Researchers at Osaka University have identified a protein that is involved in treatment resistance in lung cancer cells carrying a common cancer-related mutation, which could be used for predicting prognosis or treating these patients Lung cancer remains a major cause of mortality across the globe, although we are gaining a deeper understanding of the genetic […]Continue Reading ...
Researchers of the University of Bern have discovered a new molecular regulatory mechanism in unicellular parasites which has never before been observed. RNA fragments do not act as brakes in the cell apparatus, but on the contrary as “stimulants”: they boost protein production after periods of stress. The classic molecular-biological narrative has a simple form: […]Continue Reading ...
More than 30 years have passed since the amyloid precursor protein was first identified. In the late 1980s, several research teams across the globe traced the protein fragment found in amyloid plaques back to a gene located on chromosome 21. The gene encodes a longer protein that is cleaved into several fragments, one of which […]Continue Reading ...
Mr Jonathan Bernardini and Associate Professor Grant Dewson. Credit: The Walter and Eliza Hall Institute Australian researchers have discovered how a protein linked to Parkinson’s disease may protect cells such as neurons in the brain. The study revealed how a protein called Parkin—which is lost in certain forms of Parkinson’s disease – ‘buys time’ for […]Continue Reading ...
As the proteomics technology develops and human genomic analysis becomes easier to execute, molecules involved in the regulation of biochemical signaling pathways have become interesting subjects for researchers. Earlier research was based on assumptions that metabolic cascades such as phosphorylation was linear. However, current studies indicate a multi-network signaling cascade. The interlinked signals performing in […]Continue Reading ...
Scientists at Rice University have developed synthetic protein switches to control the flow of electrons. The proof-of-concept, metal-containing proteins made in the Rice lab of synthetic biologist Joff Silberg are expressed within cells upon the introduction of one chemical and are functionally activated by another chemical. If the proteins have been placed in the cell, […]Continue Reading ...
When humans experience stress, their inner turmoil may not be apparent to an outside observer. But many animals deal with stressful circumstances – overcrowded conditions, not enough food – by completely remodeling their bodies. These stress-induced forms, whether they offer a protective covering or more camouflaged coloration, can better withstand the challenge and help the […]Continue Reading ...
Drug that mimics function of protein could one day become an effective therapy to fight Ebola virus Researchers have discovered a human protein that helps fight the Ebola virus and could one day lead to an effective therapy against the deadly disease, according to a new Northwestern Medicine study. The newly discovered ability of the […]Continue Reading ...
Researchers at the University of Arizona have discovered a way of preventing mosquito eggs from hatching, potentially paving the way for drugs that could serve as “birth control” within mosquito populations. Vera Larina | Shutterstock Lead author Dr. Jun Isoe and colleagues hope the approach may provide a way of interrupting mosquito reproduction and reducing […]Continue Reading ...
Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers. In laboratory studies, investigators found that expression of the protein, called beta-1,4-galactosyltransferase-V (beta-1,4-GalT-V), was increased in human colorectal cancer tumor cells compared with normal […]Continue Reading ...
There’s a theory in immunology, called the molecular mimicry hypothesis, that autoimmunity (where the immune system turns on the body’s own tissues) is the result of mistaken identity: The immune system confuses a tiny chunk of a protein residing in a healthy person’s body for a chunk of a protein found in an infectious microbial pathogen, […]Continue Reading ...
Proteins are polymers of amino acids that are linked by peptide bonds and they are one of the major classes of bio-molecules existing in a living organism. Proteins are involved in various cellular functions and events like cell signaling, cell adhesion, metabolic reactions, in the generation of immune response and many more. Proteins are known […]Continue Reading ...
Babies born with pontocerebellar hypoplasia type Ib often do not survive past one year. Born with an underdeveloped brain, infants struggle to move, feed and even breathe. Scientists have little understanding about the biology behind the deadly disease besides knowing that a genetic mutation is implicated. Now, researchers at the University of Arizona College of […]Continue Reading ...
Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential. Scientists have been trying to understand why and how this happens in order […]Continue Reading ...
Credit: CC0 Public Domain New research reveals how a single protein interferes with the immune system when exposed to the bacterium that causes Legionnaires’ disease, findings that could have broad implications for development of medicines to fight disease and infection. “Our immune system protects us from deadly infections, but successful pathogens have evolved many effective […]Continue Reading ...
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