Breaking News
December 17, 2017 - AHA: Regional Plan for Cath Lab Activation Improves STEMI Outcomes
December 17, 2017 - Breathing exercises help asthma patients with quality of life
December 17, 2017 - Researchers explore how toxic protein clusters linked to Parkinson’s disrupt brain cells
December 17, 2017 - Autism traits linked to risk of depression, suicidal thoughts in people with psychosis
December 17, 2017 - Jimmie Holland’s Long Medical Odyssey
December 17, 2017 - Controversial MS Treatment Found to Be Ineffective: MedlinePlus Health News
December 17, 2017 - Time of day affects test results for asthma, researchers find
December 17, 2017 - Scientists create atomic scale map that tracks how brain signals connect to neurons
December 17, 2017 - Tips for buying safe toys during the holidays – and year-round
December 17, 2017 - CardioBrief: Will Entresto Sell Big After All?
December 17, 2017 - Water baths as good as bleach baths for treating eczema
December 17, 2017 - Valley fever cases see sharp increase in November, say UVA experts
December 17, 2017 - New Insight on Killer Fungus Threatening Bats
December 17, 2017 - Early Atherosclerosis Defies ‘Normal’ Cholesterol
December 17, 2017 - CRF1 stress receptor is regulator of mast cell activity during stress
December 17, 2017 - CREST Failed to Dampen Enthusiasm for Carotid Stenting in Elderly
December 17, 2017 - Rising levels of HIV drug resistance
December 17, 2017 - Aging brain’s failure to coordinate deep-sleep brainwaves makes older adults forget
December 17, 2017 - Rural Workers Have Higher Exposures to COPD-Causing Pollutants
December 17, 2017 - Don’t Delay Hip Fracture Surgery. Here’s Why: MedlinePlus Health News
December 17, 2017 - NIH launches HIV prevention trial of long-acting injectable medication in women
December 17, 2017 - Op-Ed: Get Ready for a Tsunami of ECGs
December 17, 2017 - Observation care may save more than thought
December 17, 2017 - Scientists explore effectiveness of action video games to combat dyslexia
December 17, 2017 - Teens Acting Badly? Smog Could Be to Blame
December 17, 2017 - FDA Says ‘Yes’ to Short-Acting Insulin Admelog
December 17, 2017 - Vaping popular among teens; opioid misuse at historic lows
December 17, 2017 - Lower Urinary Symptoms Occur in Almost All Patients with SSc
December 17, 2017 - Genetic mutation in extended Amish family in Indiana protects against aging and increases longevity (Update)
December 16, 2017 - Butler Hospital launches international Alzheimer’s disease prevention study
December 16, 2017 - iMedicalApps: Virtual Reality Boosts Self-Confidence for Med Students
December 16, 2017 - Researchers validate five new genes responsible for Amyotrophic Lateral Sclerosis
December 16, 2017 - New genetic analysis of candidiasis reveals surprising fungal sex secrets
December 16, 2017 - New high precision machine-learning model could help accelerate drug discovery
December 16, 2017 - Groundbreaking gene therapy trial brings cure for hemophilia closer
December 16, 2017 - Racial Differences Seen in IgG4 Disease
December 16, 2017 - Treacher Collins Syndrome
December 16, 2017 - New approach to tracking how deadly ‘superbugs’ travel could slow their spread
December 16, 2017 - Muscle paralysis may promote breakdown of bones
December 16, 2017 - WSU scientists create injectable dye to track progression of diseases
December 16, 2017 - Kaiser Permanente delivers clot-busting drugs to stroke patients more than twice as fast as national rates
December 16, 2017 - Some Great Holiday Foods for Weight Loss
December 16, 2017 - Shared Decision-Making Strategies for Lung Ca Screening Get High Marks
December 16, 2017 - Lactic acid bacteria can protect against Influenza A virus, study finds
December 16, 2017 - Cancer immunotherapy’s effectiveness may depend on patient’s genetic makeup
December 16, 2017 - Researchers explore patient-doctor conversations, best practices linked to opioid tapering
December 16, 2017 - ‘Virtual child’ to help professionals learn key techniques to treat children with autism
December 16, 2017 - IU scientists discover way to make drug treatment more successful against malaria
December 16, 2017 - Prostate cancer researchers find significant disparities between two liquid biopsy providers
December 16, 2017 - ED-Diagnosed Lung Ca Patients Worse Off: Clin Onc News Report
December 16, 2017 - Calcium in Urine Test: MedlinePlus Lab Test Information
December 16, 2017 - Pregnancy-related conditions taken together leave moms—and dads—at risk
December 16, 2017 - Research uncovers mechanism implicated in defective function of tumor-associated dendritic cells
December 16, 2017 - OncoBreak: Stubborn Racial Disparities; Paid Medical Leave & Chemo; DIY Gene Tests
December 16, 2017 - Critical link between obesity and diabetes has been identified
December 16, 2017 - Transfusion dependence reduces access to high-quality end-of-life care for leukemia patients
December 16, 2017 - Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies
December 16, 2017 - FDA Approves Ixifi (infliximab-qbtx), a Biosimilar to Remicade
December 16, 2017 - Morning Break: Trump to Get Check-Up; Cancerous Transplant; Death Knell for MIPS?
December 16, 2017 - First transcatheter implant for diastolic heart failure successful
December 16, 2017 - ‘Sushi-like’ nanodiscs provide structural snapshots of misfolding proteins
December 16, 2017 - Inherited gene variation may be to blame for poor survival of patients with early-onset breast cancer
December 16, 2017 - Sign-up deadline is Friday, but some people may get extra time
December 16, 2017 - Higher Booze Taxes Might Pay Off for Public Health
December 16, 2017 - Regular Activity in Midlife Spares Joints in Women
December 16, 2017 - Rain May Not Cause Achy Joints After All: MedlinePlus Health News
December 16, 2017 - MedDiet adherence doesn’t affect acute heart failure mortality
December 16, 2017 - HKBU experts develop new generation of smart anti-cancer drug molecules
December 16, 2017 - Chronic Kidney Disease Audit finds wide variations in coding of CKD patients in primary care
December 16, 2017 - Scientists use nanoparticles to fight Mucoviscidosis
December 16, 2017 - Increasing physical activity decreases risk of death from lymphoma
December 16, 2017 - Fear compromises the health, well-being of immigrant families, survey finds
December 16, 2017 - Rejected antibiotic candidate could be worth a second look, research finds
December 16, 2017 - Is Nation on the Right Track to Combat Opioid Crisis?
December 16, 2017 - Arthritis No Longer Just a Disease of the Old: MedlinePlus Health News
December 16, 2017 - Study reveals biology behind why muscle stem cells respond differently to aging or injury
December 16, 2017 - Family members without inherited mutation have increased risk of melanoma
December 16, 2017 - Researchers reveal previously unknown mechanism that inhibits cells’ ability to develop into tumors
December 16, 2017 - Studies highlight potential of fMRI applications to detect, treat epilepsy in children
December 16, 2017 - Active surveillance proposed as first-line approach to manage patients with low-risk PMC of the thyroid
Elevated oral pathogens, less bacterial diversity linked to risk of developing precancerous gastric lesions

