Breaking News
July 21, 2018 - Genome research suggests presence of enteric fever in medieval Europe
July 21, 2018 - Risk of Sensory Deficits Drops With Rising Gestational Age
July 21, 2018 - Mum’s sleep matters—the effect of sleep on an unborn baby
July 21, 2018 - UC San Diego researchers awarded two grants for investigating stem cell-based therapies
July 21, 2018 - Cellular ‘garbage disposal’ may actually work on some of the proteins to neuronal development
July 21, 2018 - More Pregnant Women Having Heart Attacks
July 21, 2018 - Acne Breakouts | NIH News in Health
July 21, 2018 - Change health messaging to focus on potential impact to help stop the next pandemic
July 21, 2018 - Frailty associated with poor survival rates in young heart patients
July 21, 2018 - New discovery could save millions of lives from fatal fungal infections
July 21, 2018 - OBD presents latest data on the use of EpiSwitch™ in predicting patient response to immunotherapy and identifying lymphoma subtypes
July 21, 2018 - Childhood adversity increases susceptibility to addiction via immune response
July 21, 2018 - Scientists identify potential target for the treatment of binge eating
July 21, 2018 - Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer’s
July 21, 2018 - Digital media use raising risk of ADHD symptoms among the young
July 21, 2018 - Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints
July 21, 2018 - Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice
July 21, 2018 - SP PennTech introduces RW-500 rotary vial washer for biotech, pharmaceutical applications
July 21, 2018 - Researchers to study molecular mechanisms behind susceptibility of males to autism
July 21, 2018 - Fourth Published Clinical Trial Confirms Long-Term Safety of Niagen Supplementation at High Doses and Shows Potential for Improvement in Liver Health
July 21, 2018 - Greening vacant urban land reduces feelings of depression for surrounding residents
July 21, 2018 - Parents say intense gun violence in PG-13 movies appropriate for teens 15 and older
July 21, 2018 - Collaborative study to assess effects of exercise training for cognitive deficits in MS
July 21, 2018 - FAU researchers find possible cause of Parkinson’s disease in the patients’ immune system
July 21, 2018 - Protective qualities of ‘good cholesterol’ reduce after menopause
July 21, 2018 - Researchers develop new way to uncover hidden breast cancer tumors
July 21, 2018 - FDA approves first drug for treatment of adult AML patients with specific genetic mutation
July 21, 2018 - Top AI companies join hands to discover novel drugs for DMD
July 21, 2018 - Ferring announces FDA approval of ZOMACTON for injection in four new pediatric indications
July 20, 2018 - Researchers design proteins that can self-assemble into complex structures
July 20, 2018 - AVITA Medical expands management team to support launch of RECELL device to treat burns
July 20, 2018 - FDA Approves Tibsovo (ivosidenib) for Relapsed or Refractory Acute Myeloid Leukemia with an IDH1 Mutation
July 20, 2018 - Developmental screening and surveillance rates remain low, new study suggests
July 20, 2018 - TGen opens tissue donation portal to advance DIPG research
July 20, 2018 - Health impact of highly processed summertime staples
July 20, 2018 - Exergaming can improve health in overweight and obese children, study shows
July 20, 2018 - Postmenopausal factors may impact heart-protective qualities of ‘good cholesterol’
July 20, 2018 - MRI and blood test combination results in improved prostate cancer diagnosis
July 20, 2018 - Update Health Professional and Consumer on Recent Recalled Products
July 20, 2018 - Researchers trace Parkinson’s damage in the heart
July 20, 2018 - Wearable device designed to measure cortisol in sweat
July 20, 2018 - Scientists demonstrate a new regulation mechanism for skeletal muscles
July 20, 2018 - Exposure to mobile phone radiation may negatively impact memory performance in adolescents
July 20, 2018 - SUSU scientists find alternative method to treat post-traumatic stress disorder syndrome
July 20, 2018 - Gestational diabetes may increase offspring’s heart disease risk
July 20, 2018 - New vaccine could protect unborn babies from Zika virus
July 20, 2018 - Researchers find high mercury and methylmercury concentrations in traditional Tibetan medicine
July 20, 2018 - Brief Safety Plan Intervention in ER Can Cut Suicidal Behavior
July 20, 2018 - The Mount Sinai Hospital receives accreditation as geriatric emergency department
July 20, 2018 - Toward a better understanding of Parkinson’s disease
July 20, 2018 - Med school communications office wins four national awards | News Center
July 20, 2018 - Professional baseball players with faster hand-eye coordination may have better batting performance
July 20, 2018 - Study looks into mechanisms that control sleep and wakefulness
July 20, 2018 - Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments
July 20, 2018 - Research reveals long-term efficacy of drug used to treat common cause of kidney failure
July 20, 2018 - Timing of dinner associated with breast and prostate cancer risks
July 20, 2018 - Health Tip: Performing the Heimlich Maneuver
July 20, 2018 - Nearly all adolescents have eating, activity or weight-related issues
July 20, 2018 - Sage launches new web-based tool that helps explore curated genomic analyses of Alzheimer’s
July 20, 2018 - High-performance porous polymeric material for chromatography applications
July 20, 2018 - New molecule shows great promise for future treatment of many cancers
July 20, 2018 - New research project investigates alternative treatments for eye infections
July 20, 2018 - Immune T cells are built to react as fast as possible, shows study
July 20, 2018 - ZHX2 protein could offer a new treatment strategy for kidney cancer
July 20, 2018 - EKF’s Quo-Lab POC HbA1c analyzer meets international quality targets for diabetes testing
July 20, 2018 - Health burdens of very high risk drinking are potentially large, study reveals
July 20, 2018 - Using miniature drug-filled nanocarriers to target headaches and tumors
July 20, 2018 - Researchers uncover cause for progression of prostate cancer to incurable stage
July 20, 2018 - Studies highlight issues regarding black lung, opioid overdose, police violence and more
July 20, 2018 - AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia
July 20, 2018 - Researchers are one step closer to developing eye drops to treat age-related macular degeneration (AMD)
July 20, 2018 - Patients maintain muscle mass five years after surgically induced weight loss
July 20, 2018 - AMSBIO introduces new, powerful CRISPR/Cas9 gene editing kits
July 20, 2018 - PureTech Health collaborates with Roche to advance oral administration of antisense oligonucleotides
July 20, 2018 - Analysis reveals disparities in cancer death rates among minority groups
July 20, 2018 - Dr Maddy Parsons receives Royal Microscopical Society Life Science Medal
July 20, 2018 - Study finds link between DNA methylation and non-alcoholic fatty liver disease
July 20, 2018 - Military personnel with head trauma and football players with suspected CTE show similar brain changes
July 20, 2018 - Vidac Pharma Announces Initiation of Phase 2b Clinical Trial of VDA-1102 Ointment in Patients with Actinic Keratosis
July 20, 2018 - KKR is buying Envision Healthcare in a nearly $10B deal
New insights into breast implant-associated anaplastic large-cell lymphoma

