Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Therapeutic vaccine shows promise against a range of cancers

Therapeutic vaccine shows promise against a range of cancers

(HealthDay)—A personalized vaccine held an aggressive group of cancers in check among more than half of patients who received it in a small, preliminary trial, researchers report.

HER2-positive cancers are cancers that have too much of the HER2 protein on their surface. In that setting, a cancer can grow rapidly and be more likely to spread to other areas of the body. Areas known to have HER2-positive cancers include the breasts, bladder, pancreas, ovaries and stomach.

Using the patients’ own blood cells, researchers at the U.S. National Cancer Institute modified immune cells and created personalized vaccines to target HER2-positive cancers throughout the body. A benefit was seen in people with cancer in the stomach, colon and ovaries, said study author Dr. Jay Berzofsky.

The vaccine “was safe in humans without any acute or delayed side effects, and clinical benefit was observed in six of 11 patients whose data were available for analysis,” he said. Berzofsky is the chief of the vaccine branch at the Center for Cancer Research at the National Cancer Institute.

However, the purpose of the early study was only to see what dose of the vaccine should be given and that such a dose isn’t toxic, according to Dr. Otis Brawley, chief medical officer of the American Cancer Society.

Brawley said it’s a good sign to see an apparent benefit in a phase 1 trial, but cautioned that the research is “incredibly early. It’s too early to start jumping for joy. They show some clear evidence of a benefit, and it’s a good investment to pursue this lead.”

Berzofsky said the researchers don’t know the exact mechanism behind the vaccine’s success, but are continuing research to better understand how the vaccine works.

The study included 11 people given more than the lowest dose of the vaccine who were able to be evaluated. Six people—54 percent—showed a benefit from the vaccine.

One patient with ovarian cancer had a complete response that lasted 89 weeks. A complete response means that the cancer can’t be found anymore with blood or imaging tests, Brawley said.

Another patient—this one with gastroesophageal cancer—had a partial response that lasted for months, the researchers said. Partial response means that the cancer has been reduced by 50 percent or more, Brawley said.

The remaining four patients—two with colon cancer, one with ovarian cancer and one with prostate cancer—saw their disease stabilize.

The researchers plan on combining the current vaccine with a drug that can help overcome a cancer’s ability to suppress the immune system in the next phase of research. The drugs are called checkpoint inhibitors.

Brawley explained that everyone has white blood cells circulating in their blood, looking for cancer. These immune system cells find cancer cells and kill them. But cancer cells learn to outsmart these killer cells. They essentially put up a white flag to signal that they’re friendly when those white blood cells check on them. But checkpoint inhibitor drugs cover up that white flag, allowing the killer white blood cells to see the cancer cells.

Berzofsky said, “We think [this combination] could be more effective than the use of individual agents, as we believe vaccines can trigger the immune function and adding checkpoint inhibitors can overcome the inhibitory effect of the cancer.”

The findings were presented Sunday at a meeting sponsored by the Cancer Research Institute, the Association of Cancer Immunotherapy, the European Academy of Tumor Immunology and the American Association for Cancer Research, in New York City. Research presented at meetings should be considered preliminary until published in a peer-reviewed journal.


Explore further:
New cancer vaccine shows early promise for patients with HER2-positive cancers

More information:
Jay Berzofsky, M.D., Ph.D., chief, vaccine branch, Center for Cancer Research, National Cancer Institute, Bethesda, Md.; Otis Brawley, M.D., chief medical officer, American Cancer Society; Sept. 30, 2018 presentation, CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference, New York City

Learn more about cancer vaccines from the American Cancer Society.

Tagged with:

About author

Related Articles