Breaking News
July 20, 2018 - Study compares outpatient antibiotic prescribing with traditional medical, retail clinic settings
July 20, 2018 - Immediate Monitoring With ECG Patch Ups A-Fib Diagnosis Rate
July 20, 2018 - Scientists seek to better protect the eye from glaucoma
July 20, 2018 - Football training could improve bone mineral density in prostate cancer patients
July 20, 2018 - Single genetic change in gut bacteria can lead to obesity
July 20, 2018 - Research uncovers new target for therapeutic intervention in breast cancer
July 20, 2018 - WFN to highlight clean air for brain health on World Brain Day 2018
July 20, 2018 - Health Highlights: July 17, 2018
July 20, 2018 - Mom’s marijuana winds up in breast milk
July 20, 2018 - Black men could be healthier if seen by black physicians, new research suggests
July 20, 2018 - Alcoholics have persistent difficulties with emotional communication after long-term abstinence
July 19, 2018 - Researchers unravel how ALL invades the central nervous system
July 19, 2018 - Mother’s microbiome determines offspring’s risk of developing autism
July 19, 2018 - Refining standards of maternal-fetal care
July 19, 2018 - Stitching single cells together any which way you want to
July 19, 2018 - Study identifies RNA molecules that regulate male hormones in prostate cancer
July 19, 2018 - New machine-learning model shows promise in predicting undiagnosed dementia
July 19, 2018 - Sleep supports antioxidant processes, study suggests
July 19, 2018 - MiRagen Therapeutics Announces Initiation of Phase 2 Clinical Trial of MRG-201
July 19, 2018 - Unique brain ‘fingerprint’ can predict drug effectiveness
July 19, 2018 - Life on the border: Struggling to survive in Jordan
July 19, 2018 - CT scans may raise brain tumor risk
July 19, 2018 - Moderate alcohol intake linked with improved male fertility
July 19, 2018 - Alcohol-related cirrhosis mortality on the rise among young adults
July 19, 2018 - Study uncovers new protein complex that shields broken DNA ends
July 19, 2018 - Regular sunscreen use protects young people from melanoma
July 19, 2018 - Using non-invasive brain recordings to characterize activity in deep structures
July 19, 2018 - Mediterranean diet could influence academic performance through effects on sleep quality
July 19, 2018 - Woman’s pregnancy history may be linked to Alzheimer’s disease risk
July 19, 2018 - Study calls for new gold standard in research to treat non-alcoholic steatohepatitis
July 19, 2018 - Cancer patients receiving anti-PD-1 therapies may experience delayed skin reactions
July 19, 2018 - Scientists study adverse effects of carbon, silicon nanotubes and carbon nanofibers
July 19, 2018 - Keck Hospital of USC receives Magnet recognition for excellence in nursing
July 19, 2018 - Scientists identify hidden signals in RNAs that control protein synthesis
July 19, 2018 - Quadrivalent HPV Vaccine Not Tied to Spontaneous Abortion
July 19, 2018 - FDA OKs first drug made to reduce excessive sweating
July 19, 2018 - New Finnish study compares surgical treatment of shoulder impingement syndrome to placebo surgery
July 19, 2018 - New findings do no support caffeine as effective appetite suppressant or weight-loss aid
July 19, 2018 - Kite collaborates with Gadeta to develop novel gamma delta TCR therapies for various cancers
July 19, 2018 - Study evaluates Neoteryx’s VAMS technology for monitoring HbA1c levels of diabetic children
July 19, 2018 - New clinical trial examines use of adrenaline to treat cardiac arrests
July 19, 2018 - Early surgical intervention may improve outcomes for patients with mitral valve disease
July 19, 2018 - Prolonged preoperative opioid use linked to adverse outcomes after total knee and hip arthroplasty
July 19, 2018 - Biophysicists use infrared sensor as new method for drug discovery
July 19, 2018 - Rat study shows negative effects of perinatal exposure to phthalates
July 19, 2018 - Children with disabilities endure long waits for life-changing medical equipment
July 19, 2018 - Ways to stay safe while camping and hiking
July 19, 2018 - People with HIV twice as likely to suffer from heart disease
July 19, 2018 - On-the-Job Stress Relief – MedNews
July 19, 2018 - Compounds found in green tea and wine may block formation of toxic metabolites
July 19, 2018 - Gene regulator associated with protein pileup in exfoliation glaucoma
July 19, 2018 - Trump administration summons immigrant infants
July 19, 2018 - FDA grants approval for first breast cancer drug through ‘Real-Time Oncology Review’
July 19, 2018 - Five tips for men seeking plastic surgery
July 19, 2018 - Researchers discover the reasons why some people get dizzy when hearing certain sounds
July 19, 2018 - Research project investigates snake venom treatment as antibiotic alternative for eye infections
July 19, 2018 - Melanoma could soon be detected using a blood test
July 19, 2018 - Exposure to bright light may have big impact on sleep-related behavior in children
July 19, 2018 - Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice
July 19, 2018 - New proteomics studies help gain more insights into Alzheimer’s, cancer and listeriosis
July 19, 2018 - Study finds major discrepancies in prescription drug labeling pregnancy information across four countries
July 19, 2018 - Cellectar’s CLR 131 Receives FDA Orphan Drug Designation for Treatment of Ewing’s Sarcoma
July 19, 2018 - Watching the immune system in action reveals what happens when things goes wrong
July 19, 2018 - Increasing blood sugar levels improves memory and performance in older adults
July 19, 2018 - Connection between self-regulation and obesity appears to be different for girls and boys
July 19, 2018 - Researchers develop new, less destructive method for whitening teeth
July 19, 2018 - Revving up innate control of viral infection requires a three-cell ignition
July 19, 2018 - Inaccurate direct-to-consumer raw genetic data can harm patients, new research suggests
July 19, 2018 - Weight loss surgery is effective under the right situations
July 19, 2018 - BioTek awarded patent for autofocus feature on microplate reader
July 19, 2018 - Low-carb diets reduce stiffness of arteries in women and promote weight loss in men
July 19, 2018 - New review examines cannabinoids’ potential for direct treatment of cancer
July 19, 2018 - Allergic responses may help protect the skin against cancer, research suggests
July 19, 2018 - Inappropriate Prescribing of Abx High in Urgent Care Centers
July 19, 2018 - Many at risk for HIV despite lifesaving pill
July 19, 2018 - Tips for doctors and parents on the harms of marijuana use for teens
July 18, 2018 - Researchers detect presence of IgE antibodies after kidney transplantation
July 18, 2018 - New technique allows researchers to create large scale, personalized bone grafts
July 18, 2018 - Smoking May Boost Atrial Fibrillation Risk
July 18, 2018 - Genome editing method targets AIDS virus
Drug Is helping Children Stay Listening to after Platinum Tx