Elevated oral pathogens, less bacterial diversity linked to risk of developing precancerous gastric lesions

image_pdfDownload PDFimage_print

Elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer, finds a new study led by New York University College of Dentistry (NYU Dentistry) and New York University School of Medicine.

The findings, published in the November issue of the Journal of Periodontology, provide new evidence that the increase in pathogens associated with periodontal disease – a chronic, destructive disease in the gums and oral cavity – could contribute to the development of precancerous lesions of stomach cancer.

“Our study reinforces earlier findings that poor oral health is associated with an increased risk of precancerous lesions of stomach cancer,” said Yihong Li, DDS, MPH, DrPH, professor of basic science and craniofacial biology at NYU Dentistry and the study’s corresponding author.

The American Cancer Society estimated that 26,370 new cases of stomach or gastric cancer would be diagnosed in 2016, resulting in 10,703 deaths. Accumulating evidence suggests that chronic inflammation caused by oral bacterial infections may contribute to the development and progression of various types of cancer, including stomach cancer.

Although some risk factors – such as H. pylori colonization, cigarette smoking, and eating salt and preserved foods – have previously been confirmed to contribute to the development of stomach cancer, many new cases unrelated to these risk factors are diagnosed each year. Scientists have hypothesized that a group of pathogens may be responsible for causing periodontal disease and the resulting chronic systemic inflammation that may contribute to the development of gastric cancer.

This study assesses the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions – including chronic atrophic gastritis, intestinal metaplasia, and dysplasia – that may predict stomach cancer.

The researchers studied 105 individuals scheduled to receive an upper endoscopy. After the endoscopic procedure and histopathologic evaluation, 35 people were diagnosed with precancerous lesions of gastric cancer and another 70 people of the same ages without precancerous lesions were included in the study as a control group.

The researchers performed full-mouth examinations to assess participants’ periodontal conditions. Saliva and dental plaque samples were collected to evaluate colonization by several of pathogens – P. gingivalis, T. denticola, T. forsythia, and A. actinomycetemcomitans – and to characterize oral microbial diversity.

Compared with the control group, patients with precancerous lesions experienced higher prevalence of bleeding when probed (31.5 percent versus 22.4 percent), higher levels of two pathogens (T. denticola and A. actinomycetemcomitans), and less bacterial diversity in their saliva.

A further analysis, which took into account sociodemographic factors, oral health behaviors, and periodontal assessments, revealed additional predictors of precancerous lesions: elevated colonization of three pathogens (T. forsythia, T. denticola, and A. actinomycetemcomitans), decreased bacterial diversity in dental plaque, and not flossing regularly.

The researchers concluded that the colonization of periodontal pathogens and the alternated bacterial diversity in the oral cavity are important factors that, when at higher or lower levels respectively, may contribute to an increased risk of developing precancerous gastric lesions.

“Based on our findings, treatment for chronic periodontal disease and control of periodontal pathogen infections should be included in future strategies for preventing stomach cancer,” said Dr. Li.

Source:

http://www.nyu.edu/about/news-publications/news/2017/november/increased-oral-pathogens-and-decreased-bacterial-diversity-predi.html

Tagged with:

About author

Related Articles