Breaking News
February 25, 2018 - New staining method helps analyze 3D tissue samples using Nano-CT system
February 25, 2018 - Rare immune cell may prove to be potent weapon in fighting against cancer
February 25, 2018 - Connection between heart disease and cancer treatment
February 25, 2018 - Longer Endocrine Tx Better in Prostate Cancer
February 25, 2018 - Gene therapy restores normal blood glucose levels in mice with type 1 diabetes
February 25, 2018 - Desymmetrization paves way for new bioactive compounds
February 25, 2018 - Study finds underutilization of less expensive, post-acute care options for older adults
February 25, 2018 - UNIST researchers introduce new biosensing contact lens for diabetics
February 25, 2018 - Research consortium develops first 3D computer model of metabolic processes
February 25, 2018 - Adding hope to health messages may help promote preventative actions, researchers say
February 25, 2018 - Sudden Hearing Loss Recovery Hampered by Metabolic Syndrome
February 25, 2018 - First human trial of potentially game-changing diabetes treatment set to commence
February 25, 2018 - Child’s snacking patterns could be linked to genetics, study finds
February 25, 2018 - Patients with terminal cancer may be less competent to make big decisions
February 25, 2018 - Study highlights risks involved in short-term use of PICCs
February 25, 2018 - Study shows no increase in complications with ‘ad lib’ oral intake during labor
February 25, 2018 - Although Plaquenil (Hydroxychloroquine) Eases Rheumatoid Arthritis Pain it Won’t Help ‘Regular’ Arthritis
February 25, 2018 - Methotrexate May Help in Chronic Viral Arthritis
February 25, 2018 - Lack of guidance may delay a child’s first trip to the dentist
February 25, 2018 - Study shows cost-effectiveness of screening for fracture risk in older postmenopausal women
February 24, 2018 - Younger women with SCAD may benefit most from conservative treatment
February 24, 2018 - Blood Test for Concussion OK’d
February 24, 2018 - What are symptoms of an alcohol use disorder? – Rethinking Drinking
February 24, 2018 - Streamlined, cost-cutting post-treatment dental advice via iPad
February 24, 2018 - Researchers discover new regulator of the immune system
February 24, 2018 - Reducing red tape for traveling nurses
February 24, 2018 - Study supports benefits of meditation in control of attention and emotions
February 24, 2018 - Flu Vax Data ‘Only Tell Half the Story’
February 24, 2018 - Calculators – Rethinking Drinking – NIAAA
February 24, 2018 - From stem cells to a functional heart—the role of the Mesp1 gene
February 24, 2018 - Non-adherence to sleep apnea treatment linked to increased hospital readmissions
February 24, 2018 - Exercise-related posts influence health of social media pals
February 24, 2018 - Will Device Meetings in Europe Suffer Under New Ethics Rule?
February 24, 2018 - Nonstatin drug use increases by 124% in U.S., related expenditures triple
February 24, 2018 - Annual foot screening could help spot heart irregularities in people with diabetes
February 24, 2018 - Researchers developing rapid saliva test to detect Zika virus
February 24, 2018 - For Older Men, Even Light Exercise Helps
February 24, 2018 - Healthy Strategies to Beat Stress
February 24, 2018 - Cancer killing clue could lead to safer and more powerful immunotherapies
February 24, 2018 - Repeated sick days do not affect children’s learning ability, study shows
February 24, 2018 - New two-child policy in China could negatively affect women’s status and gender equality
February 24, 2018 - New research project to determine why mine dust-related lung diseases are on the rise
February 24, 2018 - A Tribute to Dr. Ray Lipicky: The Man Who Transformed Cardiology
February 24, 2018 - ClinicalTrials.gov: Child, Foster
February 24, 2018 - Study shows age doesn’t affect survival in patients with non-Hodgkin lymphoma after HCT
February 24, 2018 - Researchers explore how evolutionary processes guide pathways of cells
February 24, 2018 - Discovery may result in new medication to build stronger muscles in old age
February 24, 2018 - New study identifies possible target for treatment of dangerous allergic reactions
February 24, 2018 - Targeted vaccination can be successful in containing epidemic outbreaks
February 24, 2018 - Loxo Oncology Announces Publication of Larotrectinib Clinical Data in The New England Journal of Medicine
February 24, 2018 - ‘The Best Deals of Any Payer’: What We Heard This Week
February 24, 2018 - Blood and urine tests developed to indicate autism in children
February 24, 2018 - New low-cost microfluidic device brings single-cell technology to bedside
February 24, 2018 - Covestro and Pittsburgh Penguins announce multi-year unique partnership
February 24, 2018 - Children from low-income areas have poor outcomes after heart surgery, study finds
February 24, 2018 - Some genes can drive both metastasis and initial stages of tumor growth
February 24, 2018 - Visaris Americas announces installation of fully robotic Vision C digital X-ray suite at OGHS
February 24, 2018 - New discovery could accelerate clinical translation of stem cell-based therapies
February 24, 2018 - Respiratory disease patients with arthritis struggle to use complex inhalers
February 24, 2018 - FDA Alert: Labetalol Hydrochloride Injection by Hospira: Recall
February 24, 2018 - Flu, Tdap Vax Safe for Babies 6 Months Later
February 24, 2018 - Adults with autism show a diminished brain response to hearing their own name
February 24, 2018 - Study provides insight into neurobiology of dying
February 24, 2018 - Study finds tobacco smoke exposure among most adolescents in economically disadvantaged population
February 24, 2018 - U.S. clinical sites evaluating antibody-based therapies to prevent two common bacterial infections
February 24, 2018 - UCLA researchers use fluorescent colored proteins to trace origin of heart cells
February 24, 2018 - UC Riverside researchers discover way to halt cancer metastasis
February 24, 2018 - Home Routines Can Boost a Child’s Readiness for School
February 24, 2018 - FDA Investigating Misuse, Abuse of Gabapentinoids
February 24, 2018 - Scientists find key proteins control risk of osteoarthritis during aging
February 24, 2018 - Izon announce the launch of the qEV2 and qEV10 Exosome Isolation columns
February 24, 2018 - New CSIRO technology can create clean drinking water
February 24, 2018 - Treating sleep-disordered breathing may improve prognosis of heart failure patients
February 24, 2018 - More boys begin school a year late than girls, study finds
February 24, 2018 - Early life exposure to green space could have beneficial effects on cognitive function
February 24, 2018 - Joint Surgery: Aspirin Equals NOAC for Post-Acute VTE Prevention
February 23, 2018 - Scientists identify new marker of arthritis in mice
February 23, 2018 - Beetroot juice supplements may benefit patients with heart failure
February 23, 2018 - New study identifies novel molecular biomarkers of preeclampsia
February 23, 2018 - Researchers discover new link between gut bacteria and obesity
Weight Loss Feasible Even With Genetic Risk for Obesity

