Breaking News
January 22, 2019 - Genetic study reveals possible new routes to treating osteoarthritis
January 22, 2019 - Blood test may detect early signs of lung-transplant rejection
January 22, 2019 - Blood marker could aid in early prediction of Alzheimer’s progression
January 22, 2019 - Orthodontic treatment does not guarantee future dental health
January 22, 2019 - Rutgers researchers discover cause of bone loss in people with joint replacements
January 22, 2019 - Diversity among rural Africans extends to their gut microbiomes
January 22, 2019 - Newly developed biological system lets cells to create self-curving cornea
January 22, 2019 - VTv Therapeutics Announces Publication of Comprehensive Data in Science Translational Medicine Detailing the Discovery and Clinical Development of TTP399, including Results of Phase 2 AGATA Study
January 22, 2019 - about one in three adults with prediabetes has arthritis
January 22, 2019 - A look at how data is democratizing health care
January 22, 2019 - Alcohol-Linked Disease Overtakes Hep C As Top Reason For Liver Transplant
January 22, 2019 - Researchers identify new genes linked with age-related macular degeneration
January 22, 2019 - MPFI researchers identify synaptic logic for connections between two brain hemispheres
January 22, 2019 - New study extends our knowledge of the link between miRNAs and cancer
January 22, 2019 - Genetic changes may predict likelihood of relapse in breast cancer patients
January 22, 2019 - Antiepileptic drug use by people with Alzheimer’s disease linked to accumulation of hospital days
January 22, 2019 - IUPUI researcher receives $2.85 million grant to find ways to improve bone strength
January 22, 2019 - Precision medicine can help keep astronauts healthy during deep space missions
January 22, 2019 - Detecting signs of neurodegeneration earlier and more accurately
January 22, 2019 - Mouse studies challenge ‘inhibition’ theory of autism
January 22, 2019 - SSB launches BIOSTAT RM TX single-use bioreactor for producing consistent quality cellular products
January 22, 2019 - Experimental drug can positively modify key characteristic behavior in FXS patients
January 22, 2019 - Low-Income Women Lack Menstrual Hygiene Supplies
January 22, 2019 - Better mouse model built to enable precision-medicine research for Alzheimer’s
January 22, 2019 - Molecular profiling of precancerous lung lesions could lead to early detection and new treatments
January 22, 2019 - Genetic factors influence where fat is stored in our bodies
January 22, 2019 - The Psychology Behind Sticking to Your New Year’s Resolutions
January 22, 2019 - Scientists aim to find genetic causes of developmental abnormalities in the vagina and uterus
January 22, 2019 - New survey reveals scale of preventative healthcare challenge in the UK
January 22, 2019 - Looming Global Crisis Means People’s Diets Must Change: Experts
January 22, 2019 - Excessive social media use is comparable to drug addiction
January 22, 2019 - Researchers show how mechanical stress affects bone development
January 22, 2019 - Study takes a step closer to understanding the body’s response to opioid painkillers
January 22, 2019 - Unexpected connection found between feeding and memory centers of the brain
January 22, 2019 - A revolutionary approach transforms bone trauma treatment
January 22, 2019 - Early studies and recent clinical trials on nerve growth factor
January 22, 2019 - Dry Mouth and Older Adults: Information for Caregivers
January 22, 2019 - Are your grandparents getting tipsy at the holiday party?
January 22, 2019 - New machine learning algorithms identify early symptoms of urinary tract infections
January 22, 2019 - Young women skipping the Pap smear test due to embarrassment
January 22, 2019 - A global influenza pandemic high on the WHO’s agenda
January 22, 2019 - Amgen Makes All Repatha (evolocumab) Device Options Available In The US At A 60 Percent Reduced List Price
January 22, 2019 - Elastronics—hydrogel-based microelectronics for localized low-voltage neuromodulation
January 22, 2019 - Branched-chain amino acids in tumors can be targeted to prevent and treat cancer
January 22, 2019 - Fueling macrophages with energy to attack and eat cancer cells
January 22, 2019 - Amgen And UCB Receive Positive Vote From FDA Advisory Committee In Favor Of Approval For Evenity (romosozumab)
January 22, 2019 - Does being bilingual make children more focused? Study says no
January 22, 2019 - Study reveals new genes and biological pathways linked to osteoarthritis
January 22, 2019 - FSU study provides better understanding of spinal cord injuries
January 22, 2019 - Delaying bath for newborn babies increases breastfeeding rates, finds study
January 21, 2019 - WHO identifies non-communicable diseases as major threat to human health
January 21, 2019 - Many parents still try non-evidence-based cold prevention methods for children
January 21, 2019 - High Levels of Activity, Motor Ability Linked to Better Cognition
January 21, 2019 - Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight
January 21, 2019 - Buffalo researchers receive grant to quicken development of generic equivalents of contraceptives
January 21, 2019 - One-third of pregnant women do not believe cannabis is harmful to their fetus
January 21, 2019 - Fiderstat could be used as chemopreventative drug for intestinal cancers caused by APC gene mutations
January 21, 2019 - Modifying healthcare delivery practices may improve discussions between youth and healthcare providers
January 21, 2019 - UNIST researcher named as recipient of Merck’s 2018 Life Science Awards
January 21, 2019 - How Getting a Flu Shot Could Save Your Life
January 21, 2019 - Surgical adhesions can be treated, prevented in mice
January 21, 2019 - Increased physician-targeted marketing associated with higher opioid overdose deaths
January 21, 2019 - Researchers uncover specific microbial signatures of intestinal disease
January 21, 2019 - Researchers discover new blood vessel system in bones
January 21, 2019 - Simple blood test reliably detects signs of Alzheimer’s damage before symptoms
January 21, 2019 - Study to investigate new targeted oral treatments for severe asthma
January 21, 2019 - Plan Your Plate | NIH News in Health
January 21, 2019 - Fecal occult blood test may improve CRC outcomes in some
January 21, 2019 - Blood test detects Alzheimer’s disease years before symptoms develop
January 21, 2019 - Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS
January 21, 2019 - FDA Advisory Committee Votes on Zynquista (sotagliflozin) as Treatment for Adults with Type 1 Diabetes
January 21, 2019 - The causes and complications of snoring
January 21, 2019 - Placenta adapts and compensates when pregnant mothers have poor diets or low oxygen
January 21, 2019 - New implant could restore the transmission of electrical signals in injured central nervous system
January 21, 2019 - Rapid-acting fentanyl test strips found to be effective at reducing overdose risk
January 21, 2019 - Coronary Artery Calcium May Help Predict CVD in South Asians
January 21, 2019 - The mystery of the super-ager
January 21, 2019 - Scientists develop smart microrobots that can change shape depending on their surroundings
January 21, 2019 - Keep Moving to Keep Brain Sharp in Old Age
January 21, 2019 - Despite progress, gay fathers and their children still structurally stigmatized
Digital psychiatric therapy can ‘rewire’ the brain in children with ADHD, study shows

