Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute For some cancers, initial treatment with chemotherapy brings positive, but only temporary, results: tumors shrink, but then rebound as the cancer becomes drug-resistant. This pattern of remission-resistance-relapse is particularly true for pancreatic cancer, an aggressive disease in which early […]Continue Reading ...
Thus, the prospects for early pancreatic cancer detection are of enormous importance. Innovation Fund Denmark has just granted 13.1 million kroner for new and promising pancreatic cancer diagnostic technologies. Associate professor Birgitte Regenberg, University of Copenhagen’s Department of Biology heads the project. She and her research group have developed an extremely sensitive diagnostic method using […]Continue Reading ...
A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug’s action, research led by the University of Michigan Rogel Cancer Center found. The chemotherapy drug gemcitabine is an anti-metabolite. It’s similar to normal metabolites taken up by the cell, but […]Continue Reading ...
Credit: CC0 Public Domain Even among cancers, pancreatic cancer is an especially sinister form of disease. The one-year survival rate is extremely low, and treatment progress has lagged behind that of many other malignancies. A study published today in the journal Nature Medicine led by researchers at Huntsman Cancer Institute (HCI) at the University of […]Continue Reading ...
Lustgarten Foundation and Stand Up To Cancer, strategic partners in the Pancreatic Cancer Collective, offer comments on research published today in the journal Nature Medicine which describes a new therapeutic approach with promise for patients with pancreatic cancer. These researchers discovered a combination drug therapy that may effectively combat the disease. Based on this research, […]Continue Reading ...
One-year survival is low among patients diagnosed with pancreatic cancer. Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. Martin McMahon, PhD (left) and Conan Kinsey, MD (right) The researchers have found that a new combination therapeutic approach can effectively […]Continue Reading ...
Mayo Clinic researchers have identified a gene called “UCP-1” that may predict the development of pancreatic cancer in people with Type 2 diabetes. Their findings are published in Gastroenterology. “Developing strategies for the early detection of pancreatic cancer in people without symptoms is critical for improving survival,” says Suresh Chari, M.D., a Mayo Clinic gastroenterologist […]Continue Reading ...
Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domain Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers. The University of Texas MD Anderson Cancer Center […]Continue Reading ...
Researchers from the Experimental Oncology Group, led by Mariano Barbacid at the Spanish National Cancer Research Centre (CNIO), have published in Cancer Cell the results of a study that shows full regression of advanced pancreatic ductal adenocarcinoma (PDA) upon combined inhibition of the epidermal growth factor receptor (EGFR) and c-RAF kinase. This research project was […]Continue Reading ...
FINDINGS Researchers from UCLA’s Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world’s deadliest cancers. The combination approach uses one drug that inhibits the process — known as lysosome — that allows cancer cells to recycle essential nutrients to […]Continue Reading ...
The presence of oral bacteria in so-called cystic pancreatic tumours is associated with the severity of the tumour, a study by researchers at Karolinska Institutet in Sweden published in the journal Gut reports. It is hoped that the results can help to improve diagnosis and treatment of pancreatic cancer. Pancreatic cancer is one of the […]Continue Reading ...
Even among cancers, pancreatic cancer is an especially sinister form of disease. The one-year survival rate is extremely low, and treatment progress has lagged behind that of many other malignancies. A study published today in the journal Nature Medicine led by researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) […]Continue Reading ...
Pancreatic cancer is a grim diagnosis, with a five-year survival rate of less than 9 percent. To improve those odds, researchers at UPMC and the University of Pittsburgh School of Medicine sought genetic signatures in the largest study of its kind that could be used to better match drugs to patients and for early detection. […]Continue Reading ...
Osaka University researchers base biomarker detection and targeted therapy on the same protein from pancreatic cancer patients Of all gastrointestinal cancers, pancreatic cancer is one of the most aggressive. Because of this, it has a very low 5-year survival rate of just 5% and a median survival time below 6 months. Additionally, treatment is difficult, […]Continue Reading ...
Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers. The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that […]Continue Reading ...
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