In the past decade, knowledge of how lifestyle affects our genes, a research field called epigenetics, has grown exponentially. Researchers at Lund University have summarized the state of scientific knowledge within epigenetics linked to obesity and type 2 diabetes in a review article published in the scientific journal Cell Metabolism. Epigenetic mechanisms control the activity […]Continue Reading ...
Using a unique computational “framework” they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute (VGI) has identified 104 high-risk genes for schizophrenia. Their discovery, which was reported in the journal Nature Neuroscience, supports the view that schizophrenia is a developmental disease, one […]Continue Reading ...
Credit: CC0 Public Domain A study headed by researchers from the Danish project iPSYCH and the Broad Institute in the U.S., has found the first common genetic risk variants for autism and uncovered genetic differences in clinical subgroups of autism. The discovery means that we will in future be able to determine the genes that […]Continue Reading ...
THURSDAY, April 11, 2019 — Poverty may influence how genes function, researchers report. Specifically, they found that poverty is associated with levels of DNA methylation — which can shape gene expression — in nearly 10% of genes. The findings are significant for a number of reasons, the researchers said. “First, we have known for a […]Continue Reading ...
A team of scientists from the Wellcome Sanger Institute have identified the genes that are essential for the survival of thirty types of cancer cells. The resultant cancer dependency map will facilitate the development of novel targeted cancer treatments. The study, which is entitled “Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens”, was published in […]Continue Reading ...
Each year at least 2 million Americans are infected with bacteria that cannot be treated with antibiotics, and at least 23,000 of these people die, according to the Centers for Disease Control. These bacteria can end up in our water, which is why we use disinfectants to kill or stop them from growing to treat […]Continue Reading ...
The research group led by Prof. Alex Schier, Director of the University of Basel’s Biozentrum, has identified 30 genes associated with schizophrenia. The team was able to show which pathological changes in the brain and behavioral abnormalities are triggered by these genes. The results of the study have now been published in “Cell”. The research […]Continue Reading ...
A team of biologists and computer scientists has mapped out a network of interactions for how plant genes coordinate their response to nitrogen, a crucial nutrient and the main component of fertilizer. The work, published in the journal Nature Communications, offers a potential framework and more efficient methods that can be used to investigate a […]Continue Reading ...
Credit: CC0 Public Domain A new Northwestern University study challenges prevailing understandings of genes as immutable features of biology that are fixed at conception. Previous research has shown that socioeconomic status (SES) is a powerful determinant of human health and disease, and social inequality is a ubiquitous stressor for human populations globally. Lower educational attainment […]Continue Reading ...
11,000 people are predicted to die from acute myeloid leukemia (AML) in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors. Chemotherapy helps two out of three patients achieve remission. And recently, drug […]Continue Reading ...
Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became “misregulated” by the disease. In a report on the research, […]Continue Reading ...
Apr 12 2019 A large-scale screen of mouse mutants has revealed multiple new genes involved in hearing loss, according to a study publishing April 11 in the open-access journal PLOS Biology by Karen Steel of King’s College London and the Wellcome Sanger Institute, and colleagues. The new genes identified reveal metabolic pathways and regulatory processes […]Continue Reading ...
Bacteria in the human body are sharing genes with one another at a higher rate than is typically seen in nature, and some of those genes appear to be traveling – independent of their microbial hosts – from one part of the body to another, researchers report in the journal Scientific Reports. The findings are […]Continue Reading ...
Credit: CC0 Public Domain Over the past quarter-century, researchers have published hundreds of studies suggesting a small set of particular genes or gene-variants plays a substantial role in boosting susceptibility to depression. Such papers fueled hopes that clinicians could soon use genetic testing to simply identify those at risk, and drug companies could develop medications […]Continue Reading ...
Over the past quarter-century, researchers have published hundreds of studies suggesting a small set of particular genes or gene-variants plays a substantial role in boosting susceptibility to depression. Such papers fueled hopes that clinicians could soon use genetic testing to simply identify those at risk, and drug companies could develop medications to counteract a few […]Continue Reading ...
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