Jeff Schorey talks with an undergraduate researcher. Credit: Matt Cashore/University of Notre Dame. In part because of its resistance to many antibiotics, tuberculosis kills approximately 1.7 million people worldwide each year. But new research from the University of Notre Dame suggests that structures released by the infected cells may be used in tandem with antibiotics […]Continue Reading ...
Research led by the Centenary Institute in Sydney has found a brand new target for treating drug-resistant tuberculosis; our scientists have uncovered that the tuberculosis bacterium hijacks platelets from the body’s blood clotting system to weaken our immune systems. Tuberculosis is far from eradicated around the world and still infects more than 1,400 people per […]Continue Reading ...
For years, scientists have been trying to come up with a better way to protect people against tuberculosis, the disease caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Texas Biomedical Research Institute Professor Jordi Torrelles, Ph.D., says new hope is on the horizon after a recent experiment performed in mice showed great promise. The […]Continue Reading ...
The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The European team of scientists behind this discovery is coordinated by researchers from the Institute of Pharmacology and Structural Biology (IPBS–CNRS/UPS) and the European Molecular Biology Laboratory (EMBL). Their findings are published in Molecular […]Continue Reading ...
Tuberculosis treatment still entails the intake several antibiotics over a period of many months and is torturous for many patients. The pathogen’s increasing multidrug resistance additionally complicates this lengthy treatment, and side effects frequently lead to a discontinuation of treatment and high mortality rates. Developing alternative treatment approaches is therefore of critical importance. DZIF scientists […]Continue Reading ...
If you live in the United States, you are unlikely to come into contact with the microbe that causes tuberculosis. Your odds of encountering the microbe are so low, in fact, that risk factors for the disease can easily go unnoticed: If you happened to carry a gene that predisposed you to tuberculosis, you likely […]Continue Reading ...
Diseases and tuberculosis in particular can pose considerable challenges for wildlife. In order to avoid epidemics within populations or to treat individual animals belonging to highly endangered species, fast and reliable tests are paramount. However present tuberculosis testing in rhinos relies on skin tests developed in the 1960s and designed for cattle bearing high risk […]Continue Reading ...
Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain–or tuberculosis meningitis (TBM)–is often deadly, always hard to treat, and a particular threat to young children. It may leave survivors with lifelong brain damage. Now, researchers at Johns Hopkins Medicine report they have […]Continue Reading ...
The Cochrane Infectious Diseases Group (link is external) (CIDG), which has its editorial base at LSTM, helps prepare systematic reviews related to the diagnosis and treatment of tuberculosis. Ahead of World TB Day, this week welcomes the publication of a Special Collection on the Cochrane Library (link is external) that tracks the development of exciting […]Continue Reading ...
The discovery of the peptide as a possible future antibiotic was made when the researchers screened different antimicrobial peptides’ ability to prevent the growth of the tuberculosis bacteria Mycobacterium tuberculosis. The peptide they ended up with comes from a fairly common fungi – the ebony cup (Pseudoplectania nigrella). Today’s cure for TB are antibiotics, but […]Continue Reading ...
Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB. Credit: NIAID A team of researchers affiliated with several institutions in the U.S. and one in France has found a molecule that is effective against tuberculosis. In their paper published in the journal Science, the group identifies the molecule and describes how well it worked when tested […]Continue Reading ...
Inaccurate tests carried out on tuberculosis patients in developing countries often fail to reliably detect resistance to drugs, leading to incorrect treatment and a higher mortality rate. These are the results of study by an international group of researchers led by a team at the University of Bern published today. Around ten million people around […]Continue Reading ...
Tuberculosis, a severe infection caused by bacteria in the lungs, kills almost as many people each year as HIV/AIDS and malaria combined Millions of people with high blood sugar may be at greater risk of tuberculosis than previously thought, scientists said Friday, warning that diabetes and TB could combine to create the “perfect storm” of […]Continue Reading ...
Gram stain of meningococci from a culture showing Gram negative (pink) bacteria, often in pairs. Credit: public domain Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular threat to young […]Continue Reading ...
Last month UN member states agreed to a global plan to fight tuberculosis and allow cheaper access to vital drugs, such as bedaquiline, but estimate the cost of meeting the goal of ending the disease by 2030 at $13 billion annually From a revolutionary way of testing children for tuberculosis to a cure for a […]Continue Reading ...
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