Breaking News
February 20, 2018 - Safe sleep recommendations for parents that may help reduce child’s risk of SUID
February 20, 2018 - Why Do So Few Docs Have Buprenorphine Waivers?
February 20, 2018 - Low levels of alcohol good for the brain
February 20, 2018 - Experimental treatment improves invisible symptoms of a man with spinal cord injury
February 20, 2018 - Myriad’s EndoPredict offers better prediction of breast cancer recurrence, analysis shows
February 20, 2018 - Researchers identify fifteen genes that determine our facial features
February 20, 2018 - Morning Break: New Health IT Player; Luxturna No Bargain; Nuclear Freakout
February 20, 2018 - How does it compare? Hospice care at home, at assisted living facility, at nursing home
February 19, 2018 - Scientists develop water-soluble warped nanographene for bioimaging
February 19, 2018 - It’s Not Your Imagination: You’re Hungrier After Losing Weight
February 19, 2018 - Antihypertensive Use At Delivery Rising in Preeclampsia
February 19, 2018 - A centuries-old math equation used to solve a modern-day genetics challenge
February 19, 2018 - Liquid biopsies could be used as new predictive marker for metastatic TNBC
February 19, 2018 - Russian researchers develop new multi-layered biodegradable scaffolds
February 19, 2018 - Are ‘Vaccine Skeptics’ Responsible for Flu Deaths?
February 19, 2018 - Hidden genetic effects behind immune diseases may be missed, study suggests
February 19, 2018 - Emergency nurses experience regular verbal and physical abuse
February 19, 2018 - Study sheds light on biology that guides behavior across different stages of life
February 19, 2018 - Morning Break: Transgender Breast Feeding; Brazilian ‘Pro-Vaxxers’; Post-Stroke Exercise
February 19, 2018 - Meningitis vaccination strategy in Africa found to be effective, economical
February 19, 2018 - Researchers uncover how excess calcium may influence development of Parkinson’s disease
February 19, 2018 - Psoriasis drug also effective at reducing aortic inflammation
February 19, 2018 - Excess emissions can make serious contributions to air pollution, study shows
February 19, 2018 - Researchers reveal potential biological roots behind individuality
February 19, 2018 - Diabetes Drugs Differ on HF; School-Based Obesity Program Flop; Plaque Type in ACS
February 19, 2018 - Surgical infections linked to drug-resistant bugs, study suggests
February 19, 2018 - Poor awareness may hinder a child’s early dental care
February 19, 2018 - Research finds rising trend in incidence of merkel cell carcinoma
February 19, 2018 - Researchers uncover Ras protein’s role in uncontrolled cancer growth
February 19, 2018 - FDA Approves Apalutamide (Erleada) to Help Curb a Tough-to-Treat Prostate Cancer
February 19, 2018 - Educational Tool Boosts Cervical Length Screening
February 19, 2018 - Spider’s web inspires removable implant that may control type 1 diabetes
February 19, 2018 - Scientists develop fluorescent probe to identify cancer stem cells
February 19, 2018 - University Hospital of Santiago de Compostela participates in large pancreatic cancer study
February 19, 2018 - New blood test shows promise to revolutionize diagnosis of tick-borne diseases
February 19, 2018 - Report: Use, Not Price, Drives State Health Costs
February 19, 2018 - Emergency services crews often unprepared for diabetic crises
February 19, 2018 - Scientists in Sweden create DNA nanowires that offer hope for treatment of diseases
February 19, 2018 - ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids
February 19, 2018 - Patient exposure to X-rays depends on how dentists are paid
February 19, 2018 - Study reveals parents’ views toward children’s tanning bed use
February 19, 2018 - Shot may help reduce risk of shingles
February 19, 2018 - FDA approves first treatment to reduce risk of NSCLC progression
February 19, 2018 - FDA Expands Approval of Imfinzi (durvalumab) to Reduce the Risk of Non-Small Cell Lung Cancer Progressing
February 19, 2018 - D.C. Week: Congress Passes Spending Bill
February 19, 2018 - Heart-muscle patches made with human cells improve heart attack recovery
February 19, 2018 - FDA Approves First Blood Test to Detect Concussions
February 19, 2018 - Survival Bump in Bladder Cancer with Keytruda
February 18, 2018 - Scientists describe the mechanism of heart regeneration in the zebrafish
February 18, 2018 - Scientists uncover the structure of microtubule motor proteins
February 18, 2018 - Light-activated cancer drugs without toxic side effects are closer to becoming reality
February 18, 2018 - Pioneering research could provide novel insight into how genomic information is read
February 18, 2018 - Pearls From: David Putrino, PhD
February 18, 2018 - Researchers uncover how cancer stem cells drive triple-negative breast cancer
February 18, 2018 - Morning Break: Anti-Anti-Vaxxers; Private Piercings Prohibited; A Case for Pelvic Massage
February 18, 2018 - Lower-dose radiation effective, safe for HPV+ head and neck cancer after induction chemo
February 18, 2018 - Specialist residential service for adults with autism opens in Swansea
February 18, 2018 - FDA Moves to Limit Loperamide Doses per Package
February 18, 2018 - Alcohol use disorder – Genetics Home Reference
February 18, 2018 - Autism might be better detected using new two-minute questionnaire
February 18, 2018 - Hand hygiene-intervention practices may reduce risk of infection among nursing home patients
February 18, 2018 - Researchers develop most sophisticated mini-livers to date
February 18, 2018 - Obamacare Helped More Young Women Get Prenatal Care: Study
February 18, 2018 - School-Based Program Fails to Dent Kids’ Obesity
February 18, 2018 - Research compares neural activity in children with and without autism spectrum disorder
February 18, 2018 - Poor fitness levels increase the risk dementia, concludes study
February 18, 2018 - Risk Score May Reveal if Kids are Victims of Ill-Treatment
February 18, 2018 - Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects
February 18, 2018 - Acute treatment suppresses posttraumatic arthritis in ankle injury
February 18, 2018 - A Role for Budesonide in Autoimmune Hepatitis?
February 18, 2018 - Lupus patients exhibit altered cell proteins, a discovery with potential implications for diagnostics
February 18, 2018 - Muscle plays vital role in regulating heat loss from the hands
February 18, 2018 - High-tech brain scans can provide new way to define intelligence
February 18, 2018 - Study reveals the association between ultra-processed foods and cancer
February 18, 2018 - Prescription Opioid Use Tied to Higher Pneumonia Risk
February 18, 2018 - A non-invasive method to detect Alzheimer’s disease
February 18, 2018 - Deletion of specific enzyme leads to improvement in memory and cognitive functions
February 18, 2018 - Amyloid protein may be transmitted through neurosurgical instruments, study suggests
February 18, 2018 - Electric brain signals of males and females show differences
February 18, 2018 - American Heart Association commends McDonald’s for offering healthier menu in kids’ meals
Findings problem present method to Glut1 deficiency

