If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren’t necessarily better: some cancer cells contain a dramatic excess of nuclear pores. Salk Institute researchers reported on September 18, 2018, in the journal Genes & Development that they have devised a […]Continue Reading ...
We’ve all heard the saying that “It takes a village to raise a child.” Some scientific problems, like identifying the human skeletal stem cell, require a similar group effort. Now, a group of interdisciplinary scientists at Stanford, including stem cell researcher and plastic and reconstructive surgeon Michael Longaker, MD, and assistant professor of surgery Charles […]Continue Reading ...
The different genes within the genome must be expressed in precise levels and in the exact moment if the complex balance regulating cell activity is to be maintained. The messenger RNA (mRNA) conveys genetic information from DNA to ribosomes, where proteins are synthesized through the union of amino acids. These amino acids are supplied by […]Continue Reading ...
A study conducted at the University of California has revealed how cells use G-protein-coupled receptors (GPCRs) and their waste disposal systems to mediate inflammation. Endothelial cells stained with antibodies to track the GPCR (shown in green) and E3 ligase (shown in red) and detected by immunofluorescence confocal microscopy. Credit UC San Diego Health GPCRs are […]Continue Reading ...
G-protein-coupled receptors (GPCRs) are everywhere in our bodies. They are embedded in our cell membranes, where they act as signal transducers, allowing cells to respond to their external environments. GPCRs play a crucial role in most biological functions, including heart rate, blood pressure, vision, smell, taste and allergic responses. GPCR malfunction can lead to a […]Continue Reading ...
Using a computer model, researchers from North Carolina State University and the University of Illinois at Chicago have revealed the effect of increased amounts of cholesterol on a specific ion channel involved in regulating potassium levels in the heart. The work sheds further light on interactions between cholesterol and heart function and could have an […]Continue Reading ...
After a pathogen infects the body, the immune system responds with a remarkable — and remarkably complicated — cascade of events. Some immune cells, called lymphocytes, migrate to the site of infection; others migrate to areas of the lymph node where antibody production can begin. Profuse signaling among immune cells takes place, through both cell-to-cell […]Continue Reading ...
Sep 14 2018 The main cause of all forms of diabetes is pancreatic beta-cell dysfunction. Beta cells, found in the pancreatic islets, store and release insulin. Decades of research with animal and cellular models have expanded the knowledge on the molecular mechanisms causing the beta-cells to dysfunction.Diego Balboa‘s doctoral research now offers a more precise […]Continue Reading ...
Chan, Longaker and their colleagues had hoped to use what they learned from identifying the mouse skeletal stem cell to quickly isolate its human counterpart. But the quest turned out to be more difficult than they had anticipated. Most cell isolation efforts focus on using a technology called fluorescence activated cell sorting to separate cells […]Continue Reading ...
Cell Medica announces the treatment of the first patient world-wide to receive CMD-501, an autologous CAR-NKT therapy targeting pediatric neuroblastoma. This is the first time an engineered NKT cell therapy has been used in humans. Cell Medica is a clinical-stage biopharmaceutical company that is transforming the treatment of solid and hematological cancer by developing the […]Continue Reading ...
A little p63 goes a long way in embryonic development – and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs. But once this early work is done, p63 goes silent, sitting quietly in the genome from that point forward. Unless it is accidentally reactivated. When p63 […]Continue Reading ...
Sep 11 2018 3D imaging technology provides images of the cell cluster down to the nuclei while mitigating drug discovery risks Olympus Corporation today announced the U.S.-only launch of a new 3D cell analysis technology with ability to accurately analyze 3D cell cultures down to the nuclei, improving the reliability and accuracy of the entire […]Continue Reading ...
Treating bacterial infections with antibiotics often kills intestinal flora, leading to diarrhoea and inflammation of the gut. Often it is bacteria known as Clostridium difficile which are responsible; they proliferate when the normal microbiome is killed by antibiotics. A working group headed by Professor Dr. Dr. Klaus Aktories of the Institute of Experimental and Clinical […]Continue Reading ...
Scientists from the European Molecular Biology Laboratory (EMBL) have created the first interactive map of the proteins involved in cell division. Image Credit: Andrii Vodolazhskyi / Shutterstock The tool enables researchers to pinpoint which proteins work together to drive this essential process. The importance of this is paramount, as the failure of mitosis leads to […]Continue Reading ...
A team of researchers from Hokkaido University in Japan have discovered a molecular pathway that controls the movement of mitochondria within breast cancer cells and influences how invasive the cells are. Image Credit: Mopic / Shutterstock The study suggests that blocking the pathway could reduce cancer invasiveness and the cells’ ability to resist treatments. The […]Continue Reading ...
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