Breaking News
February 20, 2019 - Newly licensed nurses work for long hours, also have a second paid job
February 20, 2019 - Physicists identify simple mechanism used by deadly bacteria to fend off antibiotics
February 20, 2019 - FDA Grants Priority Review to Genentech’s Personalized Medicine Entrectinib
February 20, 2019 - Exposure to chemicals before and after birth is associated with a decrease in lung function
February 20, 2019 - Neuroscientists reveal that simple brain region can guide complex feats of mental activity
February 20, 2019 - Study finds new link between food allergies and multiple sclerosis
February 20, 2019 - First gene therapy operation for macular degeneration is a success
February 20, 2019 - Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs
February 20, 2019 - FDA Approves Keytruda (pembrolizumab) for the Adjuvant Treatment of Patients with Melanoma with Involvement of Lymph Node(s) Following Complete Resection
February 20, 2019 - Study identifies brain cells that modulate behavioral response to threats
February 20, 2019 - Researchers take closer look at how viruses bind cells and cause infection
February 20, 2019 - Newly developed gene therapy helps decelerate aging process
February 20, 2019 - Study suggests new treatment strategy for deadly brain cancer
February 20, 2019 - Scientists develop unique hybrid implant that imitates bone structure
February 20, 2019 - Push-ups can be tailored to meet specific needs of individuals
February 20, 2019 - CVD Does Not Modify Depression-Mortality Link in Elderly
February 20, 2019 - Electrical activity early in fruit flies’ brain development could shed light on how neurons wire the brain
February 20, 2019 - Machine learning technique helps predict which asthma patients respond to corticosteroid therapy
February 20, 2019 - Self-reported sleep duration is a useful tool to measure sleep in children, study suggests
February 20, 2019 - T-cells play key role in how the body fights follicular lymphoma
February 20, 2019 - Study shows how 3D organization of genetic material helps perpetuate the species
February 20, 2019 - Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells
February 20, 2019 - Study reveals major sex differences in management of cardiovascular risk factors among U.S. adults
February 20, 2019 - Health Tip: Get Your Child to School on Time
February 20, 2019 - Shortcut strategy for screening compounds with clinical potentials for drug development
February 20, 2019 - Common acid reflux drugs tied to elevated risk for kidney disease
February 20, 2019 - Microbiome could be culprit when good drugs do harm
February 20, 2019 - Prenatal exposure to forest fires causes stunted growth in children
February 20, 2019 - Gene therapy restores hearing in mice with congenital genetic deafness
February 20, 2019 - First molecular test predicts treatment response for kidney cancer
February 20, 2019 - New method for improved visualization of single-cell RNA- sequencing data
February 20, 2019 - Researchers capture altered brain activity patterns of Parkinson’s in mice
February 20, 2019 - A possible blood test for detecting Alzheimer’s disease before symptoms show
February 20, 2019 - Primary care physicians associated with longevity, new research finds
February 19, 2019 - New study identifies many key lessons to establish sanctioned safe consumption sites
February 19, 2019 - Single CRISPR treatment can safely and stably correct genetic disease
February 19, 2019 - Multinational initiative to study familial primary distal renal tubular acidosis
February 19, 2019 - Breakthrough study highlights the promise of cell therapies for muscular dystrophy
February 19, 2019 - Subsymptom Threshold Exercise Speeds Concussion Recovery
February 19, 2019 - Midline venous catheters – infants: MedlinePlus Medical Encyclopedia
February 19, 2019 - Searching for side effects
February 19, 2019 - Humanity is all right, probably, although human extinction remains quite possible, researcher says
February 19, 2019 - Having Anesthesia Once as a Baby Does Not Cause Learning Disabilities, New Research Shows
February 19, 2019 - Anti-cancer immunotherapy could be used to fight HIV
February 19, 2019 - Customized Micropatterning for Improved Physiological Relevance
February 19, 2019 - Unique gene therapy approach paves new way to tackle rare, inherited diseases
February 19, 2019 - Activating gene that helps excite neurons reverses depression in male mice
February 19, 2019 - Science Puzzling Out Differences in Gut Bacteria Around the World
February 19, 2019 - Cells that destroy the intestine
February 19, 2019 - On recovery, vulnerability and ritual: An exhibit in white
February 19, 2019 - Scientific Duo Gets Back To Basics To Make Childbirth Safer
February 19, 2019 - COPD patients need more support when understanding new chest symptoms
February 19, 2019 - Using light-based method for production of pharmaceutical molecules
February 19, 2019 - Scientists find link between inflammation and cancer
February 19, 2019 - The High Cost Of Sex: Insurers Often Don’t Pay For Drugs To Treat Problems
February 19, 2019 - Hearing impairment associated with accelerated cognitive decline with age
February 19, 2019 - Researchers identify multiple genetic variants associated with body fat distribution
February 19, 2019 - Influenza and common cold are completely different diseases, study shows
February 19, 2019 - Scientists untangle how microbes manufacture key antibiotic compound
February 19, 2019 - Greater primary care physician supply associated with longer life spans
February 19, 2019 - HIV-1 protein suppresses immune response more broadly than thought
February 19, 2019 - Brain imaging indicates potential success of drug therapy in depressive patients
February 19, 2019 - For 2020 Dem Hopefuls, ‘Medicare-For-All’ Is A Defining Issue, However They Define It
February 19, 2019 - Specialized lung cells appear in the developing fetus much earlier than previously thought
February 19, 2019 - KU professor discusses promise of brain-computer interface to aid, restore communication
February 19, 2019 - Highly effective solution for detecting onset of aggregation in nanoparticles
February 19, 2019 - Early marker of cardiac damage triggered by cancer treatment identified
February 19, 2019 - Antidepressant drug could save people from deadly sepsis, research suggests
February 19, 2019 - CRISPR technology creates pluripotent stem cells that are ‘invisible’ to the immune system
February 19, 2019 - New study establishes how stress favors breast cancer growth and spread
February 19, 2019 - Midlife Systemic Inflammation Linked to Later Cognitive Decline
February 19, 2019 - Therapy derived from parasitic worms downregulates proinflammatory pathways
February 19, 2019 - Antimicrobial reusable coffee cups are less likely to become contaminated with bacteria, study shows
February 19, 2019 - Harnessing the evolutionary games played by cancer cells to advance therapies
February 19, 2019 - AHA News: Heart Transplant Survivor Gets Wedding Proposal at Finish Line
February 19, 2019 - HIV hidden in patients’ cells can now be accurately measured
February 19, 2019 - Research finds reasons for sudden cardiac death in patients with stable ischemic disease
February 19, 2019 - New protocol could help physicians to rule out bacterial infections in infants
February 19, 2019 - Women experiencing miscarriage should be offered treatment choices
February 19, 2019 - New protocol can help identify febrile infants at low risk for serious bacterial infections
First probabilistic atlas of thalamus nuclei to better understand the brain

