Breaking News
August 19, 2018 - Bifidobacteria supplement colonizes gut of breastfed infants
August 19, 2018 - Why patients with Alzheimer’s markers never develop the condition
August 19, 2018 - ACA’s Medicaid expansion associated with increase in prescriptions for opioid use disorder treatment
August 19, 2018 - Important factor may be missing in models used to predict spread of epidemics from climate change
August 19, 2018 - Indian-Americans have fewer sudden infant deaths, study finds
August 19, 2018 - Experts advise against universal genomic screening of newborns
August 19, 2018 - New trial to investigate whether weight loss before conception can make mom and baby healthier
August 19, 2018 - Sun Pharma Announces FDA Approval of Cequa (cyclosporine) Ophthalmic Solution to Treat Dry Eye Disease
August 19, 2018 - Researchers examining Parkinson’s resilience
August 19, 2018 - Researchers find mechanism that prepares brain to replicate repeated actions
August 19, 2018 - Those who are emotionally stable when young may remain the most stable as they age
August 19, 2018 - URI professor develops simpler and quicker method for detecting impurity in heparin
August 19, 2018 - Mayo Medical Laboratories and NDSC collaborate to develop new patient blood-management solution
August 19, 2018 - Insight into endocrine cancers and treatment options
August 19, 2018 - HPV Legislation Doesn’t Impact Teen Sexual Behaviors
August 19, 2018 - Exenatide treatment alleviated symptoms of depression in patients
August 19, 2018 - Tufts researchers win grant to study integration of genomic sequencing into neonatal care
August 19, 2018 - Novel finger-prick test can help prevent toxoplasmosis
August 19, 2018 - Cosmetic Procedures Boost Well-Being, Poll Shows
August 19, 2018 - Responsive parenting intervention results in lower BMIs through age three
August 19, 2018 - Anticancer drugs can help plants to battle infection
August 19, 2018 - Sunscreen from bathers releases significant quantities of polluting titanium dioxide into the sea
August 19, 2018 - Case Western Reserve gets three-year grant to enhance food systems in Cleveland neighborhoods
August 19, 2018 - Teenagers can thank their parents’ positive attitude for avoiding obesity
August 19, 2018 - Body mass index positively linked with blood pressure
August 19, 2018 - New tool fills gap in Small Molecules market
August 19, 2018 - Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials
August 19, 2018 - Researchers develop molecular matrix that delivers healing stem cells to injured elderly muscles
August 19, 2018 - Teva and Regeneron Announce Positive Topline Phase 3 Fasinumab Results in Patients with Chronic Pain from Osteoarthritis of the Knee or Hip
August 19, 2018 - New study pinpoints ways to improve quality of food and nutrition research
August 19, 2018 - Ology Bioservices wins $8.4 million worth agreement to manufacture anti-Ebola monoclonal antibody
August 19, 2018 - New CRISPR technology may help eliminate mutated gene sequence
August 19, 2018 - “Zombie gene” protects elephants from cancer finds study
August 19, 2018 - Study explores how many American cities protect the rights of employed breastfeeding mothers
August 19, 2018 - FDA Approves Lenvima (lenvatinib) for First-line Treatment of Unresectable Hepatocellular Carcinoma (HCC)
August 19, 2018 - Pain: Considering Complementary Approaches (eBook)
August 19, 2018 - Autoimmune response drives vision loss in glaucoma
August 19, 2018 - Tandem Diabetes Care introduces t:slim X2 Insulin Pump with Basal-IQ Technology in the US
August 19, 2018 - Innovative platform developed to destroy cancer cells
August 19, 2018 - Lowering pH inside tumor cells can slow down spread of cancer
August 19, 2018 - Biomarker predicts kidney cancer risk years before diagnosis
August 19, 2018 - Consequences of healthcare-associated infections go beyond patients’ physical health
August 19, 2018 - New drug- free, nanotechnology-based method detects and treats oral plaque
August 19, 2018 - Integration of Opioid, Infectious Disease Treatment Needed
August 19, 2018 - How eye disorders may have influenced the work of famous painters
August 18, 2018 - Blood biomarker could help predict kidney cancer up to five years prior to diagnosis
August 18, 2018 - Dartmouth scientists create more sustainable feed for aquaculture
August 18, 2018 - Immigrants Not a Burden on U.S. Health Care: Study
August 18, 2018 - Women who eat fast food take longer to become pregnant
August 18, 2018 - Most YouTube videos on plastic surgery are misleading marketing campaigns
August 18, 2018 - The essential guide to make your laboratory more sustainable
August 18, 2018 - Loyola Medicine offers scalp cooling treatment to reduce risk of chemotherapy hair loss
August 18, 2018 - Researchers describe promising strategy to remove melanoma’s most powerful defenses
August 18, 2018 - Women with polycystic ovary syndrome dissatisfied with medical care
August 18, 2018 - Research discoveries reveal insights behind neurological degeneration
August 18, 2018 - Researchers win multi-million Euro award to conduct research into liver disease
August 18, 2018 - Survey highlights variations in practice of airway management in pediatric intensive care units
August 18, 2018 - UK students win sponsorship from Promega Corporation
August 18, 2018 - Janssen Reports Positive Topline Results for ATLAS Phase III Study of a Novel, Long Acting Injectable Two-Drug Regimen for the treatment of HIV-1
August 18, 2018 - PSD as a molecular platform for understanding synapse formation and plasticity
August 18, 2018 - Improved visual communication could help patients to make informed health-care decisions
August 18, 2018 - New algorithm helps identify and manage diabetic patients at increased fracture risk
August 18, 2018 - Microscopic insect odour detecting mechanisms discovered
August 18, 2018 - Researchers develop new approach to study how tuberculosis infects people
August 18, 2018 - FDA Approves Kalydeco (ivacaftor) for Cystic Fibrosis in Children Ages 12 to
August 18, 2018 - An ion channel differentiates newborn and mature neurons in the adult brain
August 18, 2018 - Conditions of first sexual encounter can be indicators of future HIV risk and gender-based violence
August 18, 2018 - Socio-economic position associated with pregnant women’s exposure to environmental hazards
August 18, 2018 - Study evaluates how students change their breakfast consumption when given extra time
August 18, 2018 - Chronic perinatal hypoxia linked to locomotor miscoordination, long-term cerebellar learning deficits
August 18, 2018 - Voters to settle dispute over ambulance employee break times
August 18, 2018 - AGA urges policymakers and stakeholders to improve affordability of drugs
August 18, 2018 - Increasing dietary protein may lower risk of diabetes in people with NAFLD
August 18, 2018 - New HIV therapy suppresses viral replication and increases immune cells in drug-resistant patients
August 18, 2018 - Broad Genetic Testing for NSCLC May Not Improve Survival
August 18, 2018 - Discovery opens door for synthetic opioids with less addictive qualities
August 18, 2018 - Transgenic rice plant extracts could help stop the spread of HIV
August 18, 2018 - Hologic’s Cynosure division partners with Porter Instrument to distribute nitrous oxide and oxygen system
August 18, 2018 - Two thyroid medications recalled by FDA
August 18, 2018 - Forecast Sees Abnormal Heat Worldwide Through 2022
Lamprey genes provide clues to repair spinal cord damage, finds study

