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November 19, 2018 - Experts debate over whether gut or brain is more important in regulating appetite
November 19, 2018 - Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising
November 19, 2018 - Low-Carb Diets May Work By Boosting Calorie Burn
November 19, 2018 - Key molecule responsible for learning and memory discovered
November 19, 2018 - New blood test developed for early diagnosis of ovarian cancer
November 19, 2018 - Researchers identify molecule to fight myotubular myopathy
November 19, 2018 - Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds
November 19, 2018 - Scientists equip new virus that kills carcinoma cells with protein
November 19, 2018 - Novel approach could provide painless, efficient alternative for treating eye diseases
November 19, 2018 - Protein in cell membranes of sperm plays key role in finding their way to eggs
November 19, 2018 - Parents who decline flu vaccination for their child may be exposed to limited information
November 19, 2018 - Mirati Presents Data From Ongoing Phase 2 Clinical Trial Of Mocetinostat In Combination With Durvalumab At The SITC 33rd Annual Meeting
November 19, 2018 - FDA warns of common diabetes meds’ link to dangerous genital infection
November 19, 2018 - New methods for preserving shoulder function, quality of life in breast cancer patients
November 19, 2018 - Surprising discovery about BH4 may rekindle interest in once-promising pathway
November 19, 2018 - Nabriva Therapeutics Completes Submission of New Drug Application to U.S. Food and Drug Administration for Intravenous Contepo to Treat Complicated Urinary Tract Infections
November 19, 2018 - Beating breast cancer only to die of opioid use – a sad Appalachian story
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November 19, 2018 - Alcohol ads on social media sites with pro-drinking comments increase desire to drink
November 19, 2018 - Neural networks could replace marker genes in RNA sequencing
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November 18, 2018 - Scientists succeed in increasing stability, biocompatibility of light-transducing nanoparticles
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November 18, 2018 - Pharmacist-Led Effort Cuts Inappropriate Rx in Older Adults
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November 18, 2018 - AHA and ADA launch new initiative to help people with type 2 diabetes reduce heart disease risk
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November 18, 2018 - Scientists shine new light on link between obesity and cancer
November 18, 2018 - Risk factors for cardiovascular disease closely track with changes in diet patterns
November 18, 2018 - Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
November 18, 2018 - Detectable HIV-1 in treated human liver cells found to be inert
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
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November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
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November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
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November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - New strategy to hinder emergence of antimicrobial-resistant pathogens
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November 17, 2018 - Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers
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November 17, 2018 - Obesity significantly increases risk of Type 2 diabetes and coronary artery disease
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November 17, 2018 - People with rare cancers can benefit from genomic profiling, shows research
November 17, 2018 - NIH awards over $1.8 million to husband-and-wife doctors to test new breast cancer approach
November 17, 2018 - Four-in-one antibody used to fight flu shows promise in mice
November 17, 2018 - New approach allows pathogens to be starved by blocking important enzymes
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November 17, 2018 - Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension
November 17, 2018 - FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated Systemic Anaplastic Large Cell Lymphoma or Other CD30-Expressing Peripheral T-Cell Lymphomas
November 17, 2018 - ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy
November 17, 2018 - UT Southwestern scientists selected to receive 2019 Edith and Peter O’Donnell Awards
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November 17, 2018 - Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway
November 17, 2018 - Heart Disease Leading Cause of Death in Low-Income Counties
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November 17, 2018 - Research reveals link between immunity, diabetes
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The Current issue of “The view from here” is concerned with Drug Delivery

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Drug delivery represents one of the last boxes to tick in the drug discovery project map. Perhaps it shouldn’t be that way, but it frequently is. If, however, you consider that without this, even the most potent and useful compounds will die a death. The death may be a clean one if the company strictly complies with go/no go decision points on its project map, or lingering and painful if the compound has a sufficiently powerful, political champion within the company. Modern approaches in the field of drug delivery have the potential to transform molecules, that would be difficult to advance in development, from dead as a duck into world beaters. This month’s offering features three excellent articles that highlight how nanotechnology has become an essential part of modern drug discovery by transforming certain aspects of drug delivery. 

 

The first article in this month’s offering is entitled: “Strategies for the enhanced intracellular delivery of nanomaterials”, by Cláudia Azevedo, Maria Helena Macedo and Bruno Sarmento of The University of Porto, Portugal. In this article, the authors review the most up-to-date developments in the field of intracellular delivery and the mechanisms that facilitate the efficient transit of drugs functionalized to nanomaterials to their targets. By such techniques and approaches, it is now possible to obtain novel nanomaterials that retain biological (in vitro) activity yet have significantly improve properties, such as the avoidance of lysosomal degradation and ability to reach their target. This field, combining biology, chemistry and pharmacy has the potential massively to improve the ability of promising compounds to become effective drugs.  

 

Following on from this is the article by Ryan F. Donnelly and Eneko Larrañeta of Queen’s University Belfast, UK entitled: “Microarray patches: potentially useful delivery systems for long-acting nanosuspensions”. The authors review a field that is important not only for efficiency of drug molecules, but also for patient compliance. The controlled release of more and more clinically important compounds require injection, generally, but not exclusively intramuscularly. As I’m sure you are more than aware, a significant number of patients have an almost phobic aversion to hypodermic needles. This, of course has associated issues such as injury, infection and disposal and can hinder the introduction of useful molecules, particularly in developing countries. One useful approach for delivery of such preparations is through the introduction of the compound via dissolving microneedles as microarray patches. These devices are capable of delivering of delivering microparticles into skin and they are minimally invasive and require no follow up (with respect to removal and disposal). As such, they are capable of enhancing compliance (especially in a needle averse population). The review covers various aspects of development of these systems.

 

The remaining article in this month’s offering is, perhaps not really an application of drug delivery per se but makes a nice bridge between the two previous articles. It is from Vijay Mishra, Akshay Patil, Sourav Thakur and Prashant Kesharwani, entitled: “Carbon dots: emerging theranostic nanoarchitectures”. Theranostics (therapeutic diagnostics) is a term that has been in use for perhaps 75 years from the use of radioactive isotopes of iodine salts to diagnose and treat thyroid cancer. Modern theranostics are significantly more sophisticated than this (but do not confuse sophistication with value). Kesharwani and colleagues discuss carbon dots and how they may have the potential to be of great value as theranostics in the field of oncology. Their reproducible size and shape and other physical properties, such as biocompatibility, photoluminescence and electron transfer abilities make them attractive structures for the diagnosis and drug delivery of molecules to a variety of cancer types. The advantage of drug delivery and ability to bioimage within a single structure is a great advantage of this approach.

 

 

 

Steve Carney was born in Liverpool, England and studied Biochemistry at Liverpool University, obtaining a BSc.(Hons) and then read for a PhD on the Biochemistry and Pathology of Connective Tissue Diseases in Manchester University, in the Departments of Medical Biochemistry and Histopathology. On completion of his PhD he moved to the Kennedy Institute of Rheumatology, London, where he worked with Professor Helen Muir FRS and Professor Tim Hardingham, on the biochemistry of experimental Osteoarthritis. He joined Eli Lilly and Co. and held a number of positions in Biology R&D, initially in the Connective Tissue Department, but latterly in the Neuroscience Department. He left Lilly to take up his present position as Managing Editor, Drug Discovery Today, at Elsevier. Currently, he also holds an honorary lectureship in Drug Discovery at the University of Surrey, UK. He has authored over 50 articles in peer-reviewed journals, written several book chapters and has held a number of patents. On the media front, Dr. Carney has been busy on some hush-hush projects that will be reported on later in the year.

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