First probabilistic atlas of thalamus nuclei to better understand the brain

image_pdfDownload PDFimage_print

A multidisciplinary study led by BCBL, a Basque research center, opens the door to the investigation of the structure and functions of human thalamic nuclei and their involvement in Alzheimer’s, dyslexia, epilepsy, Huntington’s and schizophrenia.

The thalamus is one of the most important structures in the human brain. Its nuclei distribute the information of the motor apparatus and of all the senses of the human being, with the sole exception of smell.

In addition, they are involved in many functions such as attention, awareness and perception. Its importance is such that, if injured, the individual in question can go into a coma.

Until now, whenever the activity of the thalamus was recorded, experts could only review it as a whole, without adequately discriminating between its nuclei, which are highly specific in their function and connections with the cerebral cortex.

Not being able to observe the activity of the thalamus according to its various specific nuclei, researchers were not able to examine their possible participation in any disease or in the behavior of healthy participants.

Now, a multidisciplinary study involving scientists from the Basque Centre on Cognition Brain and Language (BCBL), the University College London and the University of Castilla-La Mancha shows the first probabilistic atlas of the thalamus that can validly and reliably assess its different nuclei and specific functions.

This new atlas can identify the different thalamic nuclei with neuroimaging data, and in the future, it may be used for different diseases in which it is strongly involved. The results are published in Neuroimage.

Its probabilistic nature makes it the first tool of this type that can be more optimally adapted to the size and characteristics of the thalamus of any person.

“With this tool, it will be possible to advance in the clinical study of disorders such as dyslexia and diseases such as schizophrenia, epilepsy, Huntington’s and Alzheimer’s, among others,” as Kepa Paz-Alonso, BCBL researcher, has explained to Sinc.

Diagnose Alzheimer’s

In a first phase, the scientists took six human brains and subjected them to high-resolution magnetic resonance tests. Next, they laminated the 12 thalami (two per brain) in order to observe the types of neurons and to demarcate the 26 thalamic nuclei the atlas is divided into.

Once the atlas was created, the validation tests began. The researchers examined, among other things, a sample composed of 213 people with Alzheimer’s and 161 who were healthy. The probabilistic atlas made it possible to discriminate between people suffering from the disease and healthy people with 88% accuracy.

“The new atlas works well. It corresponds adequately with previous thalamic nucleus classifications, is time-accurate, adapts to multiple resonance images and can appropriately classify patients into those with and without Alzheimer’s,” says Juan Eugenio Iglesias, researcher at University College London.

Its role in dyslexia

Regarding dyslexia, Kepa Paz-Alonso claims that “thanks to this tool we’ll able to perform a more accurate and reliable examination of which thalamic nuclei are involved and how they functionally and structurally connect with different areas of the reading circuit, as well as with visual, auditory and Attention-deficit hyperactivity disorder (ADHD) areas involved in this disorder.”

“Many of the studies on dyslexia show a thalamic involvement; now we shall have a specific view of which nuclei are related. It will no longer be the thalamus as a whole, but specific nuclei, visual or auditory, and this is applicable to any function in which the nucleus and its connections are involved,” he concludes.

Source:

https://www.agenciasinc.es/en/News/A-new-atlas-of-the-thalamus-nuclei-to-better-understand-the-brain

Tagged with:

About author

Related Articles