Breaking News
October 21, 2018 - Report reveals growing impact of cannabis on young people
October 21, 2018 - NSF awards $5 million grant to help scientists magnify societal impact of research
October 21, 2018 - Fertility Rates Down for Each Urbanization Level 2007 to 2017
October 21, 2018 - Genetically engineered 3-D human muscle transplant in a murine model
October 21, 2018 - Moms’ tight work schedules may affect their children’s sleep
October 21, 2018 - AHA: No Direct Link Between Preeclampsia and Cognitive Impairment, Study Finds
October 21, 2018 - Weight loss success linked with active self-control regions of the brain
October 21, 2018 - Scripps researchers successfully test potential new smoking-cessation treatment in rodents
October 21, 2018 - More accurate and less stressful way to measure a baby’s heartbeat
October 21, 2018 - Researchers show better cardiorespiratory fitness leads to longer life
October 21, 2018 - Healthy candies for diabetic patients
October 21, 2018 - Environment impact of microplastics remains unclear
October 21, 2018 - Antibiotics for appendicitis? Surgery often not needed
October 21, 2018 - AHA and AMA recognize more than 800 medical practices, health systems for blood pressure control
October 21, 2018 - Scientists obtain clearest ever image of Ebola virus protein
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – Drugs.com MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - High diet quality associated with lower risk of death in colorectal cancer patients
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - Research provides insight into neurobiology of aggression and bullying
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Neuroscientists identify brain region that appears to be related to food preference decisions
October 21, 2018 - Deaths related to air pollution in the U.S. decreased by 47% between 1990 and 2010
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
People with genetic predisposition to later puberty have lower bone mineral density

People with genetic predisposition to later puberty have lower bone mineral density

image_pdfDownload PDFimage_print

People whose genetic makeup triggers a later-than-average start to puberty have lower bone mineral density, especially in their lower spine. Because adolescence is a critical period for accruing bone, this effect may increase a person’s risk of osteoporosis and bone fractures later in life.

“If an individual is genetically programmed for later puberty, we found that he or she tends to have lower bone mineral density during childhood as well as in adulthood,” said geneticist Struan F. A. Grant, PhD, one of three scientists from Children’s Hospital of Philadelphia (CHOP) who co-led a study published Oct. 25, 2017 in the Journal of Bone and Mineral Research.

Scientists already knew that later puberty was linked to lower bone mineral density, and that both are risk factors for osteoporosis. This study was the first to analyze the associations between genetic determinants of puberty timing and measurements of bone mineral density.

The researchers drew on data from the Bone Mineral Density in Childhood Study (BMDCS), funded by the NIH. That study included sophisticated bone and growth measurements during annual visits for up to seven years in over 2,000 healthy children, adolescents and young adults during 2002 to 2010. Babette S. Zemel, PhD, another co-study leader, was the principal investigator of the BMDCS at CHOP, where she directs the Nutrition and Growth Laboratory.

In the current research, the study team used a relatively new tool called a “genetic risk score” (GRS), which enables collective study of a group of genetic variants in one go. “We generated a genetic risk score in the BMDCS study based on hundreds of genetic variants associated with later puberty in children, and looked for associations with bone mineral density measurements,” said first author Diana Cousminer, PhD, a CHOP geneticist with expertise in the genetics of puberty. The researchers performed these analyses separately in boys and girls, and also in publicly available corresponding genetic data on bone mineral density in adults.

For both boys and girls, the GRS for later puberty associated with lower bone mineral density in both a longitudinal cohort of 933 individuals who each had up to seven assessments, and in a cross-sectional cohort of 486 individuals. The results varied according to the part of the skeleton where bone mineral density was measured, with lowest density in the lower back and hip bones.

In a separate analysis called “Mendelian Randomization,” the study team found that later puberty caused lower bone mineral density in both adult men and adult women. They also detected a strong causal effect in adolescent girls, while finding no causal relationship for adolescent boys. Cousminer said the number of boys in their analysis may not have been large enough to show a significant effect.

The current research builds on several previous studies of bone health performed by CHOP scientists, using BMDCS data. Earlier this year, they showed that gains in bone mineral continue even after teenagers attain their adult height, reinforcing the importance of late adolescence for building bone strength. A 2016 study found that children and adolescents with higher levels of physical activity had higher bone density, even when they had genetic variants that predisposed them to weaker bones. That research, co-led by Zemel and Grant, strengthened the evidence that high-impact, weight-bearing physical activity improves bone health in children and adolescents.

Other researchers have previously shown an epidemiological link between later puberty and the risk of bone fracture and osteoporosis late in life. The current study did not include data from elderly people, and so could not directly perform a genetic analysis of osteoporosis risk. Cousminer added that the CHOP team’s future studies will address this question by using data from older research subjects.

“Now that we are aware of the risks to lifelong bone health if someone is genetically predisposed to later puberty, we can work on strategies such as promoting weight-bearing physical activity, to optimize bone density during skeletal development,” said Zemel.

Source:

http://www.chop.edu/news/genes-influencing-later-puberty-cause-lower-bone-density

Tagged with:

About author

Related Articles