Drug Is helping Children Stay Listening to after Platinum Tx

image_pdfDownload PDFimage_print

Addition of the antioxidant sodium thiosulfate (STS) following cisplatin-based chemotherapy lowered the occurrence of listening to loss by way of 50% amongst kids with many varieties of most cancers, signaling “a brand new generation” wherein “the ancient paradigm of wanting to simply accept life-changing listening to loss as an inevitable value of curing most cancers is now not essential or suitable,” in line with the lead investigator of Youngsters’s Oncology Workforce ACCL0431 find out about.

The consequences, reported right here at the once a year assembly of the American Society of Pediatric Hematology/Oncology and printed previous this yr in Lancet Oncology, be offering “actual hope for making cisplatin-induced listening to loss an issue of the previous,” reported David R. Freyer, DO, MS, from Youngsters’s Health facility Los Angeles, and Keck Faculty of Drugs, College of Southern California.

“To the most efficient of our wisdom, with those effects, sodium thiosulfate turns into the primary confirmed drug examined beneath those stipulations and thus represents the most important construction in translational otoprotection analysis,” wrote the authors.

“It’s affordable to suppose some great benefits of fighting cisplatin-induced listening to loss and protracted tinnitus come with relief in their many downstream results on language acquisition, finding out, psychosocial construction, and social functioning.”

Alternatively, a post-hoc secondary evaluation of the effects mentioned right here does elevate a pink flag that are supposed to warning clinicians to curb their enthusiasm for adopting STS indiscriminately: particularly a subset of sufferers with disseminated illness, for whom survival seemed to be worse at the medication, mentioned Freyer.

Effects from the continued SIOPEL-6 trial must confidently explain this phenomenon, however for the time being, he cautiously condoned STS, which is already licensed by way of america Meals and Drug Management for the medication of cyanide poisoning.

“I believe it does is sensible to most certainly attempt to hone down at the inhabitants that seems to be at biggest possibility [of hearing loss] –i.e., those that are not up to five years of age, and I believe using STS, which is commercially to be had, most certainly must be limited to these with localized illness in gentle of our findings,” mentioned Freyer.

The find out about randomly assigned 125 pediatric most cancers sufferers with customary listening to to statement (n=64) or intravenous STS (16 g/m2; n=61) 6 hours after each and every cisplatin medication cycle.

Usual audiometry, carried out at baseline and 24 hours sooner than each and every medication, used to be in comparison to a last check at four weeks post-treatment.

Listening to loss, happened in 56.four% of sufferers beneath statement in comparison to 28.6% of STS-treated sufferers (P=zero.00022), with essentially the most marked distinction amongst sufferers beneath age five years (73.Three% as opposed to 21.four% respectively), in comparison to older sufferers (50% as opposed to 31.four%).

After adjustment for stratification variables comparable to period of cisplatin infusion or prior cranial irradiation, the possibility of listening to loss used to be considerably decrease within the STS when compared with the keep an eye on staff (OR zero·31, P=zero·0036).

And whilst there used to be no distinction in hematologic toxicity between the STS and keep an eye on teams, there used to be “a curious and unexplained upper occurrence” of renal toxicity within the STS staff (25% as opposed to 13% of player cycles), he mentioned.

For the secondary results of event-free and total survival there used to be no distinction between teams for the primary, and a non-significant lower in OS a few of the STS staff, mentioned Freyer.

According to this, the post-hoc sub-analysis by way of extent of illness used to be undertaken which confirmed no distinction amongst sufferers with localized illness, however a statistically meaningful decrease Three-year total survival amongst sufferers with disseminated illness (n=47) who had been handled with STS as opposed to no longer (relative danger ratio four.10, P=zero.0090).

Causes for this stay unclear, however may just come with the marked heterogeneity of the find out about inhabitants or the likelihood that STS is tumor protecting in addition to otoprotective, advised the find out about authors.

Both manner, this discovering items a difficult query to clinicians and oldsters, mentioned Freyer. “We are not ready actually to make medical suggestions at the foundation of this, and our find out about committee, the COG, hasn’t actually arrived at a place on that, however leaves it as much as particular person clinicians. We predict that you have to watch for the information to come back from SIOPEL-6.”

Within the intervening time, he recommends an excessively clear dialogue with the circle of relatives and in the event that they worth listening to coverage, in the event that they select to make use of the STS, it is most certainly no longer unreasonable.”

The find out about used to be funded by way of the Nationwide Most cancers Institute.

Freyer disclosed that he’s an uncompensated clinical guide for Otonomy and he had no different monetary disclosures.

Sodium theosulfate used to be supplied by way of Adherex Applied sciences (now Fennec Pharma).


Tagged with:

About author

Related Articles