Breaking News
April 20, 2018 - Metabolic Syndrome Common With Chronic Hep B Infection
April 20, 2018 - Tracking quality of life during prostate cancer treatment
April 20, 2018 - Study shows presence of beta-amyloid dimers in the brains of Alzheimer’s patients
April 20, 2018 - Researchers identify link between physical inactivity and increased risk of dying from cancer
April 20, 2018 - Breathtaking evolution amongst Indonesian tribe
April 20, 2018 - Study shows testosterone deficiency in men is associated with chronic diseases
April 20, 2018 - Simple one-page form helps improve satisfaction of patients with care
April 20, 2018 - Researchers evaluate accuracy of simple blood test to predict lung cancer
April 20, 2018 - Study looks at sperm producing ability in testicular cancer patients
April 20, 2018 - Exercise In, Vitamin D Out for Preventing Falls: U.S. Panel
April 20, 2018 - Skin cancers associated with decreased risk of developing AD
April 20, 2018 - Preserving fertility during chemotherapy
April 20, 2018 - Teva and Procter & Gamble Company terminate PGT Healthcare partnership
April 20, 2018 - People diagnosed with traumatic brain injury may have increased risk of Parkinson’s disease, shows study
April 20, 2018 - Researchers use smartphone to diagnose people infected with Loa loa worm
April 20, 2018 - College students with autism have high rate of suicidal thoughts
April 20, 2018 - Study sheds light on how the HSC niche is maintained
April 20, 2018 - Drug test spurs frank talk between hypertension patients and doctors
April 19, 2018 - Low-cost deworming drug improves female farmers’ physical fitness
April 19, 2018 - Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects
April 19, 2018 - Many European countries lack comprehensive policy to eliminate viral hepatitis
April 19, 2018 - Young people with ADHD ‘more likely’ to come from deprived neighbourhoods
April 19, 2018 - SLU professor discovers new biomarkers for chlorine gas exposure
April 19, 2018 - Study proposes new mechanism that may contribute to gender differences in weight control
April 19, 2018 - Sleep restriction therapy does not interfere with insomnia patient’s driving ability, research shows
April 19, 2018 - Deep brain stimulation offers relief to UTHealth patient with treatment-resistant depression
April 19, 2018 - Study shows fatty fish and camelina oil boost HDL and IDL cholesterol
April 19, 2018 - FDA Alert: Euphoric Capsules by Epic Products: Recall
April 19, 2018 - Researchers identify peptide produced during cartilage deterioration as a potential source of osteoarthritis pain
April 19, 2018 - New breakthrough may allow scientists to orchestrate tissue regeneration in humans
April 19, 2018 - SYGNIS AG introduces new TruePrime apoptotic cell free DNA amplification kit
April 19, 2018 - Innovative device shows promise in capturing and releasing circulating tumor cells
April 19, 2018 - Researchers shed light on role of striosomal neurons in reinforcement learning
April 19, 2018 - Genetic make-up impacts long-term effectiveness of phobia treatment
April 19, 2018 - Novel biomarker can distinguish malignant lung nodules
April 19, 2018 - Study reports promising novel approach to treat therapy resistant pediatric brain tumors
April 19, 2018 - One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy
April 19, 2018 - Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain
April 19, 2018 - Transplanted livers have a protective effect and reduce potential for organ rejection
April 19, 2018 - Researchers develop new method to study activity of inflammatory cells
April 19, 2018 - Researchers discover highly antibiotic resistant superbugs in Gulf States
April 19, 2018 - Smart-tooth technology shows promise in detecting certain diseases in high-risk patients
April 19, 2018 - Interaction between dioxin and HLA gene variant activates events associated with rheumatoid arthritis
April 19, 2018 - Eyes of adolescents could be associated with increased risk of cardiovascular disease in later life
April 19, 2018 - U.S. Women Less Likely Than Men to Get Statins After Heart Attack
April 19, 2018 - Health Canada grants cannabis cultivation license to High Park Farms
April 19, 2018 - Atypical brain development observed in preschoolers with ADHD symptoms
April 19, 2018 - SC Johnson releases annual Sustainability Report
April 19, 2018 - Positive attitudes about aging reduce risk of dementia in older adults
April 19, 2018 - Environmental pollutants found to worsen rheumatoid arthritis
April 19, 2018 - UT Southwestern scientists discover protein linked to metastatic breast cancer
April 19, 2018 - Study highlights need for further evidence to improve symptom management in end of life care
April 19, 2018 - Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer’s
April 19, 2018 - Uniqsis offers high-power LED light unit for scalable flow photochemistry reactions
April 19, 2018 - Case study shows how intravascular ultrasound imaging helps detect acute aortic syndrome
April 19, 2018 - Research reveals new mechanism by which HIV evades the immune system
April 19, 2018 - Nanodisc-delivered cancer treatment helps eliminate tumors
April 19, 2018 - Functional connectivity MRI could help detect brain disorders and diseases
April 19, 2018 - Finding better way to quantify neuropathy symptoms and treatment efficacy
April 19, 2018 - Study examines effectiveness of caregiver education about sickle cell trait
April 19, 2018 - High-resolution images of tumor vasculature using new technology
April 19, 2018 - Lack of sleep may be linked to risk factor for Alzheimer’s disease
April 19, 2018 - Study finds neurotransmitter may play a role in alcohol relapse, addiction
April 19, 2018 - Researchers build molecular networks of calcific aortic valve disease
April 19, 2018 - Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens
April 19, 2018 - Scientists decipher mechanism of chemotherapy induced female infertility
April 19, 2018 - New insight may allow researchers to design drugs that improve immune responses to vaccines
April 19, 2018 - FDA Approves Crysvita (burosumab-twza) for X-Linked Hypophosphatemia
April 19, 2018 - Researchers uncover origin of virus-fighting plasma B cells
April 19, 2018 - Study finds no evidence of lower intelligence in young children who had anesthesia
April 19, 2018 - Baboons break out of research facility briefly
April 19, 2018 - Study shows how deployment time increases risk of suicide attempt in soldiers
April 19, 2018 - Specific odors from malaria infected individuals attract more mosquitoes
April 19, 2018 - FDA Alert: Rhino 69 Extreme 50000 by AMA Wholesale: Recall
April 19, 2018 - Top HIV cure research team refutes major recent results on how to identify HIV persistence
April 19, 2018 - Experts propose new solutions to increase benefit, affordability of targeted cancer medicines
April 19, 2018 - Deficiency of innate immune adaptor TRIF shortens survival time of ALS mice
April 19, 2018 - New machine learning method offers better way to detect heart disease
April 19, 2018 - CNIO researchers determine structure of protein complex related to cell survival
April 19, 2018 - Faith-based diabetes support program launched by UTSA research team
Findings problem present method to Glut1 deficiency

