Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Taking painkillers during pregnancy is not responsible for asthma risk in children, study shows

Taking painkillers during pregnancy is not responsible for asthma risk in children, study shows

A study of almost 500,000 women indicates that taking paracetamol or other painkillers during pregnancy is not responsible for increasing the risk of asthma in children.

The research, which uses prescription data on painkillers, does support earlier findings that women taking paracetamol during pregnancy are more likely to have children who develop asthma. However, it also suggests that the painkillers are not the cause of this increase.

Researchers say their results, published in the European Respiratory Journal [1], should give women reassurance to take painkillers during pregnancy when they are prescribed by a doctor.

The research was led by Seif Shaheen, Professor of Respiratory Epidemiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK, in collaboration with Professor Catarina Almqvist and colleagues at the Karolinska Institute in Stockholm, Sweden.

Professor Shaheen was the first scientist to discover a link between paracetamol use during pregnancy and an increase in the risk of asthma in children. He said: “This link has now been seen in a number of studies in different countries, but until now there has been very little research on use of other painkillers during pregnancy and the subsequent risk of asthma in children.

“We also do not know whether the link between paracetamol and asthma is causal, in other words we don’t know whether paracetamol use in pregnancy per se is leading to more asthma, or whether some other factor is at play. The only way to be sure would be to carry out a trial where pregnant women are randomly assigned to either take paracetamol or not, but there are obvious ethical problems with this approach.”

To get around this problem, Professor Shaheen and his colleagues studied 492,999 Swedish mothers and their children. They looked at data on prescriptions for different types of painkillers during pregnancy and compared this with rates of asthma diagnosis in the children. They also looked at other data on the mothers, fathers, and any sisters and brothers.

They found that children born to mothers who had been prescribed paracetamol during pregnancy did have an increased risk of asthma, but the risk was similar when women had been prescribed opioids (such as codeine and tramadol) or migraine medication. For example, the increase in risk for asthma at five years of age was 50% for paracetamol, 42% for codeine and 48% for migraine medication.

Professor Shaheen explained: “These different types of painkillers work in different ways, but our results suggest that when women are prescribed them during pregnancy, the associated increases in children’s asthma rates are fairly similar for all types.

“Our interpretation of this is that it’s less likely that the drugs are responsible for the asthma. Instead, it seems more likely that another factor that we haven’t measured is linked to use of these drugs and to asthma risk. For example, women who are taking prescribed painkillers are likely to be suffering from chronic pain.

“Severe pain, and the stress that it causes, have profound effects on the body, including on levels of some hormones, and there is evidence for a link between high levels of mothers’ stress in pregnancy and increased risk of asthma in the offspring.

“If that’s the case then it’s important to manage chronic pain during pregnancy and we should not avoid prescribing painkillers to pregnant women when they are needed. Similarly, women should feel reassured that infrequent use of paracetamol in pregnancy, which is commonly obtained over the counter and is the recommended painkiller to take in pregnancy, is unlikely to cause asthma in their offspring.

“Our study also suggests that a clinical trial of paracetamol during pregnancy, which poses many challenges, is probably not worthwhile.”

Professor Tobias Welte, from Hannover University, Germany, is President of the European Respiratory Society and was not involved in the study. He said: “Paracetamol is the most commonly used painkiller in pregnancy, so it is important to know whether it might be a cause of childhood asthma. Previous research suggested these two were linked in some way, but this large study suggests that this may not be a simple cause and effect relationship, and this means that paracetamol should be prescribed to pregnant women who need it. However, we also need to continue studying the complex reasons why so many children develop asthma.”

Source:

https://www.europeanlung.org/en/

About author

Related Articles