Breaking News
February 22, 2019 - In the Spotlight: “The world is your oyster in geriatrics”
February 22, 2019 - Successful testing of multi-organ “human-on-a-chip” could replace animals as test subjects
February 22, 2019 - Analysis of cervical precancer shows decline in two strains of HPV
February 22, 2019 - Sugary stent eases suturing of blood vessels
February 22, 2019 - From surgery to psychiatry: A medical student reevaluates his motivations
February 22, 2019 - Is New App From Feds Your Answer To Navigating Medicare Coverage? Yes And No
February 22, 2019 - New pacemakers powered by heartbeats could reduce need for surgery
February 22, 2019 - The United States records highest drug overdose death rates
February 22, 2019 - Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy
February 22, 2019 - Vitamin D supplementation less effective in the presence of obesity, shows study
February 22, 2019 - Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
February 22, 2019 - An institutional effort to reduce the amount of opioids prescribed following lumbar surgery
February 22, 2019 - Failure to take statins leads to higher mortality rates | News Center
February 22, 2019 - New study explains why some patients report phantom sensations after limb amputation
February 22, 2019 - First motor-controlled heart valves implanted by Mainz University Medical Center
February 22, 2019 - Novel preclinical model mimics persistent interneuron loss seen in preterm infants
February 22, 2019 - Global health burden of glaucoma has increased, study reveals
February 22, 2019 - A holistic approach key to minimize treatment complexity in patients with interstitial lung disease
February 22, 2019 - 1 in 10 middle-aged Chinese adults are at high risk for heart disease, finds study
February 22, 2019 - More than half a million breast cancer patient’s lives saved by improvements in treatment
February 22, 2019 - Study finds no evidence that tougher policies prevent teenage cannabis use
February 22, 2019 - New blood test detects genetic disorders in fetuses
February 22, 2019 - Lower Self-Perception Observed in Children With Amblyopia
February 22, 2019 - Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
February 22, 2019 - Rare pulmonary defect prompts parents’ nationwide search for answers | News Center
February 22, 2019 - Lesbian and bisexual women at greater risk of being overweight, study finds
February 22, 2019 - UQ research may explain why vitamin D is essential for brain health
February 22, 2019 - Heart Attacks Rising Among Younger Women
February 22, 2019 - How your smartphone is affecting your relationship
February 22, 2019 - Orthopaedic surgeon receives prestigious award, $10 million grant | News Center
February 22, 2019 - New sepsis test could save thousands of lives
February 22, 2019 - Cervical cancer could be eradicated by 2100
February 21, 2019 - Sustained smoking cessation can lower risk of seropositive RA
February 21, 2019 - Thousands with chronic UTIs are not receiving the treatment they need
February 21, 2019 - Are teens getting high on social media? The surprising study seeking the pot-Instagram link
February 21, 2019 - Stanford expands biobank services | News Center
February 21, 2019 - Scientists identify link between drinking contexts and early onset intoxication among adolescents
February 21, 2019 - Strong social support may reduce cardiovascular disease risk in postmenopausal women
February 21, 2019 - Rapid expansion of interventions could prevent up to 13 million cases of cervical cancer within 50 years
February 21, 2019 - Motif Bio Receives Complete Response Letter From The FDA
February 21, 2019 - Researchers map previously unknown disease in children
February 21, 2019 - A skeptical look at popular diets: Going gluten-free
February 21, 2019 - Podcast: KHN’s ‘What The Health?’ How Safe Are Your Supplements?
February 21, 2019 - Factors associated with increased risk of developing surgical site infections
February 21, 2019 - Anticipatory signals in eye movements can help measure attentive capacity, learning with greater precision
February 21, 2019 - Study explores daily exposure to indoor air pollutants
February 21, 2019 - Evening exercise does not negatively affect sleep, may also reduce hunger
February 21, 2019 - Artificial intelligence technique can be used to identify alcohol misuse in trauma setting
February 21, 2019 - Overweight, obesity in adolescence associated with increased risk of renal cancer later in life
February 21, 2019 - BGU develops new AI platform for monitoring and predicting ALS progression
February 21, 2019 - Researchers discover a new promising target to improve HIV vaccines
February 21, 2019 - Brief Anesthesia in Infancy Does Not Mar Neurodevelopment
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Only half of GP practice buildings are fit for purpose
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
February 21, 2019 - Scientists can monitor brain activity to predict epileptic seizures few minutes in advance
February 21, 2019 - Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats
February 21, 2019 - ‘Apple-Shaped’ Body? ‘Pear-Shaped’? Your Genes May Tell
February 21, 2019 - Can we repair the brain? The promise of stem cell technologies for treating Parkinson’s disease
February 21, 2019 - Trump Plan To Beat HIV Hits Rough Road In Rural America
February 21, 2019 - PENTAX Medical introduces new electrosurgical and argon plasma coagulation platforms
February 21, 2019 - Trump plan to beat HIV hits rough road in rural America
February 21, 2019 - Eating blueberries every day could help decrease blood pressure
February 21, 2019 - ‘No Second Chances’ report calls for new measures to combat cardiovascular disease in Australia
February 21, 2019 - Mayo clinic researchers discuss local case studies of leprosy
February 21, 2019 - Scientists demonstrate key role of salt in allergic immune reactions
February 21, 2019 - Experts propose revising the criteria for diagnosis of Parkinson’s disease
February 21, 2019 - The med student and the machine
February 21, 2019 - Hey, Hey! Ho, Ho! Is Striking For School Nurses The Way To Go?
February 21, 2019 - Latest research encourages children to move out and learn through physical activity
February 21, 2019 - Proper oral hygiene and regular visits to dentist can promote heart health
February 21, 2019 - New, versatile technique for remote control of transplanted cells in Parkinson’s
February 21, 2019 - Why melanoma tumors in the brain may be worse?
February 21, 2019 - New project aims to improve lung disease care in Appalachia
February 21, 2019 - Drug increases melanin production in some people with albinism
February 21, 2019 - Over 1 in 3 adults miss the mark on protein, finds study
February 21, 2019 - CymaBay Therapeutics Announces Seladelpar Granted Breakthrough Therapy Designation by the FDA for the Treatment of Primary Biliary Cholangitis
UCR postdoctoral researcher wins prestigious NIH fellowship to study neural crest cells

