Cancer presents an ongoing challenge for physicians, particularly in the diagnosis and treatment of the disease. This is, amongst other things, due to tumor heterogeneity. A team of scientists from the Helmholtz Zentrum Muenchen, the Juelich Research Center, the Technical University of Munich and the Heinrich Heine University Duesseldorf has now shown that harmless purple […]Continue Reading ...
Developed by researchers at the University of Turku in Finland, an immunotherapeutic antibody therapy re-educates macrophages to activate passivated cytotoxic T cells to kill cancer. The antibody therapy prevented the growth of tumors in several mouse models. The development of the therapy has now progressed to patient testing in a phase I/II clinical trial. One […]Continue Reading ...
Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer Center of the University of Pennsylvania say they’ve identified how to fuel macrophages with the energy needed to attack and eat cancer cells. It is well established that macrophages […]Continue Reading ...
HIV-1 Virus. Credit: J Roberto Trujillo/Wikipedia In a proof-of-principle study, researchers at Johns Hopkins report that a certain liver immune cell called a macrophage contains only defective or inert HIV-1 copies, and aren’t likely to restart infection on their own in HIV-1-infected people on long-term antiretroviral therapy (ART). The study, the investigators say, strongly suggest […]Continue Reading ...
One of the main characteristics of atherosclerosis is the accumulation of lipids in the intimal layer of the arterial wall. In atherosclerotic plaques, phagocytic cells, such as macrophages, engulf atherogenic low-density lipoprotein (LDL) particles, but are unable to process them, and thus become foam cells, having cytoplasm packed with lipid droplets. Foam cells are characterized […]Continue Reading ...
Hereditary pulmonary alveolar proteinosis (herPAP) is a rare disease characterized by the slow build-up of lipo-protein material in the lungs due to the failure of highly specialized cells called macrophages, which usually eat away this material from the pulmonary air-space. On August 9 in the journal Stem Cell Reports, researchers in Germany demonstrate that a […]Continue Reading ...
August 7, 2018 Hookworms infect nearly 430 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot. The body’s immune system is critical to attacking the hookworm, resulting in damage to the body’s tissues. But just how this damage takes place — and what helps repair it — […]Continue Reading ...
July 28, 2018 When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a common class of drugs used to treat […]Continue Reading ...
During development in the womb, immune cells called macrophages go to the kidneys, and they remain there for life. Understanding the possible healing role for these macrophages after kidney damage may be crucial to helping treat patients who suffer acute kidney injury. Acute kidney injury, or AKI, is a devastating condition that develops in two-thirds […]Continue Reading ...
Many factors affect cancer treatment outcome, such as the size and location of the tumor, availability of effective treatments, and timing of intervention. But some cancers are so aggressive that outcome is poor, even after early diagnosis and chemotherapy. Researchers have focused their attention on trying to understand what makes some cancers less treatable than […]Continue Reading ...
An enzyme known to help our liver get rid of ammonia also appears to be good at protecting our retina, scientists report. Our retina, which captures light and converts it into neural signals that go to the brain so we can see, can be damaged or destroyed by conditions that reduce blood flow like diabetes, […]Continue Reading ...
Macrophages are not just the vacuum cleaners of the immune system. They also support other cells. These long-lived macrophages in the intestines of mice (in green) make contact with the nerve cells of the gastrointestinal tract (in red). The macrophages provide growth factors for the nerve cells. The nerve cells die off without the macrophages. […]Continue Reading ...
Macrophages are specialized immune cells that destroy bacteria and other harmful organisms. KU Leuven scientists, Belgium, have come to the surprising conclusion that some macrophages in the intestines of mice can survive for quite some time. Most importantly, these long-lived macrophages are vital for the survival of the nerve cells of the gastrointestinal tract. This […]Continue Reading ...
July 27, 2018 Arteries such as the aorta actively transport oxygenated blood, nutrients and cells throughout the body to keep our tissues functioning normally. Damage to the arteries can result in life-threatening cardiovascular diseases. A major type of damage involves hardening or stiffening of the vessel walls. This phenomenon, known as arterial stiffness, results in […]Continue Reading ...
Washington University researchers have found that immune cells called macrophages can trigger smooth muscle contractions in the intestinal tract, independent of nerve cells. The research in mice suggests that targeting a receptor (green) on macrophages (red) holds potential for treating chemotherapy-induced diarrhea. Credit: Center for the Study of Itch Some 50 to 80 percent of […]Continue Reading ...
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