Weight Loss Feasible Even With Genetic Risk for Obesity

image_pdfDownload PDFimage_print

Action Points

  • People with a high genetic risk for obesity lost more weight than those with low genetic risk when they adhered to a long-term healthy diet.
  • Note that the study findings may help to eliminate the misconception that a genetic predisposition will inhibit successful weight management and emphasize the critical importance of achieving healthy diets for everyone.

People with a high genetic risk for obesity lost more weight than those with low genetic risk when they stuck to a long-term healthy diet, according to a 20-year prospective cohort study.

For every standard deviation increase in diet quality score based on the Alternative Healthy Eating Index-2010 diet, BMI decreased by 0.18, corresponding to 0.50 kg (about 1.1 lbs) weight loss, in individuals at high genetic risk for obesity. For those at low risk, BMI decreased by only 0.12, corresponding to 0.35 kg weight loss (P=0.001 for the interaction), said Lu Qi, MD, PhD, of Tulane University in New Orleans, and colleagues.

For each increase in diet quality score based on the Dietary Approach to Stop Hypertension (DASH) diet, BMI dropped by 0.19 for individuals at high genetic risk for obesity, but only 0.14 for those at low risk (P=0.001), they reported in BMJ.

“Our results suggest that weight gain associated with genetic predisposition can be at least partly counteracted by improving adherence to healthy dietary patterns. Importantly, for people who are genetically predisposed to obesity, improving adherence to a healthy diet is more likely to lead to greater weight loss,” the authors said.

Although the observed genetic effects were modest in magnitude, their-long term effects could be “substantial” because they accumulate over a person’s lifetime, they explained. “Furthermore, long term, dramatic weight loss is difficult to achieve, even in the context of weight loss interventions. Therefore, even modest weight loss or simply maintaining weight from adulthood onward, compared with gaining weight, may have a substantial effect on population health,” they said.

The findings “help to dispel misconceptions that a genetic predisposition will inhibit successful weight management,” said Louisa Ells, PhD, of Teesside University in Middlesbrough, England, and colleagues, in an accompanying editorial. “The findings provide encouraging new evidence that although a better diet can improve weight loss, the effect may be greatest in those with the highest genetic predisposition for obesity.”

In addition, the study “underlines the critical importance of achieving healthy diets for everyone. This is still a challenge for many, however, with poor diet being a leading risk factor for death and disability globally. Genetic predisposition is no barrier to successful weight management and no excuse for weak health and policy responses,” Ells’ group wrote.

Qi’s group prospectively analyzed data on 8,820 women in the Nurse’s Health Study and 5,218 men in the Health Professionals Follow-Up Study. All participants had genotype data available based on genome-wide association studies and were free of diabetes, cancer, and cardiovascular disease at baseline.

Participants were categorized as having high, intermediate, or low genetic risk for obesity based on an analysis of 77 single nucleotide polymorphisms known to be associated with BMI and body weight.

Height was measured at baseline, and information on diet and changes in body weight were gathered every 4 years with questionnaires, from 1986 to 2006. The authors used multivariate generalized linear statistical models to look for associations between genetic predisposition to obesity, adherence to a healthy diet, and weight loss over time.

The biological mechanisms underlying the findings were not clear. Several genes associated with BMI are known to be involved in central appetite regulation and energy homeostasis, and they may also be responsible for the interactions observed in the study, the authors said. “However, we cannot exclude the involvement of other biological pathways, and future functional studies are needed to provide biological insights into the gene by diet interactions on weight change,” they added.

An important limitation of the study was that it included only health professionals of European descent living in the U.S., so the results may not apply to other demographic or racial/ethnic groups, Qi’s group noted.

“Our findings highlight the importance of improving adherence to a healthy diet in the prevention of weight gain, particularly in people genetically predisposed to obesity,” they concluded.

The study was funded by the NIH

Qi and co-authors, as well as Ells and co-authors, disclosed no relevant relationships with industry.

  • Reviewed by
    Robert Jasmer, MD Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner

2018-01-10T18:30:00-0500

Tagged with:

About author

Related Articles