartered physiotherapist and member of the University of Kent’s School of Sports and Exercise Sciences (SSES), the guidelines are intended to be used by orthopaedic physical therapists, academic instructors, clinical instructors, students and patients regarding the best current […]Continue Reading ...
Baseline and follow-up MRIs of the right knee of two obese women, one who lost no weight (A, B), and one who lost weight (C, D). Credit: Radiological Society of North America Obese people who lose a substantial amount of weight can significantly slow down the degeneration of their knee cartilage, but only if they […]Continue Reading ...
September 22, 2017 Other floor topographies and fabrics supply fascinating tactics to review mobile conduct and doubtlessly supply novel answers for treating joint defects. Tissue engineering strategies that simulate local cartilage may turn out helpful to create cartilage implants within the laboratory, in step with a doctoral dissertation from Umeå College. In conjunction with analysis […]Continue Reading ...
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