Breaking News
December 16, 2018 - Parents spend more time talking with kids about mechanics of using mobile devices
December 16, 2018 - Biohaven Announces Positive Results from Ongoing Rimegepant Long-Term Safety Study
December 16, 2018 - Arterial stiffness may predict dementia risk
December 16, 2018 - Study explores link between work stress and increased cancer risk
December 16, 2018 - Sex work criminalization linked to incidences of violence finds study
December 16, 2018 - Johns Hopkins researchers discover swarming behavior in fish-dwelling parasite
December 16, 2018 - Schistosomiasis prevention and treatment could help control HIV
December 16, 2018 - Early postpartum opioids linked with persistent usage
December 16, 2018 - Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies
December 16, 2018 - Advanced illumination expands capabilities of light-sheet microscopy
December 16, 2018 - Alzheimer’s could possibly be spread via contaminated neurosurgery
December 16, 2018 - Unraveling the complexity of cancer biology can prompt new avenues for drug development
December 16, 2018 - Inflammatory Bowel Disease, Prostate Cancer Linked
December 16, 2018 - Cannabis youth prevention strategy should target mental wellbeing
December 15, 2018 - Recent developments and challenges in hMAT inhibitors
December 15, 2018 - Sewage bacteria found lurking in Hudson River sediments
December 15, 2018 - CDC selects UMass Amherst biostatistician model that helps predict influenza outbreaks
December 15, 2018 - Researchers reveal brain mechanism that drives itch-evoked scratching behavior
December 15, 2018 - New computer model helps predict course of the disease in prostate cancer patients
December 15, 2018 - Obesity to Blame for Almost 1 in 25 Cancers Worldwide
December 15, 2018 - How the brain tells you to scratch that itch
December 15, 2018 - New findings could help develop new immunotherapies against cancer
December 15, 2018 - World’s largest AI-powered medical research network launched by OWKIN
December 15, 2018 - Young people suffering chronic pain battle isolation and stigma as they struggle to forge their identities
December 15, 2018 - Lifespan extension at low temperatures depends on individual’s genes, study shows
December 15, 2018 - New ingestible capsule can be controlled using Bluetooth wireless technology
December 15, 2018 - Researchers uncover microRNAs involved in the control of social behavior
December 15, 2018 - Research offers hope for patients with serious bone marrow cancer
December 15, 2018 - Link between poverty and obesity is only about 30 years old, study shows
December 15, 2018 - Mass spectrometry throws light on old case of intentional heavy metal poisoning
December 15, 2018 - BeyondSpring Announces Phase 3 Study 105 of its Lead Asset Plinabulin for Chemotherapy-Induced Neutropenia Meets Primary Endpoint at Interim Analysis
December 15, 2018 - Study finds that in treating obesity, one size does not fit all
December 15, 2018 - Tenacity and flexibility help maintain psychological well-being, mobility in older people
December 15, 2018 - Study reveals role of brain mechanism in memory recall
December 15, 2018 - High levels of oxygen encourage the brain to remain in deep, restorative sleep
December 15, 2018 - Experimental HIV vaccine strategy works in non-human primates, research shows
December 15, 2018 - Genetically modified pigs could limit replication of classical swine fever virus, study shows
December 15, 2018 - FDA Approves Herzuma (trastuzumab-pkrb), a Biosimilar to Herceptin
December 15, 2018 - Cost and weight-loss potential matter most to bariatric surgery patients
December 15, 2018 - Cancer Research UK and AstraZeneca open new Functional Genomics Centre
December 15, 2018 - New research lays out potential path for treatment of Huntington’s disease
December 15, 2018 - Prestigious R&D 100 Award presented to Leica Microsystems
December 15, 2018 - Study shows septin proteins detect and kill gut pathogen, Shigella
December 15, 2018 - Study sheds new light on disease-spreading mosquitoes
December 15, 2018 - 2017 Saw Slowing in National Health Care Spending
December 15, 2018 - Monitoring movement reflects efficacy of mandibular splint
December 15, 2018 - Study supports BMI as useful tool for assessing obesity and health
December 15, 2018 - Self-guided, internet-based therapy platforms effectively reduce depression
December 15, 2018 - Organically farmed food has bigger climate impact than conventional food production
December 15, 2018 - Faster, cheaper test has potential to enhance prostate cancer evaluation
December 15, 2018 - Researchers study abnormal blood glucose levels of patients after hospital discharge
December 15, 2018 - Swedish scientists explore direct association of dementia and ischemic stroke deaths
December 15, 2018 - Study finds 117% increase in number of dementia sufferers in 26 years
December 15, 2018 - Eczema Can Drive People to Thoughts of Suicide: Study
December 15, 2018 - Link between neonatal vitamin D deficiency and schizophrenia confirmed
December 15, 2018 - Nurse denied life insurance because she carries naloxone
December 15, 2018 - Ritalin drug affects organization of pathways that build brain networks used in attention, learning
December 15, 2018 - Research pinpoints two proteins involved in creation of stem cells
December 15, 2018 - Gut bacteria may modify effectiveness of anti-diabetes drugs
December 15, 2018 - A new type of ‘painless’ adhesive for biomedical applications
December 15, 2018 - Early physical therapy associated with reduction in opioid use
December 15, 2018 - Breast cancer protection from pregnancy begins many decades later, study finds
December 15, 2018 - How often pregnant women follow food avoidance strategy to prevent allergy in offspring?
December 15, 2018 - Using machine learning to predict risk of developing life-threatening infections
December 15, 2018 - How imaginary friends could boost children’s development
December 15, 2018 - Folate deficiency creates more damaging chromosomal abnormalities than previously known
December 15, 2018 - Study provides new insights into molecular mechanisms underlying role of amyloid in Alzheimer’s disease
December 15, 2018 - For the asking, a check is in the mail to help pay for costly drugs
December 15, 2018 - UA scientists uncover biological processes leading to rare brain disorder in babies
December 15, 2018 - The largest database on industrial poisons
December 15, 2018 - ESMO Immuno-Oncology Congress showcases novel technologies set to benefit many cancer patients
December 15, 2018 - Ovid Therapeutics Announces Plans to Move into a Phase 3 Trial in Pediatric Patients Based on End-of-Phase 2 Meeting for OV101 in Angelman Syndrome
December 15, 2018 - Left ventricular noncompaction – Genetics Home Reference
December 15, 2018 - Children’s sleep not significantly affected by screen time, new study finds
December 15, 2018 - When should dementia patients stop driving? A new guidance for clinicians
December 15, 2018 - Researchers use INTEGRA’s VIAFLO 96/384 to streamline the experimental workflow
December 15, 2018 - Researchers discover protein involved in nematode stress response
December 15, 2018 - Cancer patients have greater risk of developing shingles, study shows
December 14, 2018 - UAlberta scientists identify biomarkers for detecting Alzheimer’s disease in saliva samples
December 14, 2018 - Study uncovers link between tube travel and spread of flu-like illnesses
KNAUER high-pressure dosing pumps contribute to the success of Grillo’s new MSA synthesis

