Strength of brain network connections predicted positive outcomes (red) and negative outcomes (blue). Credit: Yale University By measuring the strength of connections between different brain networks, Yale researchers successfully predicted who would abstain from cocaine during treatment, they report Jan. 4 in the American Journal of Psychiatry. The machine-learning technique developed at Yale—called connectome-based predictive […]Continue Reading ...
Cocaine is a highly addictive psychostimulant that induces complex molecular, cellular and behavioral responses. Despite various approaches and years of pre-clinical studies, effective, mechanism-based therapies to assist with cocaine misuse and dependence are still sorely lacking. Although it is well understood that elevations of the brain chemical dopamine play a critical role in cocaine’s ability […]Continue Reading ...
Credit: CC0 Public Domain People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex. These findings from two recent studies at the University of Zurich indicate that levamisole could have a toxic effect on the brain. Drug-checking programs should therefore be expanded, argue the […]Continue Reading ...
WEDNESDAY, Oct. 31, 2018 — Fentanyl, a powerful and dangerous synthetic opioid, is now showing up in crack cocaine and causing life-threatening overdoses. Within a recent four-day period, a Philadelphia hospital treated 18 patients for an apparent opioid overdose even though they’d only been smoking crack cocaine, researchers report. “None of them had intended to […]Continue Reading ...
A pile of cocaine hydrochloride. Credit: DEA Drug Enforcement Agency, public domain A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction. The study, performed by researchers at Rutgers University, New Jersey, was published […]Continue Reading ...
August 9, 2018 Exercise can help prevent relapses into cocaine addiction, according to new research led by the University at Buffalo’s Panayotis (Peter) Thanos, PhD. “Cocaine addiction is often characterized by cycles of recovery and relapse, with stress and negative emotions, often caused by withdrawal itself, among the major causes of relapse,” says Thanos, senior […]Continue Reading ...
August 3, 2018 Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina (MUSC) in an article published online in June 2018 by Addiction Biology. “We discovered that […]Continue Reading ...
July 17, 2018 Childhood adversity permanently alters the peripheral and central immune systems, increasing the sensitivity of the body’s immune response to cocaine, reports a study by researchers at the IRCCS Santa Lucia Foundation and University of Rome “La Sapienza”, Italy. The study, published in Biological Psychiatry, showed that exposure to psychosocial stress early in […]Continue Reading ...
Researchers at The University of Texas at San Antonio have revealed significant insight into cocaine addiction, a phenomenon which has grown significantly in the United States since 2015. Now new data by UTSA shows how the release of the neurotransmitter dopamine changes when working for cocaine. Our brains naturally release dopamine to reward us for […]Continue Reading ...
THURSDAY, Nov. 8, 2018 — Cocaine is often cut with the anti-worming drug levamisole — and the combination is linked to brain damage, Swiss researchers report. “We can assume from our findings that it is not just cocaine that changes the brain, but that the adulterant levamisole has an additional harmful effect,” said research leader […]Continue Reading ...
According to the figures from Centre for Disease Prevention and Control (CDC) there has been a sharp up-rise in the cocaine overdose over the last two years. The Drug Enforcement Administration (DEA) has also said there has been an inflow of Columbian cocaine into the United States. The report from CDC states that over the […]Continue Reading ...
A study in Biological Psychiatry identifies a critical role of the orexin system in the expression of an addicted state in rats A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction. The study, […]Continue Reading ...
Ana Clara Bobadilla, Ph.D. is first author on the Addiction Biology article. Credit: Sarah PackMedical University of South Carolina Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South […]Continue Reading ...
July 27, 2018 Researchers reveal that bile acids from the gut reduce cocaine’s effects in the brain, which may offer drug addiction treatment. Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by […]Continue Reading ...
July 12, 2018 Cocaine can have a devastating effect on people. It directly stimulates the brain’s reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors. Alban de Kerchove d’Exaerde from the Université Libre de Bruxelles, Belgium, and his colleagues have now uncovered that a gene called […]Continue Reading ...
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