Breaking News
February 19, 2018 - ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids
February 19, 2018 - Patient exposure to X-rays depends on how dentists are paid
February 19, 2018 - FDA approves first treatment to reduce risk of NSCLC progression
February 19, 2018 - FDA Expands Approval of Imfinzi (durvalumab) to Reduce the Risk of Non-Small Cell Lung Cancer Progressing
February 19, 2018 - D.C. Week: Congress Passes Spending Bill
February 19, 2018 - Heart-muscle patches made with human cells improve heart attack recovery
February 19, 2018 - FDA Approves First Blood Test to Detect Concussions
February 19, 2018 - Survival Bump in Bladder Cancer with Keytruda
February 18, 2018 - Scientists describe the mechanism of heart regeneration in the zebrafish
February 18, 2018 - Scientists uncover the structure of microtubule motor proteins
February 18, 2018 - Light-activated cancer drugs without toxic side effects are closer to becoming reality
February 18, 2018 - Pioneering research could provide novel insight into how genomic information is read
February 18, 2018 - Pearls From: David Putrino, PhD
February 18, 2018 - Researchers uncover how cancer stem cells drive triple-negative breast cancer
February 18, 2018 - Morning Break: Anti-Anti-Vaxxers; Private Piercings Prohibited; A Case for Pelvic Massage
February 18, 2018 - Lower-dose radiation effective, safe for HPV+ head and neck cancer after induction chemo
February 18, 2018 - Specialist residential service for adults with autism opens in Swansea
February 18, 2018 - FDA Moves to Limit Loperamide Doses per Package
February 18, 2018 - Alcohol use disorder – Genetics Home Reference
February 18, 2018 - Autism might be better detected using new two-minute questionnaire
February 18, 2018 - Hand hygiene-intervention practices may reduce risk of infection among nursing home patients
February 18, 2018 - Researchers develop most sophisticated mini-livers to date
February 18, 2018 - Obamacare Helped More Young Women Get Prenatal Care: Study
February 18, 2018 - School-Based Program Fails to Dent Kids’ Obesity
February 18, 2018 - Research compares neural activity in children with and without autism spectrum disorder
February 18, 2018 - Poor fitness levels increase the risk dementia, concludes study
February 18, 2018 - Risk Score May Reveal if Kids are Victims of Ill-Treatment
February 18, 2018 - Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects
February 18, 2018 - Acute treatment suppresses posttraumatic arthritis in ankle injury
February 18, 2018 - A Role for Budesonide in Autoimmune Hepatitis?
February 18, 2018 - Lupus patients exhibit altered cell proteins, a discovery with potential implications for diagnostics
February 18, 2018 - Muscle plays vital role in regulating heat loss from the hands
February 18, 2018 - High-tech brain scans can provide new way to define intelligence
February 18, 2018 - Study reveals the association between ultra-processed foods and cancer
February 18, 2018 - Prescription Opioid Use Tied to Higher Pneumonia Risk
February 18, 2018 - A non-invasive method to detect Alzheimer’s disease
February 18, 2018 - Deletion of specific enzyme leads to improvement in memory and cognitive functions
February 18, 2018 - Amyloid protein may be transmitted through neurosurgical instruments, study suggests
February 18, 2018 - Electric brain signals of males and females show differences
February 18, 2018 - American Heart Association commends McDonald’s for offering healthier menu in kids’ meals
February 18, 2018 - Parents Find Kids’ Weight Report Cards Hard to Swallow
February 18, 2018 - Does a Financial Conflict of Interest Ever Expire?
February 18, 2018 - Exercise can improve Alzheimer’s symptoms
February 18, 2018 - Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency
February 17, 2018 - ‘A Time Clock to a Tissue Clock’ for Acute Stroke Care
February 17, 2018 - Cancer Care Gets Personal | NIH News in Health
February 17, 2018 - Do more youth use or do youth use more?
February 17, 2018 - Eating faster linked to obesity
February 17, 2018 - Who’s Still Smoking? ACS Report Highlights Most Vulnerable Adults
February 17, 2018 - Study of smoking and genetics illuminates complexities of blood pressure
February 17, 2018 - Study reveals new link between bone cells and blood glucose level
February 17, 2018 - Children with reading challenges may have lower than expected binocular vision test results
February 17, 2018 - Mass Shootings Trigger Change for Emergency Medicine
February 17, 2018 - ECMO helps revive woman thought to be drowned
February 17, 2018 - Learning stress-reducing techniques may benefit people with epilepsy
February 17, 2018 - Shedding Pounds Before Weight-Loss Surgery a Smart Move
February 17, 2018 - FDA Approves New Cystic Fibrosis Drug Combo
February 17, 2018 - Augmented Reality helps surgeons to ‘see through’ tissue and reconnect blood vessels
February 17, 2018 - Emotional state affects operation of the entire brain instead of being restricted to specific regions
February 17, 2018 - Apalutamide Slows Metastasis in Prostate Cancer
February 17, 2018 - Kids’ well visits linked to lower appendicitis complications
February 17, 2018 - New NK cell-based immunotherapy effective against several types of leukemia
February 17, 2018 - Producing Super-Swelled Lyotropic Crystals for Drug Development
February 17, 2018 - Pfizer Receives Breakthrough Therapy Designation from FDA for PF-04965842, an oral JAK1 Inhibitor, for the Treatment of Patients with Moderate-to-Severe Atopic Dermatitis
February 17, 2018 - Molecular Imaging Flags Risk of AAA Rupture
February 17, 2018 - Researchers identify risk factors for sleep apnea during pregnancy
February 17, 2018 - More work required to find the right drug dosage for pediatric patients
February 17, 2018 - Factors ID’d That Predict RA Remission with Etanercept
February 17, 2018 - A handout or a hand up? How we judge others guides how we help others
February 17, 2018 - ACR receives grant to focus on projects that reduce health disparities
February 17, 2018 - Pimavanserin Might Be Safer Alternative to Ease Dementia Psychosis
February 17, 2018 - Risks of Lung Screening Seen Outweighing Benefits in Many with Smoking History
February 17, 2018 - The impact of Hurricane Harvey on pregnant moms
February 17, 2018 - Gene editing tool used to detect cancer
February 17, 2018 - Researchers detail molecular atlas of cells that form brain’s blood vessels
February 17, 2018 - TUM scientists observe formation of myelin sheaths around nerve fibers
February 17, 2018 - Worst Flu Season Yet? | Medpage Today
February 17, 2018 - Finding the root cause of bronchiolitis symptoms
February 17, 2018 - Climbing stairs reduces hypertension and strengthens muscles
February 17, 2018 - Nature paper unveils bacterial division
Drug Is helping Children Stay Listening to after Platinum Tx

