Breaking News
February 21, 2018 - Early childhood immune signature predicts risk of developing asthma later on
February 21, 2018 - Stanford researchers explore how gut bacteria respond to common changes in habitat
February 21, 2018 - Household Products May Pollute the Air as Much as Your Car Does: Study
February 21, 2018 - Combo Bests Targeted Agent in mRCC
February 21, 2018 - Researchers discover brain pathway that dissociates opioid addiction from analgesia
February 21, 2018 - Scientists uncover how newly discovered gene helps grow blood vessels
February 21, 2018 - Brain’s quality control process holds clues to obesity’s roots
February 21, 2018 - Researchers to study whether menstrual cups can help prevent vaginal infections
February 21, 2018 - MS patients who feel stigmatized more likely to suffer from depression
February 21, 2018 - Vitamin D supplementation during pregnancy could protect against childhood obesity
February 21, 2018 - Lower-Quality Medical Tx Might Have Skewed Key PCI vs CABG Trials
February 21, 2018 - Love and fear are visible across the brain instead of being restricted to any brain region
February 21, 2018 - Adults with congenital heart disease have increased risk for dementia, study finds
February 21, 2018 - Clinical trial studying type 1 diabetes reaches full enrollment
February 21, 2018 - Father’s stress affects the brain development of offspring, mice study shows
February 21, 2018 - ESRD Death Declines in Vasculitis Patients
February 21, 2018 - Taking ibuprofen for long periods found to alter human testicular physiology
February 21, 2018 - Google AI device could predict a person’s risk of a heart attack
February 20, 2018 - FDA Approves Domestic Source for Tc-99m Isotopes
February 20, 2018 - Sanofi rejects refund demand faces Philippine suit over dengue vaccine (Update)
February 20, 2018 - Researchers discover that activation of specific enzyme may help suppress tumor metastasis
February 20, 2018 - Blood or marrow transplantation survivors have higher risk of cognitive impairment
February 20, 2018 - Booze Beats Pot at Being Unhealthy: Oregon Poll
February 20, 2018 - Morning Break: ’20 Years Late’; Drugs in the Dirt; Catching Flu in the Dorm
February 20, 2018 - Another piece to the puzzle in naked mole rats’ long, cancer-free life
February 20, 2018 - Scientists identify four viruses that can produce insulin-like hormones
February 20, 2018 - New e-Health solution developed to prevent cardiovascular disease, dementia in senior citizens
February 20, 2018 - New genetic risk score could help guide screening decisions for prostate cancer
February 20, 2018 - Study finds higher risk of stroke among blacks with atrial fibrillation than whites
February 20, 2018 - Physical activity could be used as strategy for diabetes prevention
February 20, 2018 - Researchers develop sensing method for early detection of cancer and diabetes
February 20, 2018 - New wearable electronics could be game-changer for stroke rehabilitation
February 20, 2018 - Immune history influences person’s response to flu vaccine
February 20, 2018 - Research findings could help develop new drugs to prevent, treat dry eye disease
February 20, 2018 - Serenity Now! Learn to Have Patience with Patients
February 20, 2018 - Computer simulation addresses the problem of blood clotting
February 20, 2018 - Women with type 1 diabetes not protected against coronary artery disease
February 20, 2018 - Persistent bloating can be a sign of ovarian cancer, warns charity
February 20, 2018 - Trump administration proposes rule to loosen curbs on short-term health plans
February 20, 2018 - Key protein involved in epigenetic regulation of gene expression guides skin cell renewal
February 20, 2018 - Heart attack symptoms often missed in women
February 20, 2018 - Diagnosis of celiac disease takes 3.5 years for patients who do not report GI symptoms
February 20, 2018 - Study reveals functional dynamics of ion channels
February 20, 2018 - Study explores link between mortality risk and combustible tobacco use
February 20, 2018 - ‘She Trusted Me, and I’d Turned Her Away’
February 20, 2018 - AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies
February 20, 2018 - Fast food makes the immune system more aggressive in the long term
February 20, 2018 - Therapeutic target for glaucoma could have treatment ramifications for Alzheimer’s and Parkinson’s
February 20, 2018 - Overcoming Negative Reviews | Medpage Today
February 20, 2018 - MyD88—villain of allergies and asthma
February 20, 2018 - Food scientists develop rapid screening technique to detect pesticide residue in vegetables
February 20, 2018 - Lab-grown cerebellar cells may help explain how ASD develops at molecular level
February 20, 2018 - Scientists explore connection between bad sleep habits and stiff blood vessels
February 20, 2018 - New Treatment Apalutamide (Erleada) Approved for Prostate Cancer That Resists Hormone Therapy
February 20, 2018 - Do You Really Need My Signature on That?
February 20, 2018 - HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection
February 20, 2018 - Diabetes does not increase work-loss years due to early retirement
February 20, 2018 - Researchers aim to find out how PTSD affects decisions of police
February 20, 2018 - UH Cleveland Medical Center explores novel treatments for uterine fibroids
February 20, 2018 - Flu Vax Efficacy 25% Against Predominant H3N2 Strain So Far
February 20, 2018 - HIV screening most optimal at 25 years of age if no risk factors
February 20, 2018 - Loyola Medicine primary care physician offers advice to minimize risk of flu
February 20, 2018 - Safe sleep recommendations for parents that may help reduce child’s risk of SUID
February 20, 2018 - Why Do So Few Docs Have Buprenorphine Waivers?
February 20, 2018 - Low levels of alcohol good for the brain
February 20, 2018 - Experimental treatment improves invisible symptoms of a man with spinal cord injury
February 20, 2018 - Myriad’s EndoPredict offers better prediction of breast cancer recurrence, analysis shows
February 20, 2018 - Researchers identify fifteen genes that determine our facial features
February 20, 2018 - Morning Break: New Health IT Player; Luxturna No Bargain; Nuclear Freakout
February 20, 2018 - How does it compare? Hospice care at home, at assisted living facility, at nursing home
February 19, 2018 - Scientists develop water-soluble warped nanographene for bioimaging
February 19, 2018 - It’s Not Your Imagination: You’re Hungrier After Losing Weight
February 19, 2018 - Antihypertensive Use At Delivery Rising in Preeclampsia
February 19, 2018 - A centuries-old math equation used to solve a modern-day genetics challenge
February 19, 2018 - Liquid biopsies could be used as new predictive marker for metastatic TNBC
February 19, 2018 - Russian researchers develop new multi-layered biodegradable scaffolds
February 19, 2018 - Are ‘Vaccine Skeptics’ Responsible for Flu Deaths?
February 19, 2018 - Hidden genetic effects behind immune diseases may be missed, study suggests
February 19, 2018 - Emergency nurses experience regular verbal and physical abuse
February 19, 2018 - Study sheds light on biology that guides behavior across different stages of life
Weight-Loss Surgery’s Benefits Wane Over Time for Diabetics