New insights into breast implant-associated anaplastic large-cell lymphoma

image_pdfDownload PDFimage_print

For the past seven years, the U.S. Food and Drug Administration has reported on cases of a type of lymphoma associated with breast implants. Earlier this month, the FDA noted a rise in the amount of these cases over the past year – 414 cases – up from 359 in the previous year. Andrew M. Evens, DO, MSc, FACP, director of the Lymphoma Program and associate director for clinical services at Rutgers Cancer Institute of New Jersey, and medical director of the oncology service line at RWJBarnabas Health, shares some insight.

Q: The disease in question is called breast implant-associated anaplastic large-cell lymphoma. What can you tell us about it?

A: The first case of breast-implant associated (BIA) anaplastic large cell lymphoma (ALCL) was reported in 1997. ALCL is a peripheral T-cell lymphoma (PTCL). PTCL is a T-cell lymphoma, which are generally uncommon types of non-Hodgkin lymphoma. Of all non-Hodgkin lymphomas, approximately 15 percent are T-cell. Among these 15 percent, there are approximately 12 different types of T-cell lymphomas, of which ALCL is one. Generally speaking, ALCL is an aggressive form of non-Hodgkin lymphoma, but it is treatable and potentially curable.

Q: The FDA notes while not conclusive, this type of lymphoma is more likely to occur in women who have implants with a textured coating. What do you know about this association?

A: Initial reports of the association of BIA-ALCL were reported as an 18-fold risk of ALCL in women who had breast implants versus those who did not. In a recent updated Dutch analysis, the number of women with implants needed to cause one breast-ALCL case before age 75 years was 6,920. In addition, among patients who develop BIA-ALCL, approximately 80 percent occur with macrotextured implants versus smooth implants. The presumed factors involved in the development of lymphoma are a local inflammatory reaction to the breast implant materials.

Q: What are some misconceptions surrounding this issue?

A: Lymphoma often occurs in the lymph nodes and blood; however, it may occur anywhere in the body, including the breast. The most common cancer to occur in the breast is “breast cancer;” however other cancers, such as lymphoma, may rarely involve the breast as well as many other locations in the body (e.g., brain, skin, stomach, liver, etc.). Additionally, even though there is a slightly increased risk of lymphoma in patients who have breast implants, lymphomas may involve the breast in patients without implants too.

Q: The FDA cites current literature that estimates breast implant-associated anaplastic large-cell lymphoma may develop in 1 in 3,817 to 30,000 women with textured implants. What do women considering implants need to be aware of with regard to this issue?

A: There are a number of locations with sources of information including the FDA. It is important to highlight that despite the association of breast implants with ALCL, the frequency of this occurring is uncommon. Any unexplained symptoms such as a lump, pain, and/or redness of the breast should be examined further by a healthcare provider. Further workup including mammogram, MRI, PET scan and possible biopsy may be needed to determine the exact cause of symptoms. In addition, patients with low levels of localized BIA-ALCL may be managed potentially with surgery alone while more disseminated cases may warrant chemotherapy for treatment. Overall, survival rates are very good for BIA-ALCL.

Source:

https://www.cinj.org/closer-look-association-between-breast-implants-and-uncommon-form-cancer

Tagged with:

About author

Related Articles