Drug Is helping Children Stay Listening to after Platinum Tx

image_pdfDownload PDFimage_print

Addition of the antioxidant sodium thiosulfate (STS) following cisplatin-based chemotherapy lowered the occurrence of listening to loss by way of 50% amongst kids with many varieties of most cancers, signaling “a brand new generation” wherein “the ancient paradigm of wanting to simply accept life-changing listening to loss as an inevitable value of curing most cancers is now not essential or suitable,” in line with the lead investigator of Youngsters’s Oncology Workforce ACCL0431 find out about.

The consequences, reported right here at the once a year assembly of the American Society of Pediatric Hematology/Oncology and printed previous this yr in Lancet Oncology, be offering “actual hope for making cisplatin-induced listening to loss an issue of the previous,” reported David R. Freyer, DO, MS, from Youngsters’s Health facility Los Angeles, and Keck Faculty of Drugs, College of Southern California.

“To the most efficient of our wisdom, with those effects, sodium thiosulfate turns into the primary confirmed drug examined beneath those stipulations and thus represents the most important construction in translational otoprotection analysis,” wrote the authors.

“It’s affordable to suppose some great benefits of fighting cisplatin-induced listening to loss and protracted tinnitus come with relief in their many downstream results on language acquisition, finding out, psychosocial construction, and social functioning.”

Alternatively, a post-hoc secondary evaluation of the effects mentioned right here does elevate a pink flag that are supposed to warning clinicians to curb their enthusiasm for adopting STS indiscriminately: particularly a subset of sufferers with disseminated illness, for whom survival seemed to be worse at the medication, mentioned Freyer.

Effects from the continued SIOPEL-6 trial must confidently explain this phenomenon, however for the time being, he cautiously condoned STS, which is already licensed by way of america Meals and Drug Management for the medication of cyanide poisoning.

“I believe it does is sensible to most certainly attempt to hone down at the inhabitants that seems to be at biggest possibility [of hearing loss] –i.e., those that are not up to five years of age, and I believe using STS, which is commercially to be had, most certainly must be limited to these with localized illness in gentle of our findings,” mentioned Freyer.

The find out about randomly assigned 125 pediatric most cancers sufferers with customary listening to to statement (n=64) or intravenous STS (16 g/m2; n=61) 6 hours after each and every cisplatin medication cycle.

Usual audiometry, carried out at baseline and 24 hours sooner than each and every medication, used to be in comparison to a last check at four weeks post-treatment.

Listening to loss, happened in 56.four% of sufferers beneath statement in comparison to 28.6% of STS-treated sufferers (P=zero.00022), with essentially the most marked distinction amongst sufferers beneath age five years (73.Three% as opposed to 21.four% respectively), in comparison to older sufferers (50% as opposed to 31.four%).

After adjustment for stratification variables comparable to period of cisplatin infusion or prior cranial irradiation, the possibility of listening to loss used to be considerably decrease within the STS when compared with the keep an eye on staff (OR zero·31, P=zero·0036).

And whilst there used to be no distinction in hematologic toxicity between the STS and keep an eye on teams, there used to be “a curious and unexplained upper occurrence” of renal toxicity within the STS staff (25% as opposed to 13% of player cycles), he mentioned.

For the secondary results of event-free and total survival there used to be no distinction between teams for the primary, and a non-significant lower in OS a few of the STS staff, mentioned Freyer.

According to this, the post-hoc sub-analysis by way of extent of illness used to be undertaken which confirmed no distinction amongst sufferers with localized illness, however a statistically meaningful decrease Three-year total survival amongst sufferers with disseminated illness (n=47) who had been handled with STS as opposed to no longer (relative danger ratio four.10, P=zero.0090).

Causes for this stay unclear, however may just come with the marked heterogeneity of the find out about inhabitants or the likelihood that STS is tumor protecting in addition to otoprotective, advised the find out about authors.

Both manner, this discovering items a difficult query to clinicians and oldsters, mentioned Freyer. “We are not ready actually to make medical suggestions at the foundation of this, and our find out about committee, the COG, hasn’t actually arrived at a place on that, however leaves it as much as particular person clinicians. We predict that you have to watch for the information to come back from SIOPEL-6.”

Within the intervening time, he recommends an excessively clear dialogue with the circle of relatives and in the event that they worth listening to coverage, in the event that they select to make use of the STS, it is most certainly no longer unreasonable.”

The find out about used to be funded by way of the Nationwide Most cancers Institute.

Freyer disclosed that he’s an uncompensated clinical guide for Otonomy and he had no different monetary disclosures.

Sodium theosulfate used to be supplied by way of Adherex Applied sciences (now Fennec Pharma).


Tagged with:

About author

Related Articles