Breaking News
February 17, 2019 - Sinks by Toilets in ICU Patient Rooms Harbor Harmful Bacteria
February 17, 2019 - Cancer cells’ plasticity makes them harder to stop
February 17, 2019 - Young cannabis users have increased risk of depression and suicidal behavior
February 17, 2019 - Tasmanian Devils Likely to Survive Cancer Scourge
February 17, 2019 - Neoadjuvant PD-1 blockade seems effective in glioblastoma
February 17, 2019 - Personal, social factors play role in enabling sustainable return to work after ill health
February 17, 2019 - Mouse studies show ‘inhibition’ theory of autism wrong
February 17, 2019 - Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins
February 17, 2019 - Use of liver grafts from older donors decreased despite better outcomes in recipients
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - Promising drug developed to rejuvenate muscle cells
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
February 16, 2019 - Testosterone is not the only hormone needed for penis development
February 16, 2019 - FDA Advisory Committee Recommends Approval of Spravato (esketamine) Nasal Spray for Adults with Treatment-Resistant Depression
February 15, 2019 - Heart surgery technology developed at Baptist Health debuts after years of secrecy
February 15, 2019 - Prescription Opioids Double Risk of Triggering Fatal Car Crash
February 15, 2019 - New study helps doctors better understand high blood pressure in pregnant women
February 15, 2019 - Beta wave control in Parkinson’s diseased brain could be a potential therapy
February 15, 2019 - Media representations of love may justify gender-based violence in young people
February 15, 2019 - Yoga May Help With Rheumatoid Arthritis Symptoms, Severity
February 15, 2019 - Obstructive sleep apnea linked to inflammation, organ dysfunction
February 15, 2019 - Master your mind: A challenge from WELL for Life
Kent State professor receives grant to study role of oxytocin in the developing brain

Kent State professor receives grant to study role of oxytocin in the developing brain

image_pdfDownload PDFimage_print

Heather Caldwell, Ph.D., a professor in Kent State University’s Department of Biological Sciences, recently received a $450,000 grant to study the role that oxytocin plays in the developing brain.

Labeled by some as “the bonding hormone,” oxytocin is well known for helping pregnant mothers with uterine contraction while in labor, milk letdown while breastfeeding and a feeling of euphoria when cuddling with their infants. But, there is still much that researchers do not know about how this hormone works in the brains of children.

The grant, which came from the National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, will enable a study on the three-year project titled “Sex differences in the developing oxytocin system.” The study will provide insight into how oxytocin affects the development of the female and male brain and contributes to the neural regulation of social behavior. Dr. Caldwell’s lab group will be the first to examine the function of oxytocin signaling during early development. Liz Aulino, a Kent State Ph.D. student in Dr. Caldwell’s lab, will focus on this topic for her dissertation.

“This research has relevance to public health because many of the neural chemicals, neural substrates and circuits that underlie social behaviors are evolutionarily conserved,” Dr. Caldwell said. “Using an animal model, we hope to improve our understanding of the contributions of oxytocin to the development of social behaviors in humans.”

The researchers aim to determine how the developing oxytocin system differs between female and males and also to identify how it differentially impacts their neurochemistry.

The brain hormones do not themselves cause behavior, but they modulate it. The key is how they interact with a receptor, in this case, a protein in the cell’s membrane. The developing mouse brain does not make oxytocin early in development, but it has oxytocin receptors ready to signal.

Emerging evidence shows that, during early brain development, oxytocin helps to organize neural circuits in the brain and that these organizational effects may help the brain develop the capacity to execute sex-specific and context-appropriate social behaviors later in life.

“We think these experiments will reveal a novel role for oxytocin in organizing sex-specific brain circuits that are critical for typical displays of social behaviors,” Dr. Caldwell said. “Across mammalian species, oxytocin is important for social cognition and social functioning, and deficits in social behaviors are characteristic of several neurodevelopmental neuropsychiatric disorders such as schizophrenia.”

This type of National Institutes of Health grant, an R15, is an Academic Research Enhancement Award (AREA) and specifically supports the research, education and training of future scientists through undergraduate research support for students interested in a career in biomedical/behavioral science. Dr. Caldwell will recruit students to collaborate with her and Ms. Aulino, as well as a technician who she plans to hire for the three-year term.

Dr. Caldwell developed an interest in the effect of hormones on behavior after doing fieldwork with sea turtles and working on mouse chemical signals as a student at the University of North Carolina Greensboro, where she earned her undergraduate and master’s degrees in biology. Her interest in how hormones affect behavior led her to pursue a doctorate at Georgia State University, which has a large National Science Foundation-supported Center for Behavioral Neuroscience. She spent four years as a postdoctoral fellow at the National Institutes of Health and joined the Kent State faculty in 2007. Dr. Caldwell has been studying how neurochemistry regulates behavior such as aggression, and her primary research focus has been on the closely linked hormones oxytocin and vasopressin.​​

Source:

https://www.kent.edu/kent/news/new-study-kent-state-researcher-examine-role-oxytocin-developing-brain

Tagged with:

About author

Related Articles