Credit: CC0 Public Domain Knee joint injuries are typically related to sports, such as football, rugby or ice hockey, but people often do not know that such injuries may lead to joint inflammation and post-traumatic osteoarthritis. In advanced post-traumatic osteoarthritis, joint cartilage breaks down completely, causing severe joint pain, lack of mobility and even social […]Continue Reading ...
A network of carbohydrate binding proteins – so-called galectins – plays an important role in the degeneration of cartilage in osteoarthritis. A research group at the MedUni Vienna was able to demonstrate this correlation, in cooperation with international study partners. In osteoarthritis, certain galectins are produced by the cartilage cells themselves and accelerate the degeneration […]Continue Reading ...
Six days after treatment with IGF-1 carried by dendrimer nanoparticles (blue), the particles have penetrated through the cartilage of the knee joint. Credit: Brett Geiger and Jeff Wyckoff Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. Some drug treatments can help alleviate the pain, but […]Continue Reading ...
A team of Spanish scientists has designed a bioreactor that allows to grow, in four weeks, human cartilage tissues in scaffolds generated by 3D printing. Likewise, said bioreactor allows real‑time monitoring through the analysis of ultrasonic signals. The team of researchers is composed of doctors, biologists, physicists and engineers led by the University of Granada […]Continue Reading ...
Development of BioPen. Credit: Biofabrication, doi: https://doi.org/10.1088/1758-5090/aad8d Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage in a form effective for implantation remains challenging in musculoskeletal tissue engineering. Existing surgical techniques including autologous chondrocyte implantation (ACI) and matrix-induced […]Continue Reading ...
Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the […]Continue Reading ...
August 13, 2018 Platelet-rich plasma (PRP) is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells (MSCs). The effects of PRP treatment on cartilage […]Continue Reading ...
Chondral defect is a kind of defect which refers to focal area damage to the articular cartilage. This defect also damages the bone which is lying underneath the cartilage. Symptoms indicating this condition might not occur immediately in life but chondral cartilage defects are very common. Damage in the cartilage may occur due to injury […]Continue Reading ...
Credit: CC0 Public Domain Researchers from the Faculty of Chemical Technology, Kaunas University of Technology (KTU), Lithuania are developing an artificial bone that can be used to treat osteoarthritis. The bi-functional composite imitates the complex osteochondral structure of a joint, i.e. both cartilage and bone tissues. According to the World Health Organisation, around 10 percent […]Continue Reading ...
Oct 31 2018 Researchers of Valencia’s Polytechnic University (UPV), the University of Notre Dame (USA) and the Technological University of Auckland (New Zealand), along with multinational company Zimmer, have developed a new material that improves the quality and durability of the articular cartilage implants used in knee operations. According to the tests carried out, with […]Continue Reading ...
Knee joint injuries are typically related to sports, such as football, rugby or ice hockey, but people often do not know that such injuries may lead to joint inflammation and post-traumatic osteoarthritis. In advanced post-traumatic osteoarthritis, joint cartilage breaks down completely, causing severe joint pain, lack of mobility and even social isolation. However, the mechanisms […]Continue Reading ...
Researchers from the Faculty of Chemical Technology, Kaunas University of Technology (KTU), Lithuania are developing an artificial bone, which can be used for treating of the most common joint disease – osteoarthritis. The bi-functional composite imitates the complex osteochondral structure of a joint, i.e. both cartilage and bone tissues. According to the World Health Organization, […]Continue Reading ...
In an Arthritis & Rheumatology study of 221 patients with knee osteoarthritis and meniscal tears, increases in inflammation of the synovial membrane–whether persistently extensive or intermittent–were linked with cartilage damage over time.Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers To help prevent possible complications such as nonunion at large fracture sites, researchers have developed a cartilage matrix that mimics the early stages of repair and provides the essential structural and biological properties needed by bone-forming cells to divide and grow. A new study describing the methods used for […]Continue Reading ...
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