Mammalian embryos are unlike those of any other organism as they must grow within the mother’s body. While other animal embryos grow outside the mother, their embryonic cells can get right to work accepting assignments, such as head, tail or vital organ. By contrast, mammalian embryos must first choose between forming the placenta or creating […]Continue Reading ...
To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports. “We have also developed a more efficient strategy to make muscles from human stem cells. Scientists […]Continue Reading ...
The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. Congenital heart disease is the leading cause […]Continue Reading ...
Researchers have succeeded in converting human skin cells into blood stem cells in an international collaboration project. “This is a first step on the way to generating fully functional blood stem cells in a petri dish which, in the future, could be transplanted into patients with blood diseases”, says Filipe Pereira, the researcher from Lund […]Continue Reading ...
Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients’ healthy tissue – often with fatal consequences. Researchers at the University of Zurich have now identified a molecule that plays a key role in this process. Blocking this molecule […]Continue Reading ...
Researchers have developed a way to grow human platelets in the laboratory from stem cells derived from fat tissue. The achievement, reported today in the journal Blood, suggests manufactured platelets could eventually reduce the reliance on donated platelets to help patients with cancer and other disorders. Platelets are a component of blood that helps with […]Continue Reading ...
Working in the lab of Craig Jordan, Ph.D., first author Courtney Jones shows that leukemia stem cells depend on amino acid metabolism, and that the drug venetoclax blocks this action, killing the cells. Credit: University of Colorado Cancer Center Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of […]Continue Reading ...
Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of your cells rip apart sugar to release the “bang” of energy. Sometimes they rip apart fats, and in a pinch, cells can even metabolize protein. Cancer cells do things a little differently. First, most cancer cells continue to depend […]Continue Reading ...
Rapid drug response screening for leukemia stem cells offers clues to relapse and to improving patient-specific therapies Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia (AML). Research on the drug responses of leukemia stem cells may reveal why some attempts […]Continue Reading ...
The human brain is comprised of billions of different types of cells. These cells are then organized into sophisticated networks, each of which determines a specific function of the brain. But how do the neurons, or nerve cells that form these networks, find the right network? And what happens when they don’t? To find out, […]Continue Reading ...
Royal jelly — the specialized goop that honeybees use to cultivate a new queen for a hive — is legendary among elementary-school-aged science nerds. (I state this with confidence from my sample size of one.) Somehow nurse bees cultivate royalty from lowly larvae that would normally become plain Jane worker bees simply by tweaking their diet. It’s […]Continue Reading ...
Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. This breakthrough published in the journal ‘Nature’ will facilitate the manufacturing of pancreatic islet cells from stem cells and might help […]Continue Reading ...
Tracing the developmental lineage tree of HSPCs Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather the location of the mutations in the DNA is relevant. Using the mutation patterns in the hematopoietic stem and progenitor cells […]Continue Reading ...
Epigenetic therapies — targeting enzymes that alter what genes are turned on or off in a cell — are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant. Researchers at Boston Children’s Hospital now report that at least one epigenetic therapy that initially looked promising […]Continue Reading ...
Treating pre-cancerous stem cells at an early stage could be key to preventing bowel cancer in people born with a very high risk of the disease, according to a study in mice presented at the 2018 NCRI Cancer Conference. Previous research has suggested that stem cells play a key role in the development of cancer, […]Continue Reading ...
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