Findings problem present method to Glut1 deficiency

image_pdfDownload PDFimage_print
Jianzhong Su is a professor and chair of arithmetic at The College of Texas at Arlington. Credit score: UTA

Researchers at The College of Texas at Arlington and the College of Texas Southwestern Scientific Middle have found out that nutrition adjustments and early prognosis may just lend a hand results for sufferers with Glucose Transporter Sort 1 Deficiency, a unprecedented pediatric neurological dysfunction that may motive motor developmental issues and cause seizures and epilepsy.

“We got down to explain problems surrounding the prognosis and remedy of the illness throughout the advent of the primary registry to assemble detailed clinical and remedy historical past from a huge vary of sufferers, together with phenotypes or characteristics, remedy historical past and genetic knowledge,” mentioned Dr. Juan Pascual, a neurologist and director of the Uncommon Mind Issues Program at UT Southwestern’s O’Donnell Mind Institute.

“Our information means that the one maximum vital issue figuring out sure affected person end result is an early age of prognosis, and likewise demonstrates that choice nutritional remedies can radically strengthen affected person well being over the long-term.”

The effects had been revealed as of late in JAMA Neurology in an editorial titled: “Scientific Sides of Glucose Transporter Sort 1 Deficiency: Data from a International Registry.” UTA’s Jianzhong Su, professor and chair of arithmetic, and Dr. Jian Hao, a member of Dr. Su’s analysis staff, had been co-authors at the paper.

The analysis effects mirrored information from a registry of 181 sufferers situated international, for the length from Dec. 1, 2013 to Dec. 1, 2016.

“We used a number of statistical strategies adapted to handle the age of onset of more than a few sorts of the illness, related manifestations, herbal historical past, remedy efficacy and diagnostic procedures,” Dr. Su mentioned.

“Those elements had been correlated in a predictive mathematical style designed to lead analysis at the foundation of medical options at prognosis,” he added.

The 3 primary novel effects are:

  • The effectiveness of other nutritional remedies, such because the “changed” Atkins nutrition. The time period “changed” describes the decrease carbohydrate restrict in comparison to Atkins suggestions and the emphasis of excessive fats meals as is needed at the ketogenic nutrition.
  • The life of structural mind defects equivalent to white topic abnormalities in a single quarter of instances, as observed in MRI scans;
  • The favorable affect of early prognosis and remedy without reference to remedy modality and mutation kind.

Those effects problem the present approaches to the illness, such because the perceived absolute requirement of a ketogenic or high-fat, low-carbohydrate nutrition, the assumed loss of structural mind defects and the possible life of genotype: phenotype correlations.

“Sufferers who had been identified early and placed on an good enough nutrition did really well,” Dr. Su mentioned. “Screening for this illness amongst small children with developmental delays or issues equivalent to seizures inside the first 12 months of lifestyles may just make a vital affect on results.”

The analysis used to be supported via a Carrier Bundle Grant from UT Southwestern’s Middle for Translational Drugs, which used to be given to the collaboration of Dr. Pascual’s lab and Dr. Su’s staff to increase this research and extra analysis on person affected person’s electroencephalogram or EEG imaging research to localize the assets of ordinary mind alerts.

Morteza Khaledi, dean of UTA’s Faculty of Science, underlined the significance of this paintings within the context of UTA’s strategic topics of well being and the human situation and data-driven discovery inside the Strategic Plan 2020: Daring Answers|International Have an effect on.

“The paintings of Dr. Su’s staff in mathematical research gave the researchers the ability to extract significant conclusions from huge information units with an overly excessive stage of rigor,” Khaledi mentioned. “Those tendencies and associations won’t were observed in different ways.”

Discover additional:
Epilepsy: Some other doable Zika risk to small children

Additional info:
JAMA Neurology (2017). DOI: 10.1001/jamaneurol.2017.0298

Magazine reference:
Archives of Neurology

Supplied via:
College of Texas at Arlington

Tagged with:

About author

Related Articles