UCR postdoctoral researcher wins prestigious NIH fellowship to study neural crest cells

image_pdfDownload PDFimage_print

Rebekah Charney, a postdoctoral researcher in the School of Medicine at the University of California, Riverside, has been awarded the prestigious Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship by the National Institute of Dental and Craniofacial Research of the National Institutes of Health.

The fellowship provides $177,000 to support Charney for three years to study the earliest events underlying the formation of neural crest cells.

Charney, who joined UCR in 2016 after receiving her doctoral degree at UC Irvine, explained that neural crest cells are a stem cell population unique to vertebrates. They migrate extensively throughout the developing embryo and form numerous derivatives, including neurons, pigment cells, and most of the bone and connective tissue in the face. Their improper development leads to multiple pathologies, including very common birth defects such as cleft lip and cleft palate and aggressive cancers such as neuroblastoma. However, major questions regarding the formation of neural crest cells remain unanswered.

“The molecular mechanisms underlying the earliest stages of neural crest cell formation remain uncharacterized, and this fellowship precisely aims to address this issue,” Charney said.

At UCR, Charney works in the laboratory of Martín I. García-Castro, an associate professor of biomedical sciences. Under the fellowship, Charney will be sponsored by Garcia-Castro and co-sponsored by Nicole zur Nieden, an associate professor in the Department of Molecular, Cell and Systems Biology. On the research project, Charney will also collaborate with Thomas Girke, an associate professor of bioinformatics at UCR.

“The research enabled by this fellowship brings together multiple research groups from across the UCR campus,” Charney said. “Together, we will integrate cutting-edge, genome-wide technology with embryology and stem cell biology in order to uncover the processes underlying key developmental decisions.”

García-Castro, her sponsor, emphasized that this is the first instance this fellowship has been awarded to a postdoctoral researcher performing work in the School of Medicine since accreditation. “Dr. Charney is an outstanding postdoctoral scholar who joined the Division of Biomedical Sciences with a glowing academic record,” he said. “Since her arrival, Rebekah has made great strides in her research implementing creative approaches to decipher the molecular interactions that initiate the formation of the neural crest, and has been very successful in crafting research funding applications and getting our research published.

“She is a smart, tenacious and tireless scientist who has already been recognized for her capacity and promise to lead a very productive research career in academia,” he continued. “At the same time, she has distinguished herself through service towards other members of the School of Medicine and UCR community, including envisioning and initiating workshops for postdoctoral scholars, and mentoring undergrads. I am thrilled to have her performing her postdoctoral work with us, and look forward to her continued positive impact on the UCR and scientific community.”

Charney’s work under this fellowship pioneers gene network studies of neural crest cell specification at previously uncharacterized early stages of development. Neural crest cells are thought to arise from committed ectoderm cells – one of the three germ layers that serve as the foundation for the tissues and organs that make up the adult body – in a region of the embryo called the neural plate border. Evidence from the García-Castro laboratory and others, however, suggest a much earlier origin of neural crest cells that is prior to the committed segregation of the germ layers.

“The goal of this work is to investigate how transcription factors function in regulating the earliest stages of neural crest formation,” Charney said. “Using CRISPR/Cas9 genome editing technology, select genes will be removed from human embryonic stem cells, and I will assess the effect of their loss on the formation of human neural crest cells. The role of these factors will also be tested in animal models of development, for example in the chick embryo.”

Charney noted that the immediate outcomes of the research are addressing key biological questions of neural crest formation and processes governing cell fate decisions during development. Understanding how neural crest cells are formed, and how this process is disrupted in a disease state, however, can help lead to novel therapeutics. Such projects are already underway in the García-Castro lab.

Tagged with:

About author

Related Articles