Breaking News
April 25, 2018 - Researchers discover key link between fat, immune cells and heat regulation
April 25, 2018 - Studies provide advanced knowledge about renal cancer
April 25, 2018 - Researchers develop low-cost, portable laboratory on a phone to detect infections
April 25, 2018 - Early treatment improves leg ulcer healing rates
April 25, 2018 - U.S. FDA and European Medicines Agency Accept Regulatory Submissions for Review of Dacomitinib to Treat Metastatic Non-Small Cell Lung Cancer with EGFR-Activating Mutations
April 25, 2018 - Redefined Alzheimer’s biology has implications for drug design
April 25, 2018 - BetterYou’s Iron Oral Spray recognized as ‘Best New Health and Nutrition Product’
April 24, 2018 - New imaging technology to effectively screen for colorectal cancer among young adults
April 24, 2018 - UW developmental psychologist wins 2018 Alan T. Waterman Award
April 24, 2018 - Adipose-derived mesenchymal stem cells combined with fibrin matrix influences restoration of motor functions
April 24, 2018 - Exposure to toxin found in sheep may be linked to development of MS
April 24, 2018 - FDA Approves Intravenous Formulation of Akynzeo (fosnetupitant/palonosetron) for Chemotherapy-Induced Nausea and Vomiting
April 24, 2018 - Is Alzheimer’s caused by disruptions to the brain’s energy supply?
April 24, 2018 - Low concentrations of antibiotics can develop high antibiotic resistance in bacteria
April 24, 2018 - Imagined and real movements have similar brain mechanisms, research suggests
April 24, 2018 - Alcoholic drinks affect oral bacteria tied to diseases
April 24, 2018 - Mechanism in Non-Contact ACL Tears Similar in Men, Women
April 24, 2018 - Five best practices to help reduce unplanned acute care for cancer patients
April 24, 2018 - Buprenorphine may be safer than methadone if treatment duration is longer, study suggests
April 24, 2018 - NF-κB1 gene known to drive cancer development is critical for preventing stomach cancers
April 24, 2018 - New tool helps blind, low-vision users navigate modern webpages more easily
April 24, 2018 - Hippo pathway plays essential role in embryonic development of the mouse heart
April 24, 2018 - Vegetarian diet and Mediterranean diet close to each other in health benefits
April 24, 2018 - FSU receives $1.5 million federal grant for innovative suicide prevention research
April 24, 2018 - Health Tip: Screening for Cancer in Older Adults
April 24, 2018 - Investigators highlight potential of exercise in addressing substance abuse in teens
April 24, 2018 - Study shows people might develop dementia later and live with it for a shorter period of time
April 24, 2018 - EMBL scientists develop new illumination method to manage neuropathic pain
April 24, 2018 - New compound could offer pain-relieving properties without risk of addiction
April 24, 2018 - New drug treatment could be promising therapeutic approach for millions with asthma
April 24, 2018 - Study provides guidance on using cannabis for treatment of stress, anxiety, and depression
April 24, 2018 - By Royal approval: Queen’s Award success for Elucigene
April 24, 2018 - The role of ‘extra’ DNA in cancer evolution and therapy resistance
April 24, 2018 - Researchers identify tools that caregivers could use to detect delirium in older adults
April 24, 2018 - What to Look Out For
April 24, 2018 - Drugs prescribed for newborns vary widely between NICUs, study finds
April 24, 2018 - FM4200 pressure-resistant mass flow meter from Sensirion
April 24, 2018 - Study links past experiences with bias and avoidance of doctors in women with higher BMI
April 24, 2018 - Role of extrachromosomal pieces of DNA in cancer development and treatment resistance
April 24, 2018 - Rehabilitation technique for stroke appears beneficial for multiple sclerosis patients
April 24, 2018 - Women who find purpose and meaning in life less likely to have anxiety, study shows
April 24, 2018 - Catalyst Pharmaceuticals Announces Submission of New Drug Application for Firdapse for Treatment of Lambert-Eaton Myasthenic Syndrome
April 24, 2018 - Suicide and homicide rates show large racial disparities across US states
April 24, 2018 - Scientists develop tissue-engineered models to better understand cancer metastases
April 24, 2018 - NuProbe to commercialize Wyss Institute’s new technology to facilitate precision medicine
April 24, 2018 - Special series explores pasteurized donor human milk use for hospitalized infants
April 24, 2018 - Slight changes in patient’s position during radiotherapy may impact survival chances
April 24, 2018 - FDA Approves Tagrisso (osimertinib) as First-Line Treatment for EGFR-Mutated Non-Small Cell Lung Cancer
April 24, 2018 - After knee replacement, play on
April 24, 2018 - Contact precautions do not limit spread of drug-resistant bacteria in ICUs
April 24, 2018 - Researchers discover genetic catalysts that accelerate evolution of antibiotic resistance in bacteria
April 24, 2018 - WPI researcher launches mobile app for assessing perinatal depression in women
April 24, 2018 - Researchers identify superior blood-based biomarker for assessing sports-related concussions
April 24, 2018 - Gene Therapy Found to Be Promising for β-Thalassemia
April 24, 2018 - Bariatric surgery can lead to changes in relationship status
April 24, 2018 - GPs must embrace digital technologies to make healthcare access easier for patients
April 24, 2018 - Novel stem cell therapy may transform current paradigms for treating heart failure patients
April 24, 2018 - Maternal depression during and after pregnancy linked to poorer child neurodevelopment
April 24, 2018 - Vitamin D and magnesium supplements provide right nutritional support to athletes
April 24, 2018 - Could a Tattoo Someday Spot Your Cancer?
April 24, 2018 - Throat reflexes differ in people with tetraplegia and sleep apnea
April 24, 2018 - Study shows no increased risk of breast cancer recurrence after DIEP flap reconstruction
April 24, 2018 - Nearly three-quarters of commonly used medical scopes tainted by bacteria
April 24, 2018 - Home-based treatment program offers robust and sustained relief for IBS patients
April 24, 2018 - New IntelliCyt Cy-Clone PLUS streamlines clone ranking and selection for cell line development
April 24, 2018 - Scientists examine how specific eating patterns could help fight cancer and obesity
April 24, 2018 - Study sheds new light on how bilinguals process language
April 24, 2018 - Probiotics can improve liver health, shows study
April 24, 2018 - Study may explain how chemoresistance evolves over time in some triple-negative breast cancers
April 24, 2018 - Role of midbrain in encoding identity errors
April 23, 2018 - Salamander study provides clues for treating spinal cord injuries
April 23, 2018 - Relaxation after work could give better night’s sleep
April 23, 2018 - Loneliness on its way to becoming Britain’s most lethal condition
April 23, 2018 - Low-cost blood test for multiple myeloma can deliver same diagnostic information as bone biopsy
April 23, 2018 - Metabolic differences may contribute to postpartum weight retention in black moms
April 23, 2018 - Time-Related Deployment Factors Predict Suicide Attempt Risk
April 23, 2018 - Are newborns ugly? Research says newborns rated ‘less cute’ than older babies
April 23, 2018 - Prenatal marijuana use linked to increased chance of low birth weights
April 23, 2018 - Researchers identify target gene in P. aeruginosa infection
April 23, 2018 - New studies related to causes of liver degradation and possible treatments
Study elucidates underlying cause of brain injury in stroke