KNAUER high-pressure dosing pumps contribute to the success of Grillo’s new MSA synthesis

image_pdfDownload PDFimage_print

The Berlin-based manufacturer of laboratory measuring instruments KNAUER Wissenschaftliche Geräte GmbH reported today that its high-pressure metering pumps played an important role in the development of the groundbreaking new manufacturing process of methanesulfonic acid (MSA) directly from methane and sulfur trioxide, which was successfully realized by researchers from Duisburg’s Grillo-Werke AG.

KNAUER dosing pumps. Credit: KNAUER

Currently methanesulfonic acid is already produced on an industrial scale. Its strongly acidic but non-oxidizing properties make it an interesting catalyst for many reactions in organic chemistry, especially in polymerizations.

Methanesulfonic acid is also used in electroplating and increasingly also in industrial cleaners, where it is used as a substitute for phosphoric, hydrochloric or sulfuric acid, because it is less harmful to the environment at comparable or greater efficacy than the mineral acids used previously.

The preparation of methanesulfonic acid is currently relatively expensive, because of multi-stage processes, which are partly dependent on toxic intermediates such as dimethyl disulfide.

The direct reaction of methane with sulfur trioxide would be the most obvious solution. Researchers worldwide have long been experimenting with the direct activation of methane.

As early as in the 1950s, a US patent was filed using sulfur trioxide, however, the achieved yields of methanesulfonic acid were low and the number of unwanted by-products high.

The Grillo researchers took a different approach than most other researchers. They relied on relatively mild temperatures below 100 degrees Celsius and pressures around 50 bar only.

The cunning in their process is an activator molecule that triggers sulfonation and can easily be re-synthesized from MSA and sulfuric acid in a secondary process. By the way, sulfuric acid serves as a solvent in the process.

A tricky part of the new MSA synthesis is the precise metering of sulfur trioxide (SO3) into the chemical reactor. Sulfur trioxide is only liquid in a narrow temperature range between 32°C and 44°C, reacts violently when in contact with water and chars most plastics very quickly. This means that it is very difficult to handle.

In search of suitable pumps for this task, we had already received a few cancellations from suppliers before turning to KNAUER. KNAUER also could not offer us a model off the shelf, but they were the only manufacturer to embark on a little development trip,”

said Dr. Timo Ott, Head of Product and Process Development for the chemistry branch at Grillo.

KNAUER high-pressure dosing pumps are based on HPLC technology and inherently provide high chemical resistance, excellent flow rate precision, and low pulsation.

However, pumping liquid sulfur trioxide required customization, especially with regard to plastic parts in the flow path. Another important prerequisite for the success was the powerful pump head heating offered by KNAUER in order to keep sulfur trioxide fluid even at low flow rates or necessary stops.

It is part of our company philosophy that we find beneficial solutions for our customers and together with them. We are particularly pleased that we were able to make our contribution to the success of Grillo’s MSA synthesis, which is, in my opinion, a research project of global importance,”

Dr. Christian Benkhäuser, Head of Hardware Development at KNAUER.

The special feature of the methanesulfonic acid production process developed by the Grillo researchers is that it works much more efficiently than previous processes and makes methane usable as a carbon source for sulfonation.

Certainly, with this process methane is becoming more important as a raw material. Wasting methane through flaring will hopefully become less common. Using biogas as a source of methane, the process can do without a fossil carbon source.

A recently published comparative life cycle assessment (LCA) study from the University of Zurich concludes that the new process has a three times smaller environmental impact than previous methods. Greenhouse gas emissions are 85% lower.

When the new manufacturing process for methanesulfonic acid will be introduced on an industrial scale, the environment will benefit of it,”

Dr. Biertümpel is Head of R & D in the Chemistry Branch of Grillo-Werke AG and the company’s Sustinability Officer

He is Head of R & D in the Chemistry Branch of Grillo-Werke AG and the company’s Sustainability Officer.

Something else is already clear today: It is worthwhile, as Grillo has done here, to leave the beaten path, it is also worthwhile, like KNAUER, not to say hastily “we can’t deliver that” and it is fun working together to develop new solutions.

Source:

https://www.knauer.net/en/usually-in-the-background-today-they-are-in-the-spotlight-knauer-high-pressure-dosing-pumps/n24318

Tagged with:

About author

Related Articles