THURSDAY, Nov. 8, 2018 — Cocaine is often cut with the anti-worming drug levamisole — and the combination is linked to brain damage, Swiss researchers report. “We can assume from our findings that it is not just cocaine that changes the brain, but that the adulterant levamisole has an additional harmful effect,” said research leader […]Continue Reading ...
WEDNESDAY, Oct. 31, 2018 — Fentanyl, a powerful and dangerous synthetic opioid, is now showing up in crack cocaine and causing life-threatening overdoses. Within a recent four-day period, a Philadelphia hospital treated 18 patients for an apparent opioid overdose even though they’d only been smoking crack cocaine, researchers report. “None of them had intended to […]Continue Reading ...
A pile of cocaine hydrochloride. Credit: DEA Drug Enforcement Agency, public domain A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction. The study, performed by researchers at Rutgers University, New Jersey, was published […]Continue Reading ...
August 9, 2018 Exercise can help prevent relapses into cocaine addiction, according to new research led by the University at Buffalo’s Panayotis (Peter) Thanos, PhD. “Cocaine addiction is often characterized by cycles of recovery and relapse, with stress and negative emotions, often caused by withdrawal itself, among the major causes of relapse,” says Thanos, senior […]Continue Reading ...
August 3, 2018 Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina (MUSC) in an article published online in June 2018 by Addiction Biology. “We discovered that […]Continue Reading ...
July 17, 2018 Childhood adversity permanently alters the peripheral and central immune systems, increasing the sensitivity of the body’s immune response to cocaine, reports a study by researchers at the IRCCS Santa Lucia Foundation and University of Rome “La Sapienza”, Italy. The study, published in Biological Psychiatry, showed that exposure to psychosocial stress early in […]Continue Reading ...
June 28, 2018 Unlike with alcohol or nicotine, there is not a pharmacological option available to individuals addicted to cocaine to help them stop using the drug. However, researchers at the University of Alabama at Birmingham believe the tool to help individuals treat their addiction may very well exist. Researchers in the School of Public […]Continue Reading ...
According to the figures from Centre for Disease Prevention and Control (CDC) there has been a sharp up-rise in the cocaine overdose over the last two years. The Drug Enforcement Administration (DEA) has also said there has been an inflow of Columbian cocaine into the United States. The report from CDC states that over the […]Continue Reading ...
A study in Biological Psychiatry identifies a critical role of the orexin system in the expression of an addicted state in rats A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction. The study, […]Continue Reading ...
Ana Clara Bobadilla, Ph.D. is first author on the Addiction Biology article. Credit: Sarah PackMedical University of South Carolina Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South […]Continue Reading ...
July 27, 2018 Researchers reveal that bile acids from the gut reduce cocaine’s effects in the brain, which may offer drug addiction treatment. Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by […]Continue Reading ...
July 12, 2018 Cocaine can have a devastating effect on people. It directly stimulates the brain’s reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors. Alban de Kerchove d’Exaerde from the Université Libre de Bruxelles, Belgium, and his colleagues have now uncovered that a gene called […]Continue Reading ...
May 31, 2018 A study in Biological Psychiatry has identified unique genetic changes in the brain’s reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal. The findings reveal important information on how cocaine addiction reprograms gene expression and provide insight into the molecular basis […]Continue Reading ...
The green fluorescent ‘dots’ above show where Exendin-4, an FDA-approved drug used to treat diabetes and obesity, ends up in the brain. The drug activates receptors for glucagon-like peptide 1 or GLP-1, a hormone that reduces food intake. The blue and red coloring indicate neurons and astrocytes, respectively. Credit: University of Pennsylvania Cocaine and other […]Continue Reading ...
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