Lamprey genes provide clues to repair spinal cord damage, finds study

image_pdfDownload PDFimage_print

Researchers have found that several genes within an ancient species of fish can be used to provide clues in the treatment of spinal cord damage. The study titled, “Highly Conserved Molecular Pathways, Including Wnt Signaling, Promote Functional Recovery from Spinal Cord Injury in Lampreys,” appeared in the latest issue of the journal Scientific Reports.

River lamprey. Image Credit: Krot44 / Shutterstock

River lamprey. Image Credit: Krot44 / Shutterstock

The American researchers have noted that several of these ancient genes are involved in the peripheral nervous system of mammals. The study was led by researchers at the Marine Biological Laboratory (MBL) of the Eugene Bell Center for Regenerative Biology and Tissue Engineering, and the Feinstein Institute for Medical Research. The team obtained protein making profiles in the genetic coding of the lamprey fish spinal cords and brains after they created a spinal cord injury (SCI). They used a sequencer called the RNA-Seq to check the changes that occurred in the genes after the injury in the fish.

Jennifer Morgan, Ph.D., director of the MBL’s Eugene Bell Center for Regenerative Biology and Tissue Engineering and co-author of the study explained that several genes that were found in the fish to change the transcription profiles were found to be overlapping with the mammalian genes. These genes help in the regeneration of the mammalian peripheral nervous system.

Most mammals can only regenerate their peripheral nervous systems after injury. Some of the fish such as lampreys and other animals such as reptiles and amphibians are capable of spontaneously regenerate following spinal cord injury say researchers. Lampreys especially are adept at regenerating even a completely severed spinal cord and resume swimming without any treatment. Morgan explains that they can go to complete swimming from complete paralysis ina period of 10 to 12 weeks. Humans have diverged from these jawless eel like fish from their ancestors around 550 million years back say the authors.

Ona Bloom, Ph.D., at the Feinstein Institute for Medical Research and the Zucker School of Medicine at Hofstra/Northwell said that the scientific world was aware of the regeneration capacity of the lampreys but was not aware of how they were doing it. The molecular level mechanism was not clear. These genes have now been found to exist in the mammals too. Some of these include those for, “axon guidance and regeneration, synaptic transmission, neural patterning and neurodegeneration.” The authors find that the lamprey central nervous system us analogous to humans and other vertebrates that have jaws unlike the lampreys.

For this study the team obsevered the genetic workings of the lampreys after their spinal cords were severed. They took their observations at several points including ones within hours after injury, until the fish had completely recovered at the end of 3 months. They noted that genes changed with the time as the regeneration progressed to completion. The changes in the transcription genes were also seen in the brains they noted. “One of the most surprising findings from this study is the robust and complex transcriptional responses occurring in the lamprey brain after SCI,” authors write. In fact at the time of recovery, they noted 238 newly formed and expressed transcripts in the spinal cord and 88 new transcripts in the brain. Morgan explains that this shows that the brain and spinal cord changes during regeneration process significantly.

The team also found that 3 percent of these new transcripts were from the Wnt pathways. These belong to the “Wnt and Frizzled gene families,” the researchers add. These 19 mammalian Wnt genes are seen commonly among many animal species they say. These pathways have been shown to play a role in spinal injury. Zebrafish and salamanders have been shown to use this pathway for regeneration in previous experiments. Morgan said that when they stopped these Wnt signaling pathway using certain drugs, the lampreys could not recover from their spinal injury and could not swim again. The reason why this pathway works how it does is what the team is studying now.

Source:

https://www.nature.com/articles/s41598-017-18757-1

Tagged with:

About author

Related Articles