Weight-Loss Surgery’s Benefits Wane Over Time for Diabetics

image_pdfDownload PDFimage_print

TUESDAY, Jan. 16, 2018 — In the relative short-run, weight-loss surgery helped obese people struggling with type 2 diabetes experience marked improvement in diabetes-related health issues, new research reports.

But, their ability to control blood sugar, blood pressure and cholesterol levels diminished over time, the study found. That raises questions as to how long the benefits can be maintained further down the road.

“We found that adding gastric bypass [weight-loss surgery] did provide significant benefit at five years after surgery,” said study author Dr. Charles Billington. “But the size of the benefit declined substantially from the first to the fifth year.”

Billington is a professor of medicine at the University of Minnesota in Minneapolis.

The study began with 120 patients with type 2 diabetes from the United States and Taiwan. Half underwent weight-loss surgery while the other half had only lifestyle interventions.

After a year, 50 percent of the 60 participants who’d had weight-loss surgery had reached targeted blood sugar, blood pressure and cholesterol levels associated with diabetes control. However, “the slide in achievement of the triple endpoint target among the gastric bypass group was from 50 percent at one year to 23 percent at five years,” Billington said.

By comparison, 16 percent of the 60 study participants who did not have weight-loss surgery met the three diabetes control targets after a year. That fell to 4 percent after five years, according to the study.

Billington said the drop-off in effectiveness probably was not a question of regaining weight after surgery. Participants’ weights were found to be “fairly stable” between two and five years after the procedure, he said.

Instead, he suggested that much of the benefit loss “may be related to withdrawal of the intense [post-surgery] lifestyle and medical management after two years, when the participants were transitioned to usual medical care.”

The study appears in the Jan. 16 issue of Journal of the American Medical Association.

The benefits of weight-loss surgery, however, extend beyond people with diabetes, another study in the same journal issue reported.

It found that weight-loss surgery can greatly decrease obese people’s odds of dying in the four to five years after the procedure.

The study found “lower mortality rates — up to 50 percent [lower] — in the obese patient undergoing surgery, as opposed to matched obese patients who continue with usual care,” said lead study author Orna Reges. She’s an epidemiologist at the Clalit Research Institute in Tel Aviv, Israel.

“These results are in line with previous results, which demonstrated the benefit of bariatric surgery to reduce all-cause mortality in the short term,” Reges said.

The benefit might stem from people’s ability to maintain weight loss, the researchers said.

Reges’ study tracked nearly 8,400 people in Israel for an average of 4.5 years after their weight-loss surgery. Their outcomes were compared with those of more than 25,000 obese people who did not have weight-loss surgery.

About 60 percent of those who’d had surgery maintained much of their weight loss, compared with 8 percent of those who hadn’t had surgery.

In the diabetes study, which involved only people who were obese and had the blood sugar disease, participants had been dealing with diabetes for nine years, on average.

Though the diabetes-control benefits achieved right after surgery did taper off over time, most people’s readings were still better at the five-year point than they had been before their surgery, according to the study results.

Generally, blood sugar control held up the best, compared with blood pressure and cholesterol control, Billington said.

Whether weight-loss surgery is worth it for people with diabetes, Billington said, is “a matter of perspective.”

“The improvement in achievement of the triple endpoint [markers] is significant, but may not be large enough to warrant the adverse events,” he said. People who’d had surgery had more gastrointestinal problems such as small bowel obstructions and leaks, the study found.

“The surgery group did get better blood sugar control at the price of more adverse events,” Billington said.

Dr. John Morton, chief of bariatric and minimally invasive surgery at Stanford University School of Medicine in California, was less equivocal.

“This paper again demonstrates the strong superiority of surgical management versus lifestyle changes for treatment of obesity and diabetes,” he said.

But Morton acknowledged that the surgery’s protective impact did appear to weaken and offered possible explanations.

For one thing, the study participants had “long-standing, poorly controlled diabetes,” he noted. “Consequently, treatment of late-stage disease … will be harder to eradicate. The study highlights the need for earlier referral for treatment.

“In addition, a sizable portion of patients were of Asian background, who can have diabetes at much lower weights, indicating a different course of disease for these patients, independent of weight,” Morton said.

More information

The American Society for Metabolic and Bariatric Surgery has more on weight-loss surgery and diabetes.

© 2018 HealthDay. All rights reserved.

Posted: January 2018

Tagged with:

About author

Related Articles