Findings problem present method to Glut1 deficiency

image_pdfDownload PDFimage_print
Jianzhong Su is a professor and chair of arithmetic at The College of Texas at Arlington. Credit score: UTA

Researchers at The College of Texas at Arlington and the College of Texas Southwestern Scientific Middle have found out that nutrition adjustments and early prognosis may just lend a hand results for sufferers with Glucose Transporter Sort 1 Deficiency, a unprecedented pediatric neurological dysfunction that may motive motor developmental issues and cause seizures and epilepsy.

“We got down to explain problems surrounding the prognosis and remedy of the illness throughout the advent of the primary registry to assemble detailed clinical and remedy historical past from a huge vary of sufferers, together with phenotypes or characteristics, remedy historical past and genetic knowledge,” mentioned Dr. Juan Pascual, a neurologist and director of the Uncommon Mind Issues Program at UT Southwestern’s O’Donnell Mind Institute.

“Our information means that the one maximum vital issue figuring out sure affected person end result is an early age of prognosis, and likewise demonstrates that choice nutritional remedies can radically strengthen affected person well being over the long-term.”

The effects had been revealed as of late in JAMA Neurology in an editorial titled: “Scientific Sides of Glucose Transporter Sort 1 Deficiency: Data from a International Registry.” UTA’s Jianzhong Su, professor and chair of arithmetic, and Dr. Jian Hao, a member of Dr. Su’s analysis staff, had been co-authors at the paper.

The analysis effects mirrored information from a registry of 181 sufferers situated international, for the length from Dec. 1, 2013 to Dec. 1, 2016.

“We used a number of statistical strategies adapted to handle the age of onset of more than a few sorts of the illness, related manifestations, herbal historical past, remedy efficacy and diagnostic procedures,” Dr. Su mentioned.

“Those elements had been correlated in a predictive mathematical style designed to lead analysis at the foundation of medical options at prognosis,” he added.

The 3 primary novel effects are:

  • The effectiveness of other nutritional remedies, such because the “changed” Atkins nutrition. The time period “changed” describes the decrease carbohydrate restrict in comparison to Atkins suggestions and the emphasis of excessive fats meals as is needed at the ketogenic nutrition.
  • The life of structural mind defects equivalent to white topic abnormalities in a single quarter of instances, as observed in MRI scans;
  • The favorable affect of early prognosis and remedy without reference to remedy modality and mutation kind.

Those effects problem the present approaches to the illness, such because the perceived absolute requirement of a ketogenic or high-fat, low-carbohydrate nutrition, the assumed loss of structural mind defects and the possible life of genotype: phenotype correlations.

“Sufferers who had been identified early and placed on an good enough nutrition did really well,” Dr. Su mentioned. “Screening for this illness amongst small children with developmental delays or issues equivalent to seizures inside the first 12 months of lifestyles may just make a vital affect on results.”

The analysis used to be supported via a Carrier Bundle Grant from UT Southwestern’s Middle for Translational Drugs, which used to be given to the collaboration of Dr. Pascual’s lab and Dr. Su’s staff to increase this research and extra analysis on person affected person’s electroencephalogram or EEG imaging research to localize the assets of ordinary mind alerts.

Morteza Khaledi, dean of UTA’s Faculty of Science, underlined the significance of this paintings within the context of UTA’s strategic topics of well being and the human situation and data-driven discovery inside the Strategic Plan 2020: Daring Answers|International Have an effect on.

“The paintings of Dr. Su’s staff in mathematical research gave the researchers the ability to extract significant conclusions from huge information units with an overly excessive stage of rigor,” Khaledi mentioned. “Those tendencies and associations won’t were observed in different ways.”

Discover additional:
Epilepsy: Some other doable Zika risk to small children

Additional info:
JAMA Neurology (2017). DOI: 10.1001/jamaneurol.2017.0298

Magazine reference:
Archives of Neurology

Supplied via:
College of Texas at Arlington

Tagged with:

About author

Related Articles