Study elucidates underlying cause of brain injury in stroke

image_pdfDownload PDFimage_print

New research shows how the novel drug QNZ-46 can help to lessen the effects of excess release of glutamate in the brain – the main cause of brain injury in stroke.

Published in Nature Communications, the study shows how identifying the source of damaging glutamate in stroke leads to discovery of brain protection with QNZ-46, a novel form of preventative treatment with clinical potential.

Existing studies show that restricted blood supply promotes the excess release of glutamate. The glutamate binds to receptors, over-stimulating them and leading to the break-down of myelin – the protective sheath around the nerve fibre (axon).

Previous studies had focused on the brain’s grey matter – the area where all of the synapses operate. Now the new study focuses on white matter – the part of the brain the connects all of the grey matter together – and demonstrates that the glutamate release from axons themselves contributes to damaging myelin.

The study, led by Professor Robert Fern at the Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), is the first direct comparison of vesicular fusion within different cellular components in white matter, and it reveals extensive fusion in axons – a mechanism previously thought to be absent from white matter.

The findings support a rational approach toward a low-impact prophylactic therapy, such as QNZ-46, to protect patients at risk of stroke and other forms of excitotoxic injury (injury caused by excess glutamate).

As stroke is the second leading cause of disability and early death in the UK, Professor Fern, part of the University’s Institute of Translational and Stratified Medicine, explains the significance of the findings.

“Strokes are known to be caused by loss of blood to the brain, and there has been no way to treat the condition,” he said.

“As much as rehabilitation can be effective, there’s nothing you can do to heal the damage. This is why it has been necessary to look at how the problem is caused in the first place.

“Myelin damage results in severe functional deficit in the white matter of the brain, for example in ischemic – caused by lack of blood supply – stroke. By identifying how this happens, we have been able to show how QNZ-46 can be used to prevent the damage.

“There need to be further studies to fully understand how these findings can translate going forward, but to see that there are no negative side effects at this stage is a promising sign. By continuing further studies, we can come up with even better forms of the drug to help in stroke treatment.”

Source:

https://www.plymouth.ac.uk/news/new-research-sheds-light-on-underlying-cause-of-stroke

Tagged with:

About author

Related Articles