Digital psychiatric therapy can ‘rewire’ the brain in children with ADHD, study shows

image_pdfDownload PDFimage_print

ATENTIV, LLC, pioneers in digital therapies for Attention Deficit/Hyperactivity Disorder (ADHD) and other cognitive disorders, today announced the publication of a recently completed brain imaging study using the ATENTIVmynd Technology platform. The study demonstrated physical evidence that the brain can be ‘rewired’ or ‘re-normalized’ in children with Attention Deficit/Hyperactivity Disorder (ADHD) who were given digital psychiatric therapy. This rewiring was associated with an improvement in attention symptoms consistent with cumulative evidence from 7 prior clinical trials.

The study, entitled “Brain-computer-interface intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder“, is available online in the peer-reviewed journal Translational Psychiatry published by Nature. The study was funded by the National Medical Research Council in Singapore. The intervention was co-developed by the Institute for Infocomm Research, a research institute managed by the Agency for Science, Technology and Research in Singapore, and ATENTIV, LLC, a digital psychiatric therapeutic company, which has developed the intervention into a platform of ATENTIVmynd Games.

The brain imaging study, part of a larger randomized, controlled study of 172 children with ADHD, included 18 boys (mean age 9.00±1.50 years) who received the game intervention for 8 weeks, and a wait-list control arm of 11 boys (mean age 9.45±1.29 years) with ADHD who received no intervention. Resting state functional Magnetic Resonance Imaging (fMRI) images, along with clinical assessment of ADHD symptoms via the ADHD Rating Scale-IV (ADHD RS-IV), were obtained at baseline and at 8 weeks. Regions of the brain with correlated Brain Oxygen Level Dependent (BOLD) activity were utilized to assess functional connectivity networks (areas of the brain that work in concert).

The group receiving the game intervention had several positive statistically significant outcomes compared with the untreated group. They had reduced local processing (higher efficiency) within the salience/ventral attention (SVN) network (brain areas involved in detecting the importance of information). The reduced local processing in the SVN was correlated with fewer inattentive symptoms (r = 0.39, p=0.038). They had increased communication between the central executive network (brain areas involved in orientation to external stimuli) and the default mode network (brain areas involved in self-related processes including daydreaming and mind-wandering).

Jonathan Rubin, MD, MBA, Chief Medical Officer of ATENTIV, LLC, commented, “This study supports prior research that children with ADHD have brain networks regulating attention that work with reduced efficiency. After 8 weeks of the game intervention, abnormal brain networks regulating attention were re-wired, as seen by a change in brain network connections to a pattern that more closely resembles that of a developmentally normal brain. These findings add to the promising body of evidence from seven prior studies in over 300 children with ADHD using the ATENTIVmynd Game intervention which have demonstrated improvements in ADHD symptoms, reading, math and homework skills without the use of medication.”

Scott Kollins, PhD, Professor of Psychiatry and Behavioral Sciences at Duke University School of Medicine and Director of the Duke ADHD Program, who was not involved in the research, stated, “This new imaging study provides provocative preliminary evidence that changes in attentional functioning in ADHD patients as a result of treatment with the ATENTIVmynd™ Game is mediated through neuroplastic processes. These findings are an important step toward better understanding the mechanisms underlying novel approaches to treating ADHD.”

About ATENTIVmynd Games: ATENTIVmynd Games comprise a novel, non-pharmaceutical, digital cognitive training and therapy platform designed to provide sustained and measurable improvements in attention and inhibitory control for individuals when delivered in the clinic, school or home. The intervention product platform, ATENTIVmynd Games, is delivered via action adventure video games in which the player uses their brain waves, related to their attention state, to control the speed of an action character while the player is presented with multiple dynamic challenges that target, measure and teach the underlying cognitive skills of attention and inhibitory control. The system leverages a proprietary, non-invasive direct brain-to-computer interface to measure a user’s unique ‘cognitive signature’ from brain waves related to their attention state. Initial product applications are designed to optimize attention skills in elementary and high school children and adults. The training is conducted in 20 minute sessions for 3-5 days per week over a period of 5-8 weeks for a total of 8 hours of gameplay.

Tagged